185 computational designer jobs at 124 companies in Boston, MA
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Principal Scientist, Computational Designer (Biologics & Peptides)
Cambridge or Boston
$140k-$210k/yr OnsiteFull Time
5+ YOEPhD in computational biology/structural biology or related, expertise in protein/peptide modeling, machine-learning-guided design, leadership in cross-functional research, and ability to work with large experimental datasets.
HPC, cloud, containers, workflow orchestration, X-ray, cryo-EM, machine-learning
3w
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Principal Scientist, Computational Designer (Biologics & Peptides)
Cambridge or Boston
$140k-$210k/yr OnsiteFull Time
5+ YOEPhD in a relevant discipline, expertise in protein/peptide structure modeling and ML-guided design, ability to work with large experimental datasets, experience with HPC/cloud and containers, scientific leadership and cross-functional collaboration.
HPC, cloud, containers
4w
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Computational Chemistry Lead
Cambridge, Massachusetts, United States
$119k-$170k/yr OnsiteFull Time
5+ YOEPh.D. (or M.S.+5yrs) in computational/medicinal chemistry, experience in small-molecule drug discovery, AI-driven design, molecular modeling, CRO management, and proficiency with scientific programming and modeling software.
Schrodinger, MOE, OpenEye, Rosetta, Python, Pipeline Pilot, KNIME
2w
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Director/Senior Director, Computational Chemistry
Cambridge, Massachusetts, United States
$176k-$294k/yr OnsiteFull Time
10+ YOEPhD in chemistry-related field,10+ years industry experience with demonstrated scientific leadership and people management,deep expertise in computational medicinal chemistry,structure-based design,cheminformatics,ADME assessment,experience with heterobifunctional molecules preferred.
FEP, AI/ML
2mo
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Senior Scientist - Principal Scientist, Computational Chemistry
Boston, Massachusetts, United States
OnsiteFull Time
1+ YOEPhD in Computational Chemistry or related field; 1-3+ years biotech/pharma experience; strong physics-based and ML modeling; excellent communication; design-experience with medicinal chemistry; structure-based drug discovery innovation.
Schrodinger suite, OpenEye, MOE, Python, RDKit, scikit-learn, numpy, pandas, pytorch
1w
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Principal Scientist, Computational Protein Design
Cambridge, Massachusetts, United States
$143k-$257k/yr HybridFull Time
5+ YOEPhD and 5+ years post-graduate experience in computational protein design with de novo binder generation, ML-guided design, experimental integration, leadership, and strong publication record.
AlphaFold, AlphaFold-Multimer, Rosetta, PyRosetta, RFdiffusion, ProteinMPNN, Python
3d
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Associate Computational Biologist (Polizzi Lab)
Boston or Boston
$60k-$67k/yr OnsiteFull Time
Bachelor's degree in a STEM field; no experience required. Requires UNIX/Linux knowledge, Python and R familiarity, experimental design knowledge, analytical skills, and effective written and verbal communication.
UNIX, Linux, Python, R
1d
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Software Product Designer
Somerville, Massachusetts, United States
$110k-$165k/yr OnsiteFull Time
Experience designing complex technical products, strong human-computer interaction knowledge, user research and prototyping skills, a diverse portfolio, Figma and Adobe Creative Suite expertise, and technical collaboration experience.
Figma, Adobe Creative Suite, Qt, QML, OpenGL, CAD
3w
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Principal Scientist/Sr. Principal Scientist, Computational Chemistry & Molecular Design
Boston, Massachusetts, United States
$185k-$240k/yr HybridFull Time
10+ YOEPhD or equivalent experience in computational chemistry or related field; 10+ years' drug discovery experience for Principal (12+ for Senior Principal); expertise in structure- and ligand-based design, molecular dynamics, free energy methods, ML-driven design; strong communication.
Schr\u0000dinger, MOE, OpenEye, Python, Claude Code, Codex
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Computational Design Engineer Co-Op Spring 2027
Peabody, Massachusetts, United States
$23-$30/hr OnsiteInternship
Pursuing Bachelors or Masters in engineering, math, CS, or physics. Experience with computational design software and implicit modeling. Eligible for U.S. Secret clearance, able to pass drug screen and background check.
