39 senior fastapi developer jobs at 23 companies in Mission Viejo, CA

3mo
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Senior Software Engineer, AI
El Segundo or United States
$153k-$170k/yr RemoteFull Time
ImmunityBio
ImmunityBioNASDAQ: IBRX: Develops next-generation immunotherapies for cancer and infectious diseases.
7+ YOESenior software engineer with 7+ years of experience in Python/Typescript, AI agent frameworks, and production-grade systems.
Python, TypeScript, FastAPI, Docker, LangGraph, LangChain, CrewAI, LlamaIndex, Chroma, Milvus, Weaviate, Qdrant
1mo
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Senior Software Engineer
Boston or Encinitas
$142k-$192k/yr OnsiteFull Time
Paperless Parts
Paperless Parts: Cloud-based quoting software for custom part manufacturers.
5+ YOE5+ years experience building full-stack web applications; strong Python (Django/FastAPI), TypeScript/React, AWS, PostgreSQL, Docker, and CI/CD (Jenkins) experience; API design and mentoring skills; US citizenship or green card required.
Python, Django, FastAPI, TypeScript, React, PostgreSQL, AWS, Docker, Jenkins, Node/Express, Java/Spring
1mo
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Senior AI Engineer
United States or New York City or Palm Beach or Los Angeles or Miami or Greenwich or Westchester County or The Hamptons or San Francisco or Manhattan
$190k-$250k/yr RemoteFull Time
Atria Health Institute
Atria Health Institute: Membership-based concierge practice providing preventive, precision-based medical care.
4+ YOE4+ years building and operating LLM-powered production ML systems, strong Python, backend framework experience (FastAPI/Flask), LLM orchestration and retrieval design, Snowflake/dbt/Dagster/Airflow familiarity, evaluation systems, HIPAA/PHI knowledge, and strong written communication.
Python, FastAPI, Flask, Snowflake, dbt, Dagster, Airflow, vLLM, Triton, TGI, SGLang, LOINC, SNOMED CT, ICD-10, RxNorm, FHIR, HL7
2mo
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Senior Professional Software Engineer (Python)
Irvine or Oklahoma City or Sunrise or Oxford or Dallas or Austin
$129k-$165k/yr HybridFull Time
Cotality
Cotality: Provider of property intelligence, data, and analytics solutions.
5+ YOEBachelor's or Master's in Computer Science/AI or related, 5+ years software engineering, expert Python/FastAPI, microservices, Snowflake/Databricks, cloud (GCP/AWS/Azure), Agile (Jira/Confluence), strong communication and mentoring skills.
Python, FastAPI, Snowflake, Databricks, GCP, AWS, Azure, Jira, Confluence, YAML
3mo
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Senior Software Engineer | Remote
Los Angeles or United States
RemoteFull Time
TubeScience
TubeScience: Data-driven performance video production for social media advertising.
Senior full-stack engineer to lead frontend tooling, backend services, and cloud infrastructure for production AI integrations; strong JavaScript and Python skills, low-level language experience, media pipeline knowledge, observability and distributed systems expertise.
JavaScript, React, Vue, Angular, Python, C, C++, Rust, Zig, Next.js, FastAPI, Django, Flask, Docker, Kubernetes, PostgreSQL, MongoDB, Redis, Temporal, Airflow, Dagster, Kafka, RabbitMQ, ffmpeg, AWS, GCP, Azure
2mo
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GenAI Python Systems Engineer –Senior Manager
Chicago or Raleigh or Charlotte or Cincinnati or Cleveland or Columbia or Columbus or Dallas or Baltimore or Richmond or Rosemont or Sacramento or Boston or St. Louis or Salt Lake City or San Antonio or San Diego or San Francisco or Silicon Valley or Seattle or Spartanburg or Albany or Stamford or Tampa or Atlanta or Toledo or Austin or Tulsa or Washington or Denver or Des Moines or Detroit or Buffalo or Florham Park or Kansas City or Las Vegas or Little Rock or Los Angeles or Louisville or Birmingham or Fayetteville or Miami or Milwaukee or Minneapolis or Nashville or New Orleans or New York or Oklahoma City or Philadelphia or Phoenix or Pittsburgh or Portland
$124k-$280k/yr HybridFull Time
PwC
PwC: Providing audit, tax, and management consulting services to businesses.
8+ YOESenior Manager level with 8+ years of experience; proficient in Python, SQL, FastAPI; cloud certifications a plus; willing to travel up to 80%; Bachelor's degree required.
Python, SQL, FastAPI, Cloud Platforms, LLM techniques, Data Warehousing, Data Lakes, IAM
2w
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Senior Software Engineer - AI, CoCounsel International
Eagan or Frisco or New York City or Ann Arbor or San Francisco or Los Angeles or Irvine or McLean or Washington
$110k-$204k/yr HybridFull Time
Thomson Reuters
Thomson ReutersNASDAQ: TRI: Provides professional software, data, and news services globally.
