5d
Save
Mark Applied
Hide
Senior Manager: Manufacturing - Downstream Bulk Drug Substance
Holly Springs, North Carolina, United States
$136k-$184k/yr OnsiteFull Time
2+ MgmtLeadership of 24/7 downstream purification manufacturing, commissioning/qualification experience, workforce planning, training, GMP compliance, and technical problem solving; managerial experience required.
3w
Save
Mark Applied
Hide
Specialist Manufacturing – Process Owner - Upstream / Downstream / Services
Holly Springs, North Carolina, United States
$108k-$146k/yr OnsiteFull Time
2+ YOETechnical expertise in upstream/downstream/manufacturing services, GMP experience, MES/EBR familiarity, process ownership, troubleshooting, SOP authoring; degree and biotech operations experience required (varies by degree).
Manufacturing Execution Systems (MES), Electronic Batch Record (EBR)
1mo
Save
Mark Applied
Hide
Senior Manager Process Engineering - Bulk Drug Substance - Downstream
Holly Springs, North Carolina, United States
$149k-$201k/yr OnsiteFull Time
2+ MgmtRequires substantial engineering and leadership experience to manage process/equipment engineering for downstream biologics manufacturing, support commissioning/qualification, ensure cGMP compliance, and lead continuous improvement.
Chromatography, Viral Filtration, UFDF, CIP/SIP
3d
Save
Mark Applied
Hide
Front Line Manufacturing Manager (Bulk Drug Substance - Downstream) - Night Shift
Holly Springs, North Carolina, United States
$106k-$144k/yr OnsiteFull Time
3+ YOEManagerial manufacturing role in downstream biologics production; requires manufacturing/operations experience, prior people leadership, strong cGMP and regulatory knowledge, and technical/process expertise.
Microsoft, EBR/MES, Delta V, Electronic quality systems
4d
Save
Mark Applied
Hide
Technical Application Specialist, Downstream Biopharm Materials - Research Triangle Park
Burlington or Research Triangle Park or North Carolina or South Carolina or Georgia or Florida or Texas
$86k-$178k/yr FieldFull Time
5+ YOEBachelor's in chemical engineering/biochemistry,5+ years biopharma process development experience,2+ years customer-facing technical/commercial experience,knowledge of upstream/downstream operations and regulatory impact,excellent communication and presentation skills.
CRM
4d
Save
Mark Applied
Hide
Digital Operations Associate, Downstream
Holly Springs, North Carolina, United States
OnsiteFull Time
Supports deployment and sustainment of digital manufacturing tools in a cGMP environment; foundational cGMP knowledge, attention to detail, ability to follow procedures, and willingness to support 24/7 operations.
Manufacturing Execution Systems (MES), PI, DCS, PLC, LIMS, ERP, electronic logbooks, data historian
4d
Save
Mark Applied
Hide
Technical Application Specialist, Downstream Biopharm Materials - Research Triangle Park (301991)
Burlington or Research Triangle Park or South Carolina or Georgia or Florida or Texas
$86k-$178k/yr HybridFull Time, Part Time
5+ YOEBachelors in chemical engineering/biochemistry,5+ years biopharma process experience,2+ years customer-facing technical/commercial experience,knowledge of upstream/downstream operations and regulatory impact,excellent communication and presentation skills.
1mo
Save
Mark Applied
Hide
Process Engineer - Solution Prep, Upstream, and Downstream
Holly Springs, North Carolina, United States
$88k-$119k/yr OnsiteFull Time
2+ YOEDegree in engineering (multiple education/experience alternatives) plus 2+ years engineering experience (min). Must support GMP biopharmaceutical commissioning, qualification, troubleshooting, and 24/7 operational coverage; up to 10% travel.
Data Analytics, Root Cause Analysis (RCA), Statistical Process Control (SPC), Six Sigma, Predictive Maintenance
1mo
Save
Mark Applied
Hide
Senior Process Engineer - Solution Prep, Upstream, and Downstream
Holly Springs, North Carolina, United States
$115k-$156k/yr OnsiteFull Time
4+ YOEQualifications include advanced degree or equivalent experience (Doctorate OR Master’s +2 yrs OR Bachelor’s +4 yrs OR Associate +8 yrs OR HS +10 yrs). Preferred: chemical/mechanical engineering, 6+ yrs relevant with 5+ yrs in biopharma ops, GMP equipment experience, tech transfer, commissioning/qualification, regulated environment experience, and o...
weigh and dispense equipment, solution preparation vessels, cell culture reactors, centrifugation, chromatography, viral filtration skids, UFDF skids, autoclaves, clean in place (CIP) systems, clean steam, water for injection
3w
Save
Mark Applied
Hide
Specialist Manufacturing New Product Introduction (NPI):Downstream Readiness
Holly Springs, North Carolina, United States
$108k-$146k/yr OnsiteFull Time
2+ YOEBiologics manufacturing background with cross-functional project management, GMP experience, technical writing, and 2+ years biotechnology operations experience (varies by degree).
