89 senior software engineer python jobs at 22 companies in Danville, VA

PromotedHiringCafe
Founding Backend / Infra Engineer
Cupertino, CA, US
$160k-$300k/yr On-SiteFull Time
HiringCafe
HiringCafe: Building a 100× better job search engine to take on Indeed and LinkedIn.
Own the crawlers, pipelines, and infrastructure powering a real-time job search engine. Strong Node.js and Python fundamentals; bonus points for security and reverse-engineering chops.
Node.js, Python, Elasticsearch, Redis
PromotedHiringCafe
Founding Full-stack / Product Engineer
Cupertino, CA, US
$130k-$300k/yr On-SiteFull Time
HiringCafe
HiringCafe: Building a 100× better job search engine to take on Indeed and LinkedIn.
Help us build a 100× better job search engine. We need a full-stack engineer with great taste, sharp fundamentals, and a track record of shipping polished product on React/Next.js plus a real backend (Firebase, Elasticsearch, Redis, Stripe).
React, Next.js, TypeScript, Firebase, Elasticsearch, Redis, Stripe
1mo
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Principal Python Backend Engineer
Durham, North Carolina, United States
$107k-$216k/yr OnsiteFull Time
Fidelity Investments
Fidelity Investments: Provides investment management, retirement planning, and brokerage services.
7+ YOE7+ years software engineering, strong Python backend, distributed systems, performance tuning, event-driven data pipelines, API/SDK development, DevOps (Docker/Kubernetes) knowledge.
Python, Kubernetes, Docker, AWS, SQL, NoSQL, ETL, APIs
2mo
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Senior System Software Engineer – Data Center GPU Compute Diagnostics
Durham, North Carolina, United States
$224k-$357k/yr OnsiteFull Time
NVIDIA
NVIDIANASDAQ: NVDA: Designs GPU-accelerated computing and artificial intelligence hardware.
12+ YOESenior system software engineer with 12+ years of experience in GPU/software validation, diagnostics, and stress testing.
C/C++, Python, Linux device drivers, CUDA kernels, GPU compute workloads, NCCL, PCIe, NVLink
2d
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Senior Software Engineer - GPU Local AI Platforms
Santa Clara or Austin or Westford or Durham or Seattle
$224k-$431k/yr OnsiteFull Time
NVIDIA
NVIDIANASDAQ: NVDA: Designs graphics processing units and artificial intelligence hardware.
12+ YOE12+ years software engineering experience with GPU computing or ML systems, strong Python or C++ skills, GPU kernel optimization (CUDA/Triton), container engineering, and LLM inference knowledge.
Python, C++, CUDA, Triton, Docker, OCI, NVIDIA Container Toolkit, NCCL, RCCL
2mo
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Python/AI Product Engineer (Durham, NC, US)
Durham or Pittsburgh
HybridFull Time
ACA Group
ACA Group: Regulatory compliance and risk management solutions for financial services.
Senior/lead AI developer with Python, cloud-native AI, LangChain/LangGraph, AWS, and enterprise-grade experience.
Python, AWS, LangChain, LangGraph, cloud, LLM, APIs, microservices, databases, vector search, RAG
3mo
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HPE Morpheus Enterprise - Principal Software Engineer
Fort Collins or Durham or Houston
$152k-$349k/yr HybridFull Time
Hewlett Packard Enterprise
Hewlett Packard EnterpriseNYSE: HPE: Provides edge-to-cloud IT infrastructure and platform services.
10+ YOESenior level backend software engineer with Java/Python-like languages, Linux, REST APIs, and cloud experience.
Java, Groovy, Ruby, Python, Linux, REST APIs, SQL, NoSQL, Virtualization, ITSM, CI/CD, Maven, Gradle, Git, Cloud (AWS, Azure, Google Cloud)
4w
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Senior Software Engineer, Google Cloud Storage
Raleigh or Durham
$174k-$253k/yr OnsiteFull Time
Google
GoogleNASDAQ: GOOGL: Provides online search, advertising, cloud computing, and consumer electronics.
5+ YOEBachelor's or equivalent experience; 5+ years programming in C++, Go, or Python; 3+ years developing large-scale infrastructure/distributed systems; 3+ years with Kubernetes and IaaS; 3+ years testing/maintaining software and 2+ years software design/architecture.
