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82 principal data scientist jobs at 39 companies in California

3mo
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Principal Data Scientist - Immunology - (2 positions)
Titusville or Cambridge or Raritan or Spring House or San Diego
$117k-$201k/yr HybridFull Time
Johnson & Johnson
Johnson & JohnsonNYSE: JNJ: Develops and manufactures pharmaceutical drugs and medical devices.
5+ YOEPrincipal Data Scientist with bioinformatics/biomedical data expertise; 5+ years health informatics; semantic tech, ontologies, knowledge graphs; PhD or Master preferred.
Semantic Web, SPARQL, RDF, OWL, Graph Databases, Neo4j, Amazon Neptune, REST, GraphQL, Docker, CI/CD, Jenkins, GitLab, Azure DevOps, SQL, NoSQL, Proteomics, Genomics
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Principal Data Scientist
South San Francisco, California, United States
$174k-$217k/yr OnsiteFull Time
Structure Therapeutics
Structure TherapeuticsNASDAQ: GPCR: Developing oral small molecule medicines for chronic diseases
12+ YOE12+ years data science with production software experience; ML/DL proficiency; cloud and CI/CD; strong communication and collaboration.
Python, R, Scikit-learn, TensorFlow, PyTorch, AWS, Docker, CI/CD, GitHub
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Principal Data Scientist
San Francisco, California, United States
$135k-$242k/yr OnsiteFull Time
Autodesk
AutodeskNASDAQ: ADSK: Developing software for architecture, engineering, and entertainment industries.
8+ YOE8+ years in data science or applied ML with product analytics experience; expertise in predictive modeling, instrumentation, and AI/ML products; strong communication.
Python, SQL, Machine Learning, LLMs, Retrieval-Augmented Generation, Vector Databases
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1mo
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Principal Data Scientist
United States or San Francisco or New York City
$143k-$275k/yr OnsiteFull Time
Microsoft
MicrosoftNASDAQ: MSFT: Develops software, services, devices, and cloud computing solutions.
5+ YOEAdvanced degree in quantitative field with multi-year data science experience (minimum 5+ yrs), experience managing structured/unstructured data, model evaluation, data acquisition, and strong communication skills; U.S. citizenship verification required.
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2mo
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Principal Data Scientist - Oncology
Cambridge or San Diego or Spring House or Titusville or Raritan
$117k-$201k/yr HybridFull Time
Johnson & Johnson
Johnson & JohnsonNYSE: JNJ: Provides pharmaceutical products and medical technology healthcare solutions.
5+ YOEPhD or Master's in relevant field; 5+ years health informatics; knowledge graphs/ontologies; SPARQL/RDF/OWL; programming and DevOps; willingness to travel (<15%).
SPARQL, RDF, OWL, Neo4j, Amazon Neptune, Jenkins, GitLab, Azure DevOps, Docker, Singularity, RDF Triple Stores
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3d
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Principal Data Scientist
San Francisco, California, United States
$206k-$269k/yr HybridFull Time
Atlassian
AtlassianNASDAQ: TEAM: Develops software for team collaboration and project management.
8+ YOE8+ years in data science or related fields; SQL and Python or R proficiency; statistical analysis, experimentation, data visualization, executive advising, and business strategy experience.
SQL, Python, R, Tableau, R-Shiny, MicroStrategy, SAP BusinessObjects, Looker
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1w
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Principal Data Scientist
Canada or San Diego or South San Francisco
$188k-$210k/yr RemoteFull Time
Veracyte
VeracyteNASDAQ: VCYT: Provides genomic diagnostic tests for precise cancer diagnosis.
8+ YOEPhD in data science, machine learning, applied math, or equivalent; 8+ years in data/applied science; Python, computer vision, statistical modeling, cloud computing, and technical leadership experience.
Python, AWS
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1d
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Principal Data Scientist
San Francisco or New York City or Bellevue or Burbank
$228k-$423k/yr HybridFull Time
Warner Bros. Discovery
Warner Bros. DiscoveryNasdaq: WBD: Produces and distributes multimedia entertainment content and news worldwide.
8+ YOEMaster's degree in a quantitative field required; PhD preferred. Requires 8+ years in machine learning, AI, or data science, recommender systems expertise, SQL, big data, and Python-based ML platforms.
SQL, AWS, Snowflake, Spark, Google Cloud, Python, TensorFlow, Keras, PyTorch
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Principal Data Scientist
Oakland, California, United States
$163k-$277k/yr HybridFull Time
PG&E
PG&ENYSE: PCG: Provides natural gas and electric service in California.
8+ YOE8+ years data science/AI engineering experience (2 years with doctorate), bachelor’s in quantitative field or equivalent, deep Python and cloud AI experience, agentic AI and MLOps expertise, strong communication and leadership.
Python, AWS Bedrock, AWS AgentCore, LangGraph, LangChain, CrewAI, APIs, CI/CD, vector databases
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2w
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Principal Data Scientist
Palmdale, California, United States
$125k-$188k/yr OnsiteFull Time
Northrop Grumman
Northrop GrummanNYSE: NOC: Develops and manufactures advanced aerospace, defense, and space systems.
5+ YOEActive DoD Secret clearance, 5+ years' relevant experience (with bachelor's), expertise in SQL, ETL, Python, Airflow, BI (Tableau/PowerBI), Gitlab, and Agile workflows.
