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202 sr principal software engineer jobs at 99 companies in Massachusetts

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Principal Software Engineer
Atlanta or Boston or Morristown or Plano or St. Louis or St. Petersburg or Hyderabad
HybridFull Time
Zelis
Zelis: Providing healthcare payment and claims cost management solutions.
8+ YOE8+ years backend software engineering; degree or equivalent; cloud, IaC, CI/CD; APIs; strong communication; leadership.
TypeScript, Node.js, PostgreSQL, Angular, AWS, Terraform, Elasticsearch, CI/CD, SASS
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Principal Software Engineer
Waltham or North Bethesda
$200k-$225k/yr HybridFull Time
Xometry
XometryNASDAQ: XMTR: Operates an AI-powered marketplace for custom manufacturing and prototyping.
8+ YOE8–12+ years of software development; expert in Python, React/TypeScript, AWS; strong system architecture and enterprise integration experience; Bachelor's degree in CS/Engineering or related field.
Python, React, TypeScript, AWS
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Principal Software Engineer
Wellesley, Massachusetts, United States
$144k-$288k/yr HybridFull Time
CVS Health
CVS HealthNYSE: CVS: Provides retail pharmacy, health insurance, and pharmacy benefit management services.
8+ YOE8+ years software experience; 4+ years as technical leader; strong Python/Java; cloud (GCP); microservices; ML; real-time systems; UI (React/Angular).
Python, Java, GCP, React, Angular, Machine Learning, OCR, LLMs
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Principal Software Engineer (Cloud)
Boston, Massachusetts, United States
HybridFull Time
Seven AI
Seven AI: Provides autonomous AI agents for enterprise security operations.
15+ YOE15+ years software engineering; cloud-native distributed systems; leadership; backend languages (Rust, Python, TypeScript, Go); cloud platforms (AWS, GCP, Azure); strong communication; AI-assisted tooling familiarity.
Rust, Python, TypeScript, Go, AWS, GCP, Azure, Claude Code, Codex, Cursor
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3d
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Principal Software Engineer
Dublin or Cambridge or United States or Singapore or Australia or Belgium or Canada or France or Germany or Ireland or Japan or Latin America or Netherlands or Spain or Sweden or United Kingdom or India
HybridFull Time
HubSpot
HubSpotNYSE: HUBS: AI-powered customer platform for marketing, sales, and service.
5+ YOEPrincipal-level backend engineer with distributed financial systems expertise, publicly traded company experience, strong architecture and executive communication skills, and experience evolving complex legacy systems.
Corex
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Principal Software Engineer - AI
Boston, Massachusetts, United States
$120k-$180k/yr OnsiteFull Time
New Balance: Designs and manufactures athletic footwear, apparel, and sports equipment.
10+ YOE10+ years software development with 4+ years AI/ML and LLMs; extensive Python, agentic frameworks, and Microsoft AI ecosystem experience.
Python, LangChain, LangGraph, Semantic Kernel, Azure OpenAI Service, Azure AI Search, Microsoft Copilot Studio, React, RESTful APIs, ERPs, CRMs, SQL, NoSQL
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Principal Software Engineer, Data
Cambridge or San Francisco
$204k-$348k/yr HybridFull Time
Lila Sciences
Lila Sciences: Develops an AI platform for autonomous scientific research and discovery.
8+ YOE8-15 years of backend-focused engineering; full stack experience; AWS, Kubernetes; API design; data pipelines; Python; collaboration with scientists and engineers.
React, TypeScript, Nx, Tailwind, FastAPI, SQL/NoSQL, Python, Pydantic, SQLAlchemy, SQLModel, Django, Airflow, Prefect, Temporal, Dagster, pandas, numpy, scipy, jax, pytorch, AWS, Kubernetes, Terraform, CloudFormation, GitHub Actions
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Principal Software Engineer
Cambridge, Massachusetts, United States
$300k-$500k/yr OnsiteFull Time
Blitzy
Blitzy: Autonomous AI platform for enterprise software development.
Hands-on, production-focused senior IC with full-stack expertise across backend, frontend, infra, and AI systems; strong Python, cloud, databases, and LLM tooling; ownership of critical systems.
