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720 senior python engineer jobs at 177 companies in San Diego, CA

PromotedHiringCafe
Founding Backend / Infra Engineer
Cupertino, CA, US
$160k-$300k/yr On-SiteFull Time
HiringCafe
HiringCafe: Building a 100× better job search engine to take on Indeed and LinkedIn.
Own the crawlers, pipelines, and infrastructure powering a real-time job search engine. Strong Node.js and Python fundamentals; bonus points for security and reverse-engineering chops.
Node.js, Python, Elasticsearch, Redis
Help us #BeatIndeed & #BeatLinkedIn
PromotedHiringCafe
Founding Full-stack / Product Engineer
Cupertino, CA, US
$130k-$300k/yr On-SiteFull Time
HiringCafe
HiringCafe: Building a 100× better job search engine to take on Indeed and LinkedIn.
Help us build a 100× better job search engine. We need a full-stack engineer with great taste, sharp fundamentals, and a track record of shipping polished product on React/Next.js plus a real backend (Firebase, Elasticsearch, Redis, Stripe).
React, Next.js, TypeScript, Firebase, Elasticsearch, Redis, Stripe
Help us #BeatIndeed & #BeatLinkedIn
1mo
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GenAI Python Systems Engineer –Senior Manager
Chicago or Raleigh or Charlotte or Cincinnati or Cleveland or Columbia or Columbus or Dallas or Baltimore or Richmond or Rosemont or Sacramento or Boston or St. Louis or Salt Lake City or San Antonio or San Diego or San Francisco or Silicon Valley or Seattle or Spartanburg or Albany or Stamford or Tampa or Atlanta or Toledo or Austin or Tulsa or Washington or Denver or Des Moines or Detroit or Buffalo or Florham Park or Kansas City or Las Vegas or Little Rock or Los Angeles or Louisville or Birmingham or Fayetteville or Miami or Milwaukee or Minneapolis or Nashville or New Orleans or New York or Oklahoma City or Philadelphia or Phoenix or Pittsburgh or Portland
$124k-$280k/yr HybridFull Time
PwC
PwC: Providing audit, tax, and management consulting services to businesses.
8+ YOESenior Manager level with 8+ years of experience; proficient in Python, SQL, FastAPI; cloud certifications a plus; willing to travel up to 80%; Bachelor's degree required.
Python, SQL, FastAPI, Cloud Platforms, LLM techniques, Data Warehousing, Data Lakes, IAM
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2mo
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Senior Software Engineer
Arlington or San Diego or Woburn
$139k-$180k/yr HybridFull Time
Systems & Technology Research
Systems & Technology Research: Develops advanced technology for national security and defense applications.
5+ YOESenior software engineer with strong C++, Python/MATLAB, RT real-time systems, security clearance eligibility.
C++, Python, MATLAB, CI/CD, Windows, Linux
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Senior Engineer, Satellite Resource Optimization
Austin or San Diego
OnsiteFull Time
Apple
AppleNASDAQ: AAPL: Designs and sells consumer electronics, software, and online services.
5+ YOESenior engineer with distributed systems, satellite networks experience; proficiency in Python/Go/C++; MS in Electrical Engineering or Computer Science with 5+ years of distributed systems or satellite networks; export-controlled information access eligibility.
Python, Go, C++
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Senior SoC STA Engineer
San Diego, California, United States
OnsiteFull Time
InnoPhase IoT
InnoPhase IoT: Develops ultra-low power wireless semiconductor platforms for IoT devices.
10+ YOESenior SoC timing sign-off ownership; 10+ years in chip-level STA; Cadence Tempus; Python/Tcl scripting; strong cross-functional collaboration.
Cadence Tempus, Python, Tcl, DFT tools, CPDF/UPF tools
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1mo
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Senior Automation Engineer, High-Throughput Screening
La Jolla, California, United States
$94k-$174k/yr OnsiteFull Time
Novartis
NovartisNew York Stock Exchange: NVS: Develops and manufactures innovative prescription medicines for patients.
4+ YOEBachelor's in Engineering with 4+ years in lab automation; Python programming; strong troubleshooting; good communication.
Python
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1mo
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Senior Principal Systems Engineer
Oklahoma City or Melbourne or San Diego or Palmdale
$116k-$213k/yr OnsiteFull Time
Northrop Grumman
Northrop GrummanNYSE: NOC: Develops and manufactures advanced aerospace, defense, and space systems.
8+ YOESenior Principal Systems Engineer with 8+ years experience in STEM; active Secret or higher clearance; SAP clearance preferred; location flexible across multiple US sites.
