HiringCafe
MissouriRemote · Hybrid · Onsite · Field · All Environments
MissouriRemote · Hybrid · Onsite · Field · All Environments
MissouriRemote · Hybrid · Onsite · Field · All Environments
MissouriRemote · Hybrid · Onsite · Field · All Environments
478 senior python developer jobs at 182 companies in Missouri
5d
Save
Mark Applied
Hide
GenAI Python Systems Engineer – Senior Associate
Chicago or Raleigh or Charlotte or Cincinnati or Cleveland or Columbia or Columbus or Dallas or Baltimore or Richmond or Rosemont or Sacramento or Boston or St. Louis or Salt Lake City or San Antonio or San Diego or San Francisco or Seattle or Albany or Stamford or Tampa or Atlanta or Toledo or Austin or Tulsa or Washington or Denver or Des Moines or Detroit or Buffalo or Florham Park or Fort Worth or Greensboro or Hartford or Houston or Indianapolis or Grand Rapids or Irvine or Jacksonville or Kansas City or Las Vegas or Little Rock or Los Angeles or Louisville or Birmingham or Fayetteville or Miami or Milwaukee or Minneapolis or Nashville or New Orleans or New York City or Oklahoma City or Philadelphia or Phoenix or Pittsburgh or Portland
$77k-$202k/yr OnsiteFull Time
3+ YOEBachelor's degree and 3+ years of experience required. Preferred fields include data science, AI, computer science, information systems, or engineering. Python, machine learning, NLP, and cloud or data platform credentials preferred.
Python, AWS, Google Cloud, Microsoft Azure, Databricks, Snowflake, machine learning libraries, NLP
2mo
Save
Mark Applied
Hide
Senior Software Engineer - GoLang and Python
St. Louis or Missouri or Minnesota or Nebraska or Kansas or Iowa
$88k-$157k/yr OnsiteFull Time
Extensive experience with Python and Go, API design (REST,gRPC), GKE/GCP, microservices, CI/CD, DevOps, IaC (Terraform), SQL, Git, observability, messaging (Kafka, Pub/Sub), and integrating AI/MCP into systems.
Python, GoLang, REST, gRPC, Google Kubernetes Engine, Google Cloud Platform, Model Context Protocol (MCP), Datadog, OpenTelemetry, SQL, Git, GitHub, GitLab, Terraform, Apache Kafka, Google Pubsub, AWS SNS/SQS, Istio
3w
Save
Mark Applied
Hide
Principal Software Engineer - Python
Kansas City or San Francisco
$150k-$300k/yr RemoteFull Time
12+ YOE12+ years software development experience, production Python required, enterprise SaaS and scalability expertise, experience mentoring engineers, strong communication, unrestricted US work authorization.
Python, Git, FastAPI, Pydantic
1mo
Save
Mark Applied
Hide
Senior Application Developer
Denver or Springfield or Sterling or St. Louis
$75k-$158k/yr OnsiteFull Time
8+ YOEBachelor's in CS or related,8+ years software development experience,expert Java and/or Python,REST APIs,databases,CI/CD,GIT,TS/SCI clearance and polygraph willingness.
Java, Python, ArcGIS, GeoServer, OpenLayers, Cesium, Kubernetes, AWS/C2S, Git, CI/CD
1w
Save
Mark Applied
Hide
Senior Full Stack Engineer
California or Colorado or Connecticut or Florida or Georgia or Illinois or Indiana or Kansas or Louisiana or Massachusetts or Maryland or Michigan or Minnesota or Missouri or North Carolina or New Hampshire or New Jersey or Nevada or New York or Ohio or Oregon or Pennsylvania or South Carolina or South Dakota or Tennessee or Texas or Virginia or Washington or Wisconsin
$136k-$185k/yr RemoteFull Time
7+ YOEBachelor's preferred; 7+ years in full-stack development, data warehousing, SQL, and relational databases. Requires AWS, Redshift, PostgreSQL, Python, CI/CD, ETL, UI, cloud architecture, and mentoring expertise.
AWS, Amazon Redshift, PostgreSQL, Python, Scrum, Scaled Agile Framework (SAFe), Extreme Programming, GitHub, Jenkins, Tableau, Qlik, Amazon QuickSight, SQL, Oracle, SQL Server, Teradata, AWS CLI, PowerShell, Unix shell, AWS Glue, Alteryx, AWS Amplify, Amazon CloudFront, React, Vue, Node.js, HTML, C#, CSS, C++, JavaScript, HTTP, REST APIs, Git, Docker, AWS CloudFormation, YAML, AWS CodeCommit, jQuery
1w
Save
Mark Applied
Hide
Senior Full-Stack Developer - AI
Farmers Branch or Idaho or Arkansas or Texas or Georgia or Montana or Iowa or Wisconsin or Oregon or Washington or New York or District of Columbia or Connecticut or Nebraska or Rhode Island or Tennessee or Kentucky or Ohio or West Virginia or Maryland or Massachusetts or South Carolina or Missouri or Utah or Arizona or South Dakota or Pennsylvania or New Hampshire or Vermont or Minnesota or New Mexico or Michigan or California or Maine or North Dakota or Kansas or Indiana or New Jersey or Nevada or Louisiana or Mississippi or Oklahoma or Alabama or Virginia or Scottsdale or Illinois or North Carolina or Colorado or Florida or Wyoming or Delaware
$83k-$222k/yr HybridFull Time
7+ YOERequires 7+ years software development, 5+ years scalable microservices and REST APIs, 3+ years Python and messaging systems, 2+ years technical leadership, cloud, CI/CD, Git, containers, and orchestration experience.
Java, Spring Boot, React, REST APIs, JPA, Python, FastAPI, Flask, Kafka, RabbitMQ, ActiveMQ, AWS SQS/SNS, LangGraph, LangChain, GCP, GKE, Cloud Run, Cloud Build, IAM, Jenkins, GitHub Actions, Argo, GitHub, GitLab, Docker, Kubernetes, MongoDB Atlas, Claude, OpenAI, Gemini, Vertex AI
2mo
Save
Mark Applied
Hide
Senior Software Engineer, Cloud and AI
Lincoln or Grand Island or Kearney or Kansas City or Overland Park or West Des Moines or Omaha
OnsiteFull Time
6+ YOE6+ years software development experience; expertise with Google Cloud Platform, AI integration, serverless and container technologies, Python/JavaScript/TypeScript, SQL/NoSQL, CI/CD, IaC, REST/GraphQL APIs, and secure cloud development.
Google Cloud Platform (GCP), Cloud Run, Cloud Functions, Google Kubernetes Engine (GKE), Cloud SQL, Spanner, Firestore, Bigtable, Agent Development Kit, Antigravity, TensorFlow, PyTorch, Docker, Python, JavaScript, TypeScript, REST, GraphQL, Apigee, API Gateway, GitLab, OpenTofu, Terraform, SQL
1d
Save
Mark Applied
Hide
Senior DevOps Engineer
Springfield or St. Louis
$120k-$162k/yr OnsiteFull Time
6+ YOE6+ years of related experience, bachelor's degree or 2 additional IT experience years, Linux, CI/CD, cloud, Kubernetes/OpenShift, infrastructure as code, Python/BASH, security, databases, and TS/SCI with CI polygraph.
GitLab CI/CD, Linux, Jenkins, CircleCI, OIDC, OAuth, Auth2, ArgoCD, DNS, Kubernetes, OpenShift, AWS, Terraform, OpenShift Containerized Platform, CloudFormation, AWS CDK, Ansible, Chef, Puppet, SQL, Python, BASH, Elasticsearch, Prometheus, Thanos, Alloy, Loki, Mimir, Tempo, Grafana, Nginx, Traefik, Apache HTTP Server, HAProxy, Envoy, NCE CORE
1d
Save
Mark Applied
Hide
Senior AI Engineer
United States or Alabama or Arizona or California or Colorado or Connecticut or District of Columbia or Florida or Georgia or Idaho or Illinois or Indiana or Iowa or Maryland or Massachusetts or Michigan or Minnesota or Mississippi or Missouri or Nebraska or Nevada or New Jersey or New York or North Carolina or Ohio or Oregon or Pennsylvania or South Carolina or Tennessee or Texas or Utah or Virginia or Washington or West Virginia
RemoteFull Time
6+ YOE6+ years of software engineering experience, including 2+ recent years delivering ML- and LLM-powered features to production. Requires strong Python, ML evaluation, LLM, SQL, and full-stack engineering skills.
Anthropic, Claude, ElevenLabs, Python, FastAPI, Celery, Rails, React, ElasticSearch, Snowflake, dbt, Hex, Claude Code, SQL
3w
Save
Mark Applied
Hide
Senior DevOps Engineer
Springfield or St. Louis
$144k-$194k/yr OnsiteFull Time
6+ YOE6+ years of related experience, bachelor's in a relevant engineering or computer science field or 2 additional IT years, Linux, CI/CD, ArgoCD, Kubernetes/OpenShift, cloud, infrastructure as code, Python/BASH, SQL, and TS/SCI with CI polygraph.