Python, Node.js, REST, gRPC, AWS, GCP, Azure, Kubernetes, Terraform, PostgreSQL, MySQL, MongoDB, Cassandra, DynamoDB, Neo4j, Vector databases, LangSmith, OpenAI, Anthropic, Frontend
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Sr. Principal Software Engineer
Burlington or United States or Europe or Asia or North America
$141k-$226k/yr RemoteFull Time
Cerence
CerenceNASDAQ: CRNC: Develops AI-powered voice assistants and software for automotive vehicles.
Proven experience optimizing ML inference in production, deep GPU architecture knowledge, hands-on CUDA kernel development, quantization techniques (INT8/INT4/FP4/FP8/AWQ/GPTQ), and edge/embedded deployment expertise.
vLLM, TensorRT‑LLM, llama.cpp, QAIRT, CUDA, AWQ, GPTQ
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Sr Principal C++ Software Engineer
Burlington or United States
$140k-$260k/yr OnsiteFull Time
Cadence Design Systems
Cadence Design SystemsNASDAQ: CDNS: Develops computational software and hardware for electronic system design.
10+ YOEStrong C++ software development, C/C++ and STL programming, data structures, algorithms, complexity and performance tradeoffs, plus a BS with 10, MS with 7, or PhD with 5 years of experience.
C++, C, STL, C++23, Linux, TCP/IP
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Principal Software Developer - SafeTrace
Boston, Massachusetts, United States
$104k-$176k/yr OnsiteFull Time
Haemonetics
HaemoneticsNYSE: HAE: Manufactures medical devices for blood and plasma management.
10+ YOE10+ years software engineering with 5+ years in principal/architect roles; expert C# or Java/Python; experience with REST APIs, microservices, event-driven systems, CI/CD, containerization, SQL/NoSQL, AWS and Terraform; security and compliance (OWASP, OIDC, SAML2, SOC2, ISO27001, HIPAA).
C#, Java, Python, RESTful APIs, Microservices, Domain-driven design, CI/CD, Event-driven architecture, Service-oriented architecture, High-availability, Containerization, SQL, NoSQL, Epic, AWS, ECS, EKS, RDS, Lambda, S3, SQS, CloudFormation, Terraform, OWASP, OIDC, SAML2, SOC2, ISO27001, HIPAA
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Principal Software Engineer - Core Infrastructure (Python/C++)
Newton or Mounds View
$153k-$229k/yr OnsiteFull Time
Medtronic
MedtronicNYSE: MDT: Developing and manufacturing medical technologies and therapies globally.
7+ YOEBachelor's or higher with 7+ years (or 5+ years with a Master’s; 3+ years with a PhD) in relevant software/engineering roles.
Python, C++, Linux, Real-time/embedded systems, IPC, Data pipelines, Software architecture
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Principal Engineer
Alabama or Arizona or Arkansas or California or Colorado or Connecticut or Florida or Georgia or Hawaii or Idaho or Illinois or Indiana or Iowa or Kansas or Kentucky or Maryland or Massachusetts or Michigan or Minnesota or Missouri or Nevada or New Hampshire or New Jersey or New Mexico or New York or North Carolina or Ohio or Oklahoma or Oregon or Pennsylvania or Rhode Island or South Carolina or Tennessee or Texas or Vermont or Virginia or Washington or Wisconsin
$210k-$262k/yr RemoteFull Time
Fuze Health
Fuze Health: Integrated digital health, home diagnostics, and virtual pharmacy platform.
10+ YOEBachelor's in CS or related; 10+ years software engineering experience with 3+ years at staff/principal level; deep expertise in AWS, PostgreSQL, Ruby on Rails, Python, TypeScript/JavaScript; experience building scalable, high-throughput systems; strong communication; U.S. work authorization required.
AWS, PostgreSQL, Ruby on Rails, Python, TypeScript, JavaScript, Slack, GSuite, Jira, HL7, FHIR, NCPDP, EHR
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Principal Software Engineer - Python
Boston, Massachusetts, United States
$150k-$300k/yr RemoteFull Time
Veeva Systems
Veeva SystemsNYSE: VEEV: Cloud-based software solutions for the global life sciences industry.
