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200 founding software engineer jobs at 121 companies in United States

3mo
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Founding Software Engineer
San Francisco, California, United States
$150k-$250k/yr OnsiteFull Time
Tamarind Bio
Tamarind Bio: AI-powered drug-discovery platform providing web and API access to computational biology tools for biotech and biopharma scientists.
Founding software engineer with full-stack expertise; strong AWS, Docker, CUDA, TensorFlow/PyTorch; React; onsite in SF; equity.
Python, React, AWS, Docker, CUDA, Conda, TensorFlow, PyTorch, Slurm, Bash, APIs, Web apps
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3mo
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Founding Software Engineer - Backend
San Francisco, California, United States
$125k-$300k/yr OnsiteFull Time
Hypercubic
Hypercubic: AI-native mainframe modernization platform serving enterprises and governments with tools to understand, operate, and transform COBOL systems.
0+ YOEFounding backend engineer with strong engineering and design taste; ownership over architecture and engineering culture. Experience with AI-powered systems and legacy modernization is a plus.
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4mo
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Founding Software Engineer
San Francisco, California, United States
$160k-$300k/yr OnsiteFull Time
Lance
Lance: Hospitality AI-agent startup serving hotel operators with autonomous agents for guest calls, sales, and hotel operations.
Proficient in software development; experience with ML/AI; design scalable systems; strong collaboration; startup mindset; BS or higher in CS/Engineering.
Python, JavaScript, Cloud infrastructure, Deployment pipelines, Machine Learning
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3mo
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Founding Engineer - Software
San Francisco or United States
$200k-$350k/yr RemoteFull Time
uRun
uRun: AI infrastructure helping model labs, builders, and research teams run real-time interactive video and stateful inference.
7+ YOE7+ years backend experience; proficient in TypeScript/Node.js or Python/Go; API design, distributed systems; cloud, containers, performance, and concurrency; real-time/latency-sensitive systems.
TypeScript, Node.js, Python, Go, WebRTC, WebSockets, Kubernetes, Observability, Cloud, Containers
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2w
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Founding Software Engineer, Full-Stack & Platform
Boston or New York City
$160k-$190k/yr HybridFull Time
Vincer
Vincer: AI decision-support software gives life sciences and medtech sales teams continuous field guidance and manager reinforcement.
5+ YOERequires 5+ years of full-time software engineering experience, full-stack development with strong backend/API/platform skills, real-time or low-latency systems experience, and end-to-end cloud infrastructure ownership.
CRM, Veeva, Salesforce, Slack, Microsoft Teams
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1w
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Founding Software Engineer (ML-Infra)
Seattle, Washington, United States
$180k-$250k/yr OnsiteFull Time
Reflection Robotics
Reflection Robotics: Seattle robotic automation building robot foundation models and same-day high-precision systems for manufacturers.
Strong systems engineering, distributed training and large-scale ML experience, PyTorch proficiency, multi-cloud experience, orchestration or scheduling expertise, and willingness to work weekdays in person in Seattle.
PyTorch, AWS, GCP, Azure, PyTorch Distributed, DeepSpeed, Ray, Kubernetes, FinOps
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2mo
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Founding Engineer
San Francisco, California, United States
$175k-$225k/yr OnsiteFull Time
Clera
Clera: AI-powered talent agent matching candidates to startup roles.
2+ YOEComputer Science degree required, 2+ years professional software engineering experience, strong CS fundamentals, startup experience valued, proficiency in Python (typed scientific Python).
Python
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1w
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Founding Engineer
New York City, New York, United States
$150k-$300k/yr OnsiteFull Time
Asymptote Labs
Asymptote Labs: AI security giving enterprises telemetry, detection, and response controls for agent activity.
5+ YOE5+ years building production software, infrastructure, developer tools, data platforms, or distributed systems; strong backend, distributed systems, databases, APIs, architecture, and product engineering skills.
Beacon, MCP, eBPF
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3mo
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Founding Engineer
New York City, New York, United States
$170k-$200k/yr OnsiteFull Time
Alden Labs
Alden Labs: Private AI healthcare software serving home care agencies with agents that automate coordination, scheduling, and communications.
3+ YOEFull-stack software engineer with 3+ years, skilled in React/NextJS, Express, PostgreSQL; strong ownership; healthcare and AI interest; able to ship features end-to-end.
React, NextJS, Express, PostgreSQL
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3mo
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Founding Software Engineer
San Francisco, California, United States
$160k-$220k/yr OnsiteFull Time
Kovari
Kovari: Venture-backed robotics building general-purpose hospitality robots for hotels and other physical businesses.