DOORS, Python, Scripting, EVMS, CAMEO, CI/CD
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2mo
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Senior Mechanical Engineer - Optical Alignment Machines
San Diego, California, United States
$165k-$225k/yr OnsiteFull Time
Monarch Quantum
Monarch Quantum: Building integrated photonics systems for quantum computing and sensing.
5+ YOEBachelor’s in mechanical engineering, physics, or related field; 5+ years in precision automation/robotics; SolidWorks and Python experience; knowledge of materials and fabrication; export-controlled information eligibility.
SolidWorks, Python, ANSYS Workbench
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Senior Electronics Engineer
San Diego, California, United States
$150k-$200k/yr OnsiteFull Time
Seasats
Seasats: Builds autonomous surface vessels for persistent maritime intelligence.
5+ YOEBS in Electrical Engineering with 5+ years hands-on hardware design and shipping; experience with Altium Designer; PCB layout, debugging, and battery/power systems; ability to obtain security clearance.
Altium Designer, PCB Design, Embedded systems, C/C++, Python
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Senior Presales Systems Engineer - HPE Networking
San Diego, California, United States
$166k-$343k/yr RemoteFull Time
Hewlett Packard Enterprise
Hewlett Packard EnterpriseNYSE: HPE: Provides edge-to-cloud IT infrastructure and platform services.
15+ YOESenior presales engineer with extensive networking, security, cloud, and automation experience; 15+ years preferred; strong customer-facing and leadership skills.
Python, Jupyter, Ansible, Terraform, GitLab, AWS, Azure, GCP, NAC 802.1X, EVPN/VXLAN, MPLS, SD-WAN, VMware NSX, Juniper, Cisco, Arista, Firewalls, SIEM, SOAR
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3mo
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Senior Manufacturing Engineer, NPI
San Diego, California, United States
$121k-$164k/yr OnsiteFull Time
Firestorm Labs
Firestorm Labs: Develops and manufactures low-cost 3D-printed unmanned aerial vehicles.
5+ YOEBachelor’s in Manufacturing/Mechanical/Industrial Engineering; 5+ years manufacturing engineering; US citizen for ITAR; experience scaling processes; GD&T; CAD tools; AS9100/AS9102; cross-functional leadership.
SolidWorks, Power BI, Python, Epsilon3, Solumina, Arena PLM
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3mo
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Senior Systems Engineer – Communication & Sensing Systems
Carlsbad, California, United States
$181k-$285k/yr OnsiteFull Time
Viasat
ViasatNASDAQ: VSAT: Provider of global satellite-based connectivity and secure communication solutions.
10+ YOEAdvanced degree in Electrical or Computer Engineering; 10+ years in algorithmic system design; programming in C++, C, MATLAB, Python; RF systems and waveform design expertise; strong communication; active US Secret or Top Secret clearance; travel up to 25%.
C, C++, MATLAB, Python, RF systems, waveform design
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2mo
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Senior Security Engineer
Austin or Chicago or Dallas or Denver or Los Angeles or San Diego or San Francisco
$131k-$169k/yr HybridFull Time
Karbon
Karbon: Practice management software for accounting firms.
4+ YOESenior Security Engineer with 4+ years in security or development; strong communication; cloud and AI experience; hands-on with security tooling and threat modelling.
DotnetCSharp, JavaScript, React, EmberJS, Python, Azure, AWS, GCP, PowerShell, Bash, GitHub Copilot, Burp Suite
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3mo
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Senior NPI Test Engineer
San Diego, California, United States
$117k-$167k/yr HybridFull Time
Semtech
SemtechNASDAQ: SMTC: Produces high-performance analog and mixed-signal semiconductor products
8+ YOEBachelor's in Electrical or Computer Engineering; 8+ years semiconductor test; 5+ years mixed-signal/RF test; proven NPI leadership for high-speed ICs.
Advantest V93000, SmarTest, Teradyne uFlex, C/C++, Python, TCL, Cadence, Altium, RF/microwave test, SUT/DFT
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3mo
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Senior Component Engineer
Dallas or Boston or San Diego
$122k-$184k/yr OnsiteFull Time
Shield AI
Shield AI: Develops autonomous flight software and unmanned aircraft for defense.
5+ YOEB.S. in engineering; 5+ years of experience; PLM (Arena, Teamcenter), ECAD (Altium); strong balance of performance, cost, and supply risk.
Arena, Teamcenter, Altium, Python, SQL
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1mo
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Senior Systems Engineer
Arlington or Mount Laurel or Fall River or San Diego
$114k-$273k/yr HybridFull Time
Innovative Defense Technologies
Innovative Defense Technologies: A defense technology delivering mission-critical software and automated systems to government customers.
5+ YOEAbility to obtain/maintain Secret clearance; 5+ years experience; bachelor’s degree in systems engineering or equivalent experience; proficiency with C, C++, Python, JavaScript, Java, Linux, Git, Agile, DevSecOps; familiarity with tactical Navy combat systems.
C, C++, Python, JavaScript, Java, Linux, shell scripting, Git, Make, Maven, Ant, X-Windows, Jenkins, Jira, Atlassian, VMware vSphere, Azure, AEGIS Weapon System Common Source Library (CSL), Ship Self Defense System (SSDS) Single Source Library (SSL), Agentic AI, Large Language Models (LLMs), Model Based System Engineering (MBSE), DevSecOps
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Senior Cloud Engineer
United States or Atlanta or Los Angeles or Chicago or San Diego or Austin
RemoteFull Time
Tractian
Tractian: Provides AI-driven industrial IoT solutions for predictive equipment maintenance.
5+ YOE5+ years cloud engineering/DevSecOps experience; strong AWS and OCI knowledge; Kubernetes, Terraform, Helm, Docker, GitHub Actions; monitoring with Datadog/Grafana/OpenTelemetry/Sentry; scripting in Python/Bash/PowerShell; security/compliance experience (SOC2, ISO 27001).
AWS, OCI, GCP, Azure, Kubernetes, Terraform, Helm, Docker, AWS ECS, EKS, OKE, GitHub Actions, GitHub Enterprise, Cloudflare, Datadog, Grafana, OpenTelemetry, Sentry, Jira, Python, Bash, PowerShell, Docker Kompose, SOC2, ISO 27001
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Senior Security Engineer
San Diego, California, United States
$145k-$180k/yr HybridFull Time
Faro Health
Faro Health: Software platform for clinical trial protocol design and orchestration.
6+ YOE6+ years security engineering experience, 3+ years cloud security (Azure preferred), vulnerability management, app security (SAST/DAST/SCA), SIEM/CSPM/MDR experience, scripting (Python/PowerShell/Bash), and compliance knowledge (SOC 2, ISO, NIST).
Azure, AWS, GCP, CVSS, SAST, DAST, SCA, SIEM, CSPM, MDR, CI/CD, Terraform, ARM, Bicep, Python, PowerShell, Bash, SOC 2, ISO 27001, ISO 9001, ISO 42001, NIST 800-53, LLM, RAG
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2mo
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Senior Backend Engineer (Ruby on Rails/Python) - Content Foundations
San Francisco or Atlanta or Austin or Boston or Chicago or Dallas or Denver or Houston or Jacksonville or Los Angeles or Miami or New York City or Phoenix or Portland or Sacramento or Salt Lake City or San Diego or Seattle or Washington, D.C. or Ottawa or Toronto or Vancouver or Mexico City
$120k-$217k/yr HybridFull Time
Scribd
Scribd: Subscription-based digital library for e-books, audiobooks, and documents.
7+ YOE7+ years software engineering; experience with ingestion pipelines, ETL, and content processing; proficient in Ruby, Python, or Go; AWS and distributed workflows; strong DB design; effective communicator.
Ruby, Python, Go, AWS, SQL, NoSQL, ETL, LLM
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Senior Systems Engineer (FT) ("Ingeniero Senior de Sistemas")
San Diego, California, United States
$120k-$150k/yr OnsiteFull Time
Evans Hotels
Evans Hotels: Operates premier luxury hotels and resorts in San Diego.
8+ YOE8-10 years in systems and infrastructure engineering; Windows/AD; networking; virtualization; automation; PowerShell; Python a plus.
XCP-ng, TrueNAS Scale, pfSense, Active Directory, Microsoft 365, PowerShell, Python, VMware
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2mo
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Senior AI Engineer, Agentic Systems
San Diego, California, United States
$144k-$215k/yr RemoteFull Time
Teradata
TeradataNew York Stock Exchange: TDC: Provides cloud data analytics and enterprise AI software platforms.
3+ YOE3–6 years software engineering; 2+ years building agentic AI systems; experience implementing agent skills/plugins; Python proficiency; knowledge of planning loops, tool APIs, and prompt engineering.
Python, Go, OpenAI API, Anthropic API, Google API, agent framework
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