SystImmune
Posted 2w ago

Research Associate/Senior Research Associate, Protein Engineering

SystImmune
Redmond, Washington, United States
$60k-$85k/yrOnsiteFull Time
Responsibilities
  • designing libraries
  • generating libraries
  • selecting leads
Requirements
  • BS or MS in a related field,1+ year industrial drug development experience,1+ year hands-on display or genomics experience,cell culture and molecular biology skills,NGS and flow cytometry experience preferred
Technical tools mentioned
NGS sequencingflow cytometryFACS

Job description

SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Redmond, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials. SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company's success.

We are seeking a skilled Research Associate/Senior Research Associate with experience in utilizing display technologies (yeast/phage) in protein engineering, directed evolution, or binder discovery.  This is a laboratory-based role that will be supporting protein engineering efforts in discovering novel binders and novel protein leads/scaffolds.  The position will join a growing protein engineering team in an innovative organization and reports to the Director of Protein Engineering.  The ideal candidate will be a quick learner with a broad experience set with direct expertise in a display technology and/or an adjacent field including but not limited to high throughput molecular biology, antibody/binder discovery, and protein engineering.
Industry experience in biologics drug development is required. 

Key Responsibilities
  • Design and generate display libraries with guidance from experimental and computational data.  This includes library preparation and QC, NGS sequencing, and flow cytometry-based lead selection. 
  • Culture engineered yeast for use in lead selection and sorting. 
  • Construct/convert immune-based repertoires from immunized animal sources for use in both discovery and protein engineering campaigns.   
  • Troubleshoot technical issues and implement solutions to optimize lead molecules, ensuring data quality and integrity throughout the discovery and optimization process. 

Required Qualifications
  • BS or MS in immunology, biochemistry, molecular biology, structural biology, or a related field. Title and compensation commensurate with experience
  • 1+ year industrial drug development experience
  • 1+ years of hands-on experience in an aspect of display campaigns or genomics approaches in protein design or directed evolution projects  
  • Demonstrated proficiency in one or more of the following workstreams: library design and generation, display-based selection, and assay development 
  • Strong molecular biology background and experience.  Library generation experience is a plus 
  • Cell culture experience (bacterial, mammalian, and/or yeast) is required 
  • Experience in FACS-based selection and sorting preferred 
  • Excellent problem-solving skills, with the ability to troubleshoot technical issues and implement effective solutions 
  • Outstanding organizational skills, attention to detail, and the ability to manage multiple projects simultaneously in a fast-paced environment 
  • Strong communication and interpersonal skills, with the ability to collaborate effectively within multidisciplinary teams 
  • On-site work is mandatory 

Work Environment
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.  
This individual will work in cell culture laboratory alongside other scientists and in a standard business office with desktop business equipment and a moderate noise level.   

Physical Demands
The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job.  
While performing the duties of this job, the employee is regularly required to sit for long periods of time. This individual must be able to operate standard laboratory and business equipment. 


Compensation and Benefits:
The expected base salary range for this position is $60,000 - $85,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s level qualifications, experience, and skills.
While most offers typically fall within the low to mid-point of the range, we may extend an offer toward the higher end for exceptional candidates whose background and expertise exceeds the requirements of the role.
 
SystImmune is a leading and well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. SystImmune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.
 
We offer an opportunity for you to learn and grow while making significant contributions to the company’s success.
 
SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.

About SystImmune

Developing multi-specific antibodies and antibody-drug conjugates for cancer therapy

Year founded
2014
Employees
104
Organization type
Private
Latest investment
Raised $800.00M Corporate Round (2023) — led by Bristol Myers Squibb
Headquarters
US

