81 senior software engineer python jobs at 49 companies in South Carolina

PromotedHiringCafe
Founding Backend / Infra Engineer
Cupertino, CA, US
$160k-$300k/yr On-SiteFull Time
HiringCafe
HiringCafe: Building a 100× better job search engine to take on Indeed and LinkedIn.
Own the crawlers, pipelines, and infrastructure powering a real-time job search engine. Strong Node.js and Python fundamentals; bonus points for security and reverse-engineering chops.
Node.js, Python, Elasticsearch, Redis
PromotedHiringCafe
Founding Full-stack / Product Engineer
Cupertino, CA, US
$130k-$300k/yr On-SiteFull Time
HiringCafe
HiringCafe: Building a 100× better job search engine to take on Indeed and LinkedIn.
Help us build a 100× better job search engine. We need a full-stack engineer with great taste, sharp fundamentals, and a track record of shipping polished product on React/Next.js plus a real backend (Firebase, Elasticsearch, Redis, Stripe).
React, Next.js, TypeScript, Firebase, Elasticsearch, Redis, Stripe
1mo
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Senior Software Engineer
Greenville, South Carolina, United States
OnsiteFull Time
TRULEO: AI-powered workflow and analytics platform for law enforcement
7+ YOE7+ years software engineering; production experience with React, TypeScript, Node.js, PostgreSQL; Python, ML/MLOps; cloud and containerized deployments; able to work onsite in Greenville, SC and pass CJIS background check.
React, TypeScript, Node.js, PostgreSQL, Python, ML, ML Ops, SOC 2, FBI CJIS
1w
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AWS Python Developer
Lafayette or Knoxville or Columbia
$96k-$157k/yr HybridFull Time
CGI
CGINYSE: GIB: Provides information technology and business consulting services.
5+ YOE5+ years Python development, AWS serverless (Lambda, Step Functions, S3, ECS), SQL/NoSQL (RDS, DynamoDB), Terraform/CloudFormation, GitLab CI/CD, Java familiarity; Bachelor's degree required.
AWS, Lambda, Step Functions, S3, ECS, RDS, DynamoDB, Terraform, CloudFormation, GitLab, Python, Java, Angular, Azure, GCP, RESTful API
1mo
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Senior API Engineer (Python / AWS)
Fort Mill or Charlotte or Austin
$106k-$177k/yr HybridFull Time
LPL Financial
LPL FinancialNASDAQ: LPLA: Provides wealth management and brokerage services to financial advisors.
7+ YOE7+ years in software/API/cloud development; Python API development; AWS Lambda/API Gateway; Terraform; CI/CD; production support.
Python, AWS, Terraform, OAuth2, JWT, IAM, Amazon API Gateway, AWS Lambda, CloudWatch, OpenTelemetry
1mo
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Senior Platform Software Engineer
Needham or California or Connecticut or Florida or Georgia or Illinois or Massachusetts or Maryland or Maine or Michigan or New Hampshire or New Jersey or New York or North Carolina or Pennsylvania or Rhode Island or South Carolina or Tennessee or Texas or Utah or Washington or Virginia
$150k-$172k/yr RemoteFull Time
Advisor360°
Advisor360°: Provides an integrated SaaS platform for wealth management firms.
8+ YOE8+ years platform/software engineering experience; hands-on Jenkins (Groovy), Python, Ansible, Kubernetes, .NET (C#); CI/CD, RESTful APIs, observability (Dynatrace, ELK Stack); on-call participation and mentoring experience.
Jenkins, Groovy, Python, Kubernetes, .NET (C#), Ansible, RESTful APIs, Dynatrace, ELK Stack, Angular
2mo
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Senior Software Engineer I
Fort Mill or Tempe
HybridFull Time
Shutterfly
Shutterfly: Manufacturer and retailer of personalized photo products and professional photography services.
6+ YOE6+ years in application development; Java, Spring Boot, Python; 3+ years AWS; driven to build scalable systems; experience with Agile and CI/CD; mentorship capabilities.
Java, Spring Boot, Python, AWS, React, Angular, RabbitMQ, GraphQL, Terraform, REST
1mo
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Senior Software Engineer
New York City or Arizona or California or Colorado or Connecticut or Florida or Georgia or Maine or Maryland or Massachusetts or Michigan or Minnesota or New Jersey or New York or North Carolina or Oregon or Rhode Island or South Carolina or Tennessee or Texas or Virginia or Utah or Wisconsin
$165k-$185k/yr RemoteFull Time
Electric
Electric: Provides automated IT management and security services for businesses.