Argo CD, GitLab CI/CD, Linux, Jenkins, CircleCI, OIDC, OAuth, Auth2, GitOps, DNS, HTTP, TCP/IP, Kubernetes, OpenShift, AWS, Terraform, CloudFormation, AWS CDK, Ansible, Chef, Puppet, SQL, ORMs, Python, BASH, Elasticsearch, Prometheus, Thanos, Alloy, Loki, Mimir, Tempo, Grafana, Nginx, Traefik, Apache HTTP Server, HAProxy, Envoy
2w
Save
Mark Applied
Hide
Senior Software Engineer
Columbia, Missouri, United States
RemoteFull Time
7+ YOERequires 7+ years of development experience, 5+ years designing scalable services and APIs, production SaaS experience, object-oriented programming, event streaming, CI/CD, cloud platforms, observability, and remote collaboration.
AWS, Kubernetes, Python, Kafka, Flink, Snowflake, OpenSearch, PostgreSQL, TypeScript, React, CDKTF, Terraform, Go, Java, Scala, C#, Metaflow
2w
Save
Mark Applied
Hide
Senior Software Engineer
Columbia, Missouri, United States
RemoteFull Time
7+ YOERequires 7+ years of development experience, 5+ years designing scalable services and APIs, production SaaS knowledge, object-oriented programming, event streaming, CI/CD, cloud platforms, observability, and remote collaboration.
AWS, Kubernetes, Python, Kafka, Flink, Snowflake, OpenSearch, PostgreSQL, TypeScript, React, CDKTF, Terraform, Go, Java, Scala, C#, Metaflow
1mo
Save
Mark Applied
Hide
BackEnd Software Engineer (Experienced or Senior)
Berkeley or Saint Louis
$127k-$217k/yr OnsiteFull Time
5+ YOERequires bachelor’s degree, active U.S. Secret clearance, 5+ years backend development experience with Java/Go/Python and SQL, experience with infrastructure, CI/CD, containerization, and Agile.
Java, Spring, Oracle SQL, SQL Server, PL/SQL, Go, Python, JavaScript, NodeJS, ReactJS, C++, GitLab, CI/CD, Docker, Kubernetes, Kafka, NiFi, Redis, RabbitMQ, AWS
1mo
Save
Mark Applied
Hide
BackEnd Software Engineer (Experienced or Senior)
Berkeley or Saint Louis
$127k-$217k/yr OnsiteFull Time
5+ YOE5+ years backend development experience (Java, Go, Python), SQL/DB experience, bachelor’s degree, active U.S. Secret security clearance, Agile experience, CI/CD and containerization familiarity.
Java, Spring, Oracle SQL, SQL Server, PL/SQL, Go, Python, C++, GitLab, CI/CD, Docker, Kubernetes, JavaScript, NodeJS, ReactJS, Kafka, NiFi, Redis, RabbitMQ, AWS
1mo
Save
Mark Applied
Hide
Senior Application Developer
Denver or St. Louis or Sterling or Springfield
$75k-$158k/yr OnsiteFull Time
8+ YOEBachelor's or equivalent,8+ years software development experience,expertise in Java and/or Python,REST APIs,relational and non-relational databases,CI/CD and Git,TS/SCI clearance with polygraph required.
Java, Python, ArcGIS, GeoServer, OpenLayers, Cesium, Kubernetes, AWS, Git, CI/CD
1w
Save
Mark Applied
Hide
Senior C++ Software Engineer
St. Louis, Missouri, United States
OnsiteFull Time
5+ YOERequires 5+ years of full-cycle software development, 3+ years of object-oriented C++ development, strong communication and analytical skills, debugging, testing, collaboration, and software design expertise.
C++, Linux, Python, Unix, PowerShell, JavaScript, Node.js, Oracle, SQL
4d
Save
Mark Applied
Hide
Senior AI/ML Engineer
United States or Alabama or Arkansas or Arizona or Florida or Georgia or Iowa or Idaho or Illinois or Indiana or Kansas or Louisiana or Maryland or Missouri or Mississippi or North Carolina or North Dakota or Nebraska or New Mexico or Nevada or Oregon or Oklahoma or Pennsylvania or South Carolina or South Dakota or Tennessee or Texas or Utah or Phoenix
RemoteFull Time
5+ YOEPreferred bachelor's degree or 8+ years related experience; 5+ years designing AI/ML, LLM, or agentic systems preferred; strong Python, architecture, integration, cloud, governance, and production experience.
