39 senior software engineer python jobs at 27 companies in Columbus, IN

PromotedHiringCafe
Founding Backend / Infra Engineer
Cupertino, CA, US
$160k-$300k/yr On-SiteFull Time
HiringCafe
HiringCafe: Building a 100× better job search engine to take on Indeed and LinkedIn.
Own the crawlers, pipelines, and infrastructure powering a real-time job search engine. Strong Node.js and Python fundamentals; bonus points for security and reverse-engineering chops.
Node.js, Python, Elasticsearch, Redis
PromotedHiringCafe
Founding Full-stack / Product Engineer
Cupertino, CA, US
$130k-$300k/yr On-SiteFull Time
HiringCafe
HiringCafe: Building a 100× better job search engine to take on Indeed and LinkedIn.
Help us build a 100× better job search engine. We need a full-stack engineer with great taste, sharp fundamentals, and a track record of shipping polished product on React/Next.js plus a real backend (Firebase, Elasticsearch, Redis, Stripe).
React, Next.js, TypeScript, Firebase, Elasticsearch, Redis, Stripe
1w
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Senior Software Engineer
Plano or Boston or Portsmouth or Indianapolis or Columbus
HybridFull Time
Liberty Mutual
Liberty Mutual: Provider of global property and casualty insurance products.
5+ YOE5+ years software engineering experience; strong data structures, algorithms, system design; proficiency in Python or Java; EMR not mentioned; experience with layered architectures and agile delivery.
Python, Java, React, Node.js, Spring Boot, AWS, RESTful services, RDS
1w
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Senior Software Engineer
Plano or Boston or Portsmouth or Indianapolis or Columbus
$106k-$197k/yr HybridFull Time
Liberty Mutual
Liberty Mutual: Provides diversified property, casualty, and commercial insurance products.
5+ YOE5+ years software engineering experience, strong foundation in data structures and algorithms, proficiency in Python or Java, experience with Java/React/Node.js/Spring Boot/AWS/REST/RDS, agile experience, strong communication.
Python, Java, React, Node.js, Spring Boot, AWS, RESTful services, RDS
1w
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Senior Software Engineer
Plano or Boston or Portsmouth or Indianapolis or Columbus
$106k-$197k/yr HybridFull Time
Liberty Mutual Insurance
Liberty Mutual Insurance: Global provider of property and casualty insurance products.
5+ YOE5+ years software engineering experience; proficiency with Python or Java, React, Node.js, Spring Boot, AWS, RESTful services and RDS; strong algorithms, system design, and communication skills; bachelor's or master's in technical/business field or equivalent experience.
Python, Java, React, Node.js, Spring Boot, AWS, RESTful services, RDS
2w
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Senior Software Engineer II, Toolpath Algorithms
Salt Lake City or Dallas or Indianapolis
$198k-$248k/yr RemoteFull Time
Dandy
Dandy: Provides digital dental laboratory services and practice management software.
Experienced software engineer with production C++/Python/TypeScript skills, deep toolpath/CNC or 6DoF robotics experience, computational geometry and simulation proficiency, and willingness to travel up to 30%.
C++, python, TypeScript, Three.js, WebGL, WebGPU, WGSL, WASM, Emscripten, React, ROS, CGAL, Open CASCADE, HLSL, GLSL, CUDA
2w
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Software Development Engineer (Lead)
Columbus or Austin or Dallas or Detroit or Hagerstown or Atlanta or Houston or Akron or Birmingham or Indianapolis or Charlotte or Minnetonka or Cincinnati or Cleveland
$70k-$140k/yr OnsiteFull Time
Huntington
HuntingtonNASDAQ: HBAN: Provides regional commercial, consumer, and mortgage banking services.
7+ YOEBachelor's degree, 7+ years software/platform/cloud engineering, experience with Java and/or Python, distributed systems, APIs, Pub/Sub/Dataflow/Apigee and CI/CD; GCP experience preferred.
Java, Python, SQL, GCP, Pub/Sub, Spring Boot, REST APIs, Dataflow, BigQuery, CI/CD, Apigee
2mo
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Sr. Staff Software Engineer - AI Chat
Indianapolis, Indiana, United States
$126k-$224k/yr OnsiteFull Time
Eli Lilly and Company
Eli Lilly and CompanyNYSE: LLY: Researches and manufactures medicines for human health.
