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233 computational scientist jobs at 89 companies in San Francisco, CA

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Computational Scientist, Lung Transplant Immunology
San Francisco, California, United States
$64k-$195k/yr OnsiteFull Time
University of California
University of California: A public research university system providing education and healthcare.
5+ YOEAdvanced computational/statistical skills for end-to-end analysis of multimodal genomic datasets; strong R and Python proficiency; experience with reproducible workflows, HPC/cloud environments, and publication record in high-dimensional modalities.
R, Bioconductor, Seurat, Python, scanpy, anndata, scikit-learn, pandas, Linux, SLURM, Git, GitHub, conda, mamba, renv, Nextflow, Snakemake, Microsoft Visual Studio, AWS, GCP, UCSF Wynton, AWS HealthOmics
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Scientist, Computational Biology
Menlo Park, California, United States
$130k-$150k/yr HybridFull Time
MyOme
MyOme: Provides clinical whole genome analysis for personalized health insights.
Ph.D. or Master's in quantitative biosciences with relevant experience; hands-on biobank and multi-omic analysis; proficiency in Python/R, version control, cloud biobank environments; strong statistical and epidemiological skills.
Python, R, Git, DNAnexus, Terra, AWS, GCP
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2w
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Scientist II/Senior Scientist, Computational Biophysics
Cambridge or London or San Francisco
$141k-$218k/yr OnsiteFull Time
Lila Sciences
Lila Sciences: Develops an AI platform for autonomous scientific research and discovery.
PhD or equivalent experience in computational biophysics/chemistry, deep hands-on MD and free-energy expertise, experience with OpenMM/OpenFE, ability to define and validate biophysics workflows for drug discovery.
OpenMM, OpenFE, LLM
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Senior Scientist, Computational Biology
South San Francisco or Seattle or London
$136k-$170k/yr OnsiteFull Time
Xaira Therapeutics
Xaira Therapeutics: Develops AI models for protein and antibody drug discovery.
5+ YOEPhD in a quantitative biology field, 5+ years industry/applied research, deep single-cell RNA‑seq and Perturb‑seq expertise, experience integrating large-scale datasets, production workflow development (Nextflow), Docker, AWS, Python (numpy, pandas, scanpy, scikit-learn), Unix, and GitHub.
Nextflow, Docker, AWS, Python, numpy, pandas, scanpy, scikit-learn, Unix, GitHub
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Beyond Moore Computational Research Scientist
Berkeley or California
$95k-$227k/yr HybridFull Time, Temporary
Lawrence Berkeley National Laboratory
Lawrence Berkeley National Laboratory: Conducts scientific research to address global challenges.
3+ YOEPhD in computing discipline, minimum 3 years postdoctoral or equivalent research experience, expertise in processor/accelerator design, SPICE/Verilog, CAD/EDA tools, C++/Python, FPGA flows, and record of publications.
Spice, Verilog, C++, Python, Perl, UNIX shell scripts, make, configure, CHISEL, PyMTL, FPGA, CAD, EDA, ASIC
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Scientist - Computational Biophysics
Emeryville, California, United States
$100k-$180k/yr OnsiteFull Time
Astera Institute
Astera Institute: Conducts fundamental research in artificial intelligence and longevity science.
PhD in bioinformatics/computational biology/ML, strong protein structure knowledge, experience building large bioinformatic pipelines and managing high-dimensional datasets, proficiency fine-tuning ML models and integrating PLM/LLM/experimental data.
PLM, LLM, ESM, AlphaFold, Transformer
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Staff Computational Scientist (Electric Grid Simulations
Mountain View or United States or United Kingdom or Chile or New Zealand or Australia or Brazil
$166k-$259k/yr HybridFull Time
X, The Moonshot Factory
X, The Moonshot FactoryNASDAQ: GOOGL: Develops early-stage technologies and experimental projects.
6+ YOEMaster's or PhD in Electrical Engineering; 6+ years in power systems or power electronics modeling and simulation; programming in Python, Java, C/C++, or similar; expertise in power systems and numerical methods.
Python, Java, C, C++, JAX, Julia, Machine Learning
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Staff Computational Scientist (Electric Grid Simulations
Mountain View or United States or United Kingdom or Chile or New Zealand or Australia or Brazil
$166k-$259k/yr HybridFull Time
Alphabet
AlphabetNASDAQ: GOOGL: Holding providing internet, software, and AI services.
6+ YOEMaster's or PhD in Electrical Engineering, 6+ years in power systems or power electronics modeling and simulation, programming experience, and expertise in power systems, numerical methods, and large-scale networks.
Python, Java, C, C++, JAX, Julia, Machine Learning
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Scientist/Sr. Scientist, Computational Chemistry
San Francisco, California, United States
OnsiteFull Time
General Proximity
General Proximity: Develops proximity-based medicines to treat undruggable disease proteins.
3+ YOEPhD-preferred computational chemist with 3+ years in pharma/biotech, hands-on SBDD and ligand-based design, experience with cheminformatics, AI/ML molecular design, Python and RDKit, and cross-functional collaboration.
Schrödinger, MOE, CCDC tools, ChemAxon, KNIME, Pipeline Pilot, RDKit, DataWarrior, Spotfire, AlphaFold, Python
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Scientist, Computational Biology
Palo Alto, California, United States
$135k-$187k/yr HybridFull Time
Arc Institute
Arc Institute: Conducts biomedical research to understand and treat complex human diseases.
0+ YOEPhD in relevant field, 0–4 years postdoctoral/professional research experience, hands-on single-cell/perturbational/multi-omic analysis, expertise in perturb-seq or microglia single-cell analysis, Python proficiency, reproducible workflows, strong collaboration and communication; onsite minimum 3 days/week.
