147 principal scientist jobs at 57 companies in Fairview, CA
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Principal Scientist
San Carlos, California, United States
$165k-$205k/yr OnsiteFull Time
8+ YOEPhD preferred (or MS/BS with extensive experience). 8+ years post-PhD (or equivalent), strong antibody/protein engineering, expression/purification, molecular biology, project leadership, publications/patents, and experience mentoring staff and managing collaborations.
2w
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Principal Scientist
South San Francisco, California, United States
$143k-$266k/yr OnsiteFull Time
3+ YOEPhD and 3+ years industry experience designing and executing small-molecule metabolomics/lipidomics assays, operating LC-MS platforms, and applying computational/Generative AI tools for data analysis.
Generative AI, LC-HRMS, LC-MS/MS, UHPLC, triple quadrupole
1mo
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Principal Scientist, Process Sciences
South San Francisco, California, United States
$155k-$180k/yr OnsiteFull Time
7+ YOEPhD/MS/BS in engineering or biological sciences with extensive process development and scale-up experience; expertise in cell therapy manufacturing, DOE, data analysis (Python/R), regulatory support, and technical leadership.
Python, R
5d
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Senior Principal Scientist, Pharmacokinetics
South San Francisco, California, United States
$194k-$306k/yr OnsiteFull Time
12+ YOEMaster's with 15+ years or Ph.D. with 12+ years in a relevant scientific discipline; extensive DMPK/ADME expertise, translational PK/PD experience, scientific leadership, and people management skills.
In Vitro Assays
2mo
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Principal Data Scientist
San Francisco, California, United States
$135k-$242k/yr OnsiteFull Time
8+ YOE8+ years in data science or applied ML with product analytics experience; expertise in predictive modeling, instrumentation, and AI/ML products; strong communication.
Python, SQL, Machine Learning, LLMs, Retrieval-Augmented Generation, Vector Databases
1mo
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Principal Scientist, Inflammation
South San Francisco, California, United States
$154k-$208k/yr OnsiteFull Time
2+ YOEPhD/PharmD/MD with 2+ years or Master’s with 5+ years or Bachelor’s with 7+ years in drug discovery; deep immunology experience, publication record, assay and in vivo expertise.
ELISA, MSD, flow cytometry, single-cell RNA sequencing (scRNA-Seq), CRISPR/Cas9
3mo
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Principal Data Scientist
South San Francisco, California, United States
$174k-$217k/yr OnsiteFull Time
12+ YOE12+ years data science with production software experience; ML/DL proficiency; cloud and CI/CD; strong communication and collaboration.
Python, R, Scikit-learn, TensorFlow, PyTorch, AWS, Docker, CI/CD, GitHub
3mo
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Principal Scientist, Bioinformatics
South San Francisco, California, United States
$180k-$215k/yr HybridFull Time
5+ YOELead computational analysis of single-cell and spatial omics data; develop scalable pipelines; collaborate cross-functionally to support translational medicine.
Python, R, AWS, single-cell RNA-seq
2mo
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Principal Scientist, Analytical Operations
Foster City, California, United States
$196k-$253k/yr OnsiteFull Time
5+ YOESenior QC scientist for small-molecule clinical programs; requires deep analytical chemistry and cGMP QC experience, ability to manage external labs, author CMC, and lead cross-functional teams.
2w
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Principal Scientist, Clinical Research - Immunology/Dermatology
Rahway or South San Francisco or Boston or North Wales
$256k-$403k/yr HybridFull Time
5+ YOEM.D., D.O., or equivalent doctoral medical degree; 5+ years of clinical or development experience; scientific scholarship; clinical trial expertise; immunology, dermatology, statistics, and collaboration skills.
Investigational New Drug (IND)
2mo
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Principal Scientist, Cancer Pharmacology, Translational Research
Redwood City, California, United States
$190k-$238k/yr OnsiteFull Time
5+ YOEPhD in Pharmacology or Cancer Biology; 5+ years in oncology drug discovery; leadership and PK/PD expertise.
