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1,164 senior python engineer jobs at 327 companies in Palmdale, CA

PromotedHiringCafe
Founding Backend / Infra Engineer
Cupertino, CA, US
$160k-$300k/yr On-SiteFull Time
HiringCafe
HiringCafe: Building a 100× better job search engine to take on Indeed and LinkedIn.
Own the crawlers, pipelines, and infrastructure powering a real-time job search engine. Strong Node.js and Python fundamentals; bonus points for security and reverse-engineering chops.
Node.js, Python, Elasticsearch, Redis
Help us #BeatIndeed & #BeatLinkedIn
PromotedHiringCafe
Founding Full-stack / Product Engineer
Cupertino, CA, US
$130k-$300k/yr On-SiteFull Time
HiringCafe
HiringCafe: Building a 100× better job search engine to take on Indeed and LinkedIn.
Help us build a 100× better job search engine. We need a full-stack engineer with great taste, sharp fundamentals, and a track record of shipping polished product on React/Next.js plus a real backend (Firebase, Elasticsearch, Redis, Stripe).
React, Next.js, TypeScript, Firebase, Elasticsearch, Redis, Stripe
Help us #BeatIndeed & #BeatLinkedIn
1mo
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GenAI Python Systems Engineer –Senior Manager
Chicago or Raleigh or Charlotte or Cincinnati or Cleveland or Columbia or Columbus or Dallas or Baltimore or Richmond or Rosemont or Sacramento or Boston or St. Louis or Salt Lake City or San Antonio or San Diego or San Francisco or Silicon Valley or Seattle or Spartanburg or Albany or Stamford or Tampa or Atlanta or Toledo or Austin or Tulsa or Washington or Denver or Des Moines or Detroit or Buffalo or Florham Park or Kansas City or Las Vegas or Little Rock or Los Angeles or Louisville or Birmingham or Fayetteville or Miami or Milwaukee or Minneapolis or Nashville or New Orleans or New York or Oklahoma City or Philadelphia or Phoenix or Pittsburgh or Portland
$124k-$280k/yr HybridFull Time
PwC
PwC: Providing audit, tax, and management consulting services to businesses.
8+ YOESenior Manager level with 8+ years of experience; proficient in Python, SQL, FastAPI; cloud certifications a plus; willing to travel up to 80%; Bachelor's degree required.
Python, SQL, FastAPI, Cloud Platforms, LLM techniques, Data Warehousing, Data Lakes, IAM
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1mo
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Python Test Automation Engineer
Los Angeles, California, United States
$140k-$150k/yr OnsiteFull Time
EPAM Systems
EPAM SystemsNYSE: EPAM: Provides global digital platform engineering and software development services.
Bachelor's in a relevant engineering or CS field; proven experience building Python-based test automation frameworks, robotic automation fixtures integration, Git/GitHub/GitLab, UNIX, and Jenkins; sensor validation experience; Master's degree preferred.
Python, UNIX, Jenkins, Git, GitHub, GitLab, CI/CD, Anthropic Claude, Claude Code, LinkedIn Learning
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2mo
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Senior GNC Engineer
Moorpark, California, United States
$150k-$164k/yr OnsiteFull Time
Quantum-Systems
Quantum-Systems: Develops and manufactures autonomous AI-powered unmanned aerial systems.
5+ YOESenior GNC Engineer with 5+ years in drone flight dynamics, control, state estimation; lead GNC algorithms; U.S. citizen; potential security clearance; Moorpark office commute.
MATLAB, Simulink, Python, C/C++, PX4, ArduPilot, ROS/ROS2, Gazebo, PX4 SITL, MATLAB/Simulink, SITL
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1mo
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Senior Electromechanical Engineer
El Segundo, California, United States
$151k-$227k/yr OnsiteFull Time
The Aerospace Corporation
The Aerospace Corporation: Provides technical expertise and research for national space programs.
10+ YOESenior electromechanical engineer with 10+ years in electromechanical control systems, verification, and space hardware; bachelor's in a STEM field; willing to obtain security clearance; able to travel up to 25%.
MATLAB/Simulink, LabVIEW, SolidWorks, C/C++, Python
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2w
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Senior Software Automation and Controls Engineer - Python & PLCs
El Segundo, California, United States
$169k-$216k/yr OnsiteFull Time
Varda Space Industries
Varda Space Industries: Develops in-orbit manufacturing platforms and reentry capsules for pharmaceuticals.