Python
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Computational Materials Scientist - Postdoctoral Researcher
Livermore, California, United States
$123k/yr OnsiteFull Time
Lawrence Livermore National Laboratory
Lawrence Livermore National Laboratory: Develops science and technology for United States national security.
PhD in materials-related field, ability to obtain DOE Q-level clearance (U.S. citizenship required), expertise in CALPHAD, ICME, uncertainty quantification, and scientific software development; experience with thermodynamic tools and strong publication record.
Thermo-Calc, Pandat, FactSage, PyCalphad, Thermochimica, OpenCalphad, High Performance Computing, Materials Acceleration Platform
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Computational Clinical Scientist II, Clinical Bioinformatics
Redwood City, California, United States
$132k-$166k/yr HybridFull Time
Revolution Medicines
Revolution MedicinesNASDAQ: RVMD: Developing precision oncology therapies for RAS-addicted cancers
2+ YOEM.S. or Ph.D. in bioinformatics, biology, data science, or related field; 2+ years of pharmaceutical or biotech bioinformatics experience; R or Python programming and clinical data analysis expertise.
R, Python, GATK, Salmon, OncoKB, VEP, IDE, version control systems, GDC, TCGA, clusters, containers, cloud computing
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Principal Scientist (Computational Chemistry)
South San Francisco, California, United States
$145k-$269k/yr OnsiteFull Time
Roche
RocheSIX Swiss Exchange: ROG: Roche provides innovative pharmaceutical and diagnostic healthcare solutions.
0+ YOEPh.D. in computational chemistry/biophysics or related; expertise in molecular modeling, induced proximity discovery, Python, HPC/cloud; strong communication and cross-functional collaboration skills.
Python, MOE, Schrodinger, OpenEye, Rosetta, HPC, AI/ML
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Scientist, Computational Protein Design, San Francisco Bay Area, CA
Mountain View, California, United States
OnsiteFull Time
Adimab
Adimab: Developing therapeutic human antibodies using a yeast-based discovery platform.
2+ YOEPhD in a relevant field, 2+ years post-PhD experience in computational protein/binder design, strong structural and energetic analysis skills, proficiency with RFAntibody, BindCraft, Protenix, strong Python skills, and publication/patent record.
RFAntibody, BindCraft, Protenix, Python
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Research Scientist, Life Sciences (Computational)
San Francisco, California, United States
$300k-$320k/yr HybridFull Time
Anthropic
Anthropic: Developing safe and reliable artificial intelligence systems.
PhD or equivalent industry research experience in computational biology or related field; track record of end-to-end computational biology research; proficiency with Linux, cloud compute, and scientific programming; strong communication with biologists and ML researchers.
Claude, Linux
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Computational Chemist (Machine Learning) I / II
Berkeley, California, United States
$165k-$180k/yr OnsiteFull Time
Aralez Bio
Aralez Bio: Produces noncanonical amino acids for drug development through biocatalysis.
2+ YOEPh.D. or Master’s in computational chemistry/chemoinformatics,2+ years post-grad experience,expertise in ML for molecular property prediction,chemoinformatics (RDKit),Python,data pipelines,SQL,strong communication with lab scientists.
RDKit, REINVENT, Python, numpy, pandas, scipy, SQL
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Senior Scientist - Computational Protein Design
South San Francisco, California, United States
$146k-$198k/yr OnsiteFull Time
Amgen
AmgenNASDAQ: AMGN: Develops and manufactures biotechnology medicines for serious diseases.
PhD/MD/PharmD or Master’s with relevant protein design experience; strong computational design background; programming in Python; experience with AI/ML in protein design; cross-functional collaboration.
Python, AlphaFold, ProteinMPNN, RFdiffusion, Cloud computing, HPC
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Senior Principal Research Scientist, Computational Chemistry
South San Francisco, California, United States
$196k-$242k/yr HybridFull Time
IDEAYA Biosciences
IDEAYA BiosciencesNASDAQ: IDYA: Develops precision medicine oncology therapies for cancer patients.
9+ YOEPhD in computational chemistry or related field, 9+ years of pharmaceutical or biotechnology experience, expertise in computational drug discovery, programming, data analysis, machine learning, and drug design software.
Schrödinger, MOE, OpenEye, Machine Learning, Artificial Intelligence, Molecular Dynamics, Quantum Mechanics, Cheminformatics, Programming, Scripting, Statistics, Data Analysis
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Machine Learning Scientist / Senior Machine Learning Scientist
South San Francisco, California, United States
$170k-$233k/yr OnsiteFull Time
Calico
Calico: Researching aging biology to develop longevity-improving therapies.
5+ YOEPhD in computational biology, bioinformatics, computer science, or related field; strong publication record; 0-5 years (Scientist) or 5+ years (Senior Scientist) in industry or academia; deep ML expertise; genomics knowledge; onsite four days/week.
Python, TensorFlow, PyTorch, Genomics data, DNA sequence analysis
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Research Scientist Graduate (Computational Imaging-PICO) - 2027 Start (PhD)
San Jose, California, United States
OnsiteFull Time
ByteDance
ByteDance: Developing AI-driven content platforms and mobile applications.
PhD in CS/ECE/Imaging or related, strong foundation in image processing/computational photography/ML, proficiency with PyTorch or TensorFlow and Python/MATLAB, familiarity with C/C++, and hands-on hardware experimentation skills.
PyTorch, TensorFlow, Python, MATLAB, C, C++
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