41 principal scientist jobs at 13 companies in Alpine, CA
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Principal Data Scientist - Immunology - (2 positions)
Titusville or Cambridge or Raritan or Spring House or San Diego
$117k-$201k/yr HybridFull Time
5+ YOEPrincipal Data Scientist with bioinformatics/biomedical data expertise; 5+ years health informatics; semantic tech, ontologies, knowledge graphs; PhD or Master preferred.
Semantic Web, SPARQL, RDF, OWL, Graph Databases, Neo4j, Amazon Neptune, REST, GraphQL, Docker, CI/CD, Jenkins, GitLab, Azure DevOps, SQL, NoSQL, Proteomics, Genomics
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Principal Scientist
Carlsbad, California, United States
$113k-$170k/yr OnsiteFull Time
15+ YOEBS or MS in Chemistry, Analytical Science, or related field, or equivalent experience; 15+ years in GLP/GMP analytical environments with method validation, transfer, leadership, and mentoring experience.
qPCR, ddPCR, HPLC, CE-SDS, ELISA, FTIR, Gel Electrophoresis, Microsoft Excel, Laboratory Information Management System
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Principal Scientist
Carlsbad, California, United States
$113k-$170k/yr OnsiteFull Time
15+ YOEBS or MS in Chemistry, Analytical Science, or related field and 15+ years in GLP/GMP analytical environments, with method validation, analytical testing, mentoring, quality systems, and regulatory experience.
qPCR, ddPCR, HPLC, CE-SDS, ELISA, FTIR, Gel Electrophoresis, UPLC, PCR, Laboratory Information Management System
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Senior Principal Scientist 1
San Diego, California, United States
$180k-$240k/yr OnsiteFull Time
10+ YOEPhD (or equivalent) with 10+ years industry experience in subcutaneous drug delivery, proven in vivo preclinical study expertise, device experience preferred, strong data analysis and communication skills.
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Principal Scientist, Pharmaceutical Development
San Diego, California, United States
$131k-$179k/yr OnsiteFull Time
6+ YOELead CMC development, analyze parenteral drug product, manage CROs/CMOs, and ensure regulatory readiness across early discovery to commercialization.
DoE, QbD, Analytical Methods, Regulatory Submissions, CMC, Technology Transfer
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Principal Scientist, Clinical Research, Immunology
San Diego or Massachusetts or Rahway or North Wales
$256k-$403k/yr HybridFull Time
5+ YOEM.D., D.O., M.D./PhD, or D.O./PhD and at least 5 years of clinical or development experience; scientific scholarship, clinical research, and cross-functional collaboration required.
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Principal Scientist, Early Pipeline Development
La Jolla, California, United States
$109k-$222k/yr OnsiteFull Time
3+ YOEPhD in bioprocessing/biochemical engineering/gene therapy,3+ years process development experience,people management,downstream purification expertise,AKTA experience,and strong communication and problem-solving skills.
AKTA purification systems, electronic lab notebook, Python (Programming Language), Machine Learning (ML)
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Senior Principal Scientist, Neuropsychiatry Discovery
San Diego, California, United States
$137k-$236k/yr OnsiteFull Time
10+ YOEPhD and 10+ years in neuroscience/biochemistry/molecular biology with drug discovery experience, assay development, collaboration, and ability to leverage AI-enabled tools.
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Principal Scientist, Clinical Research, Immunology
San Diego or North Wales or Massachusetts or Rahway
$256k-$403k/yr HybridFull Time
5+ YOEM.D., D.O., or equivalent doctoral medical degree; 5+ years of clinical or development experience; scientific scholarship; collaboration and clinical trial expertise required.
