31 senior fastapi developer jobs at 16 companies in Simi Valley, CA

3mo
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Senior Software Engineer, AI
El Segundo or United States
$153k-$170k/yr RemoteFull Time
ImmunityBio
ImmunityBioNASDAQ: IBRX: Develops next-generation immunotherapies for cancer and infectious diseases.
7+ YOESenior software engineer with 7+ years of experience in Python/Typescript, AI agent frameworks, and production-grade systems.
Python, TypeScript, FastAPI, Docker, LangGraph, LangChain, CrewAI, LlamaIndex, Chroma, Milvus, Weaviate, Qdrant
1mo
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Senior AI Engineer
United States or New York City or Palm Beach or Los Angeles or Miami or Greenwich or Westchester County or The Hamptons or San Francisco or Manhattan
$190k-$250k/yr RemoteFull Time
Atria Health Institute
Atria Health Institute: Membership-based concierge practice providing preventive, precision-based medical care.
4+ YOE4+ years building and operating LLM-powered production ML systems, strong Python, backend framework experience (FastAPI/Flask), LLM orchestration and retrieval design, Snowflake/dbt/Dagster/Airflow familiarity, evaluation systems, HIPAA/PHI knowledge, and strong written communication.
Python, FastAPI, Flask, Snowflake, dbt, Dagster, Airflow, vLLM, Triton, TGI, SGLang, LOINC, SNOMED CT, ICD-10, RxNorm, FHIR, HL7
2mo
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Senior Software Engineer | Remote
Los Angeles or United States
RemoteFull Time
TubeScience
TubeScience: Data-driven performance video production for social media advertising.
Senior full-stack engineer to lead frontend tooling, backend services, and cloud infrastructure for production AI integrations; strong JavaScript and Python skills, low-level language experience, media pipeline knowledge, observability and distributed systems expertise.
JavaScript, React, Vue, Angular, Python, C, C++, Rust, Zig, Next.js, FastAPI, Django, Flask, Docker, Kubernetes, PostgreSQL, MongoDB, Redis, Temporal, Airflow, Dagster, Kafka, RabbitMQ, ffmpeg, AWS, GCP, Azure
2mo
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GenAI Python Systems Engineer –Senior Manager
Chicago or Raleigh or Charlotte or Cincinnati or Cleveland or Columbia or Columbus or Dallas or Baltimore or Richmond or Rosemont or Sacramento or Boston or St. Louis or Salt Lake City or San Antonio or San Diego or San Francisco or Silicon Valley or Seattle or Spartanburg or Albany or Stamford or Tampa or Atlanta or Toledo or Austin or Tulsa or Washington or Denver or Des Moines or Detroit or Buffalo or Florham Park or Kansas City or Las Vegas or Little Rock or Los Angeles or Louisville or Birmingham or Fayetteville or Miami or Milwaukee or Minneapolis or Nashville or New Orleans or New York or Oklahoma City or Philadelphia or Phoenix or Pittsburgh or Portland
$124k-$280k/yr HybridFull Time
PwC
PwC: Providing audit, tax, and management consulting services to businesses.
8+ YOESenior Manager level with 8+ years of experience; proficient in Python, SQL, FastAPI; cloud certifications a plus; willing to travel up to 80%; Bachelor's degree required.
Python, SQL, FastAPI, Cloud Platforms, LLM techniques, Data Warehousing, Data Lakes, IAM
1w
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Senior Software Engineer - AI, CoCounsel International
Eagan or Frisco or New York City or Ann Arbor or San Francisco or Los Angeles or Irvine or McLean or Washington
$110k-$204k/yr HybridFull Time
Thomson Reuters
Thomson ReutersNASDAQ: TRI: Provides professional software, data, and news services globally.
4+ YOE4+ years backend engineering experience with Python, FastAPI, PostgreSQL, AWS; production agentic AI and LLM integration experience; strong debugging, architecture, and collaboration skills.
Python, FastAPI, PostgreSQL, AWS, OpenAI, Anthropic
2h
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Senior Software Engineer, Enterprise Applications
Long Beach, California, United States
$135k-$267k/yr OnsiteFull Time
Vast
Vast: Develops and operates commercial artificial-gravity space stations.
6+ YOEBachelor’s degree or equivalent experience, 6+ years of software development, and experience building, shipping, and supporting complex data-intensive full-stack applications.
React, Vue, GraphQL, Node.js, OAuth, Terraform, FastAPI, PostgreSQL, MySQL, SQL Server
1w
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Senior Principal Software Engineer - TS/SCI
Long Beach, California, United States
$198k-$297k/yr OnsiteFull Time
Rocket Lab
Rocket LabNasdaq: RKLB: Operates launch vehicles and manufactures satellites for space missions.
15+ YOE15+ years software development experience with embedded and ground systems, proficiency in C/C++ and Python, active TS/SCI clearance and U.S. eligibility, bachelor\u0019s degree in engineering or computer science required.
