18 protein design jobs at 15 companies in Massachusetts
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Principal Scientist, Computational Protein Design
Cambridge, Massachusetts, United States
$143k-$257k/yr HybridFull Time
5+ YOEPhD and 5+ years post-graduate experience in computational protein design with de novo binder generation, ML-guided design, experimental integration, leadership, and strong publication record.
AlphaFold, AlphaFold-Multimer, Rosetta, PyRosetta, RFdiffusion, ProteinMPNN, Python
1mo
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Director, Protein Sciences
Spring House or Cambridge
$164k-$283k/yr HybridFull Time
10+ YOEPhD in related field and 10+ years in biologics discovery or protein sciences with demonstrated leadership; expertise in antigen design, structural biology, and protein engineering.
1mo
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Director, Protein Sciences
Spring House or Cambridge
$164k-$283k/yr HybridFull Time
10+ YOEPh.D. in biochemistry/structural biology/protein engineering,10+ years in biologics discovery or protein sciences,leadership experience,expertise in antigen design and structural analysis,excellent communication.
1w
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Scientist, Protein Design
Cambridge, Massachusetts, United States
$109k-$175k/yr HybridFull Time
PhD in a relevant scientific field, computational protein design experience, strong Python and Linux skills, and experience with protein structure prediction, generative design, and multidisciplinary research.
Python, Linux, RFdiffusion, ProteinMPNN, AlphaFold, Rosetta, HPC, LLM
1mo
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Principal Scientist, Protein Production & Engineering
Watertown or Massachusetts
$166k-$203k/yr HybridFull Time
10+ YOEPhD in relevant field,10+ years related experience with ≥5 years in biotech/pharma; extensive biologics and protein science expertise; ability to lead discovery, design and characterize proteins; strong communication and analytical skills.
2mo
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Scientist-Principal Scientist, Protein Design & Structure
Boston, Massachusetts, United States
OnsiteFull Time
2+ YOEPhD in Biochemistry/Molecular Biology/Biophysics with 2+ years (Scientist) or 5+ years (Senior Scientist) or 8+ years (Principal Scientist) of relevant experience in GPCR/membrane protein expression, purification, and characterization; strong leadership and collaboration skills.
Cryo-EM, FPLC, SEC, Rosetta, AI/ML
1mo
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Scientist II/Senior Scientist, Protein Sciences – Cell Binding Assays
Boston, Massachusetts, United States
$125k-$175k/yr OnsiteFull Time
3+ YOEPhD with 3+ years (or MS with 8+ years) biotech/pharma experience, expertise in mammalian cell line engineering, FACS and cell-based assay development, antibody characterization, and independent experimental design.
FACS, Flow cytometry, Cell ELISA, SPR, BLI, Biacore, Octet
5d
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Scientist, Protein Science - Purification
South San Francisco or Cambridge
$125k-$145k/yr OnsiteFull Time
3+ YOERequires MS or PhD in a relevant life science, protein purification expertise, AKTA and Unicorn proficiency, experimental design skills, and strong communication and teamwork abilities.
AKTA, Unicorn, SDS-PAGE, HPLC
1mo
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Research Scientist I - Protein Sciences and Structural Biology
Cambridge, Massachusetts, United States
$88k-$124k/yr OnsiteFull Time
0+ YOEPh.D. in a relevant life science, experience with recombinant protein design, expression, purification, and characterization; protein crystallography and biophysical methods a plus.
FPLC, SDS-PAGE, Western blot, LC/MS, AKTA pure, ITC, DSC, SPR, NMR
1mo
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Associate Director of Computational Biology & Bioinformatics
Boston, Massachusetts, United States
$200k-$240k/yr HybridFull Time
5+ YOEPhD required; 5+ years relevant experience with team leadership; strong Python and PyTorch; experience developing protein ML models, multimodal biological data, de novo protein/antibody design; cloud/HPC and data portals preferred.
Python, PyTorch, OpenAntigens, LIMS, ELN, MLOps, APIs, GPU, Next Generation Sequencing (NGS), cloud computing, high-performance computing
2mo
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Senior Scientist, Computational Biotherapeutics Engineering
Cambridge, Massachusetts, United States
$94k-$156k/yr HybridFull Time
0+ YOEPhD or Master’s with relevant years; experience with AI/ML for protein design; Python and ML libraries; large biological datasets.
Python, NumPy, SciPy, scikit-learn, PyTorch
3w
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Senior Scientist, I
Worcester, Massachusetts, United States
$97k-$184k/yr OnsiteFull Time
Design and execute purification and characterization experiments for biologics; expertise in protein structure, biophysical characterization, purification development; strong communication and problem-solving skills.
LC-MS
3mo
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Director, LNP Discovery
South Boston, Massachusetts, United States
$195k-$215k/yr OnsiteFull Time
10+ YOEPhD in a relevant field; 10+ years in lipid nanoparticles, siRNA, and protein design; experience translating mouse to non-human primate models; strong communication; leadership; IP work.
lipid nanoparticles, siRNA, protein design, bioconjugation, RNA delivery
1mo
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Scientist/Senior Scientist, Assay Development - Molecular Assay Chemistry and Biophysics
Woburn, Massachusetts, United States
$115k/yr OnsiteFull Time
Ph.D. in a relevant field, strong fundamentals in chemistry/biophysics, hands-on immunoassay and protein-detection experience, experimental design and troubleshooting skills, and ability to work onsite in Woburn, MA five days/week.
2w
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Senior Scientist I, Biotherapeutic Production Technologies
Andover, Massachusetts, United States
$125k-$175k/yr OnsiteFull Time
4+ YOEAdvanced experience in protein expression, purification, and analytical characterization; ability to design workflows, lead CRO/CDMO interactions, and develop scalable, data-rich laboratory processes. PhD or equivalent experience expected.
AI/ML, laboratory information systems
2w
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Director, Biotherapeutic Production Technologies
Somerville or Andover
$177k-$250k/yr OnsiteFull Time
10+ YOE10+ years industry experience leading protein expression and purification, expertise in stable cell line technologies, construct design, downstream purification, CRO/CDMO partnerships, and applying automation and AI/ML to production workflows.
LIMS, Electronic laboratory notebooks, structured production databases, AI/ML
1mo
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Scientist I, De Novo Discovery and Screening
Cambridge, Massachusetts, United States
$110k-$130k/yr OnsiteFull Time
0+ YOEPhD in a related field (0–2 years postdoc/industry experience), strong molecular biology and protein engineering skills (PCR, cloning, DNA/RNA handling), experience with display technologies, NGS familiarity, and ability to design and analyze screening workflows.
phage display, mRNA display, PCR, in vitro transcription/translation, high-throughput screening, next-generation sequencing, laboratory automation
1mo
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Associate Scientist II (Cambridge, MA, US, 02142)
Cambridge, Massachusetts, United States
$68k-$101k/yr OnsiteFull Time
1+ YOEB.S. in life sciences and 1+ years lab research experience with cell culture and rodent studies; proficiency in qPCR, western blot, ELISA, RNA/DNA/protein extraction; Microsoft Office and GraphPad Prism; strong experimental design and communication skills.
Microsoft Excel, Microsoft Outlook, Microsoft PowerPoint, Microsoft Word, GraphPad Prism
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