691 principal scientist jobs at 270 companies in United States

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Principal Scientist (300213)
Carlsbad, California, United States
$113k-$170k/yr OnsiteFull Time, Part Time
Merck
MerckXETRA: MRK: A science and technology providing healthcare, life science, and electronics solutions.
15+ YOE15+ years in GLP/GMP analytical environments with BS/MS in chemistry or related field (or equivalent experience). Expertise in method validation/transfer, qPCR/ddPCR/HPLC/ELISA and biologics assays, data integrity, root-cause investigations, and mentoring scientists.
qPCR, ddPCR, HPLC, UPLC, CE-SDS, ELISA, FTIR, Gel Electrophoresis, spectroscopy, cell-based assays
2mo
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Scientist-Principal Scientist, Protein Design & Structure
Boston, Massachusetts, United States
OnsiteFull Time
Superluminal Medicines
Superluminal Medicines: Accelerates small molecule drug discovery using generative AI.
2+ YOEPhD in Biochemistry/Molecular Biology/Biophysics with 2+ years (Scientist) or 5+ years (Senior Scientist) or 8+ years (Principal Scientist) of relevant experience in GPCR/membrane protein expression, purification, and characterization; strong leadership and collaboration skills.
Cryo-EM, FPLC, SEC, Rosetta, AI/ML
2mo
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Principal Data Scientist - Immunology - (2 positions)
Titusville or Cambridge or Raritan or Spring House or San Diego
$117k-$201k/yr HybridFull Time
Johnson & Johnson
Johnson & JohnsonNYSE: JNJ: Develops and manufactures pharmaceutical drugs and medical devices.
5+ YOEPrincipal Data Scientist with bioinformatics/biomedical data expertise; 5+ years health informatics; semantic tech, ontologies, knowledge graphs; PhD or Master preferred.
Semantic Web, SPARQL, RDF, OWL, Graph Databases, Neo4j, Amazon Neptune, REST, GraphQL, Docker, CI/CD, Jenkins, GitLab, Azure DevOps, SQL, NoSQL, Proteomics, Genomics
3w
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Principal Data Scientist
Austin, Texas, United States
HybridFull Time
Central Health
Central Health: Providing healthcare services to low-income residents of Travis County.
5+ YOE3+ MgmtDoctorate-level data scientist with deep applied ML and statistical modeling experience in healthcare; expertise in model validation, reproducibility, governance, cloud platforms (Azure/Snowflake), Epic data, and team leadership.
Epic (EHR), VBA (TPA), Microsoft Azure, Snowflake, NIST AI Risk Management Framework (AI RMF), ISO/IEC 42001
2mo
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Principal Scientist
Melrose Park, Illinois, United States
$80k-$95k/yr OnsiteFull Time
Fresenius Kabi
Fresenius Kabi: Provides lifesaving medicines and technologies for clinical care.
7+ YOELead and manage E&L team; design, execute and regulatory-approve E&L studies; collaborate cross-functionally; ensure cGMP compliance and regulatory readiness.
GC/MS, HR-LC/MS, ICP-MS, Soxhlet extraction, ASE, Mass spectrometry
3mo
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Principal Scientist
Las Vegas, Nevada, United States
$122k-$186k/yr OnsiteFull Time
Mission Support and Test Services: Manages and operates the Nevada National Security Site.
9+ YOEBachelor's in Health Physics, Nuclear Engineering or similar STEM; 9+ years experience; PhD preferred; strong communication; willingness to deploy worldwide; SCI access and DOE security clearances required
Office365, Radiation detection equipment, Analysis software, Programming languages
6d
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Principal Scientist
Wood Dale, Illinois, United States
OnsiteFull Time
Chem-Impex
Chem-Impex: Manufacturing and distributing laboratory chemicals for life science research.
Advanced degree (PhD or MS) in Chemistry/Biochemistry, hands-on peptide synthesis and SPPS experience, ability to translate technical insight into commercial products, presentation and customer engagement experience, willingness to travel.
3w
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Principal Scientist
Frisco, Texas, United States
$97k-$133k/yr OnsiteFull Time
Keurig Dr Pepper
Keurig Dr PepperNasdaq: KDP: Produces and distributes hot and cold beverages and coffee systems.
7+ YOEM.S. required (Ph.D. preferred), 7+ years analytical lab/R&D experience in food/beverage/CPG, expertise in method development/validation, instrumentation, data interpretation, leadership and continuous improvement.
GC/TOF, HPLC, LC/MS, GCxGC, FTIR, ICP/MS
2mo
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Principal Scientist
Darien or Darien
$110k-$120k/yr OnsiteFull Time
Henkel
HenkelXETRA: HEN3: Manufactures laundry, beauty, and adhesive products globally.
10+ YOELead hair care formulation design and scale-up; cross-functional collaboration; 10+ years in formulation development; travel up to 15%
2w
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Principal Scientist
Cherry Hill, New Jersey, United States
$118k-$135k/yr OnsiteFull Time
TPM Laboratories
TPM Laboratories: Independent contract testing laboratory for pharmaceutical and chemical industries.