Strong software engineering fundamentals; Python and C++ in Linux; hardware familiarity; ROS; cross-stack collaboration; shipping-oriented.
Python, C++, Linux, ROS
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3mo
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Founding Engineer
New York, New York, United States
$140k-$500k/yr OnsiteFull Time
Rehearsals Research
Rehearsals Research: AI customer-simulation platform that helps marketing teams predict consumer behavior with digital twins of real people.
3+ YOEBachelor's in CS/Math/Physics or equivalent; 3+ years; proven shipping software; ability to work in NYC in-person.
TypeScript, Next.js, React, CI/CD, data scraping, infrastructure tooling
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1mo
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Founding Engineer
United States
OnsiteFull Time
Tsenta
Tsenta: Private AI career agent that finds jobs, tailors resumes, and applies for job seekers.
3+ YOE3+ years shipping production software, strong full-stack ability, experience or appetite for web automation/scraping, hands-on LLM experience, high autonomy and ownership.
Workday, Greenhouse, Lever, Ashby, TypeScript, Node, MCP, LLM
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1mo
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Founding Engineer
Austin, Texas, United States
HybridFull Time
Andreessen Horowitz
Andreessen Horowitz: Private venture capital firm investing in startups from seed through growth stages and helping founders build companies.
4+ YOERequires 4+ years building production software, strong backend, API, and web skills, independent delivery, technical judgment, ownership, and comfort with speed, quality, and scalability tradeoffs.
AI, LLMs, ML
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4mo
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Founding Engineer
New York, New York, United States
HybridFull Time
Jetty
Jetty: Private AI health software helping people with chronic symptoms track patterns and prepare for medical care.
3+ YOE3–8+ years of software product experience; strong backend, end-to-end product shipping; familiarity with APIs, data models, CI/CD, observability; startup mindset; privacy-focused health tech experience bonus.
Go, Rust, Java, Swift, Frontend
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3w
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Founding Engineer (AI)
San Francisco, California, United States
$150k-$220k/yr OnsiteFull Time
Momentic
Momentic: AI-powered end-to-end testing platform for software engineering teams across web, iOS, and Android.
3+ YOERequires 3+ years of experience, LLM performance tuning, evaluations, observability, application integration, fine-tuning, evaluation dataset engineering, and proficiency with modern software technologies.
Python, TypeScript, React, Next.js, Node.js, PostgreSQL, Google Cloud, Kubernetes, Selenium, Cypress, Playwright, Together AI, Baseten
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2mo
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Founding Engineer
San Francisco, California, United States
$120k-$160k/yr OnsiteFull Time
Aurorin CAD
Aurorin CAD: AI-native CAD software for mechanical engineers and hardware teams, built to speed up computer-aided design.
Strong systems programming/native app background, experience with Swift and C++, GPU programming experience preferred, proactive and high-responsibility engineer.
Swift, C++
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1mo
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Founding Engineer
United States or California
RemoteFull Time
Athena
Athena: Private San Francis startup studio that-founds, funds, and scales AI-native and data-driven software companies.
Experienced full‑stack engineer with product instincts, proven shipped products, user research experience, and comfort working on AI systems in early‑stage environments.
LLMs, GitHub
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1mo
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Founding Engineer
San Francisco or Lausanne
HybridFull Time
Compresr
Compresr: LLM context compression for better accuracy
Experienced full-stack engineer with strong backend fundamentals, concurrency/distributed systems, AWS production deployment, Python and light frontend skills, and excellent communication.
Python, FastAPI, PostgreSQL, Supabase, Redis, AWS, Next.js, React, TypeScript, GitHub, Docker, Sentry, GitHub Actions, Claude Code
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2w
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Founding Engineer
San Francisco, California, United States
$140k-$220k/yr OnsiteFull Time
Syntro
Syntro: Private AI procurement platform helping hardware manufacturers discover, select, and manage component suppliers.
Exceptional engineer with zero-to-one complex systems experience, full-stack ability, strong judgment, and expertise in reliability, data correctness, observability, and ambiguous problem-solving.
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3mo
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Founding Engineer
San Francisco, California, United States
HybridFull Time
Double Blind Bio
Double Blind Bio: Private health-tech startup building AI agents that automate clinical-trial workflows for research sites and life-science sponsors.
Strong full-stack engineering with deep AI/ML expertise; evals, observability, production LLMs; product-minded; healthcare familiarity; fast-paced, autonomous work.
LangSmith, Braintrust, Weights & Biases, Honeyhive
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