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688 senior python developer jobs at 174 companies in San Diego, CA

PromotedHiringCafe
Founding Backend / Infra Engineer
Cupertino, CA, US
$160k-$300k/yr On-SiteFull Time
HiringCafe
HiringCafe: Building a 100× better job search engine to take on Indeed and LinkedIn.
Own the crawlers, pipelines, and infrastructure powering a real-time job search engine. Strong Node.js and Python fundamentals; bonus points for security and reverse-engineering chops.
Node.js, Python, Elasticsearch, Redis
Help us #BeatIndeed & #BeatLinkedIn
PromotedHiringCafe
Founding Full-stack / Product Engineer
Cupertino, CA, US
$130k-$300k/yr On-SiteFull Time
HiringCafe
HiringCafe: Building a 100× better job search engine to take on Indeed and LinkedIn.
Help us build a 100× better job search engine. We need a full-stack engineer with great taste, sharp fundamentals, and a track record of shipping polished product on React/Next.js plus a real backend (Firebase, Elasticsearch, Redis, Stripe).
React, Next.js, TypeScript, Firebase, Elasticsearch, Redis, Stripe
Help us #BeatIndeed & #BeatLinkedIn
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GenAI Python Systems Engineer –Senior Manager
Chicago or Raleigh or Charlotte or Cincinnati or Cleveland or Columbia or Columbus or Dallas or Baltimore or Richmond or Rosemont or Sacramento or Boston or St. Louis or Salt Lake City or San Antonio or San Diego or San Francisco or Silicon Valley or Seattle or Spartanburg or Albany or Stamford or Tampa or Atlanta or Toledo or Austin or Tulsa or Washington or Denver or Des Moines or Detroit or Buffalo or Florham Park or Kansas City or Las Vegas or Little Rock or Los Angeles or Louisville or Birmingham or Fayetteville or Miami or Milwaukee or Minneapolis or Nashville or New Orleans or New York or Oklahoma City or Philadelphia or Phoenix or Pittsburgh or Portland
$124k-$280k/yr HybridFull Time
PwC
PwC: Providing audit, tax, and management consulting services to businesses.
8+ YOESenior Manager level with 8+ years of experience; proficient in Python, SQL, FastAPI; cloud certifications a plus; willing to travel up to 80%; Bachelor's degree required.
Python, SQL, FastAPI, Cloud Platforms, LLM techniques, Data Warehousing, Data Lakes, IAM
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2mo
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Senior Software Engineer
Arlington or San Diego or Woburn
$139k-$180k/yr HybridFull Time
Systems & Technology Research
Systems & Technology Research: Develops advanced technology for national security and defense applications.
5+ YOESenior software engineer with strong C++, Python/MATLAB, RT real-time systems, security clearance eligibility.
C++, Python, MATLAB, CI/CD, Windows, Linux
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2mo
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Senior Backend Engineer (Python) - Content Understanding
San Francisco or Atlanta or Austin or Boston or Chicago or Dallas or Denver or Houston or Jacksonville or Los Angeles or Miami or New York City or Phoenix or Portland or Sacramento or Salt Lake City or San Diego or Seattle or Washington, D.C. or Ottawa or Toronto or Vancouver or Mexico City
$120k-$228k/yr HybridFull Time
Scribd
Scribd: Subscription-based digital library for e-books, audiobooks, and documents.
7+ YOE7+ years software engineering; Python 5+ years; distributed systems; AWS; Terraform; leadership; bachelor’s in CS.
Python, Scala, Airflow, Spark, Databricks, Terraform, AWS, SQS, SNS, CloudWatch, Datadog
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Senior Software Engineer
Los Angeles or Washington or San Francisco or San Diego or Seattle or London
$130k-$220k/yr OnsiteFull Time
CHAOS Industries
CHAOS Industries: Develops advanced radar and sensing systems for modern defense.
3+ YOE3+ years software development; strong Python; Azure cloud; on-call production support; must be a U.S. Person; ability to obtain security clearance.
Python, Azure, Git, CI/CD, Docker, Kubernetes, TypeScript, Java, Bash, Rust, Node.js
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2mo
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Senior Software Engineer
San Diego, California, United States
$157k-$185k/yr HybridFull Time
Faro Health
Faro Health: Software platform for clinical trial protocol design and orchestration.