4+ YOE4+ years backend engineering experience with Python, FastAPI, PostgreSQL, AWS; production agentic AI and LLM integration experience; strong debugging, architecture, and collaboration skills.
Python, FastAPI, PostgreSQL, AWS, OpenAI, Anthropic
1w
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Senior Software Engineer, Enterprise Applications
Long Beach, California, United States
$135k-$267k/yr OnsiteFull Time
Vast
Vast: Develops and operates commercial artificial-gravity space stations.
6+ YOEBachelor’s degree or equivalent experience, 6+ years of software development, and experience building, shipping, and supporting complex data-intensive full-stack applications.
React, Vue, GraphQL, Node.js, OAuth, Terraform, FastAPI, PostgreSQL, MySQL, SQL Server
2w
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Senior Principal Software Engineer - TS/SCI
Long Beach, California, United States
$198k-$297k/yr OnsiteFull Time
Rocket Lab
Rocket LabNasdaq: RKLB: Operates launch vehicles and manufactures satellites for space missions.
15+ YOE15+ years software development experience with embedded and ground systems, proficiency in C/C++ and Python, active TS/SCI clearance and U.S. eligibility, bachelor\u0019s degree in engineering or computer science required.
C, C++, python, VxWorks, embedded Linux, RTOS, DIO, AIO, ICD, RF, CAN/CAN-FD, SpaceWire, UDP/TCP, FastAPI, Golang, Rust, Typescript, Angular, InfluxDB, PostgreSQL, Git, Kubernetes, OAuth, CCSDS, Space Packet Protocol, COP-1, CFD, CI/CD
3mo
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Senior Machine Learning Engineer
Costa Mesa, California, United States
OnsiteFull Time
Kinetic Automation
Kinetic Automation: Automates digital vehicle maintenance and ADAS calibration using robotics.
Hands-on experience training and evaluating deep models for segmentation and detection (PyTorch); understanding vision transformers and 2D/3D data; strong Python skills.
Python, PyTorch, torchvision, Detectron2, MMDetection, Hugging Face Transformers, FastAPI, Docker, AWS
2mo
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Principal Software Engineer (Python)
Irvine or Oklahoma City or Sunrise or Oxford or Dallas or Austin
$155k-$180k/yr HybridFull Time
Cotality
Cotality: Provides property data, analytics, and workflow intelligence solutions.
10+ YOEMaster's or Bachelor's in CS/AI (required), 10+ years software engineering, expert Python/FastAPI, semantic/graph and RAG experience, cloud (GCP/AWS/Azure), Git/Unix, ADK, vector DBs, strong communication and leadership.
Git, Unix, Python, FastAPI, FastMCP, ADK, Vector Databases, GraphRAG, RAGAS, DeepEval, HyDE, GCP, AWS, Azure
1mo
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Senior Ground Software Engineer I - Secret Clearance
Long Beach, California, United States
$132k-$198k/yr OnsiteFull Time
Rocket Lab
Rocket LabNASDAQ: RKLB: Designs and builds launch vehicles and satellite systems.
5+ YOEBachelor's degree in engineering or a technical discipline, 5+ years developing software in Python, 2–5 years cloud engineering, scalable cloud solutions, web applications, and active Secret Clearance.
Python, Rocket Lab Ground Data System, InfluxDB, PostgreSQL, Golang, TypeScript, JavaScript, Angular, React, FastAPI, Git, SQL, Jira, Kubernetes, NodeJS, CompTIA Security +, Space Packet Protocol, COP-1
3d
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Senior Advanced AI Research Engineer
Mountain View or Milwaukee or Dallas or Columbus or Kirkland or Cincinnati or New York City or Cleveland or Oklahoma City or Austin or Albany or Chicago or St. Petersburg or Hartford or Pittsburgh or St. Louis or Miami or Sacramento or Raleigh or Minneapolis or Scottsdale or San Francisco or Morristown or Denver or Boston or Philadelphia or Des Moines or Overland Park or Los Angeles or Charlotte or Walnut Creek or Carmel or Seattle or Houston or Arlington or Atlanta or Redmond or Bentonville or Beaverton or Nashville or Detroit or San Diego
OnsiteFull Time
Accenture
AccentureNYSE: ACN: Global provider of management consulting and technology services.
5+ YOEBachelor's degree or equivalent experience, 5+ years with Python and/or Node.js/TypeScript, and 5+ years with AI/ML systems. Research-to-production experience preferred; Kubernetes, databases, tracing, and async Python are bonuses.
Python, Node.js, TypeScript, FastAPI, asyncio, Kubernetes, OpenTelemetry, CI
3w
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Senior Data Engineer
New York City or San Francisco or Los Angeles
$165k-$220k/yr HybridFull Time
Regard
Regard: A healthcare-focused software building AI-powered documentation tools to improve care delivery and clinician workflow.
