174 principal scientist jobs at 64 companies in Mendon, MA
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Scientist-Principal Scientist, Protein Design & Structure
Boston, Massachusetts, United States
OnsiteFull Time
2+ YOEPhD in Biochemistry/Molecular Biology/Biophysics with 2+ years (Scientist) or 5+ years (Senior Scientist) or 8+ years (Principal Scientist) of relevant experience in GPCR/membrane protein expression, purification, and characterization; strong leadership and collaboration skills.
Cryo-EM, FPLC, SEC, Rosetta, AI/ML
3mo
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Principal Data Scientist - Immunology - (2 positions)
Titusville or Cambridge or Raritan or Spring House or San Diego
$117k-$201k/yr HybridFull Time
5+ YOEPrincipal Data Scientist with bioinformatics/biomedical data expertise; 5+ years health informatics; semantic tech, ontologies, knowledge graphs; PhD or Master preferred.
Semantic Web, SPARQL, RDF, OWL, Graph Databases, Neo4j, Amazon Neptune, REST, GraphQL, Docker, CI/CD, Jenkins, GitLab, Azure DevOps, SQL, NoSQL, Proteomics, Genomics
1d
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Principal Scientist, DMPK
United States or Cambridge
$147k-$221k/yr OnsiteFull Time
6+ YOEPh.D. in a relevant scientific discipline and 6+ years of pharmaceutical or biotechnology industry experience, with DMPK strategy, ADME, PK/PD, regulatory filing, quantitative, and team leadership expertise.
Drug Metabolism and Pharmacokinetics (DMPK), ADME, PK/PD, RNAi, ASO, CTA, IND, NDA, PBPK
1d
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Principal Scientist, DMPK
Cambridge or Boston
$147k-$221k/yr OnsiteFull Time
6+ YOEPh.D. in a relevant scientific discipline and 6+ years of pharmaceutical or biotechnology industry experience, with DMPK strategy, ADME, PK/PD, regulatory filing, quantitative analysis, and multidisciplinary leadership expertise.
PK/PD, ADME, RNAi, ASO, CTA, IND, NDA, PBPK
1mo
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Principal Scientist, Bioanalytics
Billerica, Massachusetts, United States
$127k-$215k/yr OnsiteFull Time
5+ YOEPh.D. and 5–7+ years of regulated bioanalysis experience required, with expertise in PK, bioanalytics, immunogenicity, ligand binding, experimental design, data analysis, instrumentation, and technical reporting.
ELISA, MSD-ECLA, Gyrolab, Watson LIMS, GraphPad Prism, Veeva Vault
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Principal Scientist, Biology (Immunology)
Watertown, Massachusetts, United States
$188k-$207k/yr OnsiteFull Time
10+ YOEPhD in immunology/cell biology or related, 10+ years industry drug discovery experience, leadership in autoimmune/inflammatory programs, deep immune cell biology expertise, strong publication/patent record.
3w
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Principal Scientist, Ophthalmology Research
Westborough, Massachusetts, United States
$145k-$208k/yr OnsiteFull Time
8+ YOEPhD in a relevant scientific discipline and 8+ years of postdoctoral or industry research experience; requires ophthalmology expertise, in vivo study leadership, therapeutic modality experience, and strong scientific communication skills.
OCT, ERG
3mo
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Principal Scientist, Process Chemistry
Coventry, Rhode Island, United States
$120k-$170k/yr OnsiteFull Time
7+ YOEPhD in Chemistry or related field with 7–15 years, or MSc with 11–20 years; strong process chemistry and API development experience; GLP/GMP knowledge; leadership and client-facing skills.
Process chemistry, Retrosynthetic analysis, GxP, GMP, GLP, ICH guidance
3w
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Analytical Development Principal Scientist
Boston, Massachusetts, United States
$141k-$211k/yr OnsiteFull Time
4+ YOEPh.D. and 4+ years of analytical development experience, or M.S. with 7+ years or B.S. with 10+ years; small-molecule pharmaceuticals, chromatography, QbD, cGMP, and regulatory guideline knowledge required.
Quality by Design (QbD), cGMP, ICH, FDA, USP, ICH M7, chromatography
3mo
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Data Scientist – Simulation (Senior - Principal)
Wilmington, Massachusetts, United States
$149k-$205k/yr HybridMultiple Commitments Available
5+ YOESenior/Principal Data Scientist to lead simulation model development for robotic warehouses; 5-8 years in simulation, DES/agent-based modeling; Python and related tools.