C, C++, python, VxWorks, embedded Linux, RTOS, DIO, AIO, ICD, RF, CAN/CAN-FD, SpaceWire, UDP/TCP, FastAPI, Golang, Rust, Typescript, Angular, InfluxDB, PostgreSQL, Git, Kubernetes, OAuth, CCSDS, Space Packet Protocol, COP-1, CFD, CI/CD
3w
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Sr. Full Stack Engineer
Tempe or Burbank
$135k-$163k/yr HybridFull Time
Entertainment Partners: Provides payroll and workforce management for entertainment productions.
6+ YOE6+ years software engineering experience, strong Python (FastAPI), React.js/TypeScript, API and database expertise, CI/CD and cloud experience, LLM/AI integration, bachelor's degree or equivalent.
Python, FastAPI, React.js, TypeScript, PostgreSQL, MySQL, MongoDB, ORMs, GitHub Actions, Jenkins, Microsoft Azure DevOps, Docker, Kubernetes, AWS, Azure, OCI, OpenAI, Anthropic/Claude, LangChain, LangGraph, pgvector, Pinecone, Weaviate, WebSockets, SSE, JWT, OAuth2
1w
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Senior Principal Software Engineer - TS/SCI
Long Beach, California, United States
$198k-$297k/yr OnsiteFull Time
Rocket Lab
Rocket LabNASDAQ: RKLB: Designs and builds launch vehicles and satellite systems.
15+ YOEBachelor's degree, 15+ years software experience (embedded and ground), active TS/SCI clearance and U.S. citizenship, proficiency in C/C++ and Python, RTOS and embedded Linux experience, hardware integration and RF comms experience.
VxWorks, embedded Linux, C, C++, python, CAN, CAN-FD, SpaceWire, UDP, TCP, FastAPI, Golang, Rust, Typescript, Angular, InfluxDB, PostgreSQL, Git, Kubernetes, OAuth
1mo
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Sr. Principal Software Engineer (SW Modeler/Developer)
Redondo Beach, California, United States
$142k-$213k/yr OnsiteFull Time
Northrop Grumman
Northrop GrummanNYSE: NOC: Develops and manufactures advanced aerospace, defense, and space systems.
8+ YOEU.S. Secret clearance required; STEM degree with significant experience (BSc+8/ MSc+6/ PhD+4); expertise in backend (Python) and frontend (React) development, CI/CD, software modeling, and mission‑critical ground systems.
Python, React JS, C, C++, Cameo, FastAPI, MongoDB, Kafka, Docker, AWS Lambda, DynamoDB, API Gateway, Angular, SQS, EFS, S3, CI/CD
1w
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Staff Full Stack Engineer
Santa Monica or Brooklyn or New York City or United States
$190k-$220k/yr HybridFull Time
Pivotal Health
Pivotal Health: AI platform automating healthcare insurance claim disputes for providers.
Senior full-stack engineer with strong backend/API skills, product instincts, AI tool fluency, and experience building data-heavy services and integrations.
APIs, Python, FastAPI, React, TypeScript, React Router, Remix, PostgreSQL, SQLAlchemy, GCP
2w
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Senior Data Engineer
New York City or San Francisco or Los Angeles
$165k-$220k/yr HybridFull Time
Regard
Regard: A healthcare-focused software building AI-powered documentation tools to improve care delivery and clinician workflow.
5+ YOE5+ years data engineering experience, 3+ years PySpark and public cloud (AWS S3/EMR), strong Python and SQL, BS in CS/related or equivalent, experience with data modeling, pipelines, and on-call support.
S3, Apache Iceberg, EMR, PySpark, Dagster, Kubernetes, Clickhouse, PostgreSQL, FastAPI, Metabase, Python, SQL
2w
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Full Stack Engineer
Los Angeles, California, United States
$89k-$136k/yr RemoteFull Time
Publicis Groupe
Publicis GroupeEuronext Paris: PUB: Global communications, advertising, and digital transformation holding.
8+ YOE8+ years full-stack web development experience; expert in Node.js, JavaScript, TypeScript; React and StoryBook; Redis/Memcached and relational DBs; gRPC/REST; AWS and Docker/Kubernetes; US work authorization required.
Node.js, JavaScript, TypeScript, React, StoryBook, CSS/SASS, Redis, Memcached, MariaDB, MySQL, Postgres, gRPC, GoLang, GraphQL, Figma, Python, Flask, FastAPI, Kafka, AWS, Docker, Kubernetes
1mo
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Sr. Principal Software Engineer (SW Modeler/Developer)
Redondo Beach, California, United States
$142k-$213k/yr OnsiteFull Time
Northrop Grumman
Northrop GrummanNYSE: NOC: Designs and manufactures advanced aerospace and defense systems.