10+ YOE10+ years software engineering experience with technical leadership; 5+ years with TypeScript/JavaScript, Python, and Go; experience with React, RESTful/GraphQL APIs, Kubernetes, CI/CD and GitOps; Bachelor's in CS or related field.
TypeScript, JavaScript, Python, Go, React, Kubernetes, LGTM, Cortex, Hangar, Claude Code, GitHub Copilot, GitOps, CI/CD, RESTful APIs, GraphQL, WebSockets, SSE, LLM, MCP, A2A
1w
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Senior Software Engineer Applied AI
Indianapolis or United States
RemoteFull Time
AMC Health
AMC Health: Provides remote patient monitoring and virtual care technology.
7+ YOE7+ years building production backend systems, strong Python skills, distributed systems on cloud (AWS), hands-on LLM/generative AI experience, full ML lifecycle proficiency, and disciplined work in regulated environments. US work authorization required.
Python, AWS, LLM, AI coding assistants
1mo
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Principal Software Engineer, Salesforce & Data
San Francisco or New York City or Seattle or Indianapolis
$197k-$314k/yr OnsiteFull Time
Salesforce
SalesforceNYSE: CRM: Sells cloud-based customer relationship management and business software solutions.
12+ YOE12+ years engineering experience; deep expertise in Salesforce technologies (Apex, Lightning), data platforms, Python, SQL, Airflow, Snowflake; experience with integrations, APIs, streaming, AI developer tools, and technical leadership.
Salesforce Core, Apex, Lightning Platform, MuleSoft, Heroku, APIs, Snowflake, Airflow, Python, SQL, Claude Code, Cursor, Windsurf, GitHub Copilot, Databricks, Kafka, CI/CD, Customer 360, Data360
2d
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Sr. Software Engineer (Platform + AI)
United States or Canada or Indianapolis
$115k-$191k/yr RemoteFull Time
Bloomerang
Bloomerang: Donor management and fundraising software for nonprofit organizations
8+ YOE8+ years software engineering; hands-on AI/agent experience; strong backend service ownership; familiarity with C#/.NET preferred; experience with authentication/identity and distributed systems; strong ownership and communication.
C#/.NET, Python, TypeScript, MCP
1mo
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Lead Finance Software Engineer
Indianapolis, Indiana, United States
HybridFull Time
Elanco
ElancoNYSE: ELAN: Develops and sells health products for pets and farm animals.
5+ YOEBachelor's in IT or related, 5+ years software engineering experience, cloud-native and CI/CD experience, Kubernetes, TypeScript/JavaScript/Node/Next.js/React, experience with Azure or Google Cloud, strong communication and product-mindset.
Microsoft Azure, Google Cloud, Kubernetes, TypeScript, JavaScript, Node, Next.js, React, SAP S/4 HANA, SAP Business Technology Platform (BTP), OneStream, SAP BPC, Signavio, Python, Databricks, Power BI
3mo
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Senior Optical Engineer
Odon, Indiana, United States
$120k-$160k/yr OnsiteFull Time
Amentum
AmentumNYSE: AMTM: Provides engineering, technology, and mission support to government agencies.
7+ YOEBachelor’s in STEM with 10+ years or Master’s with 7+ years; ability to obtain US Secret clearance; multi-domain engineering leadership; EO/IR and sensor systems experience; system integration across hardware, firmware, and software.
C++, Python, MATLAB, FPGA, RF systems, Optical/photonic systems, Imaging systems, Lab instrumentation
3mo
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Senior Engineer, Control Systems Simulation
Indianapolis, Indiana, United States
OnsiteFull Time
Allison Transmission
Allison TransmissionNYSE: ALSN: Manufacturer of automatic transmissions and vehicle propulsion solutions.
7+ YOE7+ years software engineering in C, C++, C#, Python, Rust; develop data-collection/tools for embedded controls; GitHub; Visual Studio/VS Code; BS in engineering or CS.
C, C++, C#, Python, Rust, GitHub, Visual Studio, VS Code, Veristand, LabView, Matlab, Simulink, CMMI, SPICE
4w
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Sr. R&D Software Engineer
Grapevine or Boise or Dallas or Indianapolis
OnsiteFull Time
Toyota Automated Logistics
Toyota Automated LogisticsTokyo Stock Exchange: 6201: Integrated warehouse automation systems, software, and lifecycle services.
8+ YOEExpert Linux developer in C++ and Python with ROS and robotics experience; production software design, CI/CD, Git, containerization, testing, and leadership; bachelor’s degree preferred and 8+ years experience; must be eligible to work in the USA without sponsorship.