5+ YOE5+ years data engineering experience, 3+ years PySpark and public cloud (AWS S3/EMR), strong Python and SQL, BS in CS/related or equivalent, experience with data modeling, pipelines, and on-call support.
S3, Apache Iceberg, EMR, PySpark, Dagster, Kubernetes, Clickhouse, PostgreSQL, FastAPI, Metabase, Python, SQL
1d
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Senior Data Engineer
San Francisco or Los Angeles or Denver or Austin or Chicago or New York City or Seattle or Toronto or Santa Barbara or San Diego
$127k-$190k/yr RemoteFull Time
Invoca
Invoca: AI platform for conversation intelligence and revenue execution.
5+ YOE5+ years in data or software engineering; advanced Python, SQL, Databricks, Spark, and data modeling; experience with orchestration, streaming, cloud infrastructure, data quality, ML datasets, and privacy; bachelor's degree or equivalent.
Python, PySpark, Pandas, Polars, PyArrow, SQL, MySQL, PostgreSQL, Databricks, Delta Lake, Unity Catalog, Workflows, Jobs/Compute, Snowflake, BigQuery, Apache Spark, Airflow, Dagster, Kafka, Kinesis, Spark Structured Streaming, AWS, S3, IAM, FastAPI, Databricks Model Serving, SageMaker endpoints
2w
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Staff AI Platform & Reliability Engineer
Santa Ana, California, United States
$172k-$220k/yr OnsiteFull Time
eJam
eJam: Builds and scales direct-to-consumer e-commerce brands.
Senior Python/GCP engineer to design and operate AI generation services, provider integrations, billing/usage metering, tenant security and platform reliability.
Python 3.12, FastAPI, Pydantic, asyncio, Cloud Run, Pub/Sub, Cloud Tasks, GCS, Firestore, Cloud SQL/Postgres, SQLAlchemy, Alembic, Terraform, IAM/OIDC, Secret Manager, CI/CD, NestJS, TypeScript, Claude Code, Codex, Cursor
4w
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Lead Software Systems Engineer
Seal Beach, California, United States
$172k-$232k/yr OnsiteFull Time
Boeing
BoeingNYSE: BA: Designing and manufacturing commercial aircraft and defense systems.
5+ YOEActive U.S. Top Secret/SCI required, Bachelor\u0002s degree or equivalent, 5+ years software development experience for space/ground systems, Python/JavaScript/TypeScript experience, CI/CD and database experience.
Python, JavaScript, Angular, JQuery, TypeScript, Postgres, SQL, NoSQL, Java, FastAPI, CI/CD
4w
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Lead Software Systems Engineer
Seal Beach, California, United States
$172k-$232k/yr OnsiteFull Time
Boeing
BoeingNYSE: BA: Designs and manufactures aircraft, defense systems, and space technology.
5+ YOE5+ MgmtActive U.S. Top Secret/SCI clearance, Bachelor’s degree, 5+ years software development experience (Python, JavaScript, TypeScript), CI/CD and database experience, leadership and systems engineering for space/ground systems.
Python, JavaScript, TypeScript, Angular, JQuery, FastAPI, Postgres, SQL, NoSQL, Java, CI/CD
2w
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AI Staff Engineer
Long Beach, California, United States
$106k-$183k/yr HybridFull Time
SCAN Health Plan
SCAN Health Plan: Providing Medicare Advantage plans and integrated healthcare for seniors.
6+ YOEDesign and deploy enterprise AI solutions using LLMs, RAG, embeddings, prompt engineering, and agent frameworks; collaborate across data, security, and business teams; apply responsible AI practices.
Azure AI Services, Azure AI Foundry, Azure OpenAI, SharePoint, Microsoft 365, Teams, Confluence, Python, REST APIs, FastAPI, LangChain, Semantic Kernel, Databricks, Snowflake
2mo
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Senior AI Engineering
Pasadena or New York City or Houston
$150k-$275k/yr OnsiteFull Time
East West Bank
East West BankNASDAQ: EWBC: Provides commercial and consumer banking services across US and Asia.
10+ YOE10+ years in software/AI engineering, experience delivering production LLM/AI solutions, strong Python and cloud (Azure) skills, experience with ML/LLM frameworks, and fintech/regulatory domain knowledge.
Python, FastAPI, Flask, Azure OpenAI, Azure ML, Databricks, ADLS, Azure AI Search, OpenAI ChatGPT, OpenAI Codex, Anthropic Claude, Google Gemini, Microsoft Copilot, AWS Bedrock, Llama, Mistral, LangChain, LlamaIndex, Semantic Kernel, vector databases, model registries, CI/CD, MLOps, LLMOps