50 principal data scientist jobs at 24 companies in Massachusetts
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Principal Data Scientist - Immunology - (2 positions)
Titusville or Cambridge or Raritan or Spring House or San Diego
$117k-$201k/yr HybridFull Time
5+ YOEPrincipal Data Scientist with bioinformatics/biomedical data expertise; 5+ years health informatics; semantic tech, ontologies, knowledge graphs; PhD or Master preferred.
Semantic Web, SPARQL, RDF, OWL, Graph Databases, Neo4j, Amazon Neptune, REST, GraphQL, Docker, CI/CD, Jenkins, GitLab, Azure DevOps, SQL, NoSQL, Proteomics, Genomics
2mo
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Data Scientist – Simulation (Senior - Principal)
Wilmington, Massachusetts, United States
$149k-$205k/yr HybridMultiple Commitments Available
5+ YOESenior/Principal Data Scientist to lead simulation model development for robotic warehouses; 5-8 years in simulation, DES/agent-based modeling; Python and related tools.
Python, NumPy, Pandas, SciPy, SimPy, AnyLogic, Arena, Databricks, Snowflake, Grafana, Tableau, GCP, AWS, Azure, High-Performance Computing
2mo
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Principal Data Scientist - Oncology
Cambridge or San Diego or Spring House or Titusville or Raritan
$117k-$201k/yr HybridFull Time
5+ YOEPhD or Master's in relevant field; 5+ years health informatics; knowledge graphs/ontologies; SPARQL/RDF/OWL; programming and DevOps; willingness to travel (<15%).
SPARQL, RDF, OWL, Neo4j, Amazon Neptune, Jenkins, GitLab, Azure DevOps, Docker, Singularity, RDF Triple Stores
1w
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Principal Data Scientist
Boston or North America
$190k-$235k/yr RemoteFull Time
5+ YOEAdvanced degree or extensive experience in data science, expert knowledge of deep learning and ML, proficiency in Python and core data science tools, 5+ years relevant experience (PhD/Master's) or 8+ years (Bachelor's), strong communication and MLOps experience.
Python, Jupyter, GLMs, XGBoost, Transformers, Claude
4d
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Principal Data Scientist - FDE
United States or Redmond or Mountain View or Austin or Houston or Chicago or Cambridge or New York City or Atlanta
$143k-$275k/yr RemoteFull Time
3+ YOERequires a doctorate and 3+ years, master's and 5+ years, or bachelor's and 7+ years in data science or a related field; customer-facing delivery experience preferred and travel up to 25%.
AI
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Principal Data Scientist- Eng
Lowell or Atlanta
$164k-$236k/yr HybridFull Time
8+ YOEPhD + 8+ yrs or Master’s + 12+ yrs in data science/ML; proven enterprise DS strategy, MLOps and model governance experience, cloud platform expertise (GCP/BigQuery), executive communication, and senior technical leadership.
MLOps, GCP, Agent Platform, BigQuery
2mo
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Principal Data Scientist - Gen AI
Waltham or North Bethesda
$200k-$230k/yr HybridFull Time
10+ YOE10+ years applied ML/data science or PhD+6 years; bachelor's required (advanced degree preferred); expert Python, PyTorch, TensorFlow, pandas, numpy; experience with LLMs, multimodal data, AWS/SageMaker; leadership and roadmap ownership.
Python, PyTorch, TensorFlow, pandas, numpy, Amazon Web Services (AWS), AWS SageMaker, Transformers, GPT, Teamcenter, Designcenter
1w
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Principal Data Scientist - Marketing Analytics
Maple Grove or Arden Hills or Minneapolis or Massachusetts
$102k-$194k/yr HybridFull Time
8+ YOEMaster’s degree in a related quantitative field, 8+ years of data science or analytics experience, advanced Python and SQL, and experience with statistical or machine learning models and cloud analytics environments.
Python, SQL, scikit-learn, statsmodels, XGBoost, PyMC-Marketing, Google Meridian, Snowflake, MLOps, GenAI, LLM
2w
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Principal Data Scientist, GTM Data Science
Boston, Massachusetts, United States
$182k-$243k/yr OnsiteFull Time
6+ YOEExpertise in marketing science, personalization, lifecycle modeling, production ML, experimentation and causal inference; proficiency with Python, SQL, Databricks, SageMaker, Spark, MLflow; typically 6+ years experience.
Python, SQL, Databricks, AWS SageMaker, Spark, MLflow
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Principal Associate, Data Scientist - Card Intelligence
McLean or New York City or Cambridge
$162k-$201k/yr OnsiteFull Time
5+ YOEBachelor's degree plus 5 years, master's or quantitative MBA plus 3 years, or PhD in a quantitative field; data analytics, machine learning, Python, SQL, and cloud experience required or preferred.
Python, Conda, AWS, H2O, Spark, Scala, R, SQL
1mo
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Principal Associate, Data Scientist - Card Intelligence
McLean or New York City or Cambridge
$162k-$201k/yr OnsiteFull Time
5+ YOEBachelor's plus 5 years, master's/MBA plus 3 years, or PhD in a quantitative field and data analytics experience; preferred expertise in Python, machine learning, SQL, AWS, and STEM education.
