43 mes manager jobs at 24 companies in Lancaster, CA

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Director, Global MES Lead
Foster City or La Verne or Edmonton
$210k-$272k/yr OnsiteFull Time
Gilead Sciences
Gilead SciencesNASDAQ: GILD: Develops and sells medicines for life-threatening infectious diseases.
12+ YOEBachelor's in engineering or life sciences, 12+ years pharma/biotech manufacturing experience with MES/EBR systems, multi-site MES leadership, GMP knowledge, and strong stakeholder influence.
Werum PAS-X, MES, EBR, ERP, historians
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Director, Global MES Lead
Foster City or La Verne or Edmonton
$210k-$272k/yr OnsiteFull Time
Gilead Sciences
Gilead SciencesNASDAQ: GILD: Develops and sells medicines for life-threatening infectious diseases.
12+ YOEBachelor's in Engineering or Life Sciences, 12+ years in pharma/biotech manufacturing with MES/EBR experience, proven multi-site MES leadership, GMP knowledge, stakeholder influence, and product/roadmap ownership.
Werum PAS-X, MES, Electronic Batch Records (EBR), ERP, historians
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Industry X- Siemens MES Senior Manager
Boston or Milwaukee or Dallas or Columbus or Kirkland or Cincinnati or New York City or Cleveland or Oklahoma City or Austin or Albany or Chicago or St. Petersburg or Hartford or Pittsburgh or St. Louis or Miami or Sacramento or Raleigh or Minneapolis or Mountain View or Scottsdale or San Francisco or Morristown or Denver or Philadelphia or Des Moines or Overland Park or Los Angeles or Charlotte or Walnut Creek or Carmel or Seattle or Houston or Arlington or Atlanta or Redmond or Bentonville or Beaverton or Nashville or Detroit or San Diego
$133k-$311k/yr OnsiteFull Time
Accenture
AccentureNYSE: ACN: Global provider of management consulting and technology services.
8+ YOEBachelor's degree (or equivalent experience) and 8+ years with Siemens MES products; 5+ years in consulting/technical advisory for manufacturing IT; travel up to 100% may be required.
Siemens MES, ERP, PLM, Oracle, SQL Server
2w
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Manufacturing Engineer (PLM/MES/ERP)
Marietta or Fort Worth or Palmdale
$100k-$176k/yr OnsiteFull Time
Lockheed Martin
Lockheed MartinNYSE: LMT: Designs and manufactures global security and aerospace systems.
Manufacturing engineering experience, familiarity with PLM/MES/ERP systems, bachelor's degree in related discipline, ability to obtain Secret clearance, strong communication and planning skills.
3DX Product Lifecycle Management (PLM), Manufacturing Execution System (MES), SAP
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Senior Product Manager (Enterprise Software & ERP Systems)
Hawthorne or El Segundo or Los Angeles
$150k-$250k/yr OnsiteFull Time
Freeform
Freeform: Deploys autonomous AI-powered metal 3D printing factories.
5+ YOEBachelor's degree, 5+ years product management experience, familiarity with ERP/MES/PLM/MRP/WMS/QMS and manufacturing or supply chain systems, fluency with AI coding tools and ability to contribute to code, strong stakeholder alignment and roadmap ownership.
ERP, MES, PLM, MRP, WMS, QMS, Claude Code, Cursor, GitHub Copilot, Flask, Django, React, Next.js
6d
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Product Manager (Supply Chain)
Los Angeles, California, United States
$140k-$175k/yr OnsiteFull Time
First Resonance
First Resonance: Software platform for tracking and managing complex hardware manufacturing.
3+ YOE3+ years in product management or supply chain/industrial engineering, deep manufacturing supply chain knowledge, technical aptitude with APIs and data, product lifecycle ownership, and customer-facing communication skills.
NetSuite, SAP, MES, PLM, Python, JavaScript, TypeScript, SQL, APIs
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Production Manager
Los Angeles, California, United States
$120k-$170k/yr OnsiteFull Time
General Matter
General Matter: Produces enriched uranium and nuclear fuel for power generation.