12+ YOE12+ years of production Python development; enterprise SaaS; open-source tools; FastAPI; Pydantic; strong English communication; unrestricted right to work in the United States.
Python, Git, FastAPI, Pydantic
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1d
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Principal Software Engineer
Plano or Boston or Portsmouth or Indianapolis or Columbus or United States or Los Angeles or Philadelphia or San Francisco
$137k-$257k/yr HybridFull Time
Liberty Mutual
Liberty Mutual: Provides diversified property, casualty, and commercial insurance products.
8+ YOERequires 8+ years of software engineering experience, enterprise architecture and technical leadership, distributed systems expertise, cloud-native development, and proficiency with JavaScript/TypeScript, React, Node.js, and related tools.
JavaScript, TypeScript, React, Node.js, Next.js, Java, HTML/CSS, Micro Frontends, AWS, CDK, GitHub Actions, OAuth 2.0, OpenID Connect, OWASP Top 10, Playwright, JMeter, Datadog, Splunk, Bridgeway, MFE, CI/CD, DevOps, SecOps, Generative AI
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2d
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Principal Software Engineer
Columbus or Plano or Indianapolis or Boston or Portsmouth
HybridFull Time
Liberty Mutual
Liberty Mutual: Provider of global property and casualty insurance products.
8+ YOERequires 8+ years of software engineering experience, enterprise architecture and technical leadership, distributed systems, cloud-native development, security, testing, DevOps, and a technical or business degree or equivalent experience.
JavaScript, TypeScript, React, Node.js, Next.js, Java, Micro Frontends, HTML/CSS, AWS, CDK, GitHub Actions, OAuth 2.0, OpenID Connect, Playwright, JMeter, Datadog, Splunk, Microsoft Bridgeway
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Principal Software Engineer
Cambridge, Massachusetts, United States
$150k-$210k/yr HybridFull Time
Broad Institute
Broad Institute: Conducts genomic research to understand and treat human diseases.
10+ YOE10+ years' software engineering experience with a bachelor's, 8+ with a master's, or 5+ with a PhD; Java/JVM, Python, WDL or Nextflow, genomics, cloud pipelines, open-source maintenance, and release management.
Java, Python, WDL, Nextflow, GitHub, Docker, GCP, AWS, Azure, GA4GH, GATK, HTSJDK, Picard, GenomicsDB, Terra, GCS, htslib, noodles, Rust
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2d
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Principal Software Engineer/Principal AI Engineer
Philadelphia or Massachusetts
$115k-$192k/yr RemoteFull Time
Elsevier
ElsevierLondon Stock Exchange: REL: Provides scientific, technical, and medical research information and analytics.
10+ YOE10+ years software engineering experience with hands-on enterprise AI systems taken to production; BS in engineering or computer science required, advanced degree preferred; expertise in LLMs, cloud, integration, architecture, and delivery.
Microsoft?
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2d
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Principal Software Engineer/Principal AI Engineer
Philadelphia or Massachusetts
$115k-$192k/yr RemoteFull Time
RELX
RELXLondon Stock Exchange: REL: Provides information-based analytics and decision tools for professional customers.
10+ YOE10+ years of software engineering experience with enterprise AI systems, production delivery, cloud platforms, LLMs, APIs, data pipelines, architecture, Agile, CI/CD, TDD, and technical leadership. BS in engineering or computer science required.
Microsoft Azure, AWS, Google Cloud Platform, Python, Java, TypeScript, JavaScript, SQL, MCP, RAG, CI/CD, TDD, APIs
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Principal Software Engineer
Burlington, Massachusetts, United States
$178k-$230k/yr HybridFull Time
State Street
State StreetNYSE: STT: Provides investment servicing and management to institutional investors.
10+ YOE2+ MgmtBachelor's in CS/CE or equivalent, 10 years professional software engineering experience with strong Java, object-oriented design, database and automation skills; 2 years technical leadership; experience with cloud projects and CI/CD tools.
Java, C#, React, SQL, SQL Server, PowerShell, Jenkins, GIT, JavaScript, SOAP, REST, XML, JSON, Azure
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