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64 mes manager jobs at 31 companies in Palmdale, CA

1mo
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Director, Global MES Lead
Foster City or La Verne or Edmonton
$210k-$272k/yr OnsiteFull Time
Gilead Sciences
Gilead SciencesNASDAQ: GILD: Develops and sells medicines for life-threatening infectious diseases.
12+ YOEBachelor's in engineering or life sciences, 12+ years pharma/biotech manufacturing experience with MES/EBR systems, multi-site MES leadership, GMP knowledge, and strong stakeholder influence.
Werum PAS-X, MES, EBR, ERP, historians
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Director, Global MES Lead
Foster City or La Verne or Edmonton
$210k-$272k/yr OnsiteFull Time
Gilead Sciences
Gilead SciencesNASDAQ: GILD: Develops and sells medicines for life-threatening infectious diseases.
12+ YOEBachelor's in Engineering or Life Sciences, 12+ years in pharma/biotech manufacturing with MES/EBR experience, proven multi-site MES leadership, GMP knowledge, stakeholder influence, and product/roadmap ownership.
Werum PAS-X, MES, Electronic Batch Records (EBR), ERP, historians
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2mo
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Industry X- Siemens MES Senior Manager
Boston or Milwaukee or Dallas or Columbus or Kirkland or Cincinnati or New York City or Cleveland or Oklahoma City or Austin or Albany or Chicago or St. Petersburg or Hartford or Pittsburgh or St. Louis or Miami or Sacramento or Raleigh or Minneapolis or Mountain View or Scottsdale or San Francisco or Morristown or Denver or Philadelphia or Des Moines or Overland Park or Los Angeles or Charlotte or Walnut Creek or Carmel or Seattle or Houston or Arlington or Atlanta or Redmond or Bentonville or Beaverton or Nashville or Detroit or San Diego
$133k-$311k/yr OnsiteFull Time
Accenture
AccentureNYSE: ACN: Global provider of management consulting and technology services.
8+ YOEBachelor's degree (or equivalent experience) and 8+ years with Siemens MES products; 5+ years in consulting/technical advisory for manufacturing IT; travel up to 100% may be required.
Siemens MES, ERP, PLM, Oracle, SQL Server
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4w
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Manufacturing Engineer (PLM/MES/ERP)
Marietta or Fort Worth or Palmdale
$100k-$176k/yr OnsiteFull Time
Lockheed Martin
Lockheed MartinNYSE: LMT: Designs and manufactures global security and aerospace systems.
Manufacturing engineering experience, familiarity with PLM/MES/ERP systems, bachelor's degree in related discipline, ability to obtain Secret clearance, strong communication and planning skills.
3DX Product Lifecycle Management (PLM), Manufacturing Execution System (MES), SAP
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2mo
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Senior Product Manager (Enterprise Software & ERP Systems)
Hawthorne or El Segundo or Los Angeles
$150k-$250k/yr OnsiteFull Time
Freeform
Freeform: Deploys autonomous AI-powered metal 3D printing factories.
5+ YOEBachelor's degree, 5+ years product management experience, familiarity with ERP/MES/PLM/MRP/WMS/QMS and manufacturing or supply chain systems, fluency with AI coding tools and ability to contribute to code, strong stakeholder alignment and roadmap ownership.
ERP, MES, PLM, MRP, WMS, QMS, Claude Code, Cursor, GitHub Copilot, Flask, Django, React, Next.js
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2w
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Product Manager (Supply Chain)
Los Angeles, California, United States
$140k-$175k/yr OnsiteFull Time
First Resonance
First Resonance: Software platform for tracking and managing complex hardware manufacturing.
3+ YOE3+ years in product management or supply chain/industrial engineering, deep manufacturing supply chain knowledge, technical aptitude with APIs and data, product lifecycle ownership, and customer-facing communication skills.
NetSuite, SAP, MES, PLM, Python, JavaScript, TypeScript, SQL, APIs
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3w
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Production Manager
Los Angeles, California, United States
$120k-$170k/yr OnsiteFull Time
General Matter
General Matter: Produces enriched uranium and nuclear fuel for power generation.