Linux, C++, C, Python, ROS, Git, SQL, CI/CD
2w
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Technology Operations Senior Engineer
Indianapolis, Indiana, United States
HybridContract
Delan Associates
Delan Associates: Provides engineering and professional services to government agencies.
5+ YOEBachelor's degree and 5+ years in software engineering or related role; proficient with PowerShell, Bash, Python, Java, NodeJS; strong problem solving, communication, testing and DevOps experience.
PowerShell, Bash, Python, Java, NodeJS
1w
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Palantir Senior Engineer
Indianapolis, Indiana, United States
$170k-$180k/yr OnsiteFull Time
Tata Consultancy Services
Tata Consultancy ServicesNational Stock Exchange of India: TCS: Global provider of IT services, consulting, and business solutions.
8+ YOEExperience with Palantir Foundry, TypeScript, React JS, PySpark and Python; 8+ years experience; Bachelor in Computer Science; proficiency with data pipelines, ETL, testing and visualization.
Palantir Foundry, TypeScript, React JS, PySpark, Python, PyTest, Power BI, Workshop, Quiver, Slate, Contour
5d
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Lead Enterprise Software Engineer – Application & IT Operations
Riverwoods or Coppell or Tampa or Austin or Philadelphia or Chicago or Wichita or Indianapolis or Greenwood Village
$118k-$207k/yr HybridFull Time
Wolters Kluwer
Wolters KluwerEuronext Amsterdam: WKL: Provides professional information and software solutions for specialized industries.
8+ YOE8+ years experience operating cloud applications (Azure/AWS), incident response, CI/CD, observability, automation/scripting, IaC (Terraform/ARM/Bicep/CloudFormation), and leading operational excellence.
Azure, AWS, Datadog, Grafana, Prometheus, ELK, OpenSearch, Open Telemetry, PowerShell, Bash, Python, CI/CD, Terraform, Azure ARM, Bicep, AWS CloudFormation, Kubernetes
1mo
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Senior Solutions Engineer
Arlington or Atlanta or Austin or Boston or Charlotte or Chicago or Dallas or Houston or Indianapolis or Kansas City or Minneapolis or New York or Philadelphia or St Louis
$168k-$252k/yr RemoteFull Time
Amplitude
AmplitudeNasdaq: AMPL: Develops digital analytics software for tracking customer product behavior.
5+ YOE5+ years in software pre-sales; hands-on SQL, Python or R, and APIs; experience closing enterprise technical evaluations; comfortable presenting to engineers and executives.
Amplitude, Python, SQL, APIs, R, Google Analytics 4, Adobe Analytics, Mixpanel, Tableau, Looker, Microsoft Power BI
5d
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Distinguished Engineer
Atlanta or Mason or Indianapolis
HybridFull Time
Elevance Health
Elevance HealthNYSE: ELV: Provides health insurance plans and integrated healthcare services.
15+ YOEBachelor's degree and 15+ years software engineering experience designing and operating distributed systems; expertise in Python/Java, cloud, CI/CD/DevSecOps, APIs, microservices, AI/LLM architectures, and enterprise data strategies.
Python, Java, Apache Iceberg, FHIR, HL7, CI/CD, DevOps, DevSecOps, LLMs, RAG, vector databases, knowledge graphs
2mo
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Sr. AI Engineer
Indianapolis, Indiana, United States
OnsiteFull Time
Zylo
Zylo: Software platform to discover and optimize corporate SaaS subscriptions.
5+ YOE5+ years AI/ML engineering; senior-level experience; production AI agents; large-scale enterprise data; AWS Bedrock/Lambda; RAG and MCP; Python, PyTorch/TensorFlow; security/compliance.
AWS Bedrock, AWS Lambda, Python, PyTorch, TensorFlow, SQL, PySpark, LangChain, LangGraph, vector databases
1mo
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Senior Quality Assurance Engineer
Indianapolis, Indiana, United States
OnsiteFull Time
T2 Systems
T2 SystemsNASDAQ: VRRM: Providing technology and hardware for parking and mobility management.
5+ YOE5+ years QA automation or software engineering experience; bachelor's degree preferred; strong automation-first mindset; hands-on with Python/pytest/Playwright or TS/K6; experience with SQL, REST/SOAP, CI/CD, non-functional testing, and Agile.
Python, pytest, Locust, Playwright, TS, K6, SQL, REST, SOAP, Browser Dev tools, CI/CD, Github Copilot, Claude