4+ YOEU.S. Secret clearance required, STEM degree (BS/MS/PhD) with relevant years experience, expertise in backend Python and front-end React JS, CI/CD experience, software modeling/design skills, and experience with cloud and mission-critical systems.
Python, React JS, C, C++, Cameo, FastAPI, MongoDB, Kafka, Docker, AWS Lambda, DynamoDB, API Gateway, Angular, SQS, EFS, S3
1w
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AI Staff Engineer
Long Beach, California, United States
$106k-$183k/yr HybridFull Time
SCAN Health Plan
SCAN Health Plan: Providing Medicare Advantage plans and integrated healthcare for seniors.
6+ YOEDesign and deploy enterprise AI solutions using LLMs, RAG, embeddings, prompt engineering, and agent frameworks; collaborate across data, security, and business teams; apply responsible AI practices.
Azure AI Services, Azure AI Foundry, Azure OpenAI, SharePoint, Microsoft 365, Teams, Confluence, Python, REST APIs, FastAPI, LangChain, Semantic Kernel, Databricks, Snowflake
2mo
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Senior AI Engineering
Pasadena or New York City or Houston
$150k-$275k/yr OnsiteFull Time
East West Bank
East West BankNASDAQ: EWBC: Provides commercial and consumer banking services across US and Asia.
10+ YOE10+ years in software/AI engineering, experience delivering production LLM/AI solutions, strong Python and cloud (Azure) skills, experience with ML/LLM frameworks, and fintech/regulatory domain knowledge.
Python, FastAPI, Flask, Azure OpenAI, Azure ML, Databricks, ADLS, Azure AI Search, OpenAI ChatGPT, OpenAI Codex, Anthropic Claude, Google Gemini, Microsoft Copilot, AWS Bedrock, Llama, Mistral, LangChain, LlamaIndex, Semantic Kernel, vector databases, model registries, CI/CD, MLOps, LLMOps
2w
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Staff Software Engineer, Frameworks
Mountain View or Los Angeles or San Francisco
$210k-$250k/yr HybridFull Time
Commure
Commure: AI-powered software platform for healthcare workflow and administrative automation.
8+ YOE8+ years software engineering experience designing and operating secure, scalable authentication/authorization and distributed backend systems; experience with Kubernetes and cloud-native infrastructure; strong technical leadership and mentorship.
OAuth 2.0, OIDC, JWT, AWS Cognito, Python, FastAPI, Pydantic, PostgreSQL, Go, Kubernetes
2mo
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Senior Platform Engineer, Data & AI Infrastructure
Durham or New York City or Los Angeles or Phoenix
$140k-$160k/yr HybridFull Time
McKinney
McKinney: Provides strategic advertising and creative marketing services to brands.
4+ YOE4+ years of professional software engineering with backend focus; strong Python, cloud, and data tooling; experience with AI/LLM integration and security best practices.
Terraform, GitOps, Snowflake, Fivetran, DBT, Python, FastAPI, Docker, Kubernetes, OpenAI, Anthropic, Google Gemini, BigQuery, Dataform, Cloud Run, Compute Engine, Secret Manager, Artifact Registry, Cloud Build, Cloud Monitoring, IAM, Secret Management, ECR, CodePipeline, CI/CD
2w
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Full Stack Engineer
Los Angeles, California, United States
$89k-$136k/yr RemoteFull Time
Publicis Groupe
Publicis GroupeEuronext Paris: PUB: Global advertising and digital transformation agency holding.
8+ YOE8+ years full‑stack experience; expert in Node.js, JavaScript, TypeScript, React; experience with microservices, gRPC, relational databases, Redis, AWS, Docker/Kubernetes; US work authorization required.
TypeScript, gRPC, React, GoLang, Redis, Memcached, MariaDB, MySQL, Postgres, RESTful APIs, Node.js, JavaScript, StoryBook, CSS/SASS, AWS, Docker, Kubernetes, GraphQL, Flask, FastAPI, Kafka, Python, Figma
1mo
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Agentic AI Architect - Intelligence Engineering (West)
Denver or East Bay or Los Angeles or Orange County or Phoenix or Portland or Salt Lake City or San Diego or San Francisco or Seattle or Silicon Valley
$108k-$237k/yr HybridFull Time
Slalom
Slalom: Provides business and technology consulting and software engineering services.
5+ YOE5+ years software engineering experience with 2+ years on generative/agentic AI, multi-agent system design, RAG architectures, cloud AI platform deployment, Python proficiency, and strong communication skills.
Python, FastAPI, Flask, Lang Graph, Strands Agents SDK, OpenAI Agents SDK, Google ADK, LangSmith, Model Context Protocol (MCP), AWS Bedrock, Azure AI Foundry, OpenAI Service, GCP Vertex AI, Gemini, Databricks, Claude Code, Cursor, Kiro, RAGAS, DeepEval