175 principal scientist jobs at 62 companies in Epping, NH
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Scientist-Principal Scientist, Protein Design & Structure
Boston, Massachusetts, United States
OnsiteFull Time
2+ YOEPhD in Biochemistry/Molecular Biology/Biophysics with 2+ years (Scientist) or 5+ years (Senior Scientist) or 8+ years (Principal Scientist) of relevant experience in GPCR/membrane protein expression, purification, and characterization; strong leadership and collaboration skills.
Cryo-EM, FPLC, SEC, Rosetta, AI/ML
2mo
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Principal Data Scientist - Immunology - (2 positions)
Titusville or Cambridge or Raritan or Spring House or San Diego
$117k-$201k/yr HybridFull Time
5+ YOEPrincipal Data Scientist with bioinformatics/biomedical data expertise; 5+ years health informatics; semantic tech, ontologies, knowledge graphs; PhD or Master preferred.
Semantic Web, SPARQL, RDF, OWL, Graph Databases, Neo4j, Amazon Neptune, REST, GraphQL, Docker, CI/CD, Jenkins, GitLab, Azure DevOps, SQL, NoSQL, Proteomics, Genomics
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Senior Principal Scientist
Cambridge, Massachusetts, United States
$149k-$215k/yr HybridFull Time
7+ YOEPhD plus ≥7 years biopharma research experience in hematopoietic stem cell biology and mast cell disorders; experience in early/late-stage research, translational research, CRO management, regulatory submissions, and strong communication skills.
1w
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Analytical Development Principal Scientist
Boston, Massachusetts, United States
$141k-$211k/yr OnsiteFull Time
4+ YOEPh.D. and 4+ years of analytical development experience, or M.S. with 7+ years or B.S. with 10+ years; small-molecule pharmaceuticals, chromatography, QbD, cGMP, and regulatory guideline knowledge required.
Quality by Design (QbD), cGMP, ICH, FDA, USP, ICH M7, chromatography
1mo
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Principal Scientist, Biology (Immunology)
Watertown, Massachusetts, United States
$188k-$207k/yr OnsiteFull Time
10+ YOEPhD in immunology/cell biology or related, 10+ years industry drug discovery experience, leadership in autoimmune/inflammatory programs, deep immune cell biology expertise, strong publication/patent record.
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Data Scientist – Simulation (Senior - Principal)
Wilmington, Massachusetts, United States
$149k-$205k/yr HybridMultiple Commitments Available
5+ YOESenior/Principal Data Scientist to lead simulation model development for robotic warehouses; 5-8 years in simulation, DES/agent-based modeling; Python and related tools.
Python, NumPy, Pandas, SciPy, SimPy, AnyLogic, Arena, Databricks, Snowflake, Grafana, Tableau, GCP, AWS, Azure, High-Performance Computing
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Principal Scientist II/Senior Principal Scientist, Modeling & Simulation (Dual Level Posting)
Cambridge, Massachusetts, United States
$126k-$261k/yr HybridFull Time
3+ YOEPhD with 3+ years industry modeling experience (or MS with 5+ years). Expert in PK/PD,QSP,PBPK/PD, ODE modeling, parameter estimation; scripting with MATLAB and R; strong collaboration and communication skills.
MATLAB, R, agentic AI
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Principal Scientist II/Senior Principal Scientist, Modeling & Simulation (Dual Level Posting)
Cambridge, Massachusetts, United States
$126k-$261k/yr HybridFull Time
3+ YOEPh.D. (or MSc with experience) with industry modeling experience (3+ yrs PhD / 5+ yrs MS). Expert in ODE modeling, PK/PD, QSP, PBPK/PD; scripting (MATLAB, R); strong communication and cross-disciplinary collaboration.
MATLAB, R
2d
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Principal Scientist, Biomarker Bioanalytical Sciences
Cambridge, Massachusetts, United States
$141k-$188k/yr HybridFull Time
5+ YOEPhD with 5+ years or MS with 8+ years in a related scientific field; expertise in biomarker and bioanalytical assay development, validation, regulated environments, CRO oversight, data interpretation, and regulatory submissions.
PK, ADA, TE, PD, IND, CTA, BLA, MAA
3w
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Senior Principal Scientist, Analytical Sciences
Watertown, Massachusetts, United States
$71k-$187k/yr OnsiteFull Time
7+ YOEMS (7+ yrs) or BS (10+ yrs) LC-MS experience required; hands-on LC-MS/MS method development, bioanalysis, QTOF/Orbitrap/triple quadrupole operation, troubleshooting, and familiarity with RNA/LNP characterization.
