Bioinformatics Engineer – Single-cell & Bulk Transcriptomics

Cognizant Technology Solutions is seeking for Techno Functional SME with core background in Bioinformatics, Transcriptomics and GCP Cloud who could join in our team of IT professionals in a permanent role.

Role: Bioinformatics Engineer – Single-cell & Bulk Transcriptomics

Skill set: Bioinformatics, scRNA-seq, Bulk RNA-seq, GCP, Pipeline Engineering

Must have skill:

·       Experience processing scRNA-seq and bulk RNA-seq datasets (10x Genomics, SMART-seq)

·       Workflows: Cell Ranger, STARsolo, Kallisto Bustools, Alevin/Alevin Fry, Seurat/Scanpy

·       Bulk RNA-seq tools: STAR, HISAT2, Salmon, Kallisto, FastQC, Picard, DESeq2, edgeR, limma

·       Pipeline capabilities: FASTQ/BCL ingestion, QC, trimming, alignment/pseudo-alignment

·       Gene/transcript quantification, normalization, batch correction and feature selection

·       Experience in clustering, dimensionality reduction, DE analysis and trajectory inference

·       Pathway enrichment, gene signature identification and biological interpretation

·       Integration with metadata (cell types, clusters, experimental conditions)

·       Experience integrating immune repertoire pipelines (CDR extraction, clonotype metrics)

·       Python/R expertise and workflow engines (Nextflow, Snakemake, Cromwell)

·       Containerization (Docker/Singularity) and GCP services (BigQuery, GCS, Compute Engine, Composer, Pub/Sub)

·       CI/CD implementation for pipeline automation

Good to have:

·       Experience with transcriptomics repositories (GEO, ArrayExpress, Human Cell Atlas)

·       Infrastructure as Code (Terraform)

·       Experience in enterprise-scale bioinformatics platforms

Responsibilities:

·       Design and implement pipelines for transcriptomics data processing and integration

·       Perform clustering, trajectory, differential expression and pathway analysis

·       Generate standardized outputs compatible with Seurat, Scanpy, DESeq2, edgeR

·       Integrate transcriptomics with immune repertoire datasets

·       Develop scalable, modular pipelines with audit logging

·       Deploy pipelines in GCP using containerized workflows

·       Implement CI/CD for reproducible pipeline execution

·       Validate dataset integrity and biological correctness

·       Harmonize metadata and map to enterprise models

·       Create documentation and support demos/workshops

Cognizant US Corporation is an Equal Opportunity Employer Minority/Female/Disability/Veteran. If you require accessibility assistance applying for open positions in the US, please send an email with your request to [email protected]