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Principal Scientist (Carlsbad, California, US, 92009-1609)
Carlsbad, California, United States
$113k-$170k/yr OnsiteFull Time
15+ YOE15+ years GLP/GMP analytical experience; BS/MS in Chemistry or related field; expertise in method validation/transfer and advanced assays (qPCR, ddPCR, HPLC, CE-SDS, ELISA); cGMP/ICH knowledge and leadership/mentoring experience.
qPCR, ddPCR, HPLC, HPLC/UPLC, CE-SDS, ELISA, FTIR, Gel Electrophoresis, spectroscopy, cell-based assays, IQ/OQ/PQ/PM, ALCOA+, cGMP, ICH
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Senior Principal Scientist: Metabolomics/Cell Therapy Media Development
South San Francisco or San Diego
$143k-$266k/yr OnsiteFull Time
5+ YOEPhD in biological sciences/chemical engineering or related plus 5+ years R&D experience in metabolomics and/or cell culture media development; technical leadership, stakeholder management, and team development experience required.
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Senior Scientist / Principal Scientist, Bioprocess Sciences
San Diego, California, United States
$120k-$198k/yr OnsiteFull Time
6+ YOEPhD or MS in a relevant field with 6+ years experience in bacterial recombinant protein expression, purification, and bioprocess development; experience with chromatography, filtration, protein characterization, and leading projects/CDMO interactions.
FPLC, Benchling, HPLC, UPLC, LC-MS
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Principal Data Scientist
Canada or San Diego or South San Francisco
$188k-$210k/yr RemoteFull Time
8+ YOEPhD in data science, machine learning, applied math, or equivalent; 8+ years in data/applied science; Python, computer vision, statistical modeling, cloud computing, and technical leadership experience.
Python, AWS
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Principal Scientist, Structural Biologics
La Jolla, California, United States
$109k-$202k/yr OnsiteFull Time
3+ YOEPhD in biophysics/biochemistry or related,3+ years postdoc/industry structural biology experience,expertise in X-ray crystallography and/or CryoEM,protein purification and molecular biology,AI/ML interest,mentoring ability.
X-ray crystallography, CryoEM, AI/ML, LCMS, ITC, DSC, anSEC, SEC, IMAC, Affinity, laboratory automation
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PRINCIPAL SCIENTIST- (Protein Immunotherapy)
San Diego, California, United States
$120k-$150k/yr OnsiteFull Time
10+ YOEBachelor's in biology-related field (PhD preferred), 10+ years industry experience, strong immunology and flow cytometry expertise, gene‑editing and protein/antibody experience, team management and scientific communication skills.
flow cytometry, high-throughput flow cytometry platforms, CRISPR, TALEN, laboratory automation systems, protein and mRNA electroporation, viral vector systems, protein engineering
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Principal Scientist, Translational Computational Biology
San Diego, California, United States
$148k-$179k/yr OnsiteFull Time
4+ YOEBS with 8+ years, MS with 6+ years, or PhD with 4+ years in biology, pharmacology, translational research, molecular biology, or a related discipline; computational biology and data science expertise required.
AI
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Principal Scientist, Analytical Development
San Diego, California, United States
$170k-$185k/yr OnsiteFull Time
10+ YOEPhD with 10+ years industry analytical development experience, expertise in cell-based potency assays, assay validation, flow cytometry, ELISA/MSD, qPCR/ddPCR, regulatory writing, and scientific leadership.
flow cytometry, ELISA, MSD, qPCR, ddPCR, JMP
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Data Scientist, Principal - AI Product Engineering
Oakland or Washington or Ohio or District of Columbia or California or Long Beach or Arizona or Colorado or Connecticut or Florida or Georgia or Maryland or Minnesota or Nevada or Oregon or El Dorado Hills or San Diego or Woodland Hills or Alabama or Illinois or Virginia or Wisconsin or Texas or New York
$161k-$242k/yr HybridFull Time
10+ YOEBachelor's degree or equivalent practical experience and 10 years in data science, machine learning, AI/ML, software engineering, or advanced analytics. Requires Python, APIs, ML infrastructure, PyTorch, TensorFlow, LangChain, and LangGraph.
Python, PyTorch, TensorFlow, LangChain, LangGraph, Azure, Google Cloud, AWS, SQL, Spark, CI/CD, MLOps, LLMOps
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