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103 lead staff software engineer jobs at 60 companies in San Mateo, CA

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Staff Software Engineer / Technical Lead
San Francisco, California, United States
$150k-$250k/yr OnsiteFull Time
Tamarind Bio
Tamarind Bio: AI-powered platform for computational biology and drug discovery.
7+ YOE7+ years software engineering experience; staff/principal/technical lead experience; strong software architecture, distributed systems, and cloud infrastructure (AWS) experience; mentorship and technical leadership; onsite in San Francisco.
AWS, EC2, S3, DynamoDB, Docker, MLOps, DevOps
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Staff Software Engineer, Audit (Full Stack)
San Francisco, California, United States
$210k-$250k/yr RemoteFull Time
Fieldguide
Fieldguide: AI-native platform for automating audit and advisory workflows.
5+ YOESenior staff software engineer with full-stack experience, AI tooling, and ability to lead complex, ambiguous projects; strong collaboration with product/design
TypeScript, React, GraphQL, Node.js, PostgreSQL
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3mo
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Staff Software Engineer, Media Experiences
San Francisco or United States
$217k-$303k/yr RemoteFull Time
Reddit
RedditNYSE: RDDT: Social platform for community-driven discussion and content sharing.
8+ YOE8+ years software engineering; distributed systems; technical leadership; strong communication; lead cross-functional initiatives.
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3w
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Senior Staff Software Engineer, Internal Tools
Redwood City, California, United States
$241k-$331k/yr HybridFull Time
Chan Zuckerberg Initiative
Chan Zuckerberg Initiative: Funds and builds technology to solve major societal challenges.
12+ YOE12+ years building production software, tech-leading small teams, full-stack engineering, cloud infrastructure/IaC, API integrations, LLMs/agents and retrieval/knowledge systems.
MCP, LLM, Infrastructure as Code (IaC), knowledge graphs, vector stores, RAG
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5d
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Staff+ Software Engineer, Privacy
San Francisco or New York City or Seattle
$405k-$485k/yr HybridFull Time
Anthropic
Anthropic: Developing safe and reliable artificial intelligence systems.
12+ YOEBachelor’s degree or equivalent experience; 12+ years in software engineering and 3+ years leading complex projects; production-scale privacy engineering, distributed systems, data governance, and Python or Go experience.
Python, Go, differential privacy, federated learning, secure multi-party computation, GDPR, CCPA, HIPAA, EU AI Act, homomorphic encryption, secure enclaves, Claude
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Staff Software Engineer, Machine Learning Platform
San Francisco or Seattle
OnsiteFull Time
Stripe
Stripe: Provides online payment processing and financial infrastructure for businesses.
10+ YOE10+ years of software development; technical lead; production ML platform experience; cross-functional collaboration; autonomous; AI tooling experience.
AWS, SageMaker, Databricks, OpenAI, Python, Java, SQL, ML platforms
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Staff Software Engineer – Secondary Driving System
Sunnyvale or Sunnyvale
$219k-$335k/yr RemoteFull Time
General Motors
General MotorsNYSE: GM: Manufactures and sells automobiles and automotive parts globally.
8+ YOELead SDS software development; strong C++/ROS; 8+ years in robotics or real-time systems; experience in perception/prediction; leadership and collaboration across teams.
Modern C++, Python, ROS, TensorRT, ML tooling
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Staff Software Engineer, Platform
San Francisco or New York City
$250k-$295k/yr HybridFull Time
Unify
Unify: AI-powered platform for automating B2B sales outbound workflows.
8+ YOE8+ years software-engineering experience, 3+ years leading projects or teams, deep PostgreSQL expertise, production-grade systems experience, strong mentoring and technical leadership skills.
PostgreSQL
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Staff Software Engineer
Oakland or United States
$208k/yr RemoteFull Time
Earnest
EarnestNASDAQ: NAVI: Provides student loan refinancing and personal lending services.
3+ YOEBachelor's in CS or related plus 3 years software development; 3 years with distributed microservices, PostgreSQL, Node.js/TypeScript, client frameworks; 2 years with AWS and leading large-scale projects; strong communication.
Node.js, TypeScript, JavaScript, React/Redux, React Native, Angular, Sequelize, PostgreSQL, Docker, Mocha, Chai, Sinon, FullStory, AWS, Jira
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Staff Software Engineer
New York City or San Francisco or Seattle
$252k-$315k/yr OnsiteFull Time
Scale AI
Scale AI: Provides data and infrastructure for training artificial intelligence models.
7+ YOE7+ years engineering experience as tech lead/architect; experience with LLMs or vector databases preferred; proficient in Javascript/Typescript, SQL, Kubernetes, cloud providers; strong communication and critical thinking.
Javascript, Typescript, SQL, Kubernetes, AWS, Azure, GCP, LLMs, vector databases
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Lead/Staff Software Engineer - AI Platform
San Francisco, California, United States
OnsiteFull Time
Dynamo AI
Dynamo AI: A that provides infrastructure and evaluation frameworks to help enterprises deploy AI systems reliably, securely, and at scale.
