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226 sr principal software engineer jobs at 91 companies in Cambridge, MA

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Principal Software Engineer
Atlanta or Boston or Morristown or Plano or St. Louis or St. Petersburg or Hyderabad
HybridFull Time
Zelis
Zelis: Providing healthcare payment and claims cost management solutions.
8+ YOE8+ years backend software engineering; degree or equivalent; cloud, IaC, CI/CD; APIs; strong communication; leadership.
TypeScript, Node.js, PostgreSQL, Angular, AWS, Terraform, Elasticsearch, CI/CD, SASS
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Principal Software Engineer
Waltham or North Bethesda
$200k-$225k/yr HybridFull Time
Xometry
XometryNASDAQ: XMTR: Operates an AI-powered marketplace for custom manufacturing and prototyping.
8+ YOE8–12+ years of software development; expert in Python, React/TypeScript, AWS; strong system architecture and enterprise integration experience; Bachelor's degree in CS/Engineering or related field.
Python, React, TypeScript, AWS
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1mo
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Sr Principal Software Engineer
Nashua or Austin
$133k-$226k/yr OnsiteFull Time
BAE Systems
BAE SystemsLondon Stock Exchange: BA: Designs and manufactures advanced defense and aerospace systems.
8+ YOESecret clearance (recent or obtainable), strong C++, embedded/software development, OOP, testing/verification, familiarity with containers and DevSecOps, typically 8+ years experience.
C++, containers, DevSecOps
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Principal Software Engineer
Wellesley, Massachusetts, United States
$144k-$288k/yr HybridFull Time
CVS Health
CVS HealthNYSE: CVS: Provides retail pharmacy, health insurance, and pharmacy benefit management services.
8+ YOE8+ years software experience; 4+ years as technical leader; strong Python/Java; cloud (GCP); microservices; ML; real-time systems; UI (React/Angular).
Python, Java, GCP, React, Angular, Machine Learning, OCR, LLMs
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Principal Software Engineer (Cloud)
Boston, Massachusetts, United States
HybridFull Time
Seven AI
Seven AI: Provides autonomous AI agents for enterprise security operations.
15+ YOE15+ years software engineering; cloud-native distributed systems; leadership; backend languages (Rust, Python, TypeScript, Go); cloud platforms (AWS, GCP, Azure); strong communication; AI-assisted tooling familiarity.
Rust, Python, TypeScript, Go, AWS, GCP, Azure, Claude Code, Codex, Cursor
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4d
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Principal Software Engineer
Dublin or Cambridge or United States or Singapore or Australia or Belgium or Canada or France or Germany or Ireland or Japan or Latin America or Netherlands or Spain or Sweden or United Kingdom or India
HybridFull Time
HubSpot
HubSpotNYSE: HUBS: AI-powered customer platform for marketing, sales, and service.
5+ YOEPrincipal-level backend engineer with distributed financial systems expertise, publicly traded company experience, strong architecture and executive communication skills, and experience evolving complex legacy systems.
Corex
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Principal Software Engineer - AI
Boston, Massachusetts, United States
$120k-$180k/yr OnsiteFull Time
New Balance: Designs and manufactures athletic footwear, apparel, and sports equipment.
10+ YOE10+ years software development with 4+ years AI/ML and LLMs; extensive Python, agentic frameworks, and Microsoft AI ecosystem experience.
Python, LangChain, LangGraph, Semantic Kernel, Azure OpenAI Service, Azure AI Search, Microsoft Copilot Studio, React, RESTful APIs, ERPs, CRMs, SQL, NoSQL
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Principal Software Engineer, Data
Cambridge or San Francisco
$204k-$348k/yr HybridFull Time
Lila Sciences
Lila Sciences: Develops an AI platform for autonomous scientific research and discovery.
8+ YOE8-15 years of backend-focused engineering; full stack experience; AWS, Kubernetes; API design; data pipelines; Python; collaboration with scientists and engineers.