5+ YOEBS in engineering, 5+ years in test automation or controls, strong Python, PLC and EtherCAT experience, industrial hardware integration, TwinCAT 3 or similar PLC ecosystems, hands-on electrical and systems commissioning.
Python, EtherCAT, Modbus, RS232, RS485, TwinCAT 3, Docker, Grafana, InfluxDB, IEC 61131-3
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3mo
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Senior Test Engineer, HITL
Los Angeles, California, United States
OnsiteFull Time
Observable Space
Observable Space: Developing integrated hardware and software for persistent space observation.
5+ YOE5+ years in test engineering, embedded systems, or systems-level development; strong C/C++/Python; experience with HITL/HIL testing; embedded interfaces; test automation and CI/CD.
C/C++, Python, I2C, SPI, UART, CAN, Ethernet, Oscilloscopes, Logic analyzers, Multimeters, Embedded Linux, RTOS
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1mo
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Senior Product Software Engineer (Python)
San Francisco or Chicago or Los Angeles
$160k-$200k/yr HybridFull Time
Tyba
Tyba: AI software for modeling and operating renewable energy projects.
5+ YOE5+ years full-stack engineering experience; strong Python and React; production GraphQL experience; willingness to learn ClojureScript; familiarity with AI-assisted coding tools; strong cross-functional communication.
Python, React, GraphQL, Strawberry, ClojureScript, Cursor, Copilot, Claude Code, Warp Agent Mode, Recharts, ECharts, dbt, Snowflake, Redshift, PyTorch, AWS, PostgreSQL, Fulcro, Tailwind CSS, Clojure, Kotlin
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3mo
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Senior Process Engineer (Advanced R&D)
Los Angeles, California, United States
$140k-$200k/yr OnsiteFull Time
Freeform
Freeform: Deploys autonomous AI-powered metal 3D printing factories.
5+ YOESenior process engineer with 5+ years in complex physics-based process development; DOE, data analysis, and large data sets; materials science/physics/mechanical engineering.
MATLAB, Python, R, JMP, Minitab
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1mo
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Senior Principal Systems Engineer
Oklahoma City or Melbourne or San Diego or Palmdale
$116k-$213k/yr OnsiteFull Time
Northrop Grumman
Northrop GrummanNYSE: NOC: Develops and manufactures advanced aerospace, defense, and space systems.
8+ YOESenior Principal Systems Engineer with 8+ years experience in STEM; active Secret or higher clearance; SAP clearance preferred; location flexible across multiple US sites.
DOORS, Python, Scripting, EVMS, CAMEO, CI/CD
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2mo
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Senior Software Engineer, AI
El Segundo or United States
$153k-$170k/yr RemoteFull Time
ImmunityBio
ImmunityBioNASDAQ: IBRX: Develops next-generation immunotherapies for cancer and infectious diseases.
7+ YOESenior software engineer with 7+ years of experience in Python/Typescript, AI agent frameworks, and production-grade systems.
Python, TypeScript, FastAPI, Docker, LangGraph, LangChain, CrewAI, LlamaIndex, Chroma, Milvus, Weaviate, Qdrant
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1mo
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Senior Test Engineer
El Segundo, California, United States
$140k-$197k/yr OnsiteFull Time
Radiant
Radiant: Designs and manufactures portable, mass-produced nuclear microreactors.
2+ YOEUndergraduate engineering degree; 2+ years in engineering problem-solving, design, analysis, or testing; strong hardware-software integration experience.
Python, UNIX, Procedures testing environments
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2mo
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Senior Integration & Test Engineer
Los Angeles, California, United States
$140k-$175k/yr OnsiteFull Time
K2 Space
K2 Space: Develops high-power satellite platforms for heavy-lift launch vehicles.
5+ YOEBachelor’s in engineering; 5+ years integration/test/automation; 3+ years spacecraft testing; environmental testing experience; HITL/Flatsat experience; Python and/or Rust; Linux; contractual interfaces
Python, Rust, Linux, Electrical test equipment, HITL or Flatsat software verification testbeds
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2mo
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Senior Simulation Engineer
Los Angeles, California, United States
$170k-$215k/yr OnsiteFull Time
Apex
Apex: Mass-manufactures standardized satellite buses for commercial and government use.