Python, NumPy, Pandas, SciPy, SimPy, AnyLogic, Arena, Databricks, Snowflake, Grafana, Tableau, GCP, AWS, Azure, High-Performance Computing
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Principal Scientist II/Senior Principal Scientist, Modeling & Simulation (Dual Level Posting)
Cambridge, Massachusetts, United States
$126k-$261k/yr HybridFull Time
3+ YOEPh.D. (or MSc with experience) with industry modeling experience (3+ yrs PhD / 5+ yrs MS). Expert in ODE modeling, PK/PD, QSP, PBPK/PD; scripting (MATLAB, R); strong communication and cross-disciplinary collaboration.
MATLAB, R
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Principal Scientist II/Senior Principal Scientist, Modeling & Simulation (Dual Level Posting)
Cambridge, Massachusetts, United States
$126k-$261k/yr HybridFull Time
3+ YOEPhD with 3+ years industry modeling experience (or MS with 5+ years). Expert in PK/PD,QSP,PBPK/PD, ODE modeling, parameter estimation; scripting with MATLAB and R; strong collaboration and communication skills.
MATLAB, R, agentic AI
2w
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Principal Scientist, Biomarker Bioanalytical Sciences
Cambridge, Massachusetts, United States
$141k-$188k/yr HybridFull Time
5+ YOEPhD with 5+ years or MS with 8+ years in a related scientific field; expertise in biomarker and bioanalytical assay development, validation, regulated environments, CRO oversight, data interpretation, and regulatory submissions.
PK, ADA, TE, PD, IND, CTA, BLA, MAA
1mo
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Senior Principal Scientist, Analytical Sciences
Watertown, Massachusetts, United States
$71k-$187k/yr OnsiteFull Time
7+ YOEMS (7+ yrs) or BS (10+ yrs) LC-MS experience required; hands-on LC-MS/MS method development, bioanalysis, QTOF/Orbitrap/triple quadrupole operation, troubleshooting, and familiarity with RNA/LNP characterization.
LC-MS/MS, QTOF, Orbitrap, triple quadrupole, IP-RP, AEX, SEC-MALS, LC-CAD
1mo
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Senior Scientist II/Principal Scientist, Molecular Cloning Technologies
Cambridge, Massachusetts, United States
$143k-$215k/yr OnsiteFull Time
8+ YOEPh.D. required with 8+ years (Senior Scientist II) or 12+ years (Principal) industry/postdoc experience; deep expertise in molecular cloning, DNA assembly, vector engineering, high-throughput cloning workflows, automation, and leadership.
LIMS
3mo
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Principal Data Scientist - Oncology
Cambridge or San Diego or Spring House or Titusville or Raritan
$117k-$201k/yr HybridFull Time
5+ YOEPhD or Master's in relevant field; 5+ years health informatics; knowledge graphs/ontologies; SPARQL/RDF/OWL; programming and DevOps; willingness to travel (<15%).
SPARQL, RDF, OWL, Neo4j, Amazon Neptune, Jenkins, GitLab, Azure DevOps, Docker, Singularity, RDF Triple Stores
2d
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Principal Scientist - In Vitro Pharmacology & Biology
Lexington or Waltham or Cambridge or Plainsboro
$185k-$230k/yr OnsiteFull Time
8+ YOEMaster’s degree with 12+ years or PhD with 8+ years required; expertise in diabetes, in vitro systems, drug discovery, target validation, systems biology, bioinformatics, and RNA sequencing preferred.
scRNAseq, snRNAseq, RNAseq
2w
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Principal Scientist, mRNA-tLNP Analytical Development
Boston, Massachusetts, United States
OnsiteFull Time
6+ YOEPhD with 6+, MS with 8+, or BS with 12+ years in a relevant life science field; expertise in mRNA/LNP analytical methods, bioconjugation, potency assays, CRO oversight, GMP/GLP, and regulatory submissions.
HPLC, LC-MS, CE, ELISA, qPCR, SEC/HPLC, CRO, CDMO, IND
1mo
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Senior Principal Scientist, Small Molecule Therapeutics
Cambridge, Massachusetts, United States
OnsiteFull Time
10+ YOEPhD or equivalent with 10+ years (or MS/BS with 15+ years) in protein/structural biology; deep recombinant protein expression, purification, construct engineering, crystallography and Cryo-EM experience; CRO management and cross-functional collaboration.
Cryo-EM, X-ray crystallography, SDS-PAGE, LC-MS, SEC, SEC-MALS, DSF, DLS, SPR, ITC, MST, DNA-encoded library, AI/ML
1mo
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Senior Principal Scientist - Translational Muscle Biology
Cambridge, Massachusetts, United States
HybridFull Time
15+ YOEPhD with 15+ years or MS with 20+ years in drug discovery/biology; leadership experience; deep muscle biology and assay development expertise; mammalian cell culture and molecular/biochemical assay experience; publication record.
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