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36 principal scientist jobs at 12 companies in Santee, CA

3mo
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Principal Data Scientist - Immunology - (2 positions)
Titusville or Cambridge or Raritan or Spring House or San Diego
$117k-$201k/yr HybridFull Time
Johnson & Johnson
Johnson & JohnsonNYSE: JNJ: Develops and manufactures pharmaceutical drugs and medical devices.
5+ YOEPrincipal Data Scientist with bioinformatics/biomedical data expertise; 5+ years health informatics; semantic tech, ontologies, knowledge graphs; PhD or Master preferred.
Semantic Web, SPARQL, RDF, OWL, Graph Databases, Neo4j, Amazon Neptune, REST, GraphQL, Docker, CI/CD, Jenkins, GitLab, Azure DevOps, SQL, NoSQL, Proteomics, Genomics
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2mo
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Principal Scientist
Carlsbad, California, United States
$113k-$170k/yr OnsiteFull Time
Merck KGaA, Darmstadt, Germany
Merck KGaA, Darmstadt, GermanyFrankfurt Stock Exchange: MRK: A science and technology in healthcare, life sciences, and electronics.
15+ YOEBS or MS in Chemistry, Analytical Science, or related field, or equivalent experience; 15+ years in GLP/GMP analytical environments with method validation, transfer, leadership, and mentoring experience.
qPCR, ddPCR, HPLC, CE-SDS, ELISA, FTIR, Gel Electrophoresis, Microsoft Excel, Laboratory Information Management System
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Principal Scientist
Carlsbad, California, United States
$113k-$170k/yr OnsiteFull Time
Merck KGaA
Merck KGaAFrankfurt Stock Exchange: MRK: Develops pharmaceutical, life science, and electronics technologies.
15+ YOEBS or MS in Chemistry, Analytical Science, or related field and 15+ years in GLP/GMP analytical environments, with method validation, analytical testing, mentoring, quality systems, and regulatory experience.
qPCR, ddPCR, HPLC, CE-SDS, ELISA, FTIR, Gel Electrophoresis, UPLC, PCR, Laboratory Information Management System
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2mo
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Principal Scientist, Pharmaceutical Development
San Diego, California, United States
$131k-$179k/yr OnsiteFull Time
Neurocrine Biosciences
Neurocrine BiosciencesNASDAQ: NBIX: Develops pharmaceuticals for neurological, endocrine, and psychiatric disorders.
6+ YOELead CMC development, analyze parenteral drug product, manage CROs/CMOs, and ensure regulatory readiness across early discovery to commercialization.
DoE, QbD, Analytical Methods, Regulatory Submissions, CMC, Technology Transfer
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Senior Principal Scientist 1
San Diego, California, United States
$180k-$240k/yr OnsiteFull Time
Halozyme
HalozymeNASDAQ: HALO: Develops drug delivery technologies and therapeutic products.
10+ YOEPhD (or equivalent) with 10+ years industry experience in subcutaneous drug delivery, proven in vivo preclinical study expertise, device experience preferred, strong data analysis and communication skills.
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Principal Scientist, Clinical Research, Immunology
San Diego or Massachusetts or Rahway or North Wales
$256k-$403k/yr HybridFull Time
Merck & Co.
Merck & Co.NYSE: MRK: Develops and manufactures prescription medicines, vaccines, and animal health products.
5+ YOEM.D., D.O., M.D./PhD, or D.O./PhD and at least 5 years of clinical or development experience; scientific scholarship, clinical research, and cross-functional collaboration required.
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Associate Principal Scientist, Immunology Discovery
San Diego, California, United States
$142k-$224k/yr OnsiteFull Time
Merck & Co.
Merck & Co.NYSE: MRK: Produces prescription medicines, vaccines, and animal health products.
5+ YOEPhD with 5+ years in immunology/cell biology, strong experience in immunology assays and preclinical models, proficiency with Excel/Prism/FlowJo, leadership and cross-functional program experience.
Microsoft Excel, Prism (GraphPad), FlowJo, Meso Scale Discovery, RT-PCR
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2w
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Senior Principal Scientist, Neuropsychiatry Discovery
San Diego, California, United States
$137k-$236k/yr OnsiteFull Time
Johnson & Johnson
Johnson & JohnsonNYSE: JNJ: Provides pharmaceutical products and medical technology healthcare solutions.
10+ YOEPhD and 10+ years in neuroscience/biochemistry/molecular biology with drug discovery experience, assay development, collaboration, and ability to leverage AI-enabled tools.
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Principal Scientist, Early Pipeline Development
La Jolla, California, United States
$109k-$222k/yr OnsiteFull Time
Novartis
NovartisNew York Stock Exchange: NVS: Develops and manufactures innovative prescription medicines for patients.
3+ YOEPhD in bioprocessing/biochemical engineering/gene therapy,3+ years process development experience,people management,downstream purification expertise,AKTA experience,and strong communication and problem-solving skills.