8+ YOE8+ years software engineering experience with 4+ years on large-scale distributed systems; deep Kubernetes and cloud (AWS/Azure/GCP) expertise; hands-on with Python, TypeScript, Go; proven technical leadership and customer-facing experience.
Kubernetes, AWS, Azure, GCP, Python, TypeScript, Go
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Senior Staff Software Engineer - Pricing and Packaging
San Francisco or Denver or New York City
$189k-$278k/yr HybridFull Time
Gusto
Gusto: Cloud-based payroll and HR software for small businesses.
10+ YOE10+ years of software engineering; 2+ years as tech lead; strong backend experience; distributed systems; AI tooling experience; cross-functional collaboration; excellent communication; BS degree or equivalent.
Ruby, Java, Python, Go
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3mo
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Staff Software Engineer, Product Security
San Francisco, California, United States
$220k-$330k/yr HybridFull Time
Harvey
Harvey: AI platform for legal research and document analysis.
8+ YOE8+ years in product security, application security, and security-focused software engineering; track record of remediating vulnerabilities; leading cross-functional security initiatives; mentoring; strong programming and communication skills.
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Senior Staff Software Engineer, Performance (Tech Lead)
Santa Clara, California, United States
$191k-$334k/yr OnsiteFull Time
ServiceNow
ServiceNowNYSE: NOW: Provides a cloud platform for automating enterprise digital workflows.
12+ YOE12+ years software engineering experience with performance/scalability expertise, distributed systems, Golang, AWS, profiling/testing/monitoring tools, and database/query optimization.
Golang, AWS, Kubernetes
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1d
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Staff Engineer/Tech Lead, MSK Verticals
San Francisco, California, United States
$192k-$264k/yr HybridFull Time
Hinge Health
Hinge HealthNYSE: HNGE: Digital provider of musculoskeletal care and physical therapy
4+ YOERequires 4+ years of software engineering experience, 2+ years with TypeScript/JavaScript, cloud platforms, relational databases, distributed systems and microservices, plus 3+ years mentoring or leading engineers.
TypeScript, JavaScript, Node.js, NestJS, React, React Native, AWS, PostgreSQL, CI/CD, HIPAA, ESPP
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Staff Software Engineer, AI/ML, Google Cloud AI
Sunnyvale, California, United States
$207k-$300k/yr OnsiteFull Time
Google
GoogleNASDAQ: GOOGL: Provides online search, advertising, cloud computing, and consumer electronics.
8+ YOEBachelor's degree or equivalent; 8+ years software development; 5+ years ML-related experience; 5+ years leading ML design/infrastructure; 5+ years validating and launching software; 3+ years design/architecture.
TensorFlow, PyTorch, Vertex AI, Gemini, Distributed Computing, Large-Scale System Design, NLP, Speech Processing
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Managing Staff Software Engineer - Embedded UI
Sunnyvale, California, United States
$224k-$322k/yr OnsiteFull Time
Intuitive
IntuitiveNASDAQ: ISRG: Robotic-assisted systems for minimally invasive surgery.
10+ YOE5+ MgmtLead embedded UI engineers; strong C/C++, Qt; experience guiding teams; 10+ years in digital interfaces.
C/C++, Qt, OpenGL, Vulkan
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Staff, Software Engineer
Sunnyvale, California, United States
$143k-$286k/yr OnsiteFull Time
Walmart
WalmartNYSE: WMT: Multinational retail operating discount stores and supermarkets.
4+ YOEExperience designing and delivering cloud-native, scalable systems; leading full SDLC, API design, CI/CD, and integrating ML; strong system design and mentoring skills.
CI/CD, ML frameworks, WCAG 2.2 AA
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Staff Software Engineer / Tech Lead, ML Infrastructure
San Francisco, California, United States
$190k-$250k/yr HybridFull Time
HeartFlow
HeartFlowNASDAQ: HTFL: Provides AI-driven non-invasive cardiac diagnostic software and analysis.
8+ YOE8+ years software engineering experience in ML infrastructure or distributed systems; strong Python; experience with cloud (AWS/GCP/Azure), infra-as-code (CDK, Terraform), Ray, Kubernetes, and Apache Iceberg; mentoring and technical leadership experience.
Python, Ray, Kubernetes, Apache Iceberg, C++, CDK, Terraform, AWS, GCP, Azure
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Staff Software Engineer, Core Infrastructure
Bellevue or Seattle or San Francisco or Palo Alto or Los Angeles
$195k-$343k/yr OnsiteFull Time
Snap
SnapNYSE: SNAP: Develops social media applications and augmented reality technology.
9+ YOEBachelor's in CS/Engineering or equivalent; 9+ years software development experience (reduced with advanced degree); proven technical lead experience building and operating large-scale distributed backend systems; strong system design and leadership skills.
Go, Java, Python, C++, Kubernetes
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