48 principal data scientist jobs at 26 companies in Berkeley, CA

PromotedHiringCafe
Founding Machine Learning / AI Search Engineer
Cupertino, CA, US
$160k-$310k/yr On-SiteFull Time
HiringCafe
HiringCafe: Building a 100× better job search engine to take on Indeed and LinkedIn.
Build the ML and AI search behind HiringCafe — ranking, recommenders, retrieval, and LLM agents that surface jobs people would never find on their own.
Python, PyTorch, Elasticsearch, LLMs
2mo
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Principal Data Scientist
South San Francisco, California, United States
$174k-$217k/yr OnsiteFull Time
Structure Therapeutics
Structure TherapeuticsNASDAQ: GPCR: Developing oral small molecule medicines for chronic diseases
12+ YOE12+ years data science with production software experience; ML/DL proficiency; cloud and CI/CD; strong communication and collaboration.
Python, R, Scikit-learn, TensorFlow, PyTorch, AWS, Docker, CI/CD, GitHub
1mo
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Principal Data Scientist
United States or Redmond or Mountain View or Austin or Houston or Chicago or New York or Cambridge or Atlanta
$143k-$275k/yr OnsiteFull Time
Microsoft
MicrosoftNASDAQ: MSFT: Develops software, services, devices, and cloud computing solutions.
5+ YOEAdvanced degree in a data-related field with 5–10+ years of data-science experience depending on degree; experience managing data, modeling at scale, customer-facing project delivery preferred; must be authorized to work in the U.S. without sponsorship.
2d
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Principal, Data Scientist
Sunnyvale, California, United States
$143k-$286k/yr OnsiteFull Time
Walmart
WalmartNYSE: WMT: Multinational retail operating discount stores and supermarkets.
10+ years in data science or ML, strong expertise in statistical modeling, experimentation, production ML, GenAI/LLMs, Spark, cloud AI/ML (GCP/Azure), and stakeholder communication.
LLMs, Spark, GCP, Azure, Python, Scala, R, scikit learn, tensorflow, torch, vector databases
1w
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Data Scientist, Principal
Oakland or Washington or Ohio or District of Columbia or California or Long Beach or Arizona or Colorado or Connecticut or Florida or Georgia or Maryland or Minnesota or Nevada or Oregon or El Dorado Hills or San Diego or Woodland Hills or Alabama or Illinois or Virginia or Wisconsin or Texas or New York
$182k-$273k/yr HybridFull Time
Ascendiun
Ascendiun: Nonprofit parent overseeing health insurance and clinical service organizations.
8+ YOEAdvanced experience in applied AI/ML and software development, strong Python engineering, hands-on with deep learning and LLM frameworks, experience building production AI applications and leading ML design.
Python, PyTorch, TensorFlow, LangChain, LangGraph, SQL, Spark, Azure, Google Cloud, AWS
2w
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Senior / Principal Data Scientist - Discovery
San Mateo, California, United States
$307k-$374k/yr HybridFull Time
Roblox
RobloxNYSE: RBLX: Platform for creating and playing user-generated 3D digital experiences.
10+ YOEAdvanced quantitative degree, 10+ years data science (or 6+ with PhD) with recommendation systems experience; expertise in causal inference, experimentation, ML, and strong communication skills.
Python, R, SQL, Hive, Spark, Airflow
1mo
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Principal Data Scientist, Predictive AI
South San Francisco, California, United States
$207k-$385k/yr HybridFull Time
Roche
RocheSIX Swiss Exchange: ROG: Provides innovative pharmaceutical and diagnostic healthcare solutions.
7+ YOEBachelor's degree, 7+ years AI experience, 3+ years recommender systems/forecasting, deep learning, causal inference, proficiency with Hadoop, Spark, AWS, Python, and ML frameworks; strong communication and leadership.
Hadoop, Spark, AWS, Python, LangChain, CrewAI, TensorFlow, PyTorch, Tableau, Qlik, Data Studio
2w
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Principal Data Scientist - AI Foundations, Specialist Models
McLean or New York City or San Jose
$162k-$201k/yr OnsiteFull Time
Capital One
Capital OneNYSE: COF: Financial services offering credit cards, banking, and loans.
3+ YOEAdvanced quantitative degree plus 3–5+ years performing data analytics; hands-on experience with Python/SQL, machine learning, and cloud platforms; strong statistical and big-data skills.
Python, AWS, Spark, transformers, graph ML, Agentic AI, SQL, Scala, R
1mo
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Principal Data Automation Engineer/ Data Scientist, Supply Chain
Nashville or Santa Clara
$115k-$235k/yr OnsiteFull Time
Oracle
OracleNYSE: ORCL: Provides cloud infrastructure and enterprise software for global businesses.
7+ YOE7+ years in data engineering/analytics/AI with strong SQL and Python, ETL/ELT and data pipeline experience, BI/visualization skills, and ability to lead complex automation and analytics initiatives.
SQL, Python, Oracle Analytics Cloud, Tableau, Power BI, Oracle Fusion Cloud Applications
2mo
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Principal Applied Data Scientist - Search and Browse (NLP, Vector Search, LLMs)
Sunnyvale or Brooklyn Park
$168k-$356k/yr HybridFull Time
Target
TargetNYSE: TGT: Operates a chain of general merchandise stores and supermarkets.
8+ YOEPhD or MS in CS/Statistics/Applied Math/Physics; 8+ years ML/AI experience; semantic retrieval, vector search, LLMs; Python; architecture leadership; cross-functional influence.
Python, LLMs, NLP, Vector search, RAG, Transformers, VertexAI
6d
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Principal Scientist – Data Insights & Hypothesis Design
Chicago or Redwood City or New York City or California or New York
$150k-$200k/yr HybridFull Time
Tempus AI
Tempus AINASDAQ: TEM: Builds a data platform for AI-powered precision medicine diagnostics.