LC-MS/MS, QTOF, Orbitrap, triple quadrupole, IP-RP, AEX, SEC-MALS, LC-CAD
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Senior Scientist II/Principal Scientist, Molecular Cloning Technologies
Cambridge, Massachusetts, United States
$143k-$215k/yr OnsiteFull Time
8+ YOEPh.D. required with 8+ years (Senior Scientist II) or 12+ years (Principal) industry/postdoc experience; deep expertise in molecular cloning, DNA assembly, vector engineering, high-throughput cloning workflows, automation, and leadership.
LIMS
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Principal Associate Scientist, Biology
Cambridge, Massachusetts, United States
$108k-$128k/yr OnsiteFull Time
7+ YOEB.S. or M.S. in Biology/Biochemistry or related field; 7–10+ years in industry; strong cell-based assay and molecular biology skills; on-site collaboration.
NanoBRET, HiBiT, AlphaLISA, HTRF, qPCR, Western blotting, immunoprecipitation, pulldown assays, CRISPR/Cas9
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Principal Data Scientist - Oncology
Cambridge or San Diego or Spring House or Titusville or Raritan
$117k-$201k/yr HybridFull Time
5+ YOEPhD or Master's in relevant field; 5+ years health informatics; knowledge graphs/ontologies; SPARQL/RDF/OWL; programming and DevOps; willingness to travel (<15%).
SPARQL, RDF, OWL, Neo4j, Amazon Neptune, Jenkins, GitLab, Azure DevOps, Docker, Singularity, RDF Triple Stores
2w
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Senior Principal Research Scientist
Devens, Massachusetts, United States
$142k-$213k/yr OnsiteFull Time
9+ YOEBS in materials-related field required; 9 years research experience (or 7 with MS, 4 with PhD); hands-on ceramics synthesis, processing and characterization; familiarity with XRD/SEM/EDS and analytical methods; ability to obtain US clearance and US citizenship required.
XRD, EDS, SEM, PSD, TGA, FTIR, GC/MS, Microsoft Office, Microsoft Project, ANSYS FEM, PSpice, COMSOL Multi Physics, MATLAB, Mathematica
1mo
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Senior Principal Scientist - Translational Muscle Biology
Cambridge, Massachusetts, United States
HybridFull Time
15+ YOEPhD with 15+ years or MS with 20+ years in drug discovery/biology; leadership experience; deep muscle biology and assay development expertise; mammalian cell culture and molecular/biochemical assay experience; publication record.
3w
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Senior Principal Scientist, Small Molecule Therapeutics
Cambridge, Massachusetts, United States
OnsiteFull Time
10+ YOEPhD or equivalent with 10+ years (or MS/BS with 15+ years) in protein/structural biology; deep recombinant protein expression, purification, construct engineering, crystallography and Cryo-EM experience; CRO management and cross-functional collaboration.
Cryo-EM, X-ray crystallography, SDS-PAGE, LC-MS, SEC, SEC-MALS, DSF, DLS, SPR, ITC, MST, DNA-encoded library, AI/ML
2w
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Principal Scientist, Clinical Research - Immunology/Dermatology
Rahway or South San Francisco or Boston or North Wales
$256k-$403k/yr HybridFull Time
5+ YOEM.D., D.O., or equivalent doctoral medical degree; 5+ years of clinical or development experience; scientific scholarship; clinical trial expertise; immunology, dermatology, statistics, and collaboration skills.
Investigational New Drug (IND)
1d
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Principal Scientist, mRNA-tLNP Analytical Development
Boston, Massachusetts, United States
OnsiteFull Time
6+ YOEPhD with 6+, MS with 8+, or BS with 12+ years in a relevant life science field; expertise in mRNA/LNP analytical methods, bioconjugation, potency assays, CRO oversight, GMP/GLP, and regulatory submissions.
HPLC, LC-MS, CE, ELISA, qPCR, SEC/HPLC, CRO, CDMO, IND
1w
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Principal Scientist, Oncology Data Science (Translational Science)
Pennsylvania or United Kingdom or Stevenage or Heidelberg or Massachusetts or Cambridge or Upper Providence or Waltham or Maryland or Rockville or San Francisco or Germany
$121k-$202k/yr HybridFull Time
1+ YOEPhD or equivalent in a quantitative field, 1+ year industry or postdoctoral experience, cancer computational biology expertise, single-cell omics, statistical and machine learning, Python, and PyTorch.
Python, PyTorch, R, CI/CD, CRISPR, Perturb-seq, version control
2mo
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Sr. Principal Scientist, Clinical Operations Immunology Lead
Boston or Rahway or West Point or South San Francisco
$210k-$331k/yr HybridFull Time
12+ YOEDegree in life sciences with extensive early clinical development experience (Phase 1/early PoC); strategic and operational leadership for immunology programs; team building, cross-functional partnership, protocol and strategy review, strong communication and decision-making.
CTMS
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