7+ YOE7+ years leading CNC-focused production operations, experience standing up manufacturing facilities, strong engineering fundamentals, CNC/lathe expertise, familiarity with MES/ERP/QMS/CMMS, and bachelor\u0002s in engineering or equivalent hands-on experience.
MES, ERP, QMS, CMMS, CNC
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Principal Product Manager
Boston or Los Angeles or Seattle
$164k-$247k/yr RemoteFull Time
Re:Build Manufacturing
Re:Build Manufacturing: Provides advanced engineering and US-based contract manufacturing services.
Proven track record running hardware program execution and shipping 0-to-1 products, strong written communication, deadline discipline, credibility with hardware engineers, and comfort using AI/LLM tools.
PLM, MES, EDA, ALM, LLM
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Manufacturing Engineering Manager
Los Angeles, California, United States
$90k-$120k/yr HybridFull Time
SoLa Impact
SoLa Impact: Develops and manages affordable housing in underserved urban communities.
5+ YOE2+ MgmtLead team of manufacturing engineers; 5+ years in manufacturing with 2+ years in leadership; GD&T, CAD (SolidWorks, Inventor, AutoCAD); MES experience; Lean, process development.
SolidWorks, Inventor, AutoCAD, MES, GD&T, Lean Manufacturing, Automation
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Manager Engineering 2
Palmdale, California, United States
$147k-$220k/yr OnsiteFull Time
Northrop Grumman
Northrop GrummanNYSE: NOC: Develops and manufactures advanced aerospace, defense, and space systems.
7+ YOESTEM degree with 7–9+ years aerospace experience, active Secret clearance, ability to obtain SAP, experience in flight/production test, leadership experience, familiarity with CPLM/Teamcenter/MES/EVMS, strong communication and troubleshooting skills.
CPLM, Teamcenter, MES, EVMS
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Production Control Manager
Los Angeles, California, United States
$116k-$160k/yr OnsiteFull Time
Apex
Apex: Mass-manufactures standardized satellite buses for commercial and government use.
4+ YOE2+ MgmtU.S. Persons required; 4+ years manufacturing scheduling experience (aerospace/automotive preferred); 2+ years people leadership; proficiency with Microsoft Project, Smartsheet, Primavera P6, ERP/MRP/MES, Microsoft Excel, Power BI, and SQL.
Microsoft Office, Microsoft Project, Smartsheet, Primavera P6, ERP, MRP, MES, Microsoft Excel, Microsoft Power BI, SQL
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Site Quality Manager
Simi Valley, California, United States
$138k-$242k/yr OnsiteFull Time
Parker Hannifin
Parker HannifinNYSE: PH: Manufacturer of motion and control technologies and systems.
10+ YOEBachelor's degree required, 10+ years related experience leading quality in large or multi-site manufacturing; deep knowledge of QMS standards (ISO 9001/AS9100/IATF), CAPA/A3/8D problem solving, PFMEA, SPC, MSA, PPAP/FAI, GD&T, KPI analysis, and experience with ERP/MES and Microsoft 365.
PQP, A3, 8D, 5-Why, Fishbone, PFMEA, SPC, MSA, PPAP/FAI, GD&T, Minitab, ERP, MES, Microsoft 365
4w
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Manager, Build Engineering
Los Angeles, California, United States
$175k-$220k/yr OnsiteFull Time
Hadrian
Hadrian: Building autonomous factories for aerospace and defense manufacturing.
6+ YOE2+ Mgmt6+ years in build/production/manufacturing engineering with NPI experience, 2+ years managing engineers, strong drawing/BOM/process interpretation, cross‑functional coordination, and hands‑on factory experience.
ERP, MES, PLM, Digital work instruction tools
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Teamcenter NX Manager
Los Angeles, California, United States
$168k-$227k/yr HybridFull Time
Hermeus
Hermeus: Develops high-speed and hypersonic aircraft for defense and transportation.