6+ YOEPhD in NGS-related field,6+ years industry experience,domain expertise in oncology/neurology/immunology,large-scale clinico-genomic analysis,SQL/Python/R proficiency,and experience translating data into production products.
SQL, R, Python, Tempus Data Model (TDM)
1mo
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Principal Data Scientist - Cloud Gaming and AI
Santa Clara or California
$248k-$380k/yr HybridFull Time
NVIDIA
NVIDIANASDAQ: NVDA: Designs graphics processing units and artificial intelligence hardware.
15+ YOEMaster's/PhD or equivalent; 15+ years software experience and 8+ years in statistics/AI/ML; hands-on with Python, SQL, Java and ML frameworks; experience deploying large-scale production ML systems and leading technical teams.
Python, R, Pandas, JupyterLab, Spark, SQL, Databricks, MLFlow, Delta Lake, Grafana, Kibana, Kubeflow, Elyra, Kubernetes, Gitlab, CI/CD, MLOps, Kafka, SQS, Scikit-learn, Pytorch, TensorFlow, Java
1mo
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Principal Data Scientist - Cloud Gaming and AI
Santa Clara or United States
$248k-$380k/yr HybridFull Time
NVIDIA
NVIDIANASDAQ: NVDA: Designs GPU-accelerated computing and artificial intelligence hardware.
15+ YOEMaster's/PhD or equivalent experience in a quantitative field; 15+ years software experience and 8+ years in statistics/AI/ML; hands-on Python, SQL, Java, Scikit-learn, Pytorch, TensorFlow; experience with Spark, Pandas, Delta Lake, Databricks; excellent communication.
Python, R, Pandas, JupyterLab, Spark, SQL, Databricks, MLFlow, Delta Lake, Grafana, Kibana, Kubeflow, Elyra, Kubernetes, Gitlab, CI/CD, MLOps, Kafka, SQS, Java, Scikit-learn, Pytorch, TensorFlow, LLMs
2mo
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Principal AI Scientist - GTM Tech
Mountain View, California, United States
$274k-$370k/yr OnsiteFull Time
Intuit
IntuitNASDAQ: INTU: Provides financial software for accounting, tax, and personal finance.
3+ YOEPhD/MS in a quantitative field; 3+ years leading AI/ML; strong statistics; hands-on programming in ML/NLP; 6+ years with data manipulation and general-purpose languages; proven influencer and leader.
Python, Scala, SQL, R, ML pipelines, NLP
6d
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Principal Research Data Scientist
San Francisco, California, United States
$170k-$215k/yr HybridFull Time
HealthLeap
HealthLeap: AI clinical assistant for inpatient risk screening and prioritization.
2+ YOEPhD in statistics/biostatistics/epidemiology or related field; 2+ years non-PhD observational health research experience; deep causal inference expertise; fluency in Python; experience with EHR/claims preferred; publication track record.
Python, EHR
2mo
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Principal Scientist, Clinical Biomarkers
San Francisco, California, United States
$140k-$187k/yr HybridFull Time
Biogen
BiogenNASDAQ: BIIB: Develops therapies for neurological and neurodegenerative diseases.
5+ YOE1+ MgmtPhD and 5+ years biomarker experience; strong communication; matrixed environment; biomarker assays and data interpretation.
biomarker assays, assay validation, translational sciences
1w
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Principal Scientist, Process Sciences
South San Francisco, California, United States
$155k-$180k/yr OnsiteFull Time
Allogene Therapeutics
Allogene TherapeuticsNASDAQ: ALLO: Develops allogeneic cell therapies for cancer and autoimmune diseases
7+ YOEPhD/MS/BS in engineering or biological sciences with extensive process development and scale-up experience; expertise in cell therapy manufacturing, DOE, data analysis (Python/R), regulatory support, and technical leadership.
Python, R
2mo
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Principal Scientist, Bioinformatics
South San Francisco, California, United States
$180k-$215k/yr HybridFull Time
Nkarta
NkartaNasdaq: NKTX: Develops off-the-shelf natural killer cell therapies for diseases.
5+ YOELead computational analysis of single-cell and spatial omics data; develop scalable pipelines; collaborate cross-functionally to support translational medicine.
Python, R, AWS, single-cell RNA-seq
4w
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Senior Principal Scientist, Cardiovascular, Translational Development
Princeton or Cambridge or Brisbane
$160k-$223k/yr HybridFull Time
Bristol Myers Squibb
Bristol Myers SquibbNYSE: BMY: Develops and manufactures innovative prescription biopharmaceutical medicines.
5+ YOEPhD and 5+ years translational medicine/clinical biomarker experience in cardiovascular or related diseases; expertise with biomarker strategy, CRO interactions, project leadership, data interpretation, and scientific communication.
4w
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Senior Principal Scientist, Cardiovascular, Translational Development
Princeton or Cambridge or Brisbane
$160k-$194k/yr HybridFull Time
Bristol Myers Squibb
Bristol Myers SquibbNew York Stock Exchange: BMY: Develops and distributes innovative medicines for serious diseases.
5+ YOEPhD with 5+ years translational medicine/clinical biomarker experience in cardiovascular or related disease areas; expertise in biomarker strategy, CRO/vendor management, data analysis with bioinformaticians, scientific leadership, and regulatory support.
2mo
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Clinical Translational Scientist
San Francisco or Boston
$130k-$200k/yr OnsiteFull Time
Valius
Valius: Provides precision oncology diagnostics and molecular testing for cancer.
Senior/principal scientist experienced in oncology, translating molecular data into treatment options with strong communication to patients and clinicians.
Oncology, Clinical trial interpretation, Molecular profiling, IHC/mIF, scRNA-seq