49 principal biochemistry jobs at 27 companies in United States
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Senior / Principal Scientist, Biochemistry
Watertown, Massachusetts, United States
$158k-$184k/yr OnsiteFull Time
5+ YOEPhD in biochemistry or related field with 5+ years industry experience (or equivalent), expertise in enzyme kinetics and biochemical assay development (FP, TR-FRET, AlphaLISA, DSF), DEL hit validation, strong troubleshooting and communication skills.
FP, TR-FRET, AlphaLISA, DSF, DEL
2mo
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Principal Scientist, Head of Protein Biochemistry, Viral Vaccines
Pearl River, New York, United States
$106k-$177k/yr OnsiteFull Time
4+ YOEPhD in Biochemistry/Biophysics/Structural Biology with 4-7 years industry experience; expertise in recombinant protein expression, purification and biophysical characterization; leadership and mentoring experience.
FPLC, HPLC, Western blotting, UV-Vis, BLI
2w
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Principal Scientist
Wood Dale, Illinois, United States
OnsiteFull Time
Advanced degree (PhD or MS) in Chemistry/Biochemistry, hands-on peptide synthesis and SPPS experience, ability to translate technical insight into commercial products, presentation and customer engagement experience, willingness to travel.
1w
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Principal Scientist, Upstream Development
Rahway, New Jersey, United States
$173k-$273k/yr OnsiteFull Time
8+ YOEPh.D. with 8+ years, master's with 10+ years, or bachelor's with 14+ years in chemical engineering, bioengineering, biochemistry, or related field; upstream cell culture process development and leadership experience required.
CHO, Mammalian Cell Culture, Bioreactors, Microbioreactors, Computational Fluid Dynamics (CFD), Finite Element Analysis (FEA), Machine Learning, Metabolic Flux Analysis (MFA), Omics, Data Science, Predictive Modeling, Quality by Design, Microsoft Excel
1mo
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Associate Principal Scientist - Biotransformation
Indianapolis, Indiana, United States
$80k-$167k/yr OnsiteFull Time
Advanced degree in chemistry/biochemistry/biology (or equivalent experience), deep experience in drug metabolism/biotransformation, mass spectrometry and metabolite profiling, analytical method development, data interpretation, and scientific reporting.
MS, MS/MS, ADME
2w
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Senior Principal Scientist, Neuropsychiatry Discovery
San Diego, California, United States
$137k-$236k/yr OnsiteFull Time
10+ YOEPhD and 10+ years in neuroscience/biochemistry/molecular biology with drug discovery experience, assay development, collaboration, and ability to leverage AI-enabled tools.
2w
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Senior Principal Scientist, Neuropsychiatry Discovery
San Diego, California, United States
$137k-$236k/yr OnsiteFull Time
10+ YOEPhD plus 10+ years' experience in neuroscience/biochemistry/molecular biology, drug discovery expertise, assay and cell culture experience, strong analytical and communication skills, mentorship and cross-functional leadership.
2mo
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Principal Associate Scientist, Biology
Cambridge, Massachusetts, United States
$108k-$128k/yr OnsiteFull Time
7+ YOEB.S. or M.S. in Biology/Biochemistry or related field; 7–10+ years in industry; strong cell-based assay and molecular biology skills; on-site collaboration.
NanoBRET, HiBiT, AlphaLISA, HTRF, qPCR, Western blotting, immunoprecipitation, pulldown assays, CRISPR/Cas9
1mo
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Principal Scientist – Bioseparation & Analytical Development
Ann Arbor, Michigan, United States
OnsiteFull Time
8+ YOEBS in analytical chemistry/biochemistry or related required; 8+ years biopharma analytical development experience; deep expertise in bioseparation, LC-MS, CE, and biophysical techniques; experience with method validation and regulatory submissions.
HPLC, UPLC, UHPLC, SEC, IEX, HIC, RP-HPLC, affinity chromatography, LC-MS/MS, high-resolution MS, SEC-MALS, native MS, MAM workflows, CE-SDS, cIEF, DLS, DSC, UV/fluorescence, MALS, CD, FTIR
2mo
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Principal Scientist, Large Molecule Analytical
Rahway, New Jersey, United States
$157k-$247k/yr OnsiteFull Time
8+ YOEPhD/MS/BS in analytical chemistry/biochemistry (with required industry experience), extensive biologics analytical experience (SEC, IEX, CE, LC), assay development/validation, leadership and mentoring, regulatory writing, and strong cross-functional collaboration.