SQL, Tableau, PowerBI, Python, Airflow, Gitlab, Tableau Server, Apache Airflow
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Principal Data Scientist, Pricing
Los Angeles, California, United States
RemoteFull Time
UP.Labs
UP.Labs: Builds and scales mobility-focused startups with corporate partners.
8+ YOE8+ years in data science with pricing/revenue optimization experience; production ML deployment experience; strong quantitative modeling; ability to communicate with product and executive stakeholders.
Python, SQL, AWS, GCP, Azure, Snowflake, Databricks, dbt
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Principal Data Scientist - Games
Glendale, California, United States
$156k-$209k/yr OnsiteFull Time
The Walt Disney Company
The Walt Disney CompanyNYSE: DIS: Produces movies, operates theme parks, and provides streaming services.
10+ YOEBachelor's in quantitative field,10+ years data science experience in gaming/entertainment,proficiency in SQL and Python or R,experience with cloud analytics and experimentation,strong communication and storytelling skills.
SQL, Python, R, Snowflake, Databricks, AWS, Tableau, Looker
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1mo
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(USA) Principal, Data Scientist
Sunnyvale or Hoboken or Bellevue
$143k-$286k/yr OnsiteFull Time
Walmart
WalmartNYSE: WMT: Operates a chain of hypermarkets, discount stores, and grocery stores.
10+ YOE5+ MgmtBachelor's, master's, or doctoral degree in a quantitative field, or 7 years' analytics experience; 5+ years of technical leadership; strong ML, Python, data platforms, deployment, and communication skills.
Python, R, GCP, Azure, PySpark, Google Cloud Platform, Vertex AI, Kubeflow, Hadoop, Hive, MapReduce, HQL, Scala, GPU, CUDA, scikit-learn, TensorFlow, Torch, NLP, LLM, vector databases, WCAG 2.2 AA
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2w
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Principal, Data Scientist (Pricing)
Bentonville or Sunnyvale
$110k-$286k/yr OnsiteFull Time
Walmart
WalmartNYSE: WMT: Multinational retail operating discount stores and supermarkets.
8+ YOEPhD or advanced degree preferred; extensive pricing and data science experience (8+ years), proven track record deploying pricing models, expertise in ML, strong programming and leadership skills.
Python, R, Scala, Spark, scikit learn, TensorFlow, torch
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3w
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Principal Data Scientist - Games
Glendale, California, United States
$156k-$209k/yr OnsiteFull Time
The Walt Disney Company
The Walt Disney CompanyNYSE: DIS: Produces media content and operates global theme parks.
10+ YOE10+ years data science experience; advanced analytics, experimentation, forecasting, and behavioral segmentation for games/telemetry; strong SQL and Python/R skills; executive communication and cross-functional influence.
SQL, Python, R, Snowflake, Databricks, AWS, Tableau, Looker
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1mo
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Senior Principal Data Scientist, Advanced Forecasting
Irvine, California, United States
$145k-$205k/yr OnsiteFull Time
Edwards Lifesciences
Edwards LifesciencesNYSE: EW: Designs and manufactures medical devices for structural heart disease.
10+ YOEBachelor's degree in quantitative field, minimum 10 years experience (or 8 with Masters/4 with PhD), strong statistical and ML fundamentals, hands-on Python/R and SQL, forecasting and scenario modeling experience, excellent communication.
Python, R, SQL, Anaplan, Oracle, JDE, Concur, Salesforce.com, Databricks, Azure, AWS
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Principal Data Scientist, Google Search
Mountain View or Kirkland or New York City or Seattle or San Francisco
$307k-$427k/yr OnsiteFull Time
Google
GoogleNASDAQ: GOOGL: Provides online search, advertising, cloud computing, and consumer electronics.
15+ YOEBachelor’s degree or equivalent practical experience; 15 years in data science or quantitative fields; experience using data insights to improve products and engineering; advanced degree and product-building experience preferred.
AI
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Senior / Principal Data Scientist - Discovery
San Mateo, California, United States
$307k-$374k/yr HybridFull Time
Roblox
RobloxNYSE: RBLX: Platform for creating and playing user-generated 3D digital experiences.
10+ YOEAdvanced quantitative degree, 10+ years data science (or 6+ with PhD) with recommendation systems experience; expertise in causal inference, experimentation, ML, and strong communication skills.
Python, R, SQL, Hive, Spark, Airflow
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2w
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Principal Data Scientist, Core Shopping Data Science
Seattle or Palo Alto
$189k-$295k/yr OnsiteFull Time
Amazon
AmazonNASDAQ: AMZN: Global online retail and cloud computing technology provider.
Graduate degree in a quantitative field or equivalent experience; substantial data science industry experience; expertise in statistical inference, experimental design, sampling, Python and SQL; experience evaluating LLMs and owning high-visibility metrics.
Python, SQL, LLMs, Gecko
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3w
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Principal Associate, Data Scientist - Emerging ML
McLean or San Jose or New York City
$162k-$201k/yr OnsiteFull Time
Capital One
Capital OneNYSE: COF: Provides credit card, banking, and auto loan services.
3+ YOEQuantitative bachelor's degree plus 5 years, master's or quantitative MBA plus 3 years, or PhD; 3+ years in data analytics, machine learning, and SQL, with Python, Scala, or R experience.
Python, Scala, R, SQL, Spark, AWS
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