Python, Model Context Protocol (MCP), REST APIs, Git, CI/CD, Semantic Kernel, LangGraph, LangChain, Azure AI services, Azure OpenAI, Microsoft Certified: Azure AI Engineer Associate, Microsoft Certified: Azure Solutions Architect Expert, Microsoft Certified: DevOps Engineer Expert, AWS Certified Machine Learning Engineer - Associate, AWS Certified Machine Learning - Specialty, Google Cloud Professional Machine Learning Engineer, Databricks Certified Machine Learning Professional, Certified Kubernetes Application Developer, Certified Kubernetes Administrator
4d
Save
Mark Applied
Hide
Senior Machine Learning Engineer
United States or Alabama or Arkansas or Delaware or Florida or Georgia or Illinois or Iowa or Indiana or Kansas or Kentucky or Louisiana or Massachusetts or Maine or Michigan or Minnesota or Missouri or Mississippi or North Carolina or Nebraska or New Hampshire or Ohio or Oklahoma or Pennsylvania or Rhode Island or South Carolina or South Dakota or Tennessee or Texas or Vermont or Virginia or Wisconsin or West Virginia
RemoteFull Time
Bachelor's degree in a data-centric field, machine learning or data science experience, production model deployment experience, and strong Python and scikit-learn skills. NLP, Spark, and cloud ML experience are advantageous.
Python, scikit-learn, TensorFlow, PyTorch, Natural Language Processing (NLP), Hugging Face, Spark, AWS, GCP, Azure
1mo
Save
Mark Applied
Hide
Software Engineer: Full Stack - Python, Java or JavaScript/TypeScript (TS/SCI Clearance Required)
Alexandria or Chantilly or Englewood or Gaithersburg or Saint Louis or Tucson
OnsiteFull Time
Active TS/SCI clearance with polygraph ability, Bachelor's in CS or related, proficiency in Python/Java/JavaScript/TypeScript, cloud (AWS/Azure), containers, CI/CD, databases, and secure coding practices.
Python, Java, JavaScript, TypeScript, HTML, CSS, JSON, AJAX, REST APIs, React, Angular, Vue.js, Node.js, Spring Boot, Django, Flask, AWS, Azure, MySQL, PostgreSQL, SQL Server, Linux, Windows, Git, GitLab CI, Jenkins, JIRA, Confluence, Docker, Kubernetes, RMF, STIGs, Go, OpenSearch, Elasticsearch, S3, EC2, SQS, SNS, RDS, CloudFormation, Terraform, Ansible, GeoServer, PostGIS, OGC APIs, ESRI ArcGIS
4w
Save
Mark Applied
Hide
Senior Full Stack Engineer
St. Louis or Alpharetta
HybridFull Time
5+ YOEBachelor's or equivalent,5-7 years software development experience building full-stack cloud-native applications; front-end and back-end expertise; cloud, containerization, IaC, CI/CD, SQL/NoSQL experience; Generative AI and AI-assisted development experience preferred; must have work authorization (no sponsorship).
GitHub Copilot, Gemini, Claude, ChatGPT, Llama, Java, Python, Node.js, React, Angular, Vue.js, HTML5, CSS3, TypeScript, Google Cloud Platform, GCP, AWS, Azure, Docker, Kubernetes, Terraform, CloudFormation, GitHub Actions, Jenkins, GitLab CI, Spanner DB, Alloy DB, PostgreSQL, MySQL, MongoDB, DynamoDB, Firestore, JIRA, Confluence, GitHub, Maven, Gradle, JUnit, Mockito, Playwright, Jasmine, Celenium
Explore Jobs
Expand Your Job Search
Top Cities in Missouri for Senior Python Developer
- Senior Python Developer jobs in Kansas City, MO
- Senior Python Developer jobs in St. Louis, MO
- Senior Python Developer jobs in Springfield, MO
- Senior Python Developer jobs in Columbia, MO
- Senior Python Developer jobs in Independence, MO
- Senior Python Developer jobs in Lee's Summit, MO
- Senior Python Developer jobs in O'Fallon, MO
- Senior Python Developer jobs in Saint Joseph, MO
- Senior Python Developer jobs in Saint Charles, MO
- Senior Python Developer jobs in Blue Springs, MO
- Senior Python Developer jobs in Saint Peters, MO
- Senior Python Developer jobs in Florissant, MO
- Senior Python Developer jobs in Joplin, MO
- Senior Python Developer jobs in Chesterfield, MO
- Senior Python Developer jobs in Jefferson City, MO
- Senior Python Developer jobs in Cape Girardeau, MO
- Senior Python Developer jobs in Wildwood, MO
- Senior Python Developer jobs in Wentzville, MO
- Senior Python Developer jobs in University City, MO
- Senior Python Developer jobs in Ballwin, MO