4w
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Principal Scientist – Data Insights & Hypothesis Design
Chicago or Redwood City or New York City or California or New York
$150k-$200k/yr HybridFull Time
6+ YOEPhD in NGS-related field,6+ years industry experience,domain expertise in oncology/neurology/immunology,large-scale clinico-genomic analysis,SQL/Python/R proficiency,and experience translating data into production products.
SQL, R, Python, Tempus Data Model (TDM)
1mo
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Senior Principal Scientist (Antibody Drug Conjugate)
Alameda, California, United States
$170k-$240k/yr OnsiteFull Time
8+ YOEDeep hands-on mastery of ADC conjugation chemistry, DAR control, formulation and analytical characterization; 8+ years relevant experience (PhD) or equivalent; strong communication and cross-functional collaboration skills.
FPLC, TFF/UF-DF, HIC, SEC, RP-HPLC, LC-MS, UV-Vis
1w
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Principal Scientist, Oncology Data Science (Translational Science)
Pennsylvania or United Kingdom or Stevenage or Heidelberg or Massachusetts or Cambridge or Upper Providence or Waltham or Maryland or Rockville or San Francisco or Germany
$121k-$202k/yr HybridFull Time
1+ YOEPhD or equivalent in a quantitative field, 1+ year industry or postdoctoral experience, cancer computational biology expertise, single-cell omics, statistical and machine learning, Python, and PyTorch.
Python, PyTorch, R, CI/CD, CRISPR, Perturb-seq, version control
3mo
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Principal AI Scientist - GTM Tech
Mountain View, California, United States
$274k-$370k/yr OnsiteFull Time
3+ YOEPhD/MS in a quantitative field; 3+ years leading AI/ML; strong statistics; hands-on programming in ML/NLP; 6+ years with data manipulation and general-purpose languages; proven influencer and leader.
Python, Scala, SQL, R, ML pipelines, NLP
2mo
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Principal Scientist, Translational Genetics
South San Francisco, California, United States
$203k-$236k/yr OnsiteFull Time
6+ YOEPhD in a relevant field, 6+ years industry or postdoc experience; expertise in statistical genetics (GWAS, fine-mapping), multi-omics integration, Mendelian randomization, R/Python, PLINK/Hail, and translating genetic findings to therapeutic target ID.
R, Python, PLINK, Hail, AWS, Google Cloud, DNAnexus RAP, All of Us Workbench, EHR
1mo
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Principal Scientist- Search
New York City or San Francisco or Los Angeles or Irvine or McLean or Washington
$212k-$394k/yr HybridFull Time
8+ YOEPhD and 8+ years building and deploying production AI systems; deep expertise in information retrieval, search, NLP, RAG, knowledge graphs, LLMs; strong product sense and leadership skills.
Python, PyTorch, Hugging Face, Azure ML, Azure AI Foundry, AWS SageMaker
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Principal Applied Scientist, Ads Optimization, FAIM
Palo Alto or Seattle
$229k-$309k/yr OnsiteFull Time
5+ YOEPhD in a technical field, 5+ years in predictive modeling and analysis, programming experience, ambiguity-solving skills, and experience leading and developing scientists.
Java, C++, Python
2mo
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Supervising Principal Scientist, Process Development
South San Francisco or Bridgewater
$90k-$210k/yr OnsiteFull Time
6+ YOEBachelor's/Master's/PhD in bioengineering, chemical engineering, biology, biochemistry or related; 6+ years process development experience in cell & gene therapy; subject-matter expertise in T cell/HSC/iPSC modalities; hands-on with Miltenyi Prodigy, Lonza Cocoon, Xuri Wave; familiarity with LVV, RVV, LNP, CRISPR, TALENs, ZFNs; people management an...
Miltenyi Prodigy, Lonza Cocoon, Xuri Wave, LVV, RVV, LNP, CRISPR, TALENs, ZFNs
3w
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Principal Data Scientist
Oakland, California, United States
$163k-$277k/yr HybridFull Time
8+ YOE8+ years data science/AI engineering experience (2 years with doctorate), bachelor’s in quantitative field or equivalent, deep Python and cloud AI experience, agentic AI and MLOps expertise, strong communication and leadership.
Python, AWS Bedrock, AWS AgentCore, LangGraph, LangChain, CrewAI, APIs, CI/CD, vector databases
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