8+ YOE8+ years backend experience with modern Python stack, leadership experience, proficiency in Postgres/SQLAlchemy, AWS, Terraform, FastAPI, React/TypeScript, observability, and familiarity with AI-assisted development.
Python, FastAPI, Pydantic, PostgreSQL, SQLAlchemy, Alembic, Temporal, Redis, AWS RDS, AWS S3, AWS SQS, AWS DynamoDB, AWS ECS, AWS IAM, Terraform, React, TypeScript, Claude Code
1mo
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Senior Software Engineer
United States or New Jersey or New York or Washington or Hawaii or Alaska or Maryland or Connecticut or Rhode Island or Massachusetts or Nevada or Oregon or Arizona or Colorado or Wyoming or Texas or North Dakota or Minnesota or Missouri or Illinois or Wisconsin or Florida or Georgia or Michigan or Ohio or Virginia or Pennsylvania or Delaware or Vermont or New Hampshire or Maine or Utah or Idaho or Montana or New Mexico or South Dakota or Nebraska or Kansas or Oklahoma or Iowa or Arkansas or Louisiana or Mississippi or Alabama or Tennessee or Kentucky or Indiana or South Carolina or North Carolina or West Virginia or California
$94k-$179k/yr RemoteFull Time
Mercury Insurance
Mercury InsuranceNYSE: MCY: Provider of personal and commercial insurance coverage.
5+ YOE1+ MgmtBachelor's in CS or related (or equivalent experience); 5+ years software programming experience; 2+ years with technologies used at Mercury; 1+ year leading teams; proficiency with Java, Spring/Spring Boot, REST, MongoDB, Docker, Kubernetes, cloud and modern distributed system design.
Java, Python, Go, C++, JavaScript, Spring Framework, Spring Boot, REST, gRPC, MongoDB, Claude, ChatGPT, IntelliJ, VS Code, Apache Kafka, Apache NiFi, Amazon SQS, MS MQ, Apache Camel, Docker, Kubernetes, AWS, Google Cloud, Azure
1w
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Senior Software Engineer, Golang
Charlotte or Fort Mill or Denver or Minneapolis
$119k-$150k/yr HybridFull Time
RVO Health
RVO Health: Provides digital health information and consumer wellness solutions.
5+ YOEBachelor's or equivalent,5+ years software development experience,proficiency in Go and multiple languages,experience with testing,AWS and IaC preferred,strong problem-solving and communication skills.
Golang, Go, PHP, JavaScript, Python, TypeScript, Java, C#, C++, Node.js, GraphQL, REST APIs, NoSQL, AWS, IaC
1w
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Senior Software Development Engineer
Illinois or Mississippi or Montana or North Carolina or Louisiana or Maryland or Maine or Minnesota or Nebraska or Missouri or North Dakota or New York or New Jersey or New Mexico or Nevada or Ohio or South Carolina or Texas or Rhode Island or South Dakota or Vermont or Tennessee or Virginia or Washington or Utah or Wisconsin or West Virginia or Oregon or Wyoming or Oklahoma or Pennsylvania or Colorado or Alabama or Arizona or California or Connecticut or District of Columbia or Florida or Iowa or Arkansas or Idaho or Kansas or Delaware or Georgia or Indiana or Kentucky or Michigan or Massachusetts or New Hampshire
$83k-$222k/yr RemoteFull Time
CVS Health
CVS HealthNYSE: CVS: Provides retail pharmacy, health insurance, and pharmacy benefit management services.
5+ YOE5+ years software engineering with Java/JEE and Spring Boot, 3+ years Kafka, CI/CD, Docker/Kubernetes, 2+ years cloud experience (GCP preferred); strong data migration, ETL, security and healthcare integration experience.
