5,416 senior python developer jobs at 1,138 companies in Los Altos, CA
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Senior Python Engineer
San Francisco or Toronto or United States
$200-$300/hr RemoteContract
3+ YOE3+ years software engineering experience, strong Python expertise, full-stack and scalable systems experience, excellent communication and code-review skills.
Python, JavaScript, ReactJS, C/C++, Java, Rust, Go
2mo
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Principal Python Engineer (Modeling & Simulation)
San Francisco or Boston or United States
HybridFull Time
7+ YOE7+ years Python software development, experience with scalable APIs, Docker, cloud distributed systems, stakeholder-driven design, SDLC best practices; eligible for U.S. Top Secret clearance.
Python, Docker, REST, GraphQL, gRPC, AWS, GCP, Azure
3mo
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Senior Backend Engineer (Python)
San Francisco, California, United States
$175k-$250k/yr RemoteFull Time
4+ YOE4+ years building production back-ends in Python; real-time streaming; AWS/GCP/Azure; PostgreSQL/Redis; FastAPI/asyncio; HIPAA security.
Python, FastAPI, asyncio, WebRTC, WebSockets, gRPC, AWS, GCP, Azure, Kubernetes, Kafka, SQS, Pub/Sub, Terraform, PostgreSQL, Redis, OpenTelemetry
2mo
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GenAI Python Systems Engineer –Senior Manager
Chicago or Raleigh or Charlotte or Cincinnati or Cleveland or Columbia or Columbus or Dallas or Baltimore or Richmond or Rosemont or Sacramento or Boston or St. Louis or Salt Lake City or San Antonio or San Diego or San Francisco or Silicon Valley or Seattle or Spartanburg or Albany or Stamford or Tampa or Atlanta or Toledo or Austin or Tulsa or Washington or Denver or Des Moines or Detroit or Buffalo or Florham Park or Kansas City or Las Vegas or Little Rock or Los Angeles or Louisville or Birmingham or Fayetteville or Miami or Milwaukee or Minneapolis or Nashville or New Orleans or New York or Oklahoma City or Philadelphia or Phoenix or Pittsburgh or Portland
$124k-$280k/yr HybridFull Time
8+ YOESenior Manager level with 8+ years of experience; proficient in Python, SQL, FastAPI; cloud certifications a plus; willing to travel up to 80%; Bachelor's degree required.
Python, SQL, FastAPI, Cloud Platforms, LLM techniques, Data Warehousing, Data Lakes, IAM
3mo
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Senior Software Engineer, Developer Experience
Bellevue or Livingston or New York or San Francisco or Sunnyvale
$165k-$242k/yr HybridFull Time
7+ YOESenior software engineer with 7+ years in production platforms, distributed systems, and developer tooling.
Go, Python, Kubernetes, GitHub Actions, Buildkite, Bazel, Artifactory, MCP
1mo
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Senior Product Software Engineer (Python)
San Francisco or Chicago or Los Angeles
$160k-$200k/yr HybridFull Time
5+ YOE5+ years full-stack engineering experience; strong Python and React; production GraphQL experience; willingness to learn ClojureScript; familiarity with AI-assisted coding tools; strong cross-functional communication.
Python, React, GraphQL, Strawberry, ClojureScript, Cursor, Copilot, Claude Code, Warp Agent Mode, Recharts, ECharts, dbt, Snowflake, Redshift, PyTorch, AWS, PostgreSQL, Fulcro, Tailwind CSS, Clojure, Kotlin
2w
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Python Django Developer
San Jose or Morrisville
$64k-$140k/yr OnsiteFull Time
10+ YOEU.S. work-authorization required; 10+ years software engineering with 5+ years Python; experience with Django and Nginx; AWS GovCloud and FedRAMP/IL5 exposure preferred.
Python, Django, Nginx, AWS Gov cloud
1mo
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Senior Software Engineer - Python
San Jose or Austin
$144k-$213k/yr HybridFull Time
3+ YOE3+ years experience and a Bachelor’s degree or equivalent; strong Python backend skills (Django/Flask); familiarity with distributed systems, databases (SQL/NoSQL, Redis), messaging (SQS/SNS/Kafka/RabbitMQ/Pulsar), cloud platforms, Terraform, Git, and CI/CD.
Python, Django, Flask, Git, AWS, GCP, Azure, Terraform, SQL, NoSQL, Redis, SQS, SNS, Kafka, RabbitMQ, Pulsar, CI/CD
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Senior Software Engineer (Python), Mortgage
San Francisco, California, United States
$185k-$218k/yr HybridFull Time
5+ YOE5+ years software development, bachelor or equivalent, proficiency in Python and Javascript, RESTful API experience, strong communication and ownership.