7+ YOE7+ years administering Siemens Teamcenter and NX, experience leading PLM/engineering applications teams, strong PLM/process knowledge, troubleshooting, stakeholder partnership, and operating in high-growth hardware environments.
Siemens Teamcenter, NX, PLM, ERP, MES, CAD, JT, PDF, STEP, DXF, Agile
6d
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Factory IT Technician
Victorville, California, United States
$43-$60/hr OnsiteFull Time
Mars
Mars: Global manufacturer of confectionery, snacks, and pet care products.
3+ YOE3+ years IT/OT experience, knowledge of cyber security, MES, server and virtual infrastructure, SQL and Excel/VBA; strong communication, project and incident management skills.
MES, SQL, Microsoft Excel, VBA, Alero
3mo
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Application Engineer – Multi-Physics Simulation
Ghent or Calabasas
OnsiteFull Time
Keysight Technologies
Keysight TechnologiesNew York Stock Exchange: KEYS: Manufactures hardware and software for electronic test and measurement.
Bachelor's or Master’s in EE/ME/Physics, strong understanding of electronic design workflows, experience with engineering simulation/EDA tools, ability to translate engineering problems into product requirements, customer-facing and product ownership experience, excellent English.
Electronic Design Automation (EDA), Keysight ADS, Cadence Allegro, Cadence Celsius, Siemens FloTherm, Siemens NX, Ansys Mechanical / Icepak
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Robotics Software Engineer – Cell Therapy Automation
Tarzana, California, United States
$123k-$184k/yr HybridFull Time
AstraZeneca
AstraZenecaLondon Stock Exchange: AZN: Researches and develops medicines to treat major diseases globally.
5+ YOEBachelor's in CS/Software Eng/IT, 5+ years in IT/OT automation or robotics, cybersecurity knowledge (Zero Trust/ISA-62443/NIST), MES/LIMS/ELN integration, programming in Python/C++/C#, ROS familiarity, cloud (AWS/Microsoft Azure/GCP), and strong project management.
Python, C++, C#, ROS, UR platforms, MES, PAS-X, TULIP, LIMS, ELN, SIEM, AWS, Microsoft Azure, GCP, DoD Zero Trust Reference Architecture, ISA-62443, FDA 21 CFR Part 11, ISPE GAMP 5, DevSecOps, SAFe
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Senior Automation Engineer (cGMP) - Project Farma
Alabama or Missouri or Illinois or Florida or Georgia or Maryland or New Jersey or Texas or Pennsylvania or Indiana or Ohio or Kentucky or Colorado or Virginia or New York or North Carolina or District of Columbia or Raleigh or Boston or Philadelphia or Chicago or Indianapolis or Columbus or St. Louis or Kansas City or Houston or Dallas or Boulder or Portland or San Francisco or San Diego or Los Angeles
FieldFull Time
PerkinElmer
PerkinElmer: Provides analytical instruments and laboratory services for scientific industries.
5+ YOEBachelor's in life sciences/engineering/regulatory (or equivalent experience); 5+ years automation/digital systems experience in GMP life sciences; strong process control/MES knowledge; willingness to travel and valid driver\u0002s license; US work authorization required.
MES
4d
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Director of Product Engineering
Irwindale, California, United States
$160k-$180k/yr OnsiteFull Time
Georg Fischer
Georg FischerSIX Swiss Exchange: GF: Manufacturer of piping systems and industrial flow solutions.
5+ YOE5+ MgmtMS (EE/ME/Physics) with 5 years relevant experience or BS with 10 years; 5+ years managing R&D/engineering teams; product lifecycle and roadmap leadership; embedded systems and industrial product experience.
2mo
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Director of Industrial Performance
Los Angeles or Carson
$180k-$220k/yr OnsiteFull Time
See's Candies
See's Candies: Manufactures and retails premium boxed chocolates and candies.
10+ YOE5+ MgmtBachelor’s in IE/ME/Operations; 10+ years FMCG/food manufacturing; 5+ in leadership; proven TPM implementation; IE and labor standards expertise.
A3, Kaizen, RCA, 5 Why, SMED