7+ YOE7+ years building scalable SaaS software; microservices; TypeScript/Python/React; cloud; leadership ability; BS CS; AI/LLM integration a plus.
TypeScript, Python, React, HTML, CSS, Node.js, Docker, Azure, AWS, Google Cloud, PostgreSQL, MySQL, UV, Vite, Redis
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Senior Software Engineer JobID-0047
Arlington or Mount Laurel or San Diego
$164k-$273k/yr OnsiteFull Time
Innovative Defense Technologies
Innovative Defense Technologies: Defense technology delivering mission-critical software and systems
10+ YOEBachelor's in CS/SE or related field, 10+ years of software development, active Secret clearance, on-site with ~20% travel, proficient in Java/JavaScript/Python/C++, experience with SQL/PostgreSQL/MongoDB, SDLC leadership.
Java, JavaScript, Python, C++, SQL, PostgreSQL, MongoDB, React.js, Kubernetes, OpenShift, Docker
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2mo
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Senior Engineer, Satellite Resource Optimization
Austin or San Diego
OnsiteFull Time
Apple
AppleNASDAQ: AAPL: Designs and sells consumer electronics, software, and online services.
5+ YOEDistributed systems, satellite networks, resource allocation, Python/Go/C++, telemetry and observability, MS with 5+ years experience; export-controlled tech access.
Python, Go, C++
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3mo
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Engineering - Data Platform - Senior Software Engineer
Carlsbad, California, United States
OnsiteFull Time
LightBox
LightBox: Providing data and workflow solutions for commercial real estate.
6+ YOE6+ years of software engineering; production API/microservice experience; Python/TypeScript; cloud (AWS/GCP); containers; CI/CD; developer tooling; LLM integration patterns.
Python, TypeScript, Node.js, AWS, GCP, Docker, Kubernetes, CI/CD, APIs, Microservices, OpenAI, LiteLLM, OpenRoute, AWS BedRock
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2mo
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Senior Security Engineer
Austin or Chicago or Dallas or Denver or Los Angeles or San Diego or San Francisco
$131k-$169k/yr HybridFull Time
Karbon
Karbon: Practice management software for accounting firms.
4+ YOESenior Security Engineer with 4+ years in security or development; strong communication; cloud and AI experience; hands-on with security tooling and threat modelling.
DotnetCSharp, JavaScript, React, EmberJS, Python, Azure, AWS, GCP, PowerShell, Bash, GitHub Copilot, Burp Suite
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3mo
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Senior Software Engineer
San Diego, California, United States
$115k-$140k/yr RemoteFull Time
PickTrace
PickTrace: Provides software for farm workforce and harvest management.
4+ YOE4+ years building web-based software; proficiency in Go/Kotlin/C#/Python/Java; frontend HTML/CSS/TypeScript/React; Docker; cloud deployment; AI-assisted workflows.
Docker, GitHub Copilot, Cursor, Claude
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2mo
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Senior AI Engineer, Agentic Systems
San Diego, California, United States
$144k-$215k/yr RemoteFull Time
Teradata
TeradataNew York Stock Exchange: TDC: Provides cloud data analytics and enterprise AI software platforms.
3+ YOE3–6 years software engineering; 2+ years building agentic AI systems; experience implementing agent skills/plugins; Python proficiency; knowledge of planning loops, tool APIs, and prompt engineering.
Python, Go, OpenAI API, Anthropic API, Google API, agent framework
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2mo
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Senior Software Engineer
San Diego, California, United States
$110k-$160k/yr OnsiteFull Time
Whova
Whova: All-in-one platform for event management and attendee engagement.
Architect backend services, frontend basics, unit testing, code reviews; Bachelor or higher; strong communication; experience with MySQL, Python, React, Redis, AWS, CI/CD.
MySQL, Python, React, Redux, Redis, AWS, CI/CD
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1mo
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Senior Software Engineer
Chicago or San Diego
$163k-$199k/yr OnsiteFull Time
JLL
JLLNYSE: JLL: Global commercial real estate and investment management services.
5+ YOE5+ years software development; expert in Python, Node.js, and React; experience with IaC (Terraform), cloud platforms (AWS, Microsoft Azure, GCP), containerization, CI/CD, databases, and AI-assisted development tools; Bachelor's or equivalent; US work authorization required.
Python, Node.js, Express, NestJS, React, Redux, Terraform, CloudFormation, Ansible, AWS, Microsoft Azure, GCP, GitHub Copilot, Cursor, Amazon CodeWhisperer, OpenAI Codex, Docker, Kubernetes, ECS, GraphQL, PostgreSQL, MongoDB, Jenkins, GitLab CI, GitHub Actions, Microsoft Azure DevOps, Git
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Senior Software Engineer
San Diego, California, United States
OnsiteFull Time
Cohu
CohuNASDAQ: COHU: Provides semiconductor test, handling, and inspection equipment and services.
10+ YOE10+ years software engineering in automation/machine control; expert C/C++; Windows/Visual Studio; RTOS/embedded; fault handling; strong collaboration.
C++, C#, Visual Studio, RTOS, Embedded Linux, Qt, WPF, CI/CD, Jenkins, Git, Python, RS-232, RS-485, USB, Ethernet, CAN, I2C, SPI, SECS/GEM, SEMI standards
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Senior SoC STA Engineer
San Diego, California, United States
OnsiteFull Time
InnoPhase IoT
InnoPhase IoT: Develops ultra-low power wireless semiconductor platforms for IoT devices.
10+ YOESenior SoC timing sign-off ownership; 10+ years in chip-level STA; Cadence Tempus; Python/Tcl scripting; strong cross-functional collaboration.
Cadence Tempus, Python, Tcl, DFT tools, CPDF/UPF tools
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Senior Software Engineer
San Diego, California, United States
$146k-$155k/yr OnsiteFull Time
Foresite Labs
Foresite Labs: Incubating data-driven healthcare and life sciences companies.
3+ YOEBS in CS or Engineering (5+ yrs) or MS (3+ yrs); strong C/C++ and Python; embedded and application development experience; Linux, Docker, and git proficiency; experience with CI/CD and build systems.
C/C++, Python, Linux, Docker, git, CMake, Make, CI/CD, serial, USB, Ethernet, CAN, SPI, I2C, CANopen, Modbus, EtherCAT, gRPC, MQTT
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1mo
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Senior Autonomy Engineer
Sunnyvale or Washington or San Diego or Fort Walton Beach or Ann Arbor or London or Stuttgart or Munich or Stockholm or Bangalore or Seoul or Tokyo
£100k-£160k/yr OnsiteFull Time
Applied Intuition
Applied Intuition: Developing software and simulation infrastructure for autonomous vehicles.
5+ YOE5+ years building production software; experience with autonomous vehicle solutions for defense; end-to-end deep learning development; fluency in C++ or Python with C++; strong communication and mentoring skills; ability to hold UK security clearance.
C++, Python, PX4
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Senior Software Developer
San Diego, California, United States
$100k-$150k/yr OnsiteFull Time
The Marlin Alliance
The Marlin Alliance: Provides digital transformation and automation services to defense agencies.
Experience with React, TypeScript, and Python; strong SQL and data analysis skills; excellent communication and problem-solving; active Secret clearance required.
React, TypeScript, Python, SQL, HTML, CSS, JavaScript, C#, C, C++, Java
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Senior Software Developer, AI Labs
San Francisco or Waterloo or New York City or Seattle or Los Angeles or San Diego or Connecticut or New Jersey or United States
$136k-$274k/yr HybridFull Time
TextNow
TextNow: Provides free, ad-supported mobile calling and texting services.
5+ YOE5+ years software development experience; strong programming in Go, Python, TypeScript, or Ruby; experience with LLMs, model training, cloud deployment, AI system design, and delivering production-grade systems.
Go, Python, TypeScript, Ruby, LLMs, OpenAI, Anthropic, Google, vector databases, agent frameworks, orchestration platforms
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Senior AI Software Engineer
San Diego, California, United States
$115k-$160k/yr OnsiteFull Time
Accenture Federal Services
Accenture Federal ServicesNYSE: ACN: Provides technology and consulting services to U.S. federal agencies.
4+ YOE4+ years of software development; strong Linux (RHEL); experience with LLMs, AI tooling; advanced C/C++; GitLab CI/CD; Python; APIs and large-scale systems.
Red Hat Enterprise Linux, GitLab, C/C++, Python, LLMs, RAG, APIs, CI/CD
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