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1,356 senior python engineer jobs at 347 companies in Thousand Oaks, CA

PromotedHiringCafe
Founding Backend / Infra Engineer
Cupertino, CA, US
$160k-$300k/yr On-SiteFull Time
HiringCafe
HiringCafe: Building a 100× better job search engine to take on Indeed and LinkedIn.
Own the crawlers, pipelines, and infrastructure powering a real-time job search engine. Strong Node.js and Python fundamentals; bonus points for security and reverse-engineering chops.
Node.js, Python, Elasticsearch, Redis
Help us #BeatIndeed & #BeatLinkedIn
PromotedHiringCafe
Founding Full-stack / Product Engineer
Cupertino, CA, US
$130k-$300k/yr On-SiteFull Time
HiringCafe
HiringCafe: Building a 100× better job search engine to take on Indeed and LinkedIn.
Help us build a 100× better job search engine. We need a full-stack engineer with great taste, sharp fundamentals, and a track record of shipping polished product on React/Next.js plus a real backend (Firebase, Elasticsearch, Redis, Stripe).
React, Next.js, TypeScript, Firebase, Elasticsearch, Redis, Stripe
Help us #BeatIndeed & #BeatLinkedIn
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GenAI Python Systems Engineer –Senior Manager
Chicago or Raleigh or Charlotte or Cincinnati or Cleveland or Columbia or Columbus or Dallas or Baltimore or Richmond or Rosemont or Sacramento or Boston or St. Louis or Salt Lake City or San Antonio or San Diego or San Francisco or Silicon Valley or Seattle or Spartanburg or Albany or Stamford or Tampa or Atlanta or Toledo or Austin or Tulsa or Washington or Denver or Des Moines or Detroit or Buffalo or Florham Park or Kansas City or Las Vegas or Little Rock or Los Angeles or Louisville or Birmingham or Fayetteville or Miami or Milwaukee or Minneapolis or Nashville or New Orleans or New York or Oklahoma City or Philadelphia or Phoenix or Pittsburgh or Portland
$124k-$280k/yr HybridFull Time
PwC
PwC: Providing audit, tax, and management consulting services to businesses.
8+ YOESenior Manager level with 8+ years of experience; proficient in Python, SQL, FastAPI; cloud certifications a plus; willing to travel up to 80%; Bachelor's degree required.
Python, SQL, FastAPI, Cloud Platforms, LLM techniques, Data Warehousing, Data Lakes, IAM
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Python Test Automation Engineer
Los Angeles, California, United States
$140k-$150k/yr OnsiteFull Time
EPAM Systems
EPAM SystemsNYSE: EPAM: Provides global digital platform engineering and software development services.
Bachelor's in a relevant engineering or CS field; proven experience building Python-based test automation frameworks, robotic automation fixtures integration, Git/GitHub/GitLab, UNIX, and Jenkins; sensor validation experience; Master's degree preferred.
Python, UNIX, Jenkins, Git, GitHub, GitLab, CI/CD, Anthropic Claude, Claude Code, LinkedIn Learning
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Senior Electromechanical Engineer
El Segundo, California, United States
$151k-$227k/yr OnsiteFull Time
The Aerospace Corporation
The Aerospace Corporation: Provides technical expertise and research for national space programs.
10+ YOESenior electromechanical engineer with 10+ years in electromechanical control systems, verification, and space hardware; bachelor's in a STEM field; willing to obtain security clearance; able to travel up to 25%.
MATLAB/Simulink, LabVIEW, SolidWorks, C/C++, Python
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2mo
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Senior GNC Engineer
Moorpark, California, United States
$150k-$164k/yr OnsiteFull Time
Quantum-Systems
Quantum-Systems: Develops and manufactures autonomous AI-powered unmanned aerial systems.
5+ YOESenior GNC Engineer with 5+ years in drone flight dynamics, control, state estimation; lead GNC algorithms; U.S. citizen; potential security clearance; Moorpark office commute.
MATLAB, Simulink, Python, C/C++, PX4, ArduPilot, ROS/ROS2, Gazebo, PX4 SITL, MATLAB/Simulink, SITL
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Senior Software Automation and Controls Engineer - Python & PLCs
El Segundo, California, United States
$169k-$216k/yr OnsiteFull Time
Varda Space Industries
Varda Space Industries: Develops in-orbit manufacturing platforms and reentry capsules for pharmaceuticals.
5+ YOEBS in engineering, 5+ years in test automation or controls, strong Python, PLC and EtherCAT experience, industrial hardware integration, TwinCAT 3 or similar PLC ecosystems, hands-on electrical and systems commissioning.
Python, EtherCAT, Modbus, RS232, RS485, TwinCAT 3, Docker, Grafana, InfluxDB, IEC 61131-3
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3mo
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Senior Test Engineer, HITL
Los Angeles, California, United States
OnsiteFull Time
Observable Space
Observable Space: Developing integrated hardware and software for persistent space observation.
5+ YOE5+ years in test engineering, embedded systems, or systems-level development; strong C/C++/Python; experience with HITL/HIL testing; embedded interfaces; test automation and CI/CD.
C/C++, Python, I2C, SPI, UART, CAN, Ethernet, Oscilloscopes, Logic analyzers, Multimeters, Embedded Linux, RTOS
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Senior Product Software Engineer (Python)
San Francisco or Chicago or Los Angeles
$160k-$200k/yr HybridFull Time
Tyba
Tyba: AI software for modeling and operating renewable energy projects.
5+ YOE5+ years full-stack engineering experience; strong Python and React; production GraphQL experience; willingness to learn ClojureScript; familiarity with AI-assisted coding tools; strong cross-functional communication.
Python, React, GraphQL, Strawberry, ClojureScript, Cursor, Copilot, Claude Code, Warp Agent Mode, Recharts, ECharts, dbt, Snowflake, Redshift, PyTorch, AWS, PostgreSQL, Fulcro, Tailwind CSS, Clojure, Kotlin
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3mo
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Senior Process Engineer (Advanced R&D)
Los Angeles, California, United States
$140k-$200k/yr OnsiteFull Time
Freeform
Freeform: Deploys autonomous AI-powered metal 3D printing factories.
5+ YOESenior process engineer with 5+ years in complex physics-based process development; DOE, data analysis, and large data sets; materials science/physics/mechanical engineering.
MATLAB, Python, R, JMP, Minitab
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2mo
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Senior Software Engineer, AI
El Segundo or United States
$153k-$170k/yr RemoteFull Time
ImmunityBio
ImmunityBioNASDAQ: IBRX: Develops next-generation immunotherapies for cancer and infectious diseases.
7+ YOESenior software engineer with 7+ years of experience in Python/Typescript, AI agent frameworks, and production-grade systems.
Python, TypeScript, FastAPI, Docker, LangGraph, LangChain, CrewAI, LlamaIndex, Chroma, Milvus, Weaviate, Qdrant
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1mo
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Senior Test Engineer
El Segundo, California, United States
$140k-$197k/yr OnsiteFull Time
Radiant
Radiant: Designs and manufactures portable, mass-produced nuclear microreactors.
2+ YOEUndergraduate engineering degree; 2+ years in engineering problem-solving, design, analysis, or testing; strong hardware-software integration experience.
Python, UