102 senior python developer jobs at 47 companies in Columbus, IN

PromotedHiringCafe
Founding Backend / Infra Engineer
Cupertino, CA, US
$160k-$300k/yr On-SiteFull Time
HiringCafe
HiringCafe: Building a 100× better job search engine to take on Indeed and LinkedIn.
Own the crawlers, pipelines, and infrastructure powering a real-time job search engine. Strong Node.js and Python fundamentals; bonus points for security and reverse-engineering chops.
Node.js, Python, Elasticsearch, Redis
PromotedHiringCafe
Founding Full-stack / Product Engineer
Cupertino, CA, US
$130k-$300k/yr On-SiteFull Time
HiringCafe
HiringCafe: Building a 100× better job search engine to take on Indeed and LinkedIn.
Help us build a 100× better job search engine. We need a full-stack engineer with great taste, sharp fundamentals, and a track record of shipping polished product on React/Next.js plus a real backend (Firebase, Elasticsearch, Redis, Stripe).
React, Next.js, TypeScript, Firebase, Elasticsearch, Redis, Stripe
2mo
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Senior Engineer, Control Systems Simulation
Indianapolis, Indiana, United States
OnsiteFull Time
Allison Transmission
Allison TransmissionNYSE: ALSN: Manufacturer of automatic transmissions and vehicle propulsion solutions.
7+ YOE7+ years software engineering in C, C++, C#, Python, Rust; develop data-collection/tools for embedded controls; GitHub; Visual Studio/VS Code; BS in engineering or CS.
C, C++, C#, Python, Rust, GitHub, Visual Studio, VS Code, Veristand, LabView, Matlab, Simulink, CMMI, SPICE
1mo
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Senior AI Engineer
Chicago or Miami or New York City or Oakbrook Terrace or Nashville or South Bend or Tampa or Atlanta or Boston or Dallas or Houston or Grand Rapids or Austin or Charlotte or Indianapolis
$74k-$148k/yr OnsiteFull Time
Crowe
Crowe: Global professional services firm providing audit, tax, and consulting.
4+ YOE4–6 years AI/ML engineering; strong Python, cloud, distributed systems; deep learning frameworks; VMs and containerization; experience with LLMs and vector databases; travel up to 80%
Python, ML frameworks, AWS, Azure, Google Cloud, Docker, Kubernetes, Terraform, SageMaker, Vertex AI, Azure ML, GPU/accelerator workflows, PyTorch, TensorFlow, Hugging Face, LangChain, LlamaIndex, Pinecone, Weaviate, FAISS, OpenAI API, Azure OpenAI, Gemini, PEFT, LoRA, QLoRA, Power Platform, APIs, SDKs
4d
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Senior Software Engineer
Plano or Boston or Portsmouth or Indianapolis or Columbus
HybridFull Time
Liberty Mutual
Liberty Mutual: Provider of global property and casualty insurance products.
5+ YOE5+ years software engineering experience; strong data structures, algorithms, system design; proficiency in Python or Java; EMR not mentioned; experience with layered architectures and agile delivery.
Python, Java, React, Node.js, Spring Boot, AWS, RESTful services, RDS
3w
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Senior Software Engineer
Portsmouth or Boston or Indianapolis or Plano or Columbus
$106k-$197k/yr OnsiteFull Time
Liberty Mutual Insurance
Liberty Mutual Insurance: Global provider of property and casualty insurance products.
5+ YOE5+ years software/platform engineering experience; proficiency with Python, TypeScript/JavaScript, or Java; experience building APIs, automations, integrations, and event-driven systems on AWS; knowledge of SAML/OIDC and CI/CD.
Python, TypeScript, JavaScript, Java, RESTful services, SAML, OIDC, AWS Lambda, SQS, Kafka, GitHub Enterprise Cloud, GitHub, Atlassian Cloud, JFrog Artifactory, VS Code, IntelliJ, Codacy, GitHub Actions
3d
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Senior Software Engineer
Plano or Boston or Portsmouth or Indianapolis or Columbus
$106k-$197k/yr HybridFull Time
Liberty Mutual
Liberty Mutual: Provides diversified property, casualty, and commercial insurance products.
5+ YOE5+ years software engineering experience, strong foundation in data structures and algorithms, proficiency in Python or Java, experience with Java/React/Node.js/Spring Boot/AWS/REST/RDS, agile experience, strong communication.
Python, Java, React, Node.js, Spring Boot, AWS, RESTful services, RDS
1d
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Senior DevOps System Engineer
Indianapolis, Indiana, United States
HybridFull Time
Sallie Mae
Sallie MaeNASDAQ: SLM: Provides private student loans and personal banking products.
5+ YOE5+ years engineering experience; strong CS fundamentals, system design, production deployments; proficiency with Python/Java/Go/TypeScript, Azure DevOps, Cloud formation, PowerShell, shell; strong communication.
Python, Java, Go, TypeScript, Azure DevOps, Cloud formation, Powershell, Shell, AWS
2mo
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Senior Optical Engineer
Odon, Indiana, United States
$120k-$160k/yr OnsiteFull Time
Amentum
AmentumNYSE: AMTM: Provides engineering, technology, and mission support to government agencies.
7+ YOEBachelor’s in STEM with 10+ years or Master’s with 7+ years; ability to obtain US Secret clearance; multi-domain engineering leadership; EO/IR and sensor systems experience; system integration across hardware, firmware, and software.
C++, Python, MATLAB, FPGA, RF systems, Optical/photonic systems, Imaging systems, Lab instrumentation
2mo
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Senior Firmware Developer Engineer
Columbus, Indiana, United States
HybridFull Time
LHP Engineering Solutions
LHP Engineering Solutions: Provides functional safety engineering and embedded software for automotive systems.
7+ YOEBachelor's in EE/CE/CS,7+ years firmware experience, embedded Linux (Yocto/Buildroot/OpenWRT), C++ and Python, CI/CD (Azure Devops,Jenkins), repository and OSS management, firmware troubleshooting.
Yocto, Buildroot, OpenWRT, Azure Devops, Jenkins, C++, Python
1mo
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Automation Developer
Saint Paul or Chicago or Evansville or Indianapolis
$62k-$153k/yr OnsiteFull Time
Old National Bank
Old National Bank: Provides personal and business banking and wealth management services.
5+ YOEBachelor's in CS/Engineering/IS, 5+ years automation development, experience with UiPath/Power Automate/Automation Anywhere/Python, Git, agile familiarity, UiPath Associate a plus, willing to travel occasionally.
UiPath, Power Automate, Automation Anywhere, Python, AI/ML APIs, low-code platforms, Git, NLP
4d
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Senior Software Engineer Applied AI
Indianapolis or United States
RemoteFull Time
AMC Health
AMC Health: Provides remote patient monitoring and virtual care technology.
7+ YOE7+ years building production backend systems, strong Python skills, distributed systems on cloud (AWS), hands-on LLM/generative AI experience, full ML lifecycle proficiency, and disciplined work in regulated environments. US work authorization required.
Python, AWS, LLM, AI coding assistants
2mo
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Sr. AI Engineer
Indianapolis, Indiana, United States
OnsiteFull Time
Zylo
Zylo: Software platform to discover and optimize corporate SaaS subscriptions.
5+ YOE5+ years AI/ML engineering; senior-level experience; production AI agents; large-scale enterprise data; AWS Bedrock/Lambda; RAG and MCP; Python, PyTorch/TensorFlow; security/compliance.
AWS Bedrock, AWS Lambda, Python, PyTorch, TensorFlow, SQL, PySpark, LangChain, LangGraph, vector databases
3mo
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Senior Mechanical Engineer R&D
Indianapolis, Indiana, United States
OnsiteFull Time
Danaher
DanaherNYSE: DHR: Develops scientific instruments and diagnostic tools for healthcare markets.
5+ YOEB.S. or advanced degree in Mechanical Engineering; 5+ years (B.S.) or 3+ years (M.S.) industry experience; SolidWorks, GD&T, prototyping, machining, 3D printing; travel up to 10%.
SolidWorks, GD&T, Prototyping, Machining, 3D printing, Python
1mo
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Senior Solutions Engineer
Arlington or Atlanta or Austin or Boston or Charlotte or Chicago or Dallas or Houston or Indianapolis or Kansas City or Minneapolis or New York or Philadelphia or St Louis
$168k-$252k/yr RemoteFull Time
Amplitude
AmplitudeNasdaq: AMPL: Develops digital analytics software for tracking customer product behavior.
5+ YOE5+ years in software pre-sales; hands-on SQL, Python or R, and APIs; experience closing enterprise technical evaluations; comfortable presenting to engineers and executives.
Amplitude, Python, SQL, APIs, R, Google Analytics 4, Adobe Analytics, Mixpanel, Tableau, Looker, Microsoft Power BI
2w
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Senior Infrastructure Engineer
New York City or Indianapolis or San Francisco
$179k-$246k/yr OnsiteFull Time
Salesforce
SalesforceNYSE: CRM: Sells cloud-based customer relationship management and business software solutions.
5+ YOE5+ years with Salesforce and Data360, related technical degree required, advanced AI and automation knowledge, strong API and cloud/serverless experience (AWS), and proficiency in Python, Swift, and Go.
Agentforce, Data360, Data360 Workflows, Data Cloud, Salesforce, Python, Swift, Go, Jamf API, Workspace One UEM API, FleetDM API, Microsoft SCCM API, Microsoft Intune API, Citrix Uber API, MuleSoft, AWS, Lambda, API Gateway, Fargate, BASH, ZSH, PowerShell, CI/CD, Slack
3d
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Senior AI Engineer
Indianapolis, Indiana, United States
$100k-$150k/yr OnsiteFull Time
Tata Consultancy Services
Tata Consultancy ServicesNational Stock Exchange of India: TCS: Global provider of IT services, consulting, and business solutions.
6+ YOEBachelor of Computer Science, minimum 6 years experience, strong Python backend (FastAPI/Flask/Pydantic), Kubernetes, AWS, LLM orchestration, API integrations, and systems debugging skills.
Python, FastAPI, Flask, Pydantic, Kubernetes, AWS S3, AWS Secrets Manager, AWS ECR, AWS ECS, AWS ALB, React, OAuth, REST, SOAP, ServiceNow
1mo
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Senior Software Engineer - Aerospace Controls
Indianapolis or West Lafayette
$91k-$148k/yr HybridFull Time
Rolls-Royce
Rolls-RoyceLondon Stock Exchange: RR: Manufacturer of aircraft engines and industrial power systems.
2+ YOEU.S. citizen with a STEM engineering degree (Bachelor's with 2+ yrs, or Master’s/PhD). Experience in embedded safety-critical software and control systems, Simulink model-based design, DO-178C, CI/CD, and languages such as Python, C, C++, or Groovy.
Simulink, Python, C, C++, Groovy, Jenkins, CI/CD, DO-178C
2mo
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Technical Lead - Software Developer, Data Foundry
San Diego or San Francisco or Boston or Louisville or Indianapolis
$152k-$244k/yr OnsiteFull Time
Eli Lilly and Company
Eli Lilly and CompanyNYSE: LLY: Researches and manufactures medicines for human health.
1+ YOEDegree in a STEM field; significant scientific software development experience; proficiency in Python plus one other language, strong SQL, RESTful APIs, cloud and containerization, MLOps tooling (MLflow, W&B), and lab automation integration experience.
Python, Java, C#, Go, TypeScript, Rust, SQL, MLflow, W&B, Postgres, Redshift, Snowflake, BigQuery, Benchling, RDKit, Schrödinger, MOE, Prefect, Airflow, Nextflow, WDL, Docker, Kubernetes, Git, Linux, Bash, AWS, Azure, GCP, MCP
2mo
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AI Engineer/ML Engineer - Senior Developers - AI Training - Indianapolis, US
Indianapolis or United States
$80/hr RemoteContract
Prolific
Prolific: Platform connecting researchers and AI developers with verified participants.
BS/MS/PhD in CS or related, experience building/deploying/fine-tuning ML models in production, deep learning and LLM expertise (Prompt Engineering, RLHF, RAG), and strong analytical skills to detect bias and hallucinations.
PyTorch, TensorFlow, Keras, Python, NumPy, Pandas, Scikit-learn, Hugging Face Transformers, AWS SageMaker, Google Cloud Vertex AI, Weights & Biases, LangChain, Pinecone, Milvus, Weaviate
1mo
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Senior Data Engineer - Databricks
Indianapolis, Indiana, United States
OnsiteFull Time
Radcube
Radcube: Technology consulting and digital engineering services firm.
10+ YOE10+ years experience building AWS + Databricks Lakehouse platforms, strong SQL and Python skills, ETL/ELT pipeline and data modeling experience, data governance and CI/CD experience, Databricks certification preferred.
AWS, S3, Glue, Lambda, Redshift, Databricks, Delta Lake, SQL, Python, CI/CD
4w
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Managed Services - Senior Data Engineer - Senior Manager
Phoenix or Indianapolis or Grand Rapids or Raleigh or Charlotte or Jacksonville or Cincinnati or Cleveland or Columbia or Kansas City or Columbus or Dallas or Las Vegas or Little Rock or Baltimore or Richmond or Louisville or Rochester or Sacramento or Birmingham or St. Louis or Salt Lake City or San Antonio or Spartanburg or Albany or Tampa or Toledo or Atlanta or Tulsa or Austin or Miami or Milwaukee or Minneapolis or Denver or Des Moines or Montpelier or Detroit or Nashville or New Orleans or Buffalo or Oklahoma City or Fort Worth or Greensboro or Pittsburgh or Houston or Portland
$124k-$280k/yr OnsiteFull Time
PwC
PwC: Providing audit, tax, and management consulting services to businesses.
6+ YOEBachelor's degree and 6+ years' experience; advanced data architecture and pipeline management; proficiency with Python, Java, AWS/Redshift, DataStage, ETL, SQL Server, DB2, QlikView/Oracle BI; stakeholder engagement and team leadership.
AWS, Redshift, DataStage, ETL, SQL Server, DB2, Python, Java, QlikView, Oracle BI

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