170 principal scientist jobs at 61 companies in Colma, CA
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Principal Scientist
South San Francisco, California, United States
$143k-$266k/yr OnsiteFull Time
3+ YOEPhD and 3+ years industry experience designing and executing small-molecule metabolomics/lipidomics assays, operating LC-MS platforms, and applying computational/Generative AI tools for data analysis.
Generative AI, LC-HRMS, LC-MS/MS, UHPLC, triple quadrupole
2d
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Principal Scientist, ML – Overall Architect
San Jose, California, United States
$262k-$379k/yr OnsiteFull Time
PhD or equivalent research depth; principal-level breadth across distributed training, inference, model architecture, and data pipelines; hands-on PyTorch FSDP and parallelism expertise; cross-team architecture leadership.
PyTorch, FSDP, GenRender6, Gen6.5, GenEdit1
1w
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Principal Scientist, Diagnostics
Foster City, California, United States
$196k-$253k/yr HybridFull Time
10+ YOERequires 10+ years with a bachelor's, 8+ with a master's, or 2+ with an MD/PhD in a scientific field; oncology diagnostics or assay development experience preferred.
immunohistochemistry (IHC), next-generation sequencing (NGS), flow cytometry, digital pathology, Workday
2w
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Senior Principal Scientist, Pharmacokinetics
South San Francisco, California, United States
$194k-$306k/yr OnsiteFull Time
12+ YOEMaster's with 15+ years or Ph.D. with 12+ years in a relevant scientific discipline; extensive DMPK/ADME expertise, translational PK/PD experience, scientific leadership, and people management skills.
In Vitro Assays
1mo
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Principal Scientist, Process Sciences
South San Francisco, California, United States
$155k-$180k/yr OnsiteFull Time
7+ YOEPhD/MS/BS in engineering or biological sciences with extensive process development and scale-up experience; expertise in cell therapy manufacturing, DOE, data analysis (Python/R), regulatory support, and technical leadership.
Python, R
1mo
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Principal Scientist, Inflammation
South San Francisco, California, United States
$154k-$208k/yr OnsiteFull Time
2+ YOEPhD/PharmD/MD with 2+ years or Master’s with 5+ years or Bachelor’s with 7+ years in drug discovery; deep immunology experience, publication record, assay and in vivo expertise.
ELISA, MSD, flow cytometry, single-cell RNA sequencing (scRNA-Seq), CRISPR/Cas9
3mo
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Principal Data Scientist
South San Francisco, California, United States
$174k-$217k/yr OnsiteFull Time
12+ YOE12+ years data science with production software experience; ML/DL proficiency; cloud and CI/CD; strong communication and collaboration.
Python, R, Scikit-learn, TensorFlow, PyTorch, AWS, Docker, CI/CD, GitHub
3mo
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Principal Data Scientist
San Francisco, California, United States
$135k-$242k/yr OnsiteFull Time
8+ YOE8+ years in data science or applied ML with product analytics experience; expertise in predictive modeling, instrumentation, and AI/ML products; strong communication.
Python, SQL, Machine Learning, LLMs, Retrieval-Augmented Generation, Vector Databases
3mo
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Principal Scientist, Bioinformatics
South San Francisco, California, United States
$180k-$215k/yr HybridFull Time
5+ YOELead computational analysis of single-cell and spatial omics data; develop scalable pipelines; collaborate cross-functionally to support translational medicine.
Python, R, AWS, single-cell RNA-seq
2mo
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Principal Scientist, Analytical Operations
Foster City, California, United States
$196k-$253k/yr OnsiteFull Time
5+ YOESenior QC scientist for small-molecule clinical programs; requires deep analytical chemistry and cGMP QC experience, ability to manage external labs, author CMC, and lead cross-functional teams.
2mo
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Lead Principal Applied Scientist
Santa Clara or Seattle or United States
$158k-$355k/yr OnsiteFull Time
10+ YOE10+ years applied ML/AI research experience; expertise in dataset preparation, experiment design, model training/fine-tuning, evaluation, deployment, and publication; strong coding, version control, and leadership skills.
1w
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Principal Scientist, Clinical Research - MedTech Surgery
Santa Clara or Cincinnati
$134k-$231k/yr OnsiteFull Time
8+ YOEBachelor’s degree in biological science, engineering, or related field; advanced degree preferred; 8+ years of clinical research experience; expertise in clinical research, product development, global regulations, and clinical programs required.
1w
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Principal Scientist, Clinical Research - MedTech Surgery
Santa Clara or Cincinnati
$134k-$231k/yr OnsiteFull Time
8+ YOEBachelor’s degree in biological science, engineering, or related field; 8+ years of clinical research experience; expertise in clinical research, product development, clinical trials, regulations, and medical device or healthcare research.
3mo
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Principal Scientist, Cancer Pharmacology, Translational Research
Redwood City, California, United States
$190k-$238k/yr OnsiteFull Time
5+ YOEPhD in Pharmacology or Cancer Biology; 5+ years in oncology drug discovery; leadership and PK/PD expertise.
1mo
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Principal Scientist – Data Insights & Hypothesis Design
Chicago or Redwood City or New York City or California or New York
$150k-$200k/yr HybridFull Time
6+ YOEPhD in NGS-related field,6+ years industry experience,domain expertise in oncology/neurology/immunology,large-scale clinico-genomic analysis,SQL/Python/R proficiency,and experience translating data into production products.
SQL, R, Python, Tempus Data Model (TDM)
3w
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Principal Scientist / Associate Director – Translational Biology
South San Francisco, California, United States
$175k-$200k/yr OnsiteFull Time
8+ YOEPhD preferred in immunology, pharmacology, or related field; 8+ years relevant industry experience; expertise in autoimmune or inflammatory programs, pharmacology studies, CRO management, immunology, and scientific leadership.
3d
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Associate Principal Scientist, Clinical Research
Rahway or South San Francisco or Boston or West Point
$142k-$224k/yr HybridFull Time
3+ YOELife sciences degree plus 3–11+ years related experience depending on degree; extensive Phase 1 or Phase 2–3 trial experience, vaccine programs, project management, scientific writing, GCP, ICH, and regulatory expertise.
Good Clinical Practice (GCP), ICH guidelines, SOPs, WMA, CTD
3mo
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Principal AI Scientist - GTM Tech
Mountain View, California, United States
$274k-$370k/yr OnsiteFull Time
3+ YOEPhD/MS in a quantitative field; 3+ years leading AI/ML; strong statistics; hands-on programming in ML/NLP; 6+ years with data manipulation and general-purpose languages; proven influencer and leader.
Python, Scala, SQL, R, ML pipelines, NLP
1w
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Principal Scientist, Discovery Chemistry - San Carlos, California
San Carlos, California, United States
$165k-$207k/yr OnsiteFull Time
6+ YOEPh.D. or equivalent advanced degree and 6+ years of research experience; deep synthetic organic chemistry expertise, compound library design, parallel synthesis, SAR, drug discovery, and cross-functional collaboration required.
Electronic Laboratory Notebook (ELN), CADD, Spotfire
2mo
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Principal Scientist, Translational Genetics
South San Francisco, California, United States
$203k-$236k/yr OnsiteFull Time
6+ YOEPhD in a relevant field, 6+ years industry or postdoc experience; expertise in statistical genetics (GWAS, fine-mapping), multi-omics integration, Mendelian randomization, R/Python, PLINK/Hail, and translating genetic findings to therapeutic target ID.
R, Python, PLINK, Hail, AWS, Google Cloud, DNAnexus RAP, All of Us Workbench, EHR
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