16 protein design jobs at 14 companies in Boston, MA
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Principal Scientist, Computational Protein Design
Cambridge, Massachusetts, United States
$143k-$257k/yr HybridFull Time
5+ YOEPhD and 5+ years post-graduate experience in computational protein design with de novo binder generation, ML-guided design, experimental integration, leadership, and strong publication record.
AlphaFold, AlphaFold-Multimer, Rosetta, PyRosetta, RFdiffusion, ProteinMPNN, Python
1mo
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Director, Protein Sciences
Spring House or Cambridge
$164k-$283k/yr HybridFull Time
10+ YOEPhD in related field and 10+ years in biologics discovery or protein sciences with demonstrated leadership; expertise in antigen design, structural biology, and protein engineering.
1mo
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Director, Protein Sciences
Spring House or Cambridge
$164k-$283k/yr HybridFull Time
10+ YOEPh.D. in biochemistry/structural biology/protein engineering,10+ years in biologics discovery or protein sciences,leadership experience,expertise in antigen design and structural analysis,excellent communication.
1mo
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Principal Scientist, Protein Production & Engineering
Watertown or Massachusetts
$166k-$203k/yr HybridFull Time
10+ YOEPhD in relevant field,10+ years related experience with ≥5 years in biotech/pharma; extensive biologics and protein science expertise; ability to lead discovery, design and characterize proteins; strong communication and analytical skills.
3mo
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Scientist-Principal Scientist, Protein Design & Structure
Boston, Massachusetts, United States
OnsiteFull Time
2+ YOEPhD in Biochemistry/Molecular Biology/Biophysics with 2+ years (Scientist) or 5+ years (Senior Scientist) or 8+ years (Principal Scientist) of relevant experience in GPCR/membrane protein expression, purification, and characterization; strong leadership and collaboration skills.
Cryo-EM, FPLC, SEC, Rosetta, AI/ML
2w
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Scientist, Protein Science - Purification
South San Francisco or Cambridge
$125k-$145k/yr OnsiteFull Time
3+ YOERequires MS or PhD in a relevant life science, protein purification expertise, AKTA and Unicorn proficiency, experimental design skills, and strong communication and teamwork abilities.
AKTA, Unicorn, SDS-PAGE, HPLC
1mo
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Research Scientist I - Protein Sciences and Structural Biology
Cambridge, Massachusetts, United States
$88k-$124k/yr OnsiteFull Time
0+ YOEPh.D. in a relevant life science, experience with recombinant protein design, expression, purification, and characterization; protein crystallography and biophysical methods a plus.
FPLC, SDS-PAGE, Western blot, LC/MS, AKTA pure, ITC, DSC, SPR, NMR
2mo
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Associate Director of Computational Biology & Bioinformatics
Boston, Massachusetts, United States
$200k-$240k/yr HybridFull Time
5+ YOEPhD required; 5+ years relevant experience with team leadership; strong Python and PyTorch; experience developing protein ML models, multimodal biological data, de novo protein/antibody design; cloud/HPC and data portals preferred.
Python, PyTorch, OpenAntigens, LIMS, ELN, MLOps, APIs, GPU, Next Generation Sequencing (NGS), cloud computing, high-performance computing
3mo
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Senior Scientist, Computational Biotherapeutics Engineering
Cambridge, Massachusetts, United States
$94k-$156k/yr HybridFull Time
0+ YOEPhD or Master’s with relevant years; experience with AI/ML for protein design; Python and ML libraries; large biological datasets.
Python, NumPy, SciPy, scikit-learn, PyTorch
3mo
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Director, LNP Discovery
South Boston, Massachusetts, United States
$195k-$215k/yr OnsiteFull Time
10+ YOEPhD in a relevant field; 10+ years in lipid nanoparticles, siRNA, and protein design; experience translating mouse to non-human primate models; strong communication; leadership; IP work.
lipid nanoparticles, siRNA, protein design, bioconjugation, RNA delivery
2d
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Downstream Process Development Co-Op
Lexington, Massachusetts, United States
$28-$32/hr OnsiteInternship
Currently enrolled in a biology, chemistry, chemical engineering, bioengineering, molecular biology, or related program; familiarity with protein biochemistry, biology lab techniques, statistical analysis, experimental design, and scientific writing.
FPLC, Affinity, Ion Exchange, HIC, A280, SEC, SDS-PAGE, cIEF
2mo
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Scientist/Senior Scientist, Assay Development - Molecular Assay Chemistry and Biophysics
Woburn, Massachusetts, United States
$115k/yr OnsiteFull Time
Ph.D. in a relevant field, strong fundamentals in chemistry/biophysics, hands-on immunoassay and protein-detection experience, experimental design and troubleshooting skills, and ability to work onsite in Woburn, MA five days/week.
3w
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Senior Scientist I, Biotherapeutic Production Technologies
Andover, Massachusetts, United States
$125k-$175k/yr OnsiteFull Time
4+ YOEAdvanced experience in protein expression, purification, and analytical characterization; ability to design workflows, lead CRO/CDMO interactions, and develop scalable, data-rich laboratory processes. PhD or equivalent experience expected.
AI/ML, laboratory information systems
3w
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Director, Biotherapeutic Production Technologies
Somerville or Andover
$177k-$250k/yr OnsiteFull Time
10+ YOE10+ years industry experience leading protein expression and purification, expertise in stable cell line technologies, construct design, downstream purification, CRO/CDMO partnerships, and applying automation and AI/ML to production workflows.
LIMS, Electronic laboratory notebooks, structured production databases, AI/ML
1mo
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Scientist I, De Novo Discovery and Screening
Cambridge, Massachusetts, United States
$110k-$130k/yr OnsiteFull Time
0+ YOEPhD in a related field (0–2 years postdoc/industry experience), strong molecular biology and protein engineering skills (PCR, cloning, DNA/RNA handling), experience with display technologies, NGS familiarity, and ability to design and analyze screening workflows.
phage display, mRNA display, PCR, in vitro transcription/translation, high-throughput screening, next-generation sequencing, laboratory automation
2mo
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Associate Scientist II (Cambridge, MA, US, 02142)
Cambridge, Massachusetts, United States
$68k-$101k/yr OnsiteFull Time
1+ YOEB.S. in life sciences and 1+ years lab research experience with cell culture and rodent studies; proficiency in qPCR, western blot, ELISA, RNA/DNA/protein extraction; Microsoft Office and GraphPad Prism; strong experimental design and communication skills.
Microsoft Excel, Microsoft Outlook, Microsoft PowerPoint, Microsoft Word, GraphPad Prism
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