Python, Conda, AWS, H2O, Spark, Scala, R, SQL
1mo
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Principal Data Scientist (AI-assisted Clinical Development)
Boston, Massachusetts, United States
$169k-$314k/yr OnsiteFull Time
6+ YOEAdvanced degree in data/CS/statistics,6+ years applying statistical and ML methods in clinical/biomedical domains,experience with model development, simulation studies, deployment, and responsible AI practices.
Python, R, scikit-learn, TensorFlow, PyTorch, Stan, PyMC, brms, ML Ops
2d
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Principal Data Scientist_Boston
Boston, Massachusetts, United States
$64k-$224k/yr OnsiteFull Time, Contract
Photon: An information technology organization developing enterprise artificial intelligence capabilities.
10+ YOERequires 10–15+ years in data science, machine learning, and applied research, including 4+ years in generative AI; expertise in LLMs, RAG, Python, ML frameworks, evaluation, and cloud platforms.
GraphRAG, Knowledge Graphs, OpenAI, Claude, Gemini, Llama, Mistral, Qwen, SFT, LoRA, DPO, RLHF, PEFT, QLoRA, Pinecone, Qdrant, OpenSearch, pgvector, RAGAS, DeepEval, TruLens, Python, PyTorch, Scikit-learn, Pandas, NumPy, Azure AI Foundry, AWS Bedrock, Databricks, MLflow, Neo4j, PySpark, BLEU, ROUGE
1w
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Principal Scientist, Oncology Data Science (Translational Science)
Pennsylvania or United Kingdom or Stevenage or Heidelberg or Massachusetts or Cambridge or Upper Providence or Waltham or Maryland or Rockville or San Francisco or Germany
$121k-$202k/yr HybridFull Time
1+ YOEPhD or equivalent in a quantitative field, 1+ year industry or postdoctoral experience, cancer computational biology expertise, single-cell omics, statistical and machine learning, Python, and PyTorch.
Python, PyTorch, R, CI/CD, CRISPR, Perturb-seq, version control
4d
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Principal Scientist, Biomarker Bioanalytical Sciences
Cambridge, Massachusetts, United States
$141k-$188k/yr HybridFull Time
5+ YOEPhD with 5+ years or MS with 8+ years in a related scientific field; expertise in biomarker and bioanalytical assay development, validation, regulated environments, CRO oversight, data interpretation, and regulatory submissions.
PK, ADA, TE, PD, IND, CTA, BLA, MAA
1mo
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Principal Scientist II - Pharmacology
Cambridge, Massachusetts, United States
$126k-$234k/yr OnsiteFull Time
5+ YOEPhD with 5+ years postdoc or industry research experience, expertise in ADCs and CDX/PDX/syngeneic tumor models, cell culture, PCR, ELISA, western blot, flow cytometry; experience managing associate scientists and presenting data.
Microsoft PowerPoint, Prism, Microsoft Excel
3w
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Principal Scientist, Bioanalytics
Billerica, Massachusetts, United States
$127k-$215k/yr OnsiteFull Time
5+ YOEPh.D. in biochemistry, biology, chemistry, or related field; 5–7+ years in regulated bioanalysis; expertise in PK, bioanalytics, immunogenicity, ligand binding, experimental design, data analysis, and laboratory instrumentation.
ELISA, MSD-ECLA, Gyrolab, Watson LIMS, GraphPad Prism, Veeva Vault
2w
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Applied Hypersonics Research Principal Scientist/Engineer
Andover, Massachusetts, United States
$118k-$140k/yr OnsiteFull Time
Advanced degree or equivalent experience in chemistry, physics, or applied engineering; extensive experimental and data analysis experience; technical leadership; peer-reviewed publications; excellent written and oral English; U.S. citizenship.
Schlieren, Pitot, PLIF, IR, UV, laser absorption, emission spectroscopy, vacuum systems, plasma technologies
2mo
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Principal Software Engineer, Data
Cambridge or San Francisco
$204k-$348k/yr HybridFull Time
8+ YOE8-15 years of backend-focused engineering; full stack experience; AWS, Kubernetes; API design; data pipelines; Python; collaboration with scientists and engineers.
React, TypeScript, Nx, Tailwind, FastAPI, SQL/NoSQL, Python, Pydantic, SQLAlchemy, SQLModel, Django, Airflow, Prefect, Temporal, Dagster, pandas, numpy, scipy, jax, pytorch, AWS, Kubernetes, Terraform, CloudFormation, GitHub Actions
1mo
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Principal Scientist, Computational Biology
Cambridge, Massachusetts, United States
$167k-$202k/yr OnsiteFull Time
5+ YOEPhD in a quantitative field with 5+ years post-graduate experience; hands-on R or Python; experience with single-cell and multi-omics data, statistical and ML methods; strong communication and scientific curiosity.
R, Python, Claude
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