React, TypeScript, Nx, Tailwind, FastAPI, SQL/NoSQL, Python, Pydantic, SQLAlchemy, SQLModel, Django, Airflow, Prefect, Temporal, Dagster, pandas, numpy, scipy, jax, pytorch, AWS, Kubernetes, Terraform, CloudFormation, GitHub Actions
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Principal Software Engineer
Cambridge, Massachusetts, United States
$300k-$500k/yr OnsiteFull Time
Blitzy
Blitzy: Autonomous AI platform for enterprise software development.
Hands-on, production-focused senior IC with full-stack expertise across backend, frontend, infra, and AI systems; strong Python, cloud, databases, and LLM tooling; ownership of critical systems.
Python, Node.js, REST, gRPC, AWS, GCP, Azure, Kubernetes, Terraform, PostgreSQL, MySQL, MongoDB, Cassandra, DynamoDB, Neo4j, Vector databases, LangSmith, OpenAI, Anthropic, Frontend
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Principal Software Engineer
Westlake or Merrimack
HybridFull Time
Fidelity Investments
Fidelity Investments: Provides investment management, retirement planning, and brokerage services.
4+ YOEBachelor’s degree preferred; 4+ years software engineering; strong Python/Java, AWS, CI/CD, Spring Boot, SQL; experience with automation, AI-assisted code, and mentoring.
Python, Java, Spring Boot, AWS, EKS, Docker, REST, Maven, JSON, Tomcat, Swagger, Message Queues, Concourse, Git, Jenkins, Artifactory, Veracode, uDeploy, Selenium, Cucumber, FitNesse, Oracle, SQL
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Sr. Principal Software Engineer
Pelham, New Hampshire, United States
$132k-$252k/yr OnsiteFull Time
RTX
RTXNYSE: RTX: Provides advanced aerospace and defense systems and services.
10+ YOEBachelor's degree in a STEM field and 10 years of relevant experience; C or C++, Linux or real-time operating systems, multithreaded applications, UI/UX, and active Secret clearance required.
C, C++, Linux, VxWorks, Agile, Scrum, DevSecOps, VxWorks Workbench, Tornado, ClearCase, Git, Microsoft Windows, DOORS, MATLAB, UDP/IP, TCP/IP
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1mo
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Sr. Principal Software Engineer
Burlington or United States or Europe or Asia or North America
$141k-$226k/yr RemoteFull Time
Cerence
CerenceNASDAQ: CRNC: Develops AI-powered voice assistants and software for automotive vehicles.
Proven experience optimizing ML inference in production, deep GPU architecture knowledge, hands-on CUDA kernel development, quantization techniques (INT8/INT4/FP4/FP8/AWQ/GPTQ), and edge/embedded deployment expertise.
vLLM, TensorRT‑LLM, llama.cpp, QAIRT, CUDA, AWQ, GPTQ
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2w
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Sr Principal C++ Software Engineer
Burlington or United States
$140k-$260k/yr OnsiteFull Time
Cadence Design Systems
Cadence Design SystemsNASDAQ: CDNS: Develops computational software and hardware for electronic system design.
10+ YOEStrong C++ software development, C/C++ and STL programming, data structures, algorithms, complexity and performance tradeoffs, plus a BS with 10, MS with 7, or PhD with 5 years of experience.
C++, C, STL, C++23, Linux, TCP/IP
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Principal Software Developer - SafeTrace
Boston, Massachusetts, United States
$104k-$176k/yr OnsiteFull Time
Haemonetics
HaemoneticsNYSE: HAE: Manufactures medical devices for blood and plasma management.
10+ YOE10+ years software engineering with 5+ years in principal/architect roles; expert C# or Java/Python; experience with REST APIs, microservices, event-driven systems, CI/CD, containerization, SQL/NoSQL, AWS and Terraform; security and compliance (OWASP, OIDC, SAML2, SOC2, ISO27001, HIPAA).