C++, Go, Python, Kubernetes, IaaS, Cloud Functions, Golang, Open Network Technology for Appliance Products (ONTAP's), Storage Virtual Machines (SVMs), Role-Based Access Control (RBAC), Root-Cause/Remediation (RCR)
1w
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Senior Software Engineer - LLM Inference
San Jose or Durham or Mexico City or Vancouver or Bengaluru or Pune or Hoofddorp or Belgrade or Barcelona or Singapore or Sydney or Tokyo
$171k-$257k/yr HybridFull Time
Nutanix
NutanixNASDAQ: NTNX: Sells cloud software and hyperconverged infrastructure for enterprises.
8+ YOE8+ years building distributed, high-performance systems; strong Go/Python, Docker, Kubernetes, CI/CD; knowledge of datacenter, OS internals, virtualization, and ML frameworks.
Docker, Kubernetes, Go, Python, CI/CD, TensorFlow, PyTorch, GPUs
2mo
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Senior Software Engineer - Confluent DevProd
Poughkeepsie or Lowell or Rochester or Tucson or Research Triangle Park or Armonk or Durham or Raleigh or Boston or Bellevue or Atlanta or San Jose or Dallas or Austin or San Francisco or Seattle
$131k-$245k/yr RemoteFull Time
IBM
IBMNew York Stock Exchange: IBM: Global technology providing enterprise software, cloud, and consulting.
5+ YOEBS/MS/PhD in CS or related (or equivalent experience), 5+ years building and operating cloud services or large-scale distributed systems; proficiency with Java or Go and Python; experience with CI/CD, containers, infra-as-code; on-call/incident response experience.
Java, Go, Python, CI/CD, containers, infrastructure-as-code, Electronic developer portals
1w
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Staff Software Engineer, MWS Team
Durham or Denver or Rancho Cordova
$149k-$219k/yr RemoteFull Time
Cisco
CiscoNASDAQ: CSCO: Develops and sells networking hardware and cybersecurity software.
8+ YOEBachelor's or equivalent, 8+ years software engineering experience, 5+ years distributed systems, proficiency in Go/Python/Java, REST, cloud and Kubernetes experience, CI/CD and observability, experience with LLM/RAG pipelines preferred.
Go, Python, Java, CI/CD, Kubernetes, AWS, GCP, Azure, LLMs, RAG, MCP, REST
1mo
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Senior Command and Control Software Engineer
Clarksburg or Arlington or Durham
$140k-$220k/yr OnsiteFull Time
Forterra
Forterra: Develops autonomous ground vehicle systems and software for defense.
3+ YOE3+ years embedded/edge software experience, strong modern C++ (C++17/20) on Linux, Python for tooling, experience with real-time low-latency systems, Protobuf/data formats, CMake/Conan/Docker, and hardware bring-up.
C++, Python, NVIDIA Jetson, Linux, iceoryx2, ZeroMQ, Protobuf, TensorRT, ONNX, CMake, Conan, Docker
1mo
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Software Engineer Manager
Raleigh or Chapel Hill or Durham
RemoteFull Time
Retired.com
Retired.com: Self-directed retirement platform for alternative asset investments.
7+ YOE2+ Mgmt7+ years software development; 2+ years leading teams; strong cloud-native, scalable architecture; Agile/CI/CD; bachelor's in CS/Software Eng or related experience.
Python, JavaScript, Go, C#
4d
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Staff Software Engineer - Commercial - #4903
Menlo Park or Sunnyvale or Durham or Washington or United Kingdom
$169k-$224k/yr HybridFull Time
GRAIL
GRAILNasdaq: GRAL: Develops blood tests for early-stage multi-cancer detection.
8+ YOE8+ years building full‑stack and distributed systems; proficiency with Go/Java/Python/JS, cloud platforms, Kubernetes, microservices, databases; BS/MS in CS or equivalent experience.
Go, Java, Python, JavaScript, C++, React, Angular, Spring, Spring Boot, REST APIs, gRPC, AWS, GCP, Azure, Kubernetes, Docker, Terraform, PostgreSQL, MySQL, Redis, CI/CD, Automated Testing, Agile Development
3mo
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HPE Morpheus Enterprise - Principal Software Engineer
Ft. Collins or Durham or Houston
$152k-$349k/yr HybridFull Time
Hewlett Packard Enterprise
Hewlett Packard EnterpriseNYSE: HPE: Providing global edge-to-cloud infrastructure and IT solutions for businesses.
10+ YOE10+ years of backend software development experience; proficient in Java, Groovy, Ruby, or Python; Linux experience; RESTful APIs; SQL/NoSQL databases; CI/CD; virtualization; cloud (AWS/Azure/GCP); build tools (Maven/Gradle); Git; strong communication.