7+ YOE7+ years leading CNC-focused production operations, experience standing up manufacturing facilities, strong engineering fundamentals, CNC/lathe expertise, familiarity with MES/ERP/QMS/CMMS, and bachelor\u0002s in engineering or equivalent hands-on experience.
MES, ERP, QMS, CMMS, CNC
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3w
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Principal Product Manager
Boston or Los Angeles or Seattle
$164k-$247k/yr RemoteFull Time
Re:Build Manufacturing
Re:Build Manufacturing: Provides advanced engineering and US-based contract manufacturing services.
Proven track record running hardware program execution and shipping 0-to-1 products, strong written communication, deadline discipline, credibility with hardware engineers, and comfort using AI/LLM tools.
PLM, MES, EDA, ALM, LLM
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3mo
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Manufacturing Engineering Manager
Los Angeles, California, United States
$90k-$120k/yr HybridFull Time
SoLa Impact
SoLa Impact: Develops and manages affordable housing in underserved urban communities.
5+ YOE2+ MgmtLead team of manufacturing engineers; 5+ years in manufacturing with 2+ years in leadership; GD&T, CAD (SolidWorks, Inventor, AutoCAD); MES experience; Lean, process development.
SolidWorks, Inventor, AutoCAD, MES, GD&T, Lean Manufacturing, Automation
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2mo
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Manager Engineering 2
Palmdale, California, United States
$147k-$220k/yr OnsiteFull Time
Northrop Grumman
Northrop GrummanNYSE: NOC: Designs and manufactures advanced aerospace and defense systems.
7+ YOEActive Secret clearance, STEM degree with 7–9+ years aerospace experience, experience in flight/production test environments, prior project/team leadership, and familiarity with engineering drawings and tools like CPLM, Teamcenter, and MES.
CPLM, Teamcenter, MES, EVMS
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2mo
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Manager Engineering 2
Palmdale, California, United States
$147k-$220k/yr OnsiteFull Time
Northrop Grumman
Northrop GrummanNYSE: NOC: Develops and manufactures advanced aerospace, defense, and space systems.
7+ YOESTEM degree with 7–9+ years aerospace experience, active Secret clearance, ability to obtain SAP, experience in flight/production test, leadership experience, familiarity with CPLM/Teamcenter/MES/EVMS, strong communication and troubleshooting skills.
CPLM, Teamcenter, MES, EVMS
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3mo
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Sr IT Project Manager - PLM
El Segundo, California, United States
$175k-$205k/yr OnsiteFull Time
Mattel
MattelNASDAQ: MAT: Designs, manufactures, and markets toys and family entertainment franchises.
15+ YOE15+ years IT program/project management in PLM; global/multi-site PLM implementations; PLM platform integrations; strong leadership and stakeholder management.
PLM, CAD, ERP, MES
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1mo
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Production Control Manager
Los Angeles, California, United States
$116k-$160k/yr OnsiteFull Time
Apex
Apex: Mass-manufactures standardized satellite buses for commercial and government use.
4+ YOE2+ MgmtU.S. Persons required; 4+ years manufacturing scheduling experience (aerospace/automotive preferred); 2+ years people leadership; proficiency with Microsoft Project, Smartsheet, Primavera P6, ERP/MRP/MES, Microsoft Excel, Power BI, and SQL.
Microsoft Office, Microsoft Project, Smartsheet, Primavera P6, ERP, MRP, MES, Microsoft Excel, Microsoft Power BI, SQL
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Site Quality Manager
Simi Valley, California, United States
$138k-$242k/yr OnsiteFull Time
Parker Hannifin
Parker HannifinNYSE: PH: Manufacturer of motion and control technologies and systems.
10+ YOEBachelor's degree required, 10+ years related experience leading quality in large or multi-site manufacturing; deep knowledge of QMS standards (ISO 9001/AS9100/IATF), CAPA/A3/8D problem solving, PFMEA, SPC, MSA, PPAP/FAI, GD&T, KPI analysis, and experience with ERP/MES and Microsoft 365.
