15 associate principal scientist jobs at 10 companies in Massachusetts
5d
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Associate Principal Scientist, Clinical Research
Rahway or Boston or West Point or South San Francisco
$142k-$224k/yr HybridFull Time
3+ YOELife sciences degree plus 3–11+ years related experience, including Phase 1 or Phase 2–3 clinical trials. Requires vaccine program management, GCP/ICH knowledge, scientific writing, project leadership, data evaluation, and mentoring.
6d
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Associate Principal Scientist, Health Economic and Decision Sciences
West Point or Boston or United Kingdom or Zurich or Rahway
$157k-$247k/yr HybridFull Time
PhD preferred or master's degree in a quantitative field, plus relevant HEOR experience, oncology economic evaluation expertise, health economic modeling, HTA submissions, publications, and strong collaboration skills.
1mo
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Principal Scientist II - Pharmacology
Cambridge, Massachusetts, United States
$126k-$234k/yr OnsiteFull Time
5+ YOEPhD with 5+ years postdoc or industry research experience, expertise in ADCs and CDX/PDX/syngeneic tumor models, cell culture, PCR, ELISA, western blot, flow cytometry; experience managing associate scientists and presenting data.
Microsoft PowerPoint, Prism, Microsoft Excel
3d
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Associate Principal Scientist (Associate Director)
Waltham or Cambridge
$131k-$197k/yr HybridFull Time
5+ YOEPhD in a relevant biology discipline and 5+ years of postdoctoral or industry oncology drug discovery experience, with neuro-oncology, advanced cellular models, intracranial models, viral vectors, and PROTAC expertise.
AAV, lentivirus, CRISPR/Cas9, PROTACs, si/shRNA, 96/384-well formats
5d
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Principal Scientist/Associate Director, DMPK
Watertown or Massachusetts
$186k-$228k/yr HybridFull Time
5+ YOEMS with 8+ years of relevant experience or PhD with 5+ years of industry experience; expertise in large-molecule PK/PKPD, ADME, study design, human PK prediction, regulatory support, and cross-functional leadership.
1mo
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Associate Principal Scientist (Associate Director)
Waltham, Massachusetts, United States
$116k-$174k/yr HybridFull Time
1+ YOEPhD in cancer biology/immunology/bioengineering or related, 1 year postdoctoral experience, strong machine learning and automation background, flow cytometry and single-cell RNA-seq experience, ability to design and execute experiments independently.
multi-color flow cytometry, single-cell RNA sequencing
1mo
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Associate Principal Scientist (Associate Director)
Waltham, Massachusetts, United States
$116k-$174k/yr HybridFull Time
1+ YOEPhD in cancer biology/immunology/bioengineering,1 year post-doc, strong machine learning and automation background, cancer biology or immunology experience, flow cytometry and single-cell RNA-seq experience preferred.
machine learning, automation, multi-color flow cytometry, single-cell RNA sequencing
2mo
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Principal Associate Scientist, Target Validation
Cambridge, Massachusetts, United States
$96k-$143k/yr OnsiteFull Time
5+ YOEBS/MS in biology or related field with 5+ years industry experience; hands-on rodent in vivo dosing and tissue work; proficiency in RNA extraction, qPCR, Western blot, ELISA; mammalian cell culture; strong data analysis and communication skills.
GraphPad Prism, Microsoft Excel
3w
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Senior / Principal Associate Scientist, Advanced Cell Engineering
Boston, Massachusetts, United States
$84k-$112k/yr OnsiteFull Time
2+ YOEBachelor's or master's in biological sciences, bioengineering, or a related field; 2–3+ years relevant experience and 3–5+ years in flow cytometry, cell culture, and mammalian cell experimentation.
Cytek Aurora, Excel, Microsoft PowerPoint, GraphPad Prism, FlowJo, ELN, LIMS, Hamilton liquid handlers, AssistPlus
5d
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Senior Associate Scientist/ Principal Research Associate, Antibody and Protein Engineering
Boston, Massachusetts, United States
$80k-$97k/yr OnsiteFull Time
2+ YOEBachelor's or master's degree in a related life science and 2+ years of industry R&D experience; requires mammalian cell culture, recombinant protein expression, purification, characterization, data analysis, and scientific communication.
Bio-Layer Interferometry (BLI), ELISA, HPLC, FPLC, SDS-PAGE, HEK293, CHO, electronic laboratory notebook, FACS, AKTA-FPLC
2mo
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Principal Associate, Data Scientist - Card Intelligence
McLean or New York City or Cambridge
$162k-$201k/yr OnsiteFull Time
5+ YOEBachelor's plus 5 years, master's/MBA plus 3 years, or PhD in a quantitative field and data analytics experience; preferred expertise in Python, machine learning, SQL, AWS, and STEM education.
Python, Conda, AWS, H2O, Spark, Scala, R, SQL
3w
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Principal Associate, Data Scientist - Card Intelligence
McLean or New York City or Cambridge
$162k-$201k/yr OnsiteFull Time
5+ YOEBachelor's degree plus 5 years, master's or quantitative MBA plus 3 years, or PhD in a quantitative field; data analytics, machine learning, Python, SQL, and cloud experience required or preferred.
Python, Conda, AWS, H2O, Spark, Scala, R, SQL
1mo
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Principal Scientist / Associate Director, Agentic AI Research for Materials Science
Cambridge or San Francisco
$288k-$420k/yr OnsiteFull Time
5+ YOEPhD with 5+ years post-PhD research and applied ML experience; track record building agentic systems; expertise in LLMs, reasoning, multimodal data, materials science grounding; Python proficiency; leadership and communication skills.
Python, LLMs, HPC
2mo
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Principal Associate Scientist, Target Validation (Cambridge, MA, US, 02142)
Cambridge, Massachusetts, United States
$96k-$143k/yr OnsiteFull Time
5+ YOEBS/MS in biology or related field with 5+ years industry experience; hands-on in vivo rodent studies, molecular assays (qPCR, Western blot, ELISA), mammalian cell culture, RNA extraction; proficiency with GraphPad Prism and Excel; strong communication and documentation skills.
GraphPad Prism, Microsoft Excel
2d
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Principal Scientist / Associate Director, Process Analytical Technology (PAT) Lead
Woburn or Allston
$140k-$180k/yr HybridFull Time
10+ YOEPh.D. with 10+ years or M.S. with 12+ years in pharmaceutical or biotech PAT/process analytics; expertise in spectroscopy, image analysis, chemometrics, GMP manufacturing, control strategies, and regulatory submissions.
Process Analytical Technology (PAT), UV/Vis, NIR, Statistical Process Control (SPC), Real-Time Release Testing (RTRT), Partial Least Squares (PLS), Principal Component Analysis (PCA), Computer System Validation (CSV), GAMP 5, OpenCV, Python, Raman spectroscopy
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