Java, Groovy, Ruby, Python, Linux, RESTful APIs, SQL, NoSQL, Maven, Gradle, Git, CI/CD, AWS, Azure, Google Cloud, virtualization
3mo
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HPE Morpheus Enterprise - Principal Software Engineer
Fort Collins or Durham or Houston
$160k-$349k/yr HybridFull Time
Hewlett Packard Enterprise
Hewlett Packard EnterpriseNYSE: HPE: Provides global edge-to-cloud technology solutions and IT infrastructure services.
10+ YOE10+ years experience; Bachelor's in CS/Engineering; backend focus; Java/Groovy/Ruby/Python; Linux; REST APIs; SQL/NoSQL; CI/CD; virtualization; ITSM; cloud (AWS/Azure/GCP); build tools (Maven/Gradle); Git; architecture knowledge.
Java, Groovy, Ruby, Python, Linux, REST, SQL, NoSQL, Git, Maven, Gradle, CI/CD, AWS, Azure, Google Cloud, ITSM, Virtualization, Build Tools, Automation, Cloud
1mo
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Principal Software Engineer - Variant Knowledge Platform
Durham or United States
$180k-$205k/yr HybridFull Time
Labcorp
LabcorpNYSE: LH: Provides clinical laboratory testing and drug development services globally.
5+ YOEBachelor's degree; 5+ years REST API and backend development (e.g., Python); 2+ years designing/operating AWS cloud services; experience with API versioning, Okta-based authentication, data modeling, observability, and large-scale data migrations.
Okta, AWS, Python, AWS SQS, Snowflake, REST API
2w
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Lead Full Stack Software Engineer
Durham, North Carolina, United States
HybridFull Time
Digital Turbine
Digital TurbineNASDAQ: APPS: Platform for mobile application distribution and advertising monetization.
8+ YOE8+ years building production platforms with strong backend architecture, algorithmic fundamentals, multi-language proficiency (e.g., TypeScript, Java, Python, Go, C++), front-end framework experience (React), and working knowledge of relational/distributed data stores.
TypeScript, JavaScript, Java, Kotlin, Python, Go, Scala, C++, React, MySQL, PostgreSQL, AWS, GCP, CI/CD, containers
3mo
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AI/ML Development Senior Engineer
Durham or Lowell or Morgan Hill
OnsiteFull Time
MACOM
MACOMNASDAQ: MTSI: Designs and manufactures semiconductor products for communications infrastructure.
5+ YOEBachelor’s or Master’s in CS/AI/DS; 5-10 years AI/ML engineering; Python and ML frameworks; agentic AI; cloud-based architectures; collaboration across teams.
Python, Pandas, PyTorch, TensorFlow, LangChain, OpenAI, Anthropic, AWS Bedrock, SageMaker, Hugging Face
2mo
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Lead AI Engineer — Productivity Systems
Durham or Miami or Palo Alto or Washington
$12k-$18k/mo HybridFull Time
Nubank
NubankNYSE: NU: Digital financial platform offering banking, credit, and investment services.
Proven experience shipping LLM-powered systems in production; strong prompt/context engineering, evaluation and guardrail development, and software engineering skills (Python/TypeScript/Clojure).
Python, TypeScript, Clojure, n8n, Zapier, AWS, Claude Code, Cursor, Copilot, Slack, Google Workspace, Jira, Terraform, RAG, MCP
4d
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Principal Engineer, Resilience
Berlin or Boston or Durham or Munich or London or Valencia
HybridFull Time
commercetools
commercetools: SaaS platform for building enterprise headless commerce experiences.
5+ YOE5+ years shipping production software, 2+ years building with LLMs; full-stack ownership; experience with agents, prompt engineering, retrieval/embeddings, SQL, Python, TypeScript/Node and React.
A2UI, AG-UI, MCP, Python, TypeScript, Node, React, SQL
1mo
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Senior Platform Engineer, Data & AI Infrastructure
Durham or New York City or Los Angeles or Phoenix
$140k-$160k/yr HybridFull Time
McKinney
McKinney: Provides strategic advertising and creative marketing services to brands.
4+ YOE4+ years of professional software engineering with backend focus; strong Python, cloud, and data tooling; experience with AI/LLM integration and security best practices.
Terraform, GitOps, Snowflake, Fivetran, DBT, Python, FastAPI, Docker, Kubernetes, OpenAI, Anthropic, Google Gemini, BigQuery, Dataform, Cloud Run, Compute Engine, Secret Manager, Artifact Registry, Cloud Build, Cloud Monitoring, IAM, Secret Management, ECR, CodePipeline, CI/CD