105 protein design jobs at 80 companies in United States

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Sr. Research Associate, Protein Design
Cambridge, Massachusetts, United States
$74k-$118k/yr OnsiteFull Time
Moderna
ModernaNasdaq: MRNA: Develops and manufactures messenger RNA medicines and vaccines.
2+ YOEBachelor’s in Biochemistry/Biology/Molecular Biology with 2+ years of experience or Master’s with 1+ year; mammalian cell culture; protein expression and purification; biophysical characterization; strong communication; multi-project support.
Mammalian cell culture, FPLC, SDS-PAGE, Western blot, DSC, DSF, SEC-MALS, Flow cytometry, BLI, SPR
3w
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Scientist I, Computation Protein Design
Boulder, Colorado, United States
$140k-$175k/yr OnsiteFull Time
Alta Resource Technologies
Alta Resource Technologies: Uses synthetic biology to extract and refine critical minerals.
1+ YOEPh.D. (1–3 years) or M.S. (6+ years) in computational biology or related field; hands-on experience with protein foundation models, ML model fine-tuning, Python and modern ML frameworks, molecular modeling tools, HPC/GPU computing; US citizenship required.
BoltzGen, ESM, OpenFold, ESM-2, ESM-3, ProteinMPNN, RFdiffusion, AlphaFold, Rosetta, PyMOL, Chimera, Python, PyTorch, TensorFlow, JAX, Nextflow, Snakemake, AWS, GCP, Azure, Docker, Singularity, Dask, Ray, Spark
3mo
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Protein Designer
Emeryville, California, United States
$130k-$180k/yr OnsiteFull Time
Arcadia Science
Arcadia Science: Translates evolutionary biology into novel therapeutics and research tools.
3+ YOEPhD or equivalent in biochemistry/biophysics/bioengineering; 3+ yrs post-PhD; protein design and validation experience; familiarity with analysis tools; programming knowledge; autonomous, collaborative; strong communication.
ESM, Rosetta, Programming Languages
1mo
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Senior AI Peptide and Protein Design Engineer
Los Angeles, California, United States
$160k-$213k/yr OnsiteFull Time
Ellison Medical Institute
Ellison Medical Institute: Provides interdisciplinary cancer research and patient-centered clinical care.
5+ YOEPh.D. in Computational Peptide/Protein Design or related; 5+ years in peptide/protein design; postdoc/industry experience; strong publication record; proficient in AlphaFold, RoseTTAFold, RFdiffusion, RFpeptides, Boltz, ProteinMPNN.
AlphaFold, RoseTTAFold, RFdiffusion, RFpeptides, Boltz, ProteinMPNN
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Protein Engineer - Biosensing
Pasadena, California, United States
$90k-$165k/yr OnsiteFull Time
Convergent Research: Incubates and operates non-profit Focused Research Organizations to solve scientific bottlenecks.
Protein design, biosensor development, and project leadership; strong biology/biophysics background; advanced degree or equivalent experience; strong communication.
protein design, lab instrumentation, scripting
1mo
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Protein Design Product Owner
Thousand Oaks or Burnaby
$134k-$182k/yr RemoteFull Time
Amgen
AmgenNASDAQ: AMGN: Develops and manufactures biotechnology medicines for serious diseases.
Doctorate or Master’s with product ownership experience; or Bachelor’s with product ownership experience; or Associate with 8+ years in product ownership; strong background in ML workflows, automation, and cross-functional leadership.
Jira, UNIX/Linux, Python, PyTorch, Git, Cloud computing platforms
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Scientist, Computational Protein Design, San Francisco Bay Area, CA
Mountain View, California, United States
OnsiteFull Time
Adimab
Adimab: Developing therapeutic human antibodies using a yeast-based discovery platform.
2+ YOEPhD in a relevant field, 2+ years post-PhD experience in computational protein/binder design, strong structural and energetic analysis skills, proficiency with RFAntibody, BindCraft, Protenix, strong Python skills, and publication/patent record.
RFAntibody, BindCraft, Protenix, Python
1w
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Protein Biochemist - Research Scientist
Hanover, New Hampshire, United States
OnsiteFull Time
Dartmouth College
Dartmouth College: Providing undergraduate and graduate education and conducting scientific research.
4+ YOEPhD or equivalent in biochemistry/molecular biology, ~4 years lab experience, expertise in recombinant protein design, expression, purification and biophysical characterization; experience with structural biology and proteomics desirable.
AKTA, centrifuge, SPR, ITC, Fluorescence polarization, LC-MS/MS, X-ray crystallography, cryoEM
2w
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Senior Scientist, Protein Production
San Diego, California, United States
$94k-$183k/yr OnsiteFull Time
Novartis
NovartisNew York Stock Exchange: NVS: Develops and manufactures innovative prescription medicines for patients.
5+ YOEBS/MS in biochemistry or related field with 5+ years lab experience; expertise in recombinant protein design, expression (mammalian/insect), purification (FPLC/HPLC), and biophysical characterization (SPR, DSF, ITC, LC/MS).
FPLC, HPLC, SPR, DSF, ITC, LC/MS, cryo-EM, NMR, X-ray crystallography, electron microscopy, Machine Learning (ML)
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Protein Immunoengineering Scientist
San Francisco, California, United States
$165k-$215k/yr OnsiteFull Time
Merge Labs
Merge Labs: Developing high-bandwidth non-invasive brain-computer interfaces using biotechnology.
PhD in Immunology, Bioengineering, or related field or equivalent experience; expertise in antigen processing and immune recognition; proficiency in in vitro immune assays; experience at the intersection of immunology, protein engineering, and data-driven design.