PQP, A3, 8D, 5-Why, Fishbone, PFMEA, SPC, MSA, PPAP/FAI, GD&T, Minitab, ERP, MES, Microsoft 365
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1w
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Automation Engineer Manager
City of Industry, California, United States
$130k-$160k/yr OnsiteFull Time
Danone
DanoneEuronext Paris: BN: Global food and beverage producing dairy and plant-based goods.
5+ YOEBachelor's in engineering preferred, 5+ years automation and controls project management in CPG, strong PLC/networking/MES experience, Ignition/Wonderware/FactoryTalk/MSSQL proficiency, AutoCAD/Visio and project management skills.
Inductive Automation Ignition, Wonderware System Platform, FactoryTalk View SE, MSSQL, RSLogix 500, Studio 5000, FactoryTalk Historian, Wonderware Historian, Microsoft Office, AutoCAD, Microsoft Visio, SAP, Allen-Bradley PLC, Ethernet/IP, Modbus TCP, IO Link, AS-I, DeviceNet
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1mo
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Manager, Build Engineering
Los Angeles, California, United States
$175k-$220k/yr OnsiteFull Time
Hadrian
Hadrian: Building autonomous factories for aerospace and defense manufacturing.
6+ YOE2+ Mgmt6+ years in build/production/manufacturing engineering with NPI experience, 2+ years managing engineers, strong drawing/BOM/process interpretation, cross‑functional coordination, and hands‑on factory experience.
ERP, MES, PLM, Digital work instruction tools
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1mo
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Teamcenter NX Manager
Los Angeles, California, United States
$168k-$227k/yr HybridFull Time
Hermeus
Hermeus: Develops high-speed and hypersonic aircraft for defense and transportation.
7+ YOE7+ years administering Siemens Teamcenter and NX, experience leading PLM/engineering applications teams, strong PLM/process knowledge, troubleshooting, stakeholder partnership, and operating in high-growth hardware environments.
Siemens Teamcenter, NX, PLM, ERP, MES, CAD, JT, PDF, STEP, DXF, Agile
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2mo
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Manager, Material Flow Engineering (Hawthorne)
Hawthorne, California, United States
OnsiteFull Time
SpaceX
SpaceX: Designs and launches advanced rockets and satellite internet constellations.
3+ YOEAdvanced degree + 3+ years manufacturing/industrial experience or bachelor's + 5+ years; leadership experience; CAD (SolidWorks/NX/AutoCAD), Microsoft Excel, Power BI, SQL, Grok/Claude familiarity; APICS CPIM/CSCP desired; ability to work all shifts and provide 24x7 on-call support.
Grok, Claude, Microsoft Excel, Microsoft Power BI, SQL, Grafana, SolidWorks, NX, AutoCAD, Microsoft Word, Microsoft PowerPoint, Microsoft Visio, Microsoft Project, MRP, WMS, MES
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2d
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Director, Business Systems & Manufacturing Applications (25770)
Chatsworth or Carlsbad or Longmont or Westborough
$135k-$145k/yr HybridFull Time
NEOTech
NEOTech: Provides contract electronic manufacturing and product design engineering services.
10+ YOERequires 10+ years of manufacturing ERP, MES, or business systems leadership; multi-site experience; ERP modernization; vendor management; software development depth; people management; executive communication; and travel up to 50%.
Epicor, Aegis, Microsoft Excel, ERP, MES, BI, AI, ML, Epicor Kinetic, Epicor BPMs, BAQs, dashboards, ITAR, CUI, FDA, ISO, AS9100, LLM
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3mo
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Application Engineer – Multi-Physics Simulation
Ghent or Calabasas
OnsiteFull Time
Keysight Technologies
Keysight TechnologiesNew York Stock Exchange: KEYS: Manufactures hardware and software for electronic test and measurement.
Bachelor's or Master’s in EE/ME/Physics, strong understanding of electronic design workflows, experience with engineering simulation/EDA tools, ability to translate engineering problems into product requirements, customer-facing and product ownership experience, excellent English.
Electronic Design Automation (EDA), Keysight ADS, Cadence Allegro, Cadence Celsius, Siemens FloTherm, Siemens NX, Ansys Mechanical / Icepak
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