Size Exclusion Chromatography (SEC), Ion Exchange Chromatography (IEX), Capillary Electrophoresis (CE), Liquid Chromatography (LC)
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Sr. Principal Lab Scientist
Richmond, Virginia, United States
$102k-$172k/yr OnsiteFull Time
5+ YOEBS in biology/chemistry/biochemistry required, >5 years pharmaceutical/GMP lab experience, laboratory startup and technical leadership experience, authorized to work in the US; MS/PhD preferred.
3mo
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Principal Scientist – Antibody Discovery/Protein Design
Branford, Connecticut, United States
OnsiteFull Time
5+ YOEPhD in biochemistry, computational biology, or structural biology with 5+ years antibody/biotherapeutic engineering experience; AI/ML protein design; antibody display tech; multispecific protein design; strong cross-functional collaboration.
AI/ML, Yeast display, Phage display, Antibody engineering, Biophysical characterization, Multispecific protein design
1mo
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Principal Scientist, Analytical Development - Process Science
Louisville, Colorado, United States
$150k-$165k/yr OnsiteFull Time
6+ YOELead analytical method development, validation and transfer for proteins, viral vectors and cell therapies; supervise staff; author regulatory CMC documents; 6+ years biopharma experience (PhD route) and extensive HPLC/biochemistry expertise.
HPLC, SEC, RP, IEX, SDS-PAGE, CE, icIEF, ELISA, flow cytometry
2d
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Principal Sci, R&D - Ingredient Technology
Glenview, Illinois, United States
$104k-$130k/yr OnsiteFull Time
4+ YOEBachelor's in food science, chemistry, biochemistry, molecular biology, dairy science, food chemistry, or related field; 4–6 years' experience by degree level; ingredient technology, lipid systems, experiments, scale-up, and shelf-life expertise.
AI
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Principal Scientist I, Oncology Pharmacology
San Diego, California, United States
$94k-$174k/yr OnsiteFull Time
Bachelor’s or Master’s in pharmacology, biology, biochemistry, or related life sciences; hands-on in vivo pharmacology with rodent handling; preclinical oncology models; cell culture; strong data, collaboration, and communication skills.
In Vivo Pharmacology, Flow Cytometry, ELISA, PCR, Cell Culture, GraphPad Prism
2mo
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Principal Process Chemist - Peptide Focus
Boulder, Colorado, United States
$122k-$153k/yr OnsiteFull Time
5+ YOEPhD in Organic Chemistry/Biochemistry with peptide chemistry expertise; 5+ years in industry (CDMO or pharmaceutical/fine chemical manufacturing); large-scale peptide process development and tech transfer experience; GMP/ICH knowledge.
1mo
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Principal Research Scientist I, Multispecifics Engineering
Worcester, Massachusetts, United States
$125k-$237k/yr OnsiteFull Time
6+ YOEPhD or MS in biochemistry/biochemical engineering (or related); 6+ (PhD) or 12+ (MS) years multispecific/antibody engineering experience; protein expression/purification, analytical characterization, project and people management experience; publication/patent record preferred.
Vector NTI, Geneious, Genedata, Protein Metrics
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Principal Scientist, Purification Process Development
South San Francisco, California, United States
$159k-$207k/yr OnsiteFull Time
10+ YOEPhD in biology/biochemistry/chemical engineering or related, 10+ years of experience; purification process characterization and validation; PPQ; CMOs; analytical methods (ELISA, HPLC, UV, SDS-PAGE) and biophysical techniques.
AKTA, HPLC, LC/MS, SDS-PAGE, DLS
2mo
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Supervising Principal Scientist, Process Development
South San Francisco or Bridgewater
$90k-$210k/yr OnsiteFull Time
6+ YOEBachelor's/Master's/PhD in bioengineering, chemical engineering, biology, biochemistry or related; 6+ years process development experience in cell & gene therapy; subject-matter expertise in T cell/HSC/iPSC modalities; hands-on with Miltenyi Prodigy, Lonza Cocoon, Xuri Wave; familiarity with LVV, RVV, LNP, CRISPR, TALENs, ZFNs; people management an...
Miltenyi Prodigy, Lonza Cocoon, Xuri Wave, LVV, RVV, LNP, CRISPR, TALENs, ZFNs
1mo
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Principal Scientist I, II or III - Purification Chemist - FSP
Rahway, New Jersey, United States
OnsiteFull Time
0+ YOEBS/MS/PhD in Chemistry or Biochemistry and industry experience in semi-preparative/preparative chromatographic purification, strong wet chemistry and problem-solving skills, excellent communication.
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