Java, JEE, Spring Boot, Spring Cloud, Apache Kafka, Python, Spring Batch, GCP, GKE, Cloud Run, Cloud Build, Cloud SQL, Pub/Sub, IAM, Secret Manager, OpenTelemetry, Docker, Kubernetes, SQL, NoSQL, OAuth 2.0, OIDC, TLS, Dataflow, Git
2w
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Staff Software Engineer
United States or Alabama or Arizona or Arkansas or California or Colorado or Connecticut or Florida or Georgia or Hawaii or Idaho or Illinois or Indiana or Iowa or Kansas or Kentucky or Maryland or Massachusetts or Michigan or Minnesota or Missouri or Nevada or New Hampshire or New Jersey or New Mexico or New York or North Carolina or Ohio or Oklahoma or Oregon or Pennsylvania or Rhode Island or South Carolina or Tennessee or Texas or Vermont or Virginia or Washington or Wisconsin
$178k-$223k/yr RemoteFull Time
Fuze Health
Fuze Health: Integrated digital health, home diagnostics, and virtual pharmacy platform.
8+ YOEBachelor's in CS or equivalent, 8+ years software engineering with 3+ years as tech lead/architect, expertise in Ruby on Rails or Python, PostgreSQL, TypeScript/JavaScript, AWS; system design and healthcare compliance experience required.
Ruby on Rails, Python, PostgreSQL, TypeScript, JavaScript, AWS, ECS, RDS, Lambda, VPC, EHR
1mo
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Senior Software Engineer
San Francisco or Knoxville or New York City or Arizona or California or Colorado or Connecticut or Florida or Georgia or Illinois or Louisiana or Massachusetts or Minnesota or North Carolina or New Jersey or Nevada or New York or Ohio or Pennsylvania or South Carolina or Tennessee or Texas or Washington or Virginia or District of Columbia
$150k-$224k/yr RemoteFull Time
Verana Health
Verana Health: Curates real-world clinical data to accelerate medical research and insights.
5+ YOE5+ years backend development with Java and Spring Boot, experience with AWS, Docker, Kubernetes, CI/CD, TDD/JUnit, REST/microservices, observability (Datadog, CloudWatch, OpenTelemetry), mentoring skills, and experience with RDBMS, Elasticsearch and NoSQL.
Java, Spring Boot, AWS, GHA, Jenkins, Docker, Kubernetes, JUnit, TDD, REST, OAuth 2.0, OWASP, Elasticsearch, NoSQL, Datadog, CloudWatch, OpenTelemetry, React, WebSockets, Python, Kafka, SQS, CI/CD
2w
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Senior Backend Software Engineer
Arkansas or California or Colorado or District of Columbia or Florida or Illinois or Massachusetts or Maryland or Maine or Michigan or New Jersey or Ohio or Pennsylvania or South Carolina or Texas or Utah or Virginia or Washington
$165k-$195k/yr RemoteFull Time
SITE Technologies
SITE Technologies: Provides AI-powered property condition assessments and management software.
5+ YOE5+ years backend development experience with Python and FastAPI, strong backend architecture, relational modeling, AWS services, Docker, CI/CD, and cross-team communication.
Python, FastAPI, PostgreSQL, SQLAlchemy, Alembic, Flyway, AWS, ECS, Lambda, RDS, S3, IAM, Docker, Git, CI/CD, GitHub Actions, AWS CodePipeline, Claude Code, Cursor, Terraform, Terragrunt, Datadog, Sentry, LangGraph, Claude Code SDK, Amazon Bedrock
3w
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Principal Software Engineer - AI
Woodland Hills or Los Angeles or Alabama or Arizona or California or Colorado or Connecticut or Florida or Georgia or Illinois or Indiana or Kentucky or Massachusetts or Michigan or North Carolina or New Jersey or Nevada or New York or Ohio or Pennsylvania or South Carolina or Texas or Utah or Virginia
$200k-$230k/yr HybridFull Time
Convoso
Convoso: AI-powered contact center platform for outbound sales teams.
10+ YOE10+ years software engineering experience, 5+ years backend work in Python or PHP, expertise building LLM-based AI agent systems, production LLM API integration, MySQL proficiency, and automated testing for AI workflows.
LLM, OpenAI, Claude, GitHub Copilot, MySQL, Python, Django, Flask, PHP, Symfony, Laravel, React
3d
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Senior Staff Software Engineer - Full Stack Developer
Greenville or Barcelona
$113k-$189k/yr OnsiteFull Time
GE Vernova
GE VernovaNYSE: GEV: Designs and services technologies for global power generation and electrification.
Bachelor's in CS/Engineering or equivalent, strong programming, AWS/cloud experience, Agile, React/JavaScript, Python, SQL/PostgreSQL, automated testing experience, debugging and mentoring skills.