1mo
Save
Mark Applied
Hide
Front Line Manufacturing Manager (Bulk Drug Substance - Downstream) - Day Shift
Holly Springs, North Carolina, United States
$106k-$144k/yr OnsiteFull Time
Managerial manufacturing role in cGMP drug substance production; requires relevant degree-plus-experience pathway or extensive manufacturing experience and prior people management; strong leadership, technical, and regulatory knowledge.
Microsoft, EBR/MES, Delta V, Electronic quality systems
1w
Save
Mark Applied
Hide
Process Validation Engineer
Raleigh or Durham
$70-$80/hr OnsiteContract
5+ YOEBS in engineering, 5+ years pharmaceutical/biotech GMP process or manufacturing engineering experience, hands-on upstream/downstream/clean utilities experience, cGMP knowledge, able to work onsite in Raleigh-Durham.
3d
Save
Mark Applied
Hide
Sr. Global Market Manager, Molecular
Salt Lake City or Raleigh or Durham or St. Louis
$121k-$182k/yr HybridFull Time
7+ YOE3+ MgmtBachelor's degree,7+ years in marketing/commercial roles with 3+ years downstream marketing,experience in diagnostics preferred,advanced MS Office skills,global cross-functional collaboration and travel (~30%).
Microsoft Outlook, Microsoft Teams, Microsoft Word, Microsoft Excel
1w
Save
Mark Applied
Hide
Manufacturing Associate I / II
Durham, North Carolina, United States
OnsiteFull Time
0+ YOEPerform GMP upstream or downstream cell culture production, follow SOPs and batch records, maintain cGMP and 5S, operate and maintain bioprocess equipment, follow aseptic technique, and document per GDP.
Microsoft Office, ERP, EDMS
1mo
Save
Mark Applied
Hide
Senior Manufacturing Operator
Sanford or Princeton or Mississauga or California or North Carolina
$33-$45/hr OnsiteFull Time
4+ YOEHands-on GMP biopharmaceutical manufacturing experience executing upstream/downstream processes, equipment commissioning/validation, cGMP and data integrity adherence, PCS/MES/ERP/LIMS proficiency, SOP development, troubleshooting, and training.
ERP, LIMS, MES, PCS, QMS, BMS, DeltaV, Unicorn, Ignition, Microsoft Office
1mo
Save
Mark Applied
Hide
Senior Manufacturing Systems Engineer – DeltaV Batch
Holly Springs, North Carolina, United States
$137k-$185k/yr OnsiteFull Time
2+ YOELead automation engineering projects for upstream/downstream/solution prep using Emerson DeltaV DCS; support commissioning/qualification, 24/7 operational support, troubleshooting, SOP/cGMP documentation, and mentor engineering staff.
Emerson DeltaV, Distributed Control System (DCS), OPC, Foundation Fieldbus, Profibus
3w
Save
Mark Applied
Hide
Operational Excellence Lead: BioVectra
Boston or Folsom or Philadelphia or Wilmington or Kirkland or North Carolina or Colorado or Texas or California or Durham or Cedar Creek or Frederick or Canada or Ontario or Greater Toronto Area or Canada or Prince Edward Island or Nova Scotia or New Brunswick or Charlottetown
$147k-$275k/yr FieldFull Time
10+ YOEBachelor's or master's in life science/chemical/biochemical engineering,10+ years in GMP/regulated production with microbial fermentation and downstream purification, hands-on production-system deployment experience, strong problem-solving and coaching skills.
MES, Electronic batch records, shop-floor data systems, AI
4d
Save
Mark Applied
Hide
Senior Process Engineer, MSAT
Durham, North Carolina, United States
OnsiteFull Time
8+ YOEBachelor's in biochemistry/chemical engineering or related; 8+ years pharmaceutical/biologics experience with cGMP readiness and technology transfer; upstream/downstream expertise; monoclonal antibody process experience; FMEA risk assessment experience; eligible to work in the US.
FMEA