242 drug discovery jobs at 103 companies in United States
1mo
Save
Mark Applied
Hide
Director, Head of Drug Discovery
San Diego, California, United States
$191k-$250k/yr OnsiteFull Time
12+ YOEPhD with 12+ years pharma/biotech experience in target ID, validation and preclinical discovery; expertise in pharmacology, in vitro/in vivo modeling, biostatistics and AI-enabled discovery; experience managing discovery portfolios.
1mo
Save
Mark Applied
Hide
Head, Oncology Drug Discovery – San Diego
San Diego, California, United States
$249k-$462k/yr OnsiteFull Time
15+ YOEDoctoral degree required, 15+ years oncology drug discovery experience, deep cancer biology and translational science expertise, record delivering development candidates, multidisciplinary leadership, strong publication history.
2w
Save
Mark Applied
Hide
Senior Director, Small Molecule Drug Discovery in Inflammation Discovery
South San Francisco, California, United States
OnsiteFull Time
5+ YOE5+ MgmtDoctorate+5y or Master’s+9y or Bachelor’s+11y immunology discovery experience plus ≥5y people management; deep immunology and small-molecule drug discovery expertise required.
3mo
Save
Mark Applied
Hide
Head of Peptide Drug Discovery
South San Francisco, California, United States
$320k-$350k/yr OnsiteFull Time
12+ YOEPhD in organic/peptide/medicinal chemistry; 12+ years in biotech/pharma; proven peptide drug candidates; strong collaboration with ML and discovery teams; onsite 5 days a week.
2w
Save
Mark Applied
Hide
VP, Head of Drug Discovery
Cambridge, Massachusetts, United States
OnsiteFull Time
15+ YOE15+ MgmtPhD in organic or computational chemistry,15+ years leading multidisciplinary small-molecule discovery from hit to IND/candidate, expertise in medicinal chemistry, DMPK, structure-based and computational methods.
AI/ML, molecular modeling, molecular simulations, free-energy calculations, generative chemistry, predictive ADME models, cheminformatics, high throughput experimentation
1w
Save
Mark Applied
Hide
Associate Director, Oncology Drug Discovery Unit
Boston, Massachusetts, United States
$154k-$243k/yr OnsiteFull Time
6+ YOEPhD in a relevant field with ~6+ years industry drug discovery leadership; deep small-molecule and targeted protein degradation expertise; program leadership across discovery milestones; strong scientific judgment and cross-functional communication.
2d
Save
Mark Applied
Hide
Drug Discovery Project Leader II - Small Molecule
Saint Charles or United States
RemoteFull Time
10+ YOERequires an MSc or PhD in biological sciences or a relevant subject, 10+ years of drug discovery project leadership, clinical candidate delivery, team leadership, and strong planning, negotiation, and communication skills.
Microsoft SharePoint, Microsoft Project, Microsoft PowerPoint, Microsoft Excel
1mo
Save
Mark Applied
Hide
Senior Scientist, Drug Discovery Biochemistry & Biophysics
Redwood City, California, United States
OnsiteFull Time
3+ YOEPhD in a relevant field, 3+ years industry experience in small-molecule drug discovery, hands-on recombinant protein expression/purification, and development of biochemical, biophysical, and cellular assays with rigorous quantitative data generation.
SEC, SDS-PAGE, LC-MS, DLS, thermal shift, FR, TR-FRET, AlphaScreen, AlphaLISA, DSF, enzymatic, SPR, BLI, high content cell imaging, qPCR, NMR, X-ray crystallography, cryo-EM
2mo
Save
Mark Applied
Hide
Drug Discovery Software Engineer
New York, New York, United States
$140k-$220k/yr OnsiteFull Time
3+ YOEBS or MS in life or computer sciences; 3-5 years in lab-related software development; proficient in Python/JavaScript/C#; experience with databases and CI/CD; LIMS/ELN and cloud data mgmt experience; strong communication and collaboration skills.
Python, JavaScript, C#, Oracle, SQL Server, Aurora, LIMS, ELNs, REST API, MCP Servers, CI/CD
3mo
Save
Mark Applied
Hide
Postdoc – Drug Discovery Development and Application Scientist
Piscataway, New Jersey, United States
$64k/yr HybridFull Time
PhD in computational chemistry or related field; strong publication record; experience with MD simulations and drug discovery tools; proficiency with AMBER/GROMACS/OpenMM/CHARMM; familiarity with GitLab CI/CD.