React, JavaScript, Vite, Python, AWS, AWS Lambda, S3, DynamoDB, SQL, PostgreSQL, Jest, pytest, PowerShell, Windows
3w
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Sr. Software Engineer (SDK & Integrations)
Arizona or California or Colorado or Delaware or Maryland or Massachusetts or Missouri or New Jersey or Nevada or New York or North Carolina or Oregon or Oklahoma or Pennsylvania or South Carolina or Texas or Utah or Virginia or Washington
$150k-$180k/yr RemoteFull Time
Identity Digital: A leading registry of generic top-level domain name extensions.
5+ YOE5+ years commercial software engineering; fluency in TypeScript and Python and working proficiency in Go; strong DNS, HTTP/TLS, crypto, API design, CI/CD, and open-source publishing experience; bachelor's degree or equivalent.
TypeScript, Python, Go, LangChain, LangGraph, LlamaIndex, CrewAI, Microsoft Agent Framework, OpenAI Agents SDK, Cloudflare Workers, Fastly Compute, Vercel Edge, npm, PyPI, Go module proxy, WebAssembly (WASM), SPIFFE/SPIRE, WebID, GitHub, JWTs, JWK Sets, ES256, Ed25519
1w
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Sr. Software Engineer I, Evaluation Services
Chicago or California or Colorado or Florida or Georgia or Illinois or Indiana or Minnesota or Missouri or Montana or New Jersey or New York or North Carolina or Ohio or Oregon or Pennsylvania or South Carolina or Texas or Utah or Vermont or Virginia or Washington or Wisconsin or District of Columbia
$125k-$175k/yr HybridFull Time
NinjaTrader
NinjaTrader: Provides futures brokerage services and a trading software platform.
5+ YOE5+ years software engineering with API development and partner integrations; strong REST/WebSocket/JSON/OAuth skills; proficiency in TypeScript/JavaScript or Python; excellent troubleshooting and communication.
REST APIs, WebSockets, JSON, OAuth, Postman, curl, browser developer tools, network analyzers, TypeScript, JavaScript, Python, React, Node.js, Swagger/OpenAPI, ReadMe
3mo
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Sr Systems Engineer Charleston software integration
Charleston, South Carolina, United States
OnsiteFull Time
Elbit Systems of America
Elbit Systems of America: Provides advanced technology systems for defense and commercial aviation.
5+ YOESenior Systems Engineer with 5+ years in systems engineering; experience in software/hardware integration; defense systems; travel 30%; must have strong communication; US person and able to obtain security clearance.
Python, C/C++, MATLAB, Model Based System Engineering, System Design Tools
1w
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Senior Software Engineer Applied AI
Columbia or United States
RemoteFull Time
AMC Health
AMC Health: Provides remote patient monitoring and virtual care technology.
7+ YOE7+ years building production backend systems, strong Python, cloud/distributed systems experience, hands-on LLM/generative AI, ML lifecycle proficiency, and disciplined work in regulated environments.
Python, AWS, LLMs
2mo
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Senior AI Engineer - Agentic Systems
Atlanta or Raleigh-Durham or Phoenix or Tucson or Orlando or Nashville or Jacksonville or Houston or Greenville or Dallas or Tampa or Fort Lauderdale or Charlotte or Austin
OnsiteFull Time
DPR Construction
DPR Construction: General contractor for complex technical and sustainable construction projects.
6+ YOE6+ years production software engineering; 2+ years building LLM-powered systems; strong Python; LangChain/LangGraph experience; retrieval architectures; cloud data platforms; strong communication.
Python, LangChain, LangGraph, Snowflake Cortex, vector search
1mo
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Sr. Software Engineer - AI Innovation Team
Tukwila or Washington or Oregon or Idaho or Arizona or Texas or Georgia or South Carolina or Virginia or California or North Carolina
$110k-$205k/yr HybridFull Time
BECU
BECU: Provides banking and financial services to its members.
5+ YOEBachelor's in computer science or equivalent; 5+ years designing production software; experience with Node.js/TypeScript/React or Python, SQL, and cloud platforms (Azure/AWS/GCP); integrating AI/ML services; secure coding and TDD; mentoring experience.
Node.js, TypeScript, React, Python, SQL, Azure, AWS, GCP, Kubernetes, Azure DevOps, GitHub Actions, Jenkins, TeamCity, Git