Similar jobs

Research Associate roles near Redmond, Washington
4d
Save
Mark Applied
Hide
Research Associate I – Neurosurgery & Behavior
Seattle or Seattle
$54k-$66k/yr HybridFull Time
Allen Institute
Allen Institute: Non-profit organization conducting large-scale open science and bioscience research.
Bachelor's degree in neuroscience, biology, or related field; rodent-handling experience; ability to learn mouse surgery; and basic knowledge of mouse genetics and anatomy.
Microsoft Office, Microsoft Access, LIMS, LabTracks
6d
Save
Mark Applied
Hide
Research Associate III (Part-Time)
Seattle, Washington, United States
$31-$45/hr OnsitePart Time, Temporary
InBios International
InBios International: Develops and manufactures diagnostic tests for infectious diseases.
2+ YOEMaster's degree in a related scientific discipline, 2+ years of industry experience, molecular diagnostics expertise, PCR and qPCR experience, nucleic acid extraction, sequence analysis, and BSL-2 pathogen experience.
PCR, qPCR, automated nucleic acid extraction systems, PCR automation, robotics, mammalian cell culture, FDA EUA, 510K, PPE, FSA, 401(k), Roth IRA
1w
Save
Mark Applied
Hide
Research Associate
Seattle, Washington, United States
$81k-$95k/yr OnsiteFull Time
AltPep
AltPep: Develops disease-modifying treatments and diagnostics for amyloid diseases.
Bachelor's degree in a relevant science field, substantial hands-on wet-lab experience, strong bench techniques, quantitative analysis, meticulous documentation, and adaptability. 2+ years post-graduate lab experience preferred.
1w
Save
Mark Applied
Hide
Research Associate I, Formulation
Everett, Washington, United States
$22-$30/hr OnsiteFull Time
Altasciences
Altasciences: Provides clinical research and manufacturing services for drug development.
0+ YOEPrepare and dispense formulations, receive and document test materials, follow GLP, operate lab equipment; BS in scientific discipline or relevant experience; 0-1 years in regulated environment; Microsoft Office proficiency.
Microsoft Office
1mo
Save
Mark Applied
Hide
Research Associate I/II – Molecular Biology & Nanotechnology
Seattle, Washington, United States
$27-$34/hr OnsiteFull Time
Digital Biotechnologies
Digital Biotechnologies: Developing advanced sequencing technology for clinical diagnostics.
1+ YOEBachelor's degree in a relevant science,1+ years hands-on lab experience,expertise in microscopy,nanomaterials,molecular biology techniques,strong record keeping,analytical and troubleshooting skills,excellent communication.
Python, MATLAB, ImageJ, Electronic Laboratory Notebooks (ELNs), Atomic Force Microscopy (AFM), Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM), PCR, Next-generation sequencing (NGS)
1mo
Save
Mark Applied
Hide
Research Associate, Gene Engineering and Delivery
Seattle, Washington, United States
$76k-$92k/yr OnsiteFull Time
Bristol Myers Squibb
Bristol Myers SquibbNew York Stock Exchange: BMY: Develops and distributes innovative medicines for serious diseases.
2+ YOEDesign and clone DNA constructs, perform mammalian cell culture, transfection/transduction, viral vector production and characterization; Bachelor’s degree in a scientific discipline and ~2 years hands-on research experience preferred.
1mo
Save
Mark Applied
Hide
Research Associate, Gene Engineering and Delivery
Seattle, Washington, United States
$76k-$92k/yr OnsiteFull Time
Bristol Myers Squibb
Bristol Myers SquibbNYSE: BMY: Develops and manufactures innovative prescription biopharmaceutical medicines.
2+ YOEBachelor's degree in a scientific discipline, 2+ years hands-on molecular biology and cell culture experience preferred; skills in cloning, PCR, transfection, viral vector production, data analysis, and strong communication.
1mo
Save
Mark Applied
Hide
Senior Research Associate - Analytical Development
Seattle, Washington, United States
HybridFull Time
BrainChild Bio: Develops CAR-T cell therapies for central nervous system tumors.
2+ YOEBA/BS in a biological science, 2+ years industry lab experience, proficiency with ddPCR/qPCR and nucleic acid handling, ELN use, Microsoft Excel and Prism, assay development and cross-functional collaboration.
Microsoft Excel, Prism, ELN