43 principal scientist jobs at 17 companies in Bonsall, CA
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Principal Data Scientist - Immunology - (2 positions)
Titusville or Cambridge or Raritan or Spring House or San Diego
$117k-$201k/yr HybridFull Time
5+ YOEPrincipal Data Scientist with bioinformatics/biomedical data expertise; 5+ years health informatics; semantic tech, ontologies, knowledge graphs; PhD or Master preferred.
Semantic Web, SPARQL, RDF, OWL, Graph Databases, Neo4j, Amazon Neptune, REST, GraphQL, Docker, CI/CD, Jenkins, GitLab, Azure DevOps, SQL, NoSQL, Proteomics, Genomics
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Principal Scientist
Carlsbad, California, United States
$113k-$170k/yr OnsiteFull Time
15+ YOEBS or MS in Chemistry, Analytical Science, or related field, or equivalent experience; 15+ years in GLP/GMP analytical environments with method validation, transfer, leadership, and mentoring experience.
qPCR, ddPCR, HPLC, CE-SDS, ELISA, FTIR, Gel Electrophoresis, Microsoft Excel, Laboratory Information Management System
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Principal Scientist
Carlsbad, California, United States
$113k-$170k/yr OnsiteFull Time
15+ YOEBS or MS in Chemistry, Analytical Science, or related field and 15+ years in GLP/GMP analytical environments, with method validation, analytical testing, mentoring, quality systems, and regulatory experience.
qPCR, ddPCR, HPLC, CE-SDS, ELISA, FTIR, Gel Electrophoresis, UPLC, PCR, Laboratory Information Management System
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Senior Principal Scientist 1
San Diego, California, United States
$180k-$240k/yr OnsiteFull Time
10+ YOEPhD (or equivalent) with 10+ years industry experience in subcutaneous drug delivery, proven in vivo preclinical study expertise, device experience preferred, strong data analysis and communication skills.
2mo
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Principal Scientist, Pharmaceutical Development
San Diego, California, United States
$131k-$179k/yr OnsiteFull Time
6+ YOELead CMC development, analyze parenteral drug product, manage CROs/CMOs, and ensure regulatory readiness across early discovery to commercialization.
DoE, QbD, Analytical Methods, Regulatory Submissions, CMC, Technology Transfer
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Principal Clinical Scientist
Aliso Viejo, California, United States
$148k-$194k/yr OnsiteFull Time
5+ YOEMaster's degree in relevant science/medicine, 5+ years clinical research scientist experience, GCP knowledge, clinical protocol development, strong writing and communication, analytical skills.
PubMed, MedLine
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Principal Scientist, Clinical Research, Immunology
San Diego or Massachusetts or Rahway or North Wales
$256k-$403k/yr HybridFull Time
5+ YOEM.D., D.O., M.D./PhD, or D.O./PhD and at least 5 years of clinical or development experience; scientific scholarship, clinical research, and cross-functional collaboration required.
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Principal Scientist, Clinical Research, Immunology
San Diego or North Wales or Massachusetts or Rahway
$256k-$403k/yr HybridFull Time
5+ YOEM.D., D.O., or equivalent doctoral medical degree; 5+ years of clinical or development experience; scientific scholarship; collaboration and clinical trial expertise required.
1mo
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Principal Scientist, Early Pipeline Development
La Jolla, California, United States
$109k-$222k/yr OnsiteFull Time
3+ YOEPhD in bioprocessing/biochemical engineering/gene therapy,3+ years process development experience,people management,downstream purification expertise,AKTA experience,and strong communication and problem-solving skills.
AKTA purification systems, electronic lab notebook, Python (Programming Language), Machine Learning (ML)
2w
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Senior Principal Scientist, Neuropsychiatry Discovery
San Diego, California, United States
$137k-$236k/yr OnsiteFull Time
10+ YOEPhD and 10+ years in neuroscience/biochemistry/molecular biology with drug discovery experience, assay development, collaboration, and ability to leverage AI-enabled tools.