Python, Javascript, RESTful APIs
2mo
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Senior Software Engineer
Sunnyvale, California, United States
$160k-$185k/yr OnsiteFull Time
7+ YOE7-5 years of experience in a similar Senior Software Engineer role; proficient in RTOS, embedded systems, C#, C++, Python; GitLab CI/CD; strong communication.
C#, C++, RTOS, Python, Scripting, GitLab CI/CD
1mo
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Senior AI/ML Engineer: Python & Scientific Computing
San Francisco or New York City or United States
$175k-$250k/yr HybridFull Time
5+ YOE5+ years building scientific or quantitative data‑intensive software; expertise in scientific Python stack, object‑oriented and test‑driven development, vectorized code, machine learning, and distributed/parallel computing.
Python, NumPy, SciPy, scikit-learn, Pandas, Celery, Flask, JavaScript, Vue.js, Node.js, MongoDB, GraphQL, Linux
2mo
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Senior Software Engineer
San Francisco, California, United States
HybridFull Time
6+ YOESenior software engineer with 6+ years of production experience across frontend and backend; proficient in Python, TypeScript, React/Next.js; Docker/Kubernetes on cloud; CI/CD; and LLM frameworks.
Python, TypeScript, React, Next.js, Docker, Kubernetes, Terraform, CI/CD, LangChain, LangGraph, Anthropic SDK, OpenAI SDK, MCP, GCP, AWS
2w
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Senior Software Engineer - Python/Agentic AI
Pleasanton, California, United States
$170k-$213k/yr HybridFull Time
3+ YOEBS+5 years or MS+3 years in computer science; experience with Python/C#/Java and building SaaS/REST APIs; strong CS fundamentals, SQL, distributed systems, cloud and on-call experience.
C#, Java, Python, .NET, .NET Core, HTML, JavaScript, CSS, SQL, PostgreSQL, NoSQL, Docker, Kubernetes, Kafka, SQS, RabbitMQ, Azure, ASW, GCP
2mo
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Senior Staff Engineer - System
San Jose, California, United States
$189k-$301k/yr OnsiteFull Time
15+ YOESenior systems/DSP engineer with GNSS experience, strong C/C++, Python, and MATLAB skills; 15+ years in EE/CS; on-site in San Jose.
C/C++, Python, MATLAB, Jira, Gerrit, Git
2mo
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Senior Software Engineer
Los Angeles or Washington or San Francisco or San Diego or Seattle or London
$130k-$220k/yr OnsiteFull Time
3+ YOE3+ years software development; strong Python; Azure cloud; on-call production support; must be a U.S. Person; ability to obtain security clearance.
Python, Azure, Git, CI/CD, Docker, Kubernetes, TypeScript, Java, Bash, Rust, Node.js
2mo
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Senior DevTools Engineer
San Francisco or Boston or New York or Denver
$163k-$247k/yr HybridFull Time
5+ YOE5+ years software engineering; experience in developer tooling, software/infrastructure engineering; cloud infrastructure design and deployment; Python and TypeScript proficiency; security-aware mindset.
Python, TypeScript, AWS, GCP, Cloud infrastructure, Developer tooling
2mo
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Senior Staff, Software Engineer
Palo Alto or United States
$185k-$260k/yr HybridFull Time
10+ YOESenior-level software engineer with cloud, Python and a compiled language, life sciences exposure, and leadership experience.
Python, Rust, Java, C++, C#, AWS, Jira, Git, CI/CD
2mo
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Senior Software Engineer - AHV
San Jose, California, United States
$156k-$311k/yr HybridFull Time
Expert C and Python, kernel-level Linux/Unix knowledge, driver development, OS internals, virtualization.
C, Python, Linux, UNIX, BSD, Kernel development
2mo
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Senior Backend Engineer, Agentic
Palo Alto, California, United States
$350k-$500k/yr OnsiteFull Time
10+ YOESenior backend engineer with 10+ years in production cloud systems; strong Python, PostgreSQL, Redis; cloud experience (AWS/GCP/Azure); Kubernetes; LLM patterns; ownership and reliability.
Python, PostgreSQL, Redis, Kubernetes, Docker, Cloud Platform (AWS/GCP/Azure), LangGraph, LlamaIndex, OpenAI
2mo
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Senior Lead Software Engineer, Distributed Systems (Golang + Python on Kubernetes)
San Francisco or Cambridge or McLean or New York or San Jose
$230k-$286k/yr HybridFull Time
6+ YOE1+ MgmtBachelor’s degree; 6+ years software engineering; 1+ year cloud experience; 9+ years in Python/Golang/Node.js; 4+ years cloud services; 4+ years open source frameworks; 2+ years Kubernetes; 1+ year people management; 2+ years ML platform experience
Golang, Python, JavaScript, Java, TypeScript, SQL, HTML, CSS, Docker, Kubernetes, AWS, GCP, Azure, NoSQL, RDBMS
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