AKTA purification systems, electronic lab notebook, Python (Programming Language), Machine Learning (ML)
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Principal Scientist (Carlsbad, California, US, 92009-1609)
Carlsbad, California, United States
$113k-$170k/yr OnsiteFull Time
Merck
MerckXETRA: MRK: A science and technology providing healthcare, life science, and electronics solutions.
15+ YOE15+ years GLP/GMP analytical experience; BS/MS in Chemistry or related field; expertise in method validation/transfer and advanced assays (qPCR, ddPCR, HPLC, CE-SDS, ELISA); cGMP/ICH knowledge and leadership/mentoring experience.
qPCR, ddPCR, HPLC, HPLC/UPLC, CE-SDS, ELISA, FTIR, Gel Electrophoresis, spectroscopy, cell-based assays, IQ/OQ/PQ/PM, ALCOA+, cGMP, ICH
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1mo
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Senior Principal Scientist: Metabolomics/Cell Therapy Media Development
South San Francisco or San Diego
$143k-$266k/yr OnsiteFull Time
Roche
RocheSIX Swiss Exchange: ROG: Provides innovative pharmaceutical and diagnostic healthcare solutions.
5+ YOEPhD in biological sciences/chemical engineering or related plus 5+ years R&D experience in metabolomics and/or cell culture media development; technical leadership, stakeholder management, and team development experience required.
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2mo
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Senior Scientist / Principal Scientist, Bioprocess Sciences
San Diego, California, United States
$120k-$198k/yr OnsiteFull Time
Pivotal Life Sciences
Pivotal Life Sciences: Invests in innovative therapeutic and life sciences companies globally.
6+ YOEPhD or MS in a relevant field with 6+ years experience in bacterial recombinant protein expression, purification, and bioprocess development; experience with chromatography, filtration, protein characterization, and leading projects/CDMO interactions.
FPLC, Benchling, HPLC, UPLC, LC-MS
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5d
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Principal Data Scientist
Canada or San Diego or South San Francisco
$188k-$210k/yr RemoteFull Time
Veracyte
VeracyteNASDAQ: VCYT: Provides genomic diagnostic tests for precise cancer diagnosis.
8+ YOEPhD in data science, machine learning, applied math, or equivalent; 8+ years in data/applied science; Python, computer vision, statistical modeling, cloud computing, and technical leadership experience.
Python, AWS
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1mo
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PRINCIPAL SCIENTIST- (Protein Immunotherapy)
San Diego, California, United States
$120k-$150k/yr OnsiteFull Time
Scripps Research
Scripps Research: Conducts biomedical research to develop novel medical treatments.
10+ YOEBachelor's in biology-related field (PhD preferred), 10+ years industry experience, strong immunology and flow cytometry expertise, gene‑editing and protein/antibody experience, team management and scientific communication skills.
flow cytometry, high-throughput flow cytometry platforms, CRISPR, TALEN, laboratory automation systems, protein and mRNA electroporation, viral vector systems, protein engineering
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1mo
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Principal Scientist, Early Pipeline Development
La Jolla, California, United States
$109k-$222k/yr OnsiteFull Time
Novartis
NovartisSIX Swiss Exchange, NYSE: NOVN, NVS: A global pharmaceutical focused on research and development of innovative medicines.
3+ YOEPhD in bioprocessing/biochemical engineering/gene therapy, 3+ years process development experience, downstream purification and AKTA experience, people management, EMN documentation and strong communication.
AKTA purification systems, electronic lab notebook
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3w
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Principal Scientist, Analytical Development
San Diego, California, United States
$170k-$185k/yr OnsiteFull Time
Artiva Biotherapeutics
Artiva BiotherapeuticsNASDAQ: ARTV: Develops allogeneic natural killer cell-based therapies for various diseases.
10+ YOEPhD with 10+ years industry analytical development experience, expertise in cell-based potency assays, assay validation, flow cytometry, ELISA/MSD, qPCR/ddPCR, regulatory writing, and scientific leadership.
flow cytometry, ELISA, MSD, qPCR, ddPCR, JMP
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4d
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Data Scientist, Principal - AI Product Engineering
Oakland or Washington or Ohio or District of Columbia or California or Long Beach or Arizona or Colorado or Connecticut or Florida or Georgia or Maryland or Minnesota or Nevada or Oregon or El Dorado Hills or San Diego or Woodland Hills or Alabama or Illinois or Virginia or Wisconsin or Texas or New York
$161k-$242k/yr HybridFull Time
Ascendiun
Ascendiun: Nonprofit parent overseeing health insurance and clinical service organizations.
10+ YOEBachelor's degree or equivalent practical experience and 10 years in data science, machine learning, AI/ML, software engineering, or advanced analytics. Requires Python, APIs, ML infrastructure, PyTorch, TensorFlow, LangChain, and LangGraph.
Python, PyTorch, TensorFlow, LangChain, LangGraph, Azure, Google Cloud, AWS, SQL, Spark, CI/CD, MLOps, LLMOps
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