AMBER, GROMACS, OpenMM, CHARMM, GitLab, Python
1w
Save
Mark Applied
Hide
Senior Engineer I/II, Drug Discovery Platform
Cambridge, Massachusetts, United States
$148k-$240k/yr OnsiteFull Time
5+ YOEBachelor's degree,5+ years building production data platforms; strong Python and SQL skills; experience with scientific/lab data, AWS, and Kubernetes; database and schema design for evolving data.
Python, SQL, AWS, Kubernetes, RDKit, OpenEye, CDD Vault, Dotmatics, Benchling Registry, mzML, AnIML, Flyte, Airflow, Dagster, Temporal, Iceberg, Delta Lake, Hudi, DuckDB, Polars, Spark, ChemSpeed, Opentrons, Cursor, Claude Code
2mo
Save
Mark Applied
Hide
Head, Oncology Drug Discovery – San Diego
San Diego, California, United States
$249k-$462k/yr OnsiteFull Time
15+ YOEDoctoral degree in Biology, Biochemistry, Pharmacology; 15+ years in oncology R&D; leadership of multidisciplinary teams; expertise in small-molecule oncology and translational science; portfolio strategy and development readiness.
Biology, Biochemistry, Pharmacology, Oncology, Drug Discovery, Preclinical Development
1mo
Save
Mark Applied
Hide
Drug Hunter
San Francisco, California, United States
OnsiteFull Time
Experience in drug discovery (hit-to-lead/lead optimization), medicinal chemistry/DMPK reasoning, computational chemistry/ML, customer-facing skills, and ability to translate customer needs into experimental and analytical plans.
Python, RDKit, NumPy, SQL, Pandas
1d
Save
Mark Applied
Hide
Principal Scientist, Drug Discovery
Rahway, New Jersey, United States
$170k-$267k/yr HybridFull Time
8+ YOEPhD and/or DVM/VMD with pharmacology board certification; 8+ years in drug discovery or preclinical research focused on in vivo pharmacology; expertise in disease mechanisms, models, and regulated pharmaceutical research.
GLP, GCP, GMP
3w
Save
Mark Applied
Hide
Bioinformatics Engineer - Oligonucleotide Drug Discovery
San Francisco, California, United States
$120k-$180k/yr HybridContract, Full Time
3+ YOE3+ years experience with oligonucleotide or RNA therapeutics, drug target validation, familiarity with discovery workflows, and proficiency using AI agents.
HackerRank
2mo
Save
Mark Applied
Hide
Head of Discovery
New York or United States
$150k-$250k/yr HybridFull Time
5+ YOEPhD (or equivalent) with 5+ years drug discovery experience; hands-on experience across target selection to lead optimization; ability to evaluate AI-generated molecular outputs and make go/no-go decisions; strong scientific judgment and communication.
Python
3mo
Save
Mark Applied
Hide
Internal Program Manager, Drug Discovery
New York or Boston
HybridFull Time
Proxima: Uses AI to design proximity-based medicines for undruggable proteins.
3+ YOEBachelor's or Master's in life sciences; 3-6 years in drug discovery program management; cross-functional R&D leadership; fast-moving environment; Excel/PowerPoint; Python or GitHub a plus.
Excel, PowerPoint, Python, GitHub, Project management tools
4w
Save
Mark Applied
Hide
Sr. Dir, Biology-Discovery
Cambridge, Massachusetts, United States
$194k-$306k/yr OnsiteFull Time
10+ YOE5+ MgmtExperienced immunology translational scientist with biomarker strategy expertise, drug discovery experience, and leadership managing multiple teams; advanced degree with significant industry experience and 5+ years management.
3w
Save
Mark Applied
Hide
Director, Alliance Management- Drug Discovery Collaborations
San Diego, California, United States
$180k-$250k/yr HybridFull Time
15+ YOE15+ years managing complex drug-discovery collaborations, strong understanding of small-molecule discovery, program leadership, stakeholder management, and cross-functional coordination; BS required, advanced degree preferred.
1mo
Save
Mark Applied
Hide
Principal Scientist, Therapeutic Discovery
San Francisco, California, United States
$180k-$340k/yr OnsiteFull Time
Proven track record leading drug discovery or therapeutic research programs toward clinical application; independently designing and executing research with outputs such as publications, patents, or funded grants; strong scientific judgment and communication.
Explore Jobs