10+ YOEBS in Chemistry (advanced degree preferred), 10+ years pharmaceutical/analytical lab experience, method development/validation leadership, expertise in HPLC/UPLC/GC/dissolution/UV/FTIR and cGMP/ALCOA+/FDA/ICH/USP/EP, strong technical writing and communication.
HPLC, UPLC, GC, Dissolution, UV, FTIR, cGMP, ALCOA+, FDA, ICH, USP, EP
4w
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Principal Scientist
San Carlos, California, United States
$165k-$205k/yr OnsiteFull Time
Grifols
GrifolsMadrid Stock Exchange: GRF: Develops plasma-derived medicines and clinical diagnostic solutions.
8+ YOEPhD preferred (or MS/BS with extensive experience). 8+ years post-PhD (or equivalent), strong antibody/protein engineering, expression/purification, molecular biology, project leadership, publications/patents, and experience mentoring staff and managing collaborations.
4d
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Principal Scientist
South San Francisco, California, United States
$143k-$266k/yr OnsiteFull Time
Roche
RocheSIX Swiss Exchange: ROG: Provides innovative pharmaceutical and diagnostic healthcare solutions.
3+ YOEPhD and 3+ years industry experience designing and executing small-molecule metabolomics/lipidomics assays, operating LC-MS platforms, and applying computational/Generative AI tools for data analysis.
Generative AI, LC-HRMS, LC-MS/MS, UHPLC, triple quadrupole
2w
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Senior Principal Scientist - Bioanalytical Sciences
Tarrytown, New York, United States
$151k-$246k/yr OnsiteFull Time
Regeneron
RegeneronNasdaq: REGN: Discovers and manufactures medicines for serious diseases.
5+ YOEPhD+5 or MS+8 or BS+10 years experience in immunoassay development/validation; ability to design experiments, troubleshoot, interpret data, write protocols, and lead scientists.
1w
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Associate Principal Scientist, Biology-Discovery
Elkhorn, Nebraska, United States
$142k-$224k/yr OnsiteFull Time
Merck & Co.
Merck & Co.NYSE: MRK: Produces prescription medicines, vaccines, and animal health products.
3+ YOEPhD or DVM/PhD in relevant field, minimum 3 years poultry vaccine or regulated biologics experience, expertise in poultry disease and vaccine development, regulatory knowledge, and ability to lead projects and mentor scientists.
1d
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Senior Principal Scientist
Thousand Oaks, California, United States
$168k-$228k/yr HybridFull Time
Amgen
AmgenNASDAQ: AMGN: Develops and manufactures biotechnology medicines for serious diseases.
Doctorate or equivalent scientific degree with toxicology experience; expertise in leachables/extractables, risk-based toxicology assessments, OEL/OEB derivation, GHS classification, and regulatory guidance (ICH/ISO).
OECD Toolbox, Toxtree, Benchmark Dose (BMD), EndNote, Microsoft Office
2mo
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Principal Scientist - Formulation
Woodcliff Lake, New Jersey, United States
$135k-$165k/yr OnsiteFull Time
PDI
PDI: Manufactures infection prevention products and antiseptic wet wipes.
8+ YOEBS in Chemistry or Chemical Engineering; 8-10 years in analytical chemistry or formulation R&D; advanced degree preferred; regulated environments experience (FDA/EPA/pharma) desired.
Analytical chemistry tools, Formulation techniques, Characterization methods, Experimental design tools
3w
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Associate Principal Scientist
Princeton, New Jersey, United States
$94k-$115k/yr OnsiteFull Time
Evotec
EvotecNASDAQ: EVO: Drug discovery and development services for life science companies.
3+ YOEPhD in a scientific field, 3+ years related experience, assay development and imaging/MEA experience, strong data analysis and communication skills, Microsoft Word and Outlook proficiency.
Microsoft Word, Microsoft Outlook
1mo
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Senior Principal Scientist
Cambridge, Massachusetts, United States
$149k-$215k/yr HybridFull Time
Sanofi
SanofiEuronext Paris: SAN: Researches, develops, and manufactures medicines and vaccines globally.
7+ YOEPhD plus ≥7 years biopharma research experience in hematopoietic stem cell biology and mast cell disorders; experience in early/late-stage research, translational research, CRO management, regulatory submissions, and strong communication skills.
1mo
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Principal Scientist I
Davis or Sacramento
$131k-$205k/yr HybridFull Time
West Yost
West Yost: Engineering consulting for water, wastewater, and stormwater infrastructure.
15+ YOEBachelor's in geology/hydrogeology/environmental science, 15+ years related experience, project management experience (managing $1M+ budgets), knowledge of CA groundwater law/policy, prior supervision of direct reports, strong oral and written communication.
3w
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Temp Principal Scientist
Waltham, Massachusetts, United States
$78-$96/hr HybridContract
Viridian Therapeutics
Viridian TherapeuticsNASDAQ: VRDN: Developing optimized treatments for rare autoimmune conditions.
6+ YOEMS+8yrs or PhD+6yrs in quantitative field, clinical pharmacology programming experience, SAS or R, CDISC (STDM/ADaM), dataset cleaning and transformation for PPK/PKPD/ER analyses.
SAS, R, CDISC, STDM, ADaM