205 principal researcher jobs at 95 companies in Everett, MA
2mo
Save
Mark Applied
Hide
Principal Experience Researcher
Boston or Andover
$155k-$179k/yr HybridFull Time
12+ YOE12+ years design experience; Bachelor's in design/HCI or related; strong research portfolio; English fluency; travel 10-15%; U.S.-based; multiple software tools experience.
Figma, FigJam, Dovetail, Maze
1mo
Save
Mark Applied
Hide
Principal AI/ML Researcher
Boston, Massachusetts, United States
$270k-$300k/yr OnsiteFull Time
Advanced degree or equivalent experience in large-scale ML, deep learning and multimodal research; proven record of taking research to production and leading technical direction.
transformers, state space models, PPO, DPO, GRPO
2mo
Save
Mark Applied
Hide
Senior/Principal Researcher, Medicaid Policy and Program (Remote Eligible)
Remote or Ann Arbor or Cambridge or Chicago or Princeton or Washington or Windsor Mill
$145k-$200k/yr RemoteFull Time
10+ YOESenior state Medicaid leader with 10+ years (Sr) or 15+ years (Principal); Master’s or doctoral degree in analytics/public policy; strong quantitative/qualitative methods; excellent written/spoken communication; project leadership.
1mo
Save
Mark Applied
Hide
Cyber Researcher, Attack Emulation (Senior / Principal)
Burlington or Golden or Israel
$180k-$220k/yr RemoteFull Time
5+ YOE5+ years security research/penetration testing, 3+ years Python, strong Windows/Linux internals, reverse engineering, cloud (AWS/Azure), and proficiency with security tools (Metasploit, Nmap, Burp).
Python, Metasploit, Impacket, Nmap, Burp, IDA, Ghidra, WinDBG, Radare2, Windows, Linux, AWS, Azure
1w
Save
Mark Applied
Hide
Principal Scientist, Ophthalmology Research
Westborough, Massachusetts, United States
$145k-$208k/yr OnsiteFull Time
8+ YOEPhD in a relevant scientific discipline and 8+ years of postdoctoral or industry research experience; requires ophthalmology expertise, in vivo study leadership, therapeutic modality experience, and strong scientific communication skills.
OCT, ERG
2w
Save
Mark Applied
Hide
Senior Principal Research Scientist
Devens, Massachusetts, United States
$142k-$213k/yr OnsiteFull Time
9+ YOEBS in materials-related field required; 9 years research experience (or 7 with MS, 4 with PhD); hands-on ceramics synthesis, processing and characterization; familiarity with XRD/SEM/EDS and analytical methods; ability to obtain US clearance and US citizenship required.
XRD, EDS, SEM, PSD, TGA, FTIR, GC/MS, Microsoft Office, Microsoft Project, ANSYS FEM, PSpice, COMSOL Multi Physics, MATLAB, Mathematica
1mo
Save
Mark Applied
Hide
Principal Biostatistician
United States or Waltham
HybridFull Time
3+ YOEAdvanced biostatistics expertise with SAS, leadership, project management, clinical trial design familiarity, and 3+ years relevant experience (PhD) or 4+ years (Master's).
SAS
2w
Save
Mark Applied
Hide
Principal Engineer
Waltham, Massachusetts, United States
$173k-$193k/yr HybridFull Time
PhD (>8 yrs) or MS (>15 yrs) in Science/Engineering; expert in small-molecule process development, scale-up, tech transfer, DOE, data analysis, CDMO management; strong leadership and communication.
Process Analytical Technology (PAT)
3mo
Save
Mark Applied
Hide
Principal Technical Staff
Arlington or Woburn
$220k-$260k/yr OnsiteFull Time
8+ YOETop Secret/SCI clearance; MS with 15+ years or PhD with 8+ years in applied math, physics, EE, CS, or data science; lead large technical projects and multi-discipline teams; handle end-to-end research-to-product programs; business development and proposal experience; strong communications.
1w
Save
Mark Applied
Hide
Principal Scientist II, Translational Biomarker Strategy Lead
Cambridge, Massachusetts, United States
$114k-$212k/yr HybridFull Time
7+ YOEDoctorate in relevant field,7+ years translational research/biomarker strategy experience in pharma/biotech,experience leading cross-functional teams,strong communication and stakeholder management.
1mo
Save
Mark Applied
Hide
Senior Principal Toxicologist
Burlington, Massachusetts, United States
$131k-$190k/yr HybridFull Time
10+ YOEPhD in toxicology required, 10+ years relevant experience; DART experience preferred; recognized toxicology authority; ability to lead risk assessments, apply statistical/data science tools, and travel up to 15%.
5d
Save
Mark Applied
Hide
Principal Biostatistician FSP
United States or Cambridge
RemoteFull Time
3+ YOEPhD with 3+ years or master's degree with 6+ years in statistics, biostatistics, or a related discipline; SAS programming, leadership, collaboration, and clinical trial expertise required.
SAS, R
6d
Save
Mark Applied
Hide
Principal Scientist, Early Clinical Development, Respiratory Therapeutic Area
Boston, Massachusetts, United States
$260k-$410k/yr OnsiteFull Time
MD or MD/PhD required; clinical medicine training, pulmonology or related fellowship and board certification, biomedical research experience, scientific publications, and strong writing, presentation, and teamwork skills required.
wearable devices
1w
Save
Mark Applied
Hide
Analytical Development Principal Scientist
Boston, Massachusetts, United States
$141k-$211k/yr OnsiteFull Time
4+ YOEPh.D. and 4+ years of analytical development experience, or M.S. with 7+ years or B.S. with 10+ years; small-molecule pharmaceuticals, chromatography, QbD, cGMP, and regulatory guideline knowledge required.
Quality by Design (QbD), cGMP, ICH, FDA, USP, ICH M7, chromatography
1mo
Save
Mark Applied
Hide
Principal Scientist, Biology (Immunology)
Watertown, Massachusetts, United States
$188k-$207k/yr OnsiteFull Time
10+ YOEPhD in immunology/cell biology or related, 10+ years industry drug discovery experience, leadership in autoimmune/inflammatory programs, deep immune cell biology expertise, strong publication/patent record.
1mo
Save
Mark Applied
Hide
Principal Process Engineer
Bedford, Massachusetts, United States
$150k-$165k/yr OnsiteFull Time
12+ YOEBachelor's in engineering or science, ~12 years product development experience (8–10 with advanced degree), in‑vitro medical device experience desired, experience with validation (IQ/OQ/PQ), pFMEA, DoE, and mentoring.
2mo
Save
Mark Applied
Hide
Principal Scientist II/Senior Principal Scientist, Modeling & Simulation (Dual Level Posting)
Cambridge, Massachusetts, United States
$126k-$261k/yr HybridFull Time
3+ YOEPh.D. (or MSc with experience) with industry modeling experience (3+ yrs PhD / 5+ yrs MS). Expert in ODE modeling, PK/PD, QSP, PBPK/PD; scripting (MATLAB, R); strong communication and cross-disciplinary collaboration.
MATLAB, R
2mo
Save
Mark Applied
Hide
Kearney Healthcare & Life Sciences Practice Principal (Commercial Strategy)
Chicago or San Francisco or Dallas or Washington D.C. or New York or Boston or Atlanta
$245k-$270k/yr HybridFull Time
10+ YOEMBA preferred; 10+ years management consulting; principal-level leadership; Life Sciences commercial strategy experience
4d
Save
Mark Applied
Hide
Principal Scientist, Biomarker Bioanalytical Sciences
Cambridge, Massachusetts, United States
$141k-$188k/yr HybridFull Time
5+ YOEPhD with 5+ years or MS with 8+ years in a related scientific field; expertise in biomarker and bioanalytical assay development, validation, regulated environments, CRO oversight, data interpretation, and regulatory submissions.
PK, ADA, TE, PD, IND, CTA, BLA, MAA
3w
Save
Mark Applied
Hide
Senior Principal Scientist, Analytical Sciences
Watertown, Massachusetts, United States
$71k-$187k/yr OnsiteFull Time
7+ YOEMS (7+ yrs) or BS (10+ yrs) LC-MS experience required; hands-on LC-MS/MS method development, bioanalysis, QTOF/Orbitrap/triple quadrupole operation, troubleshooting, and familiarity with RNA/LNP characterization.
LC-MS/MS, QTOF, Orbitrap, triple quadrupole, IP-RP, AEX, SEC-MALS, LC-CAD
Explore Jobs