8+ YOE8+ years in closed-loop simulation tools (6DOF, SITL, HITL); BS in CS/CE/AE; MS a plus; proficient in C/C++, Rust, Python; Linux; Docker; CI/CD; experience with physics-based simulations.
C/C++, Rust, Python, Linux, Docker, CI/CD
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1mo
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Senior Software Engineer, Data Systems (Python)
Canada or United States or San Francisco or Los Angeles
$170k-$200k/yr RemoteFull Time
Northbeam
Northbeam: Marketing intelligence and attribution platform for eCommerce brands.
5+ YOE5+ years in data/software/integration engineering; strong Python, ETL, API/REST/GraphQL/Webhooks, auth flows; SQL and BigQuery; Airflow; Docker/Kubernetes; strong problem solving and observability skills.
Python, ETL, APIs, REST, GraphQL, Webhooks, OAuth 2.0, API keys, SQL, BigQuery, Airflow, Docker, Kubernetes
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3mo
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Senior Systems Engineer, Thermal & Fluid Dynamics
Hawthorne, California, United States
$140k-$200k/yr OnsiteFull Time
Critical Energy
Critical Energy: Builds modular power plants that convert heat into electricity.
5+ YOE5+ years in systems engineering with thermo-fluid modeling; CAD experience; Python; CFD; 1D thermo-fluid modeling; experience with heat exchangers, pumps, turbines preferred.
Siemens NX, Python, CAD, CFD, Aspen, Dymola, ANSYS, PFD, P&ID
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2mo
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Senior Data Engineer
Marina del Rey, California, United States
$160k-$180k/yr HybridFull Time
Zefr
Zefr: Provides AI-driven brand safety and suitability for social media.
8+ YOE8+ years in software/data engineering; dbt/SQL expert; strong Python; engineering degree; knowledge of systems engineering; strong communication.
dbt, SQL, Python, Snowflake, Airflow
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3mo
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Senior Data Engineer
Chicago or Los Angeles or New York or Seattle
$160k-$220k/yr OnsiteFull Time
Metropolis
Metropolis: Computer vision technology for checkout-free parking and retail payments.
5+ YOE5+ years in data engineering, Python, SQL, Snowflake/dbt; cloud experience; Bachelor's in CS/Engineering; Masters preferred; on-site four days a week.
Python, SQL, Snowflake, dbt, Airflow, AWS, Glue, MWAA, DMS, EKS, SNS, Spark, PySpark
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2mo
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Senior System Test & Automation Engineer
Los Angeles, California, United States
$130k-$180k/yr OnsiteFull Time
Motorola Solutions
Motorola SolutionsNYSE: MSI: Provides mission-critical communications and public safety technology.
5+ YOEBachelor's in Electrical/Computer Engineering or related field; 5 years embedded firmware and testing or 3 years with advanced degree; experience with embedded Linux, C/C++, Python; US citizen for government contracts.
Embedded Linux, C++, C, Python, Scripting, Lab instruments, Signal generators, Spectrum analyzers, Logic analyzers
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2mo
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Senior Security Engineer
Austin or Chicago or Dallas or Denver or Los Angeles or San Diego or San Francisco
$131k-$169k/yr HybridFull Time
Karbon
Karbon: Practice management software for accounting firms.
4+ YOESenior Security Engineer with 4+ years in security or development; strong communication; cloud and AI experience; hands-on with security tooling and threat modelling.
DotnetCSharp, JavaScript, React, EmberJS, Python, Azure, AWS, GCP, PowerShell, Bash, GitHub Copilot, Burp Suite
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3mo
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Senior Data Engineer
Calabasas, California, United States
$123k-$132k/yr OnsiteFull Time
AMH
AMHNYSE: AMH: Leasing and developing single-family rental homes across the United States.
8+ YOESenior data engineer with 8+ years experience; design/build data pipelines and platforms; ML model deployment; leadership and CI/CD.
Azure, AWS, Google Cloud, Databricks, Apache Spark, Kafka, Event Hub, IoT Hub, Power BI, Tableau, Python, CI/CD, RESTful APIs, Azure Data Factory, HDInsight, Cosmos DB, ML Studio, Azure Analysis Services, Cosmo DB, Cosmos DB
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