2mo
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Principal Scientist (Carlsbad, California, US, 92009-1609)
Carlsbad, California, United States
$113k-$170k/yr OnsiteFull Time
15+ YOE15+ years GLP/GMP analytical experience; BS/MS in Chemistry or related field; expertise in method validation/transfer and advanced assays (qPCR, ddPCR, HPLC, CE-SDS, ELISA); cGMP/ICH knowledge and leadership/mentoring experience.
qPCR, ddPCR, HPLC, HPLC/UPLC, CE-SDS, ELISA, FTIR, Gel Electrophoresis, spectroscopy, cell-based assays, IQ/OQ/PQ/PM, ALCOA+, cGMP, ICH
1mo
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Senior Principal Scientist: Metabolomics/Cell Therapy Media Development
South San Francisco or San Diego
$143k-$266k/yr OnsiteFull Time
5+ YOEPhD in biological sciences/chemical engineering or related plus 5+ years R&D experience in metabolomics and/or cell culture media development; technical leadership, stakeholder management, and team development experience required.
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Principal Scientist- Search
New York City or San Francisco or Los Angeles or Irvine or McLean or Washington
$212k-$394k/yr HybridFull Time
8+ YOEPhD and 8+ years building and deploying production AI systems; deep expertise in information retrieval, search, NLP, RAG, knowledge graphs, LLMs; strong product sense and leadership skills.
Python, PyTorch, Hugging Face, Azure ML, Azure AI Foundry, AWS SageMaker
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Senior Principal Data Scientist, Advanced Forecasting
Irvine, California, United States
$145k-$205k/yr OnsiteFull Time
10+ YOEBachelor's degree in quantitative field, minimum 10 years experience (or 8 with Masters/4 with PhD), strong statistical and ML fundamentals, hands-on Python/R and SQL, forecasting and scenario modeling experience, excellent communication.
Python, R, SQL, Anaplan, Oracle, JDE, Concur, Salesforce.com, Databricks, Azure, AWS
2mo
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Senior Scientist / Principal Scientist, Bioprocess Sciences
San Diego, California, United States
$120k-$198k/yr OnsiteFull Time
6+ YOEPhD or MS in a relevant field with 6+ years experience in bacterial recombinant protein expression, purification, and bioprocess development; experience with chromatography, filtration, protein characterization, and leading projects/CDMO interactions.
FPLC, Benchling, HPLC, UPLC, LC-MS
4d
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Principal Data Scientist
Canada or San Diego or South San Francisco
$188k-$210k/yr RemoteFull Time
8+ YOEPhD in data science, machine learning, applied math, or equivalent; 8+ years in data/applied science; Python, computer vision, statistical modeling, cloud computing, and technical leadership experience.
Python, AWS
1mo
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PRINCIPAL SCIENTIST- (Protein Immunotherapy)
San Diego, California, United States
$120k-$150k/yr OnsiteFull Time
10+ YOEBachelor's in biology-related field (PhD preferred), 10+ years industry experience, strong immunology and flow cytometry expertise, gene‑editing and protein/antibody experience, team management and scientific communication skills.
flow cytometry, high-throughput flow cytometry platforms, CRISPR, TALEN, laboratory automation systems, protein and mRNA electroporation, viral vector systems, protein engineering
1mo
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Principal Scientist, Early Pipeline Development
La Jolla, California, United States
$109k-$222k/yr OnsiteFull Time
3+ YOEPhD in bioprocessing/biochemical engineering/gene therapy, 3+ years process development experience, downstream purification and AKTA experience, people management, EMN documentation and strong communication.
AKTA purification systems, electronic lab notebook
3w
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Principal Scientist, Analytical Development
San Diego, California, United States
$170k-$185k/yr OnsiteFull Time
10+ YOEPhD with 10+ years industry analytical development experience, expertise in cell-based potency assays, assay validation, flow cytometry, ELISA/MSD, qPCR/ddPCR, regulatory writing, and scientific leadership.
flow cytometry, ELISA, MSD, qPCR, ddPCR, JMP
1mo
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Senior Principal Data Scientist, AEC
California or Washington or New York or British Columbia or Ontario or Irvine
$159k-$286k/yr RemoteFull Time
10+ YOE10+ years in data science/applied ML focused on product analytics and user behavior modeling; expertise in predictive modeling, instrumentation, AI evaluation, and experimentation; strong communication and technical leadership.
LLMs, MCP, RAG architectures, LLM-as-a-Judge, A/B testing
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