1mo
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Protein Scientist, Assistant Director or Associate Director
Carlsbad, California, United States
$144k-$196k/yr OnsiteFull Time
Ionis Pharmaceuticals
Ionis PharmaceuticalsNASDAQ: IONS: Discovers and develops RNA-targeted medicines for serious diseases.
5+ YOEPhD in a relevant discipline, 5+ years industry experience (Assistant Director) or 8+ years (Associate Director), deep expertise in protein engineering and recombinant protein expression/purification in microbial and mammalian systems, experience with protein fusion design and characterization, strong communication and leadership.
1w
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Principal Scientist, Protein Production & Engineering
Watertown or Massachusetts
$166k-$203k/yr HybridFull Time
Disc Medicine
Disc MedicineNASDAQ: IRON: Develops treatments for patients with serious hematologic diseases.
10+ YOEPhD in relevant field,10+ years related experience with ≥5 years in biotech/pharma; extensive biologics and protein science expertise; ability to lead discovery, design and characterize proteins; strong communication and analytical skills.
2d
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Scientist/Sr Scientist – Protein Production and Purification
Palo Alto, California, United States
OnsiteFull Time
Kodiak Sciences
Kodiak SciencesNASDAQ: KOD: Developing biopolymer conjugate therapeutics for retinal vascular diseases.
3+ YOEExpertise in recombinant protein expression and purification (mammalian and bacterial), chromatographic purification, biochemical/biophysical characterization, and independent experimental design and troubleshooting.
HEK293, CHO, ÄKTA FPLC, KingFisher, SDS-PAGE, SEC, DLS, UV-Vis spectroscopy, mass photometry, Isoelectric focusing (IEF)
3mo
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Director / Senior Director, Computational & Protein Sciences
Cambridge, Massachusetts, United States
$250k-$290k/yr OnsiteFull Time
Stylus Medicine
Stylus Medicine: Develops in vivo genetic medicines with recombinases and nanoparticles.
10+ YOEPhD in computational biology or related field with 10+ years (or Master’s with 14+ years) of industry experience; strong protein modeling/engineering experience; AI/ML for protein design; expert Python/R; cloud and workflow experience.
Python, R, Pandas, NumPy, Bioconductor, SciPy, PyTorch, JAX, cloud computing, workflow management systems, AlphaFold2/3, RFdiffusion, ProteinMPNN, ESM
2w
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Protein Analytics Scientist
Brisbane, California, United States
$141k-$171k/yr OnsiteFull Time
Bristol Myers Squibb
Bristol Myers SquibbNYSE: BMY: Develops and manufactures innovative prescription biopharmaceutical medicines.
Design and execute experiments, troubleshoot protocols, work independently with limited supervision, act as technical point and mentor junior team members.
5d
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Senior Scientific Director, Protein Engineering
United States
OnsiteFull Time
Neurocrine Biosciences
Neurocrine BiosciencesNASDAQ: NBIX: Develops pharmaceuticals for neurological, endocrine, and psychiatric disorders.
10+ YOEScientific leader with extensive protein/antibody engineering experience, proven team leadership, and track record advancing biologics from discovery to IND; advanced degree plus decade(s) of industry experience and expertise in construct design, expression, purification, and characterization.
LC-MS
1mo
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Sr Principal Scientist, R&D - Protein Chemist
Glenview, Illinois, United States
$121k-$151k/yr HybridFull Time
Kraft Heinz
Kraft HeinzNASDAQ: KHC: Manufacturer and global marketer of food and beverage products.
6+ YOEAdvanced degree in food science/biochemistry (or related) with 6+ years industry experience (PhD+6 / MS+7 / BS+8). Deep expertise in applied protein chemistry, experiment design, pilot plant scale-up, protein characterization, and patent documentation.
2mo
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Principal Scientist – Antibody Discovery/Protein Design
Branford, Connecticut, United States
OnsiteFull Time
EvolveImmune Therapeutics
EvolveImmune Therapeutics: Developing next-generation T cell engagers for cancer immunotherapy.
5+ YOEPhD in biochemistry, computational biology, or structural biology with 5+ years antibody/biotherapeutic engineering experience; AI/ML protein design; antibody display tech; multispecific protein design; strong cross-functional collaboration.
AI/ML, Yeast display, Phage display, Antibody engineering, Biophysical characterization, Multispecific protein design
1mo
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Scientist-Principal Scientist, Protein Design & Structure
Boston, Massachusetts, United States
OnsiteFull Time
Superluminal Medicines
Superluminal Medicines: Accelerates small molecule drug discovery using generative AI.
2+ YOEPhD in Biochemistry/Molecular Biology/Biophysics with 2+ years (Scientist) or 5+ years (Senior Scientist) or 8+ years (Principal Scientist) of relevant experience in GPCR/membrane protein expression, purification, and characterization; strong leadership and collaboration skills.
Cryo-EM, FPLC, SEC, Rosetta, AI/ML
2w
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Scientist II/Senior Scientist, Protein Sciences – Cell Binding Assays
Boston, Massachusetts, United States
$125k-$175k/yr OnsiteFull Time
Manifold Bio
Manifold Bio: Designing tissue-targeted protein therapeutics using AI and in vivo screening.
3+ YOEPhD with 3+ years (or MS with 8+ years) biotech/pharma experience, expertise in mammalian cell line engineering, FACS and cell-based assay development, antibody characterization, and independent experimental design.
FACS, Flow cytometry, Cell ELISA, SPR, BLI, Biacore, Octet