Rhino/Grasshopper, nTop, PicoGK, NX Implicit Modeling, Altair Implicit Modeling
2mo
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AIRx Director, Computational & AI Biologics Design Lead
Boston or Cambridge
$177k-$278k/yr HybridFull Time
10+ YOEPhD and 10+ years drug discovery experience with strong computational expertise in antibody/large-molecule design, Python and ML experience, cloud and MLOps familiarity, plus strong communication and leadership skills.
Python, MLOps
3mo
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Computational Sensing Research Engineer
Boston, Massachusetts, United States
$144k-$198k/yr OnsiteFull Time
PhD or MS with strong mixed-signal design; sensor signal chain, CIS, signal processing, ML for sensor data; strong publication record.
FPGAs, CMOS image sensor, readout circuitry, signal processing, machine learning
1mo
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Computational Design Research Engineer
Boston or United States
$100k-$140k/yr RemoteFull Time
5+ YOE5+ years in geometric processing, simulation, optimization, ML, or DSLs. Strong Python and ML skills, experience with CAD/CAE/CAM data, dataset and pipeline development, and MS/PhD in related field.
Python, Machine Learning, LLMs, CAD, CAE, CAM
1mo
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AI/ML Computational Science Manager
Mountain View or Milwaukee or Dallas or Columbus or Kirkland or Cincinnati or New York City or Cleveland or Oklahoma City or Austin or Albany or Chicago or St. Petersburg or Hartford or Pittsburgh or St. Louis or Miami or Sacramento or Raleigh or Minneapolis or Scottsdale or San Francisco or Morristown or Denver or Boston or Philadelphia or Des Moines or Overland Park or Los Angeles or Charlotte or Walnut Creek or Carmel or Seattle or Houston or Arlington or Atlanta or Redmond or Bentonville or Beaverton or Nashville or Detroit or San Diego
$80k-$294k/yr HybridFull Time
6+ YOE6+ years in data/ML/CS, 5+ years ML/deep learning/NLP, cloud AI/ML experience, 1+ year agentic architecture experience, Bachelor's degree or equivalent, ability to design/deploy production ML solutions.
2w
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Hardware Designer
Boston or United States
RemoteFull Time
5+ YOE5+ years electronics design experience, Bachelor's in Electrical/Computer Engineering, strong high-speed circuit and PCB design skills, experience with DDR/PCIe/SerDes, test and bring-up, and mentoring experience.
LTSpice, OrCAD Capture CIS, Cadence Allegro, Verilog, RTL, HLS, optical test sets, signal analyzers, GHz+ oscilloscopes, VNAs
2w
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EWP Designer NE
Mansfield or Warwick
OnsiteFull Time
1+ YOEAssociates degree or 2 years design experience; 1+ years design experience preferred; ability to read architectural and structural plans; strong customer service and computer/design software skills.
2w
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EWP Designer NE
Mansfield or Warwick
OnsiteFull Time
1+ YOEAssociate degree or 2 years design experience, 1–2 years design experience preferred, ability to read architectural/structural plans, strong computer and customer service skills.
1mo
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Associate Director of Computational Biology & Bioinformatics
Boston, Massachusetts, United States
$200k-$240k/yr HybridFull Time
5+ YOEPhD required; 5+ years relevant experience with team leadership; strong Python and PyTorch; experience developing protein ML models, multimodal biological data, de novo protein/antibody design; cloud/HPC and data portals preferred.
Python, PyTorch, OpenAntigens, LIMS, ELN, MLOps, APIs, GPU, Next Generation Sequencing (NGS), cloud computing, high-performance computing
3w
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Designer/Sales Specialist In-Store
Natick, Massachusetts, United States
$17-$19/hr OnsitePart Time
Design-customized spaces, 2-5 years sales/clientele experience preferred, design and spatial intelligence, strong communication, follow-up, computer skills, ability to work flexible hours.
1w
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HVAC Designer (MA, Attleboro)
Attleboro, Massachusetts, United States
OnsiteFull Time
High school diploma/GED, computer skills, ability to perform HVAC load calculations, experience with WrightSoft preferred, HVAC equipment selection, jobsite measuring and occasional deliveries, strong sales and customer skills.
WrightSoft
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