C#, Java, Python, RESTful APIs, Microservices, Domain-driven design, CI/CD, Event-driven architecture, Service-oriented architecture, High-availability, Containerization, SQL, NoSQL, Epic, AWS, ECS, EKS, RDS, Lambda, S3, SQS, CloudFormation, Terraform, OWASP, OIDC, SAML2, SOC2, ISO27001, HIPAA
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Principal Software Engineer - Core Infrastructure (Python/C++)
Newton or Mounds View
$153k-$229k/yr OnsiteFull Time
Medtronic
MedtronicNYSE: MDT: Developing and manufacturing medical technologies and therapies globally.
7+ YOEBachelor's or higher with 7+ years (or 5+ years with a Master’s; 3+ years with a PhD) in relevant software/engineering roles.
Python, C++, Linux, Real-time/embedded systems, IPC, Data pipelines, Software architecture
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3mo
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Principal Software Engineer - Python
Boston, Massachusetts, United States
$150k-$300k/yr RemoteFull Time
Veeva Systems
Veeva SystemsNYSE: VEEV: Cloud-based software solutions for the global life sciences industry.
12+ YOE12+ years of production Python development; enterprise SaaS; open-source tools; FastAPI; Pydantic; strong English communication; unrestricted right to work in the United States.
Python, Git, FastAPI, Pydantic
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2mo
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Principal Software Engineer
Westlake or Merrimack
OnsiteFull Time
Fidelity Investments
Fidelity Investments: Provides investment management, retirement planning, and brokerage services.
8+ YOEBachelor's degree and 8+ years of software engineering experience. Requires Python or Java, cloud and containerization experience, CI/CD, automation frameworks, SQL, and strong analytical communication skills.
Python, Java, Spring Boot, AWS, EKS, Docker, Spring, REST, Web Services, Maven, JSON, Apache Tomcat, Swagger, Message Queues, Selenium, Cucumber, FitNesse, SQL, Oracle, Concourse, GIT, Jenkins, Artifactory, Veracode, uDeploy
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2d
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Principal Software Engineer
Plano or Boston or Portsmouth or Indianapolis or Columbus or United States or Los Angeles or Philadelphia or San Francisco
$137k-$257k/yr HybridFull Time
Liberty Mutual
Liberty Mutual: Provides diversified property, casualty, and commercial insurance products.
8+ YOERequires 8+ years of software engineering experience, enterprise architecture and technical leadership, distributed systems expertise, cloud-native development, and proficiency with JavaScript/TypeScript, React, Node.js, and related tools.
JavaScript, TypeScript, React, Node.js, Next.js, Java, HTML/CSS, Micro Frontends, AWS, CDK, GitHub Actions, OAuth 2.0, OpenID Connect, OWASP Top 10, Playwright, JMeter, Datadog, Splunk, Bridgeway, MFE, CI/CD, DevOps, SecOps, Generative AI
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2d
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Principal Software Engineer
Columbus or Plano or Indianapolis or Boston or Portsmouth
HybridFull Time
Liberty Mutual
Liberty Mutual: Provider of global property and casualty insurance products.
8+ YOERequires 8+ years of software engineering experience, enterprise architecture and technical leadership, distributed systems, cloud-native development, security, testing, DevOps, and a technical or business degree or equivalent experience.
JavaScript, TypeScript, React, Node.js, Next.js, Java, Micro Frontends, HTML/CSS, AWS, CDK, GitHub Actions, OAuth 2.0, OpenID Connect, Playwright, JMeter, Datadog, Splunk, Microsoft Bridgeway
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1w
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Principal Software Engineer
Cambridge, Massachusetts, United States
$150k-$210k/yr HybridFull Time
Broad Institute
Broad Institute: Conducts genomic research to understand and treat human diseases.
10+ YOE10+ years' software engineering experience with a bachelor's, 8+ with a master's, or 5+ with a PhD; Java/JVM, Python, WDL or Nextflow, genomics, cloud pipelines, open-source maintenance, and release management.
Java, Python, WDL, Nextflow, GitHub, Docker, GCP, AWS, Azure, GA4GH, GATK, HTSJDK, Picard, GenomicsDB, Terra, GCS, htslib, noodles, Rust
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