82 drug discovery director jobs at 33 companies in United States

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Director, Head of Drug Discovery
San Diego, California, United States
$191k-$250k/yr OnsiteFull Time
Arcturus Therapeutics
Arcturus TherapeuticsNASDAQ: ARCT: Developing mRNA medicines for infectious diseases and rare conditions.
12+ YOEPhD with 12+ years pharma/biotech experience in target ID, validation and preclinical discovery; expertise in pharmacology, in vitro/in vivo modeling, biostatistics and AI-enabled discovery; experience managing discovery portfolios.
3w
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Senior Director, Small Molecule Drug Discovery in Inflammation Discovery
South San Francisco, California, United States
OnsiteFull Time
Amgen
AmgenNASDAQ: AMGN: Develops and manufactures biotechnology medicines for serious diseases.
5+ YOE5+ MgmtDoctorate+5y or Master’s+9y or Bachelor’s+11y immunology discovery experience plus ≥5y people management; deep immunology and small-molecule drug discovery expertise required.
2w
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Associate Director, Oncology Drug Discovery Unit
Boston, Massachusetts, United States
$154k-$243k/yr OnsiteFull Time
Takeda
TakedaTokyo Stock Exchange / New York Stock Exchange: 4502 / TAK: Researches, develops, and manufactures prescription pharmaceutical medicines.
6+ YOEPhD in a relevant field with ~6+ years industry drug discovery leadership; deep small-molecule and targeted protein degradation expertise; program leadership across discovery milestones; strong scientific judgment and cross-functional communication.
1w
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Director, Discovery Chemistry
South San Francisco, California, United States
$194k-$306k/yr OnsiteFull Time
Merck & Co.
Merck & Co.NYSE: MRK: Develops and manufactures prescription medicines, vaccines, and animal health products.
7+ YOEBachelor's with 13+ years, Master's with 9+ years, or Ph.D. with 7+ years in chemistry or a related field; bioconjugate chemistry, drug discovery, leadership, and project experience required.
1w
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Director, Discovery Chemistry
South San Francisco, California, United States
$194k-$306k/yr OnsiteFull Time
Merck & Co.
Merck & Co.NYSE: MRK: Produces prescription medicines, vaccines, and animal health products.
7+ YOEChemistry-related bachelor's with 13+ years, master's with 9+ years, or Ph.D. with 7+ years; requires bioconjugate chemistry, drug discovery, project leadership, strategic thinking, and leadership skills.
Bioconjugation, Chemistry, Drug Discovery Research, Leadership, Medicinal Chemistry, Project Leadership, Strategic Thinking, Synthetic Chemistry
3mo
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Director, Discovery Program Management
Cambridge, Massachusetts, United States
$200k-$240k/yr OnsiteFull Time
Parabilis Medicines
Parabilis Medicines: Developing helical peptide therapeutics for undruggable cancer targets.
10+ YOEBSc in Life Sciences; 10+ years drug discovery; pharma/biotech program management; AI/tools experience; oncology a plus; strong communication and collaboration.
AI tools, Project management software, JIRA, Confluence, Microsoft Excel, Microsoft PowerPoint
1mo
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Executive Director, Discovery-Oncology
Beerse or Cambridge or Spring House
$196k-$343k/yr HybridFull Time
Johnson & Johnson
Johnson & JohnsonNYSE: JNJ: Develops and manufactures pharmaceutical drugs and medical devices.
15+ YOEPhD in a relevant field, 15+ years of leadership and drug discovery experience in oncology (preferably solid tumors), demonstrated team leadership, program delivery to clinical candidates, strong communication and external network.
3w
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Senior Director, Discovery Sciences & Technologies
Foster City, California, United States
$261k-$338k/yr OnsiteFull Time
Gilead Sciences
Gilead SciencesNASDAQ: GILD: Develops and sells medicines for life-threatening infectious diseases.
15+ YOEPhD in related discipline, 15+ years drug discovery experience, expertise in biochemical/biophysical/cellular assays, protein–ligand interactions, leadership and cross‑functional collaboration skills.
mass spectrometry, HTS, high‑throughput screening, automation, data analytics
3w
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Senior Director, Discovery Sciences & Technologies
Foster City, California, United States
$261k-$338k/yr OnsiteFull Time
Gilead Sciences
Gilead SciencesNASDAQ: GILD: Develops and sells medicines for life-threatening infectious diseases.
15+ YOEPhD in biochemistry/related field,15+ years drug discovery experience,expertise in biochemical/biophysical/cellular assays,protein–ligand interactions,leadership and cross‑functional collaboration.
mass spectrometry
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Associate Director, ADC platform in Oncology Drug Discovery
Cambridge, Massachusetts, United States
$153k-$283k/yr HybridFull Time
Novartis
NovartisNew York Stock Exchange: NVS: Develops and manufactures innovative prescription medicines for patients.
5+ YOEPhD in a relevant discipline, 5+ years industry experience in ADC or oncology drug discovery, deep payload/linker/conjugation expertise, cross-functional leadership and communication skills.
4w
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Director, Alliance Management- Drug Discovery Collaborations
San Diego, California, United States
$180k-$250k/yr HybridFull Time
Iambic Therapeutics
Iambic Therapeutics: Develops novel medicines using an AI-driven discovery platform.
15+ YOE15+ years managing complex drug-discovery collaborations, strong understanding of small-molecule discovery, program leadership, stakeholder management, and cross-functional coordination; BS required, advanced degree preferred.
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Associate Director, ADC platform in Oncology Drug Discovery
Cambridge, Massachusetts, United States
$153k-$283k/yr OnsiteFull Time
Novartis
NovartisSIX Swiss Exchange, NYSE: NOVN, NVS: A global pharmaceutical focused on discovering and developing innovative medicines through research-driven drug discovery.
5+ YOEPh.D. in related discipline, 5+ years industry ADC/oncology drug discovery experience, expertise in payloads, linkers, conjugation, ADC biology, strong cross-functional leadership and communication.
1mo
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Executive Director, Head of LNP Discovery Biology
Billerica, Massachusetts, United States
$237k-$356k/yr OnsiteFull Time
Merck KGaA, Darmstadt, Germany
Merck KGaA, Darmstadt, GermanyFrankfurt Stock Exchange: MRK: A science and technology in healthcare, life sciences, and electronics.
15+ YOE5+ MgmtPhD in a relevant life science and 15+ years in drug discovery and preclinical R&D, including 5+ years leading scientific teams; expertise in LNP delivery, immunology, and preclinical research preferred.
LNP, CAR-T, CAAR-T, oligo/siRNA, GLP, Go/No-Go
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Executive Director, Discovery-Oncology
Beerse or Spring House or Cambridge
$196k-$343k/yr HybridFull Time
Johnson & Johnson
Johnson & JohnsonNYSE: JNJ: Provides pharmaceutical products and medical technology healthcare solutions.
15+ YOE15+ MgmtPhD in relevant field, 15+ years drug discovery and leadership experience in oncology (preferably solid tumors), track record advancing programs to clinical candidates, strong external network and people-management skills.
1d
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Director, Drug Development Project Management & Pipeline Strategy
Cambridge or United States
$179k-$237k/yr OnsiteFull Time
Flagship Pioneering
Flagship Pioneering: Conceives, creates, and builds life science platform companies
5+ YOEBachelor's degree in biological sciences or related field; 5–10 years of drug development experience; complex matrix project management expertise; drug discovery, clinical development, and regulatory strategy knowledge.
Microsoft Project, Smartsheet, Microsoft Office, ChatGPT, Claude, Microsoft Copilot, Notion, Microsoft SharePoint
1mo
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Executive Director, Head of LNP Discovery Biology
Billerica, Massachusetts, United States
OnsiteFull Time
Merck
MerckXETRA: MRK: A science and technology providing healthcare, life science, and electronics solutions.
15+ YOE5+ MgmtPhD in a life science, 15+ years drug discovery/preclinical R&D experience with 5+ years leading scientific teams; expertise in LNP delivery, in vivo models, IND-enabling research, and strong communication and strategic skills.
1w
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Associate Director, Discovery Portfolio Management Strategic Planner, Discovery
Cambridge or Lake County or Worcester
$142k-$269k/yr HybridFull Time
AbbVie
AbbVieNYSE: ABBV: Develops and sells innovative pharmaceutical and biopharmaceutical medicines.
5+ YOERequires BS with 10+ years, MS with 7+ years, or PhD with 5+ years in drug discovery industry experience, plus portfolio analysis, KPI reporting, communication, and cross-functional influence.
1mo
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Associate Director, Assay Development - Institute for Drug Discovery
Galveston, Texas, United States
OnsiteFull Time
UTMB Health
UTMB Health: Provides medical care, health education, and biomedical research services.
6+ YOEPh.D. in molecular biology/biochemistry/pharmacology or related plus 6 years assay development experience; expertise in biochemical and cellular assays, HTS, automation, data quality, and project management.
1mo
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Associate Director, Assay Development - Institute for Drug Discovery
Galveston, Texas, United States
OnsiteFull Time
University of Texas Medical Branch
University of Texas Medical Branch: Public academic health science center providing healthcare and education.
6+ YOEPhD plus 6+ years in assay development with HTS and automated screening workflows, expertise in biochemical and cellular assays, BSL-2 biosafety experience, project leadership and data quality control.
high-throughput screening (HTS), BSL-2, assay automation
1mo
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Executive Director, Head of LNP Discovery Biology
Billerica, Massachusetts, United States
$237k-$356k/yr OnsiteFull Time
Merck KGaA
Merck KGaAFrankfurt Stock Exchange: MRK: Develops pharmaceutical, life science, and electronics technologies.
15+ YOE5+ MgmtPhD in a relevant life science discipline and 15+ years in drug discovery and preclinical R&D, including 5+ years leading scientific teams. Expertise in LNP delivery, in vivo studies, and IND-enabling research.
LNP, CAR-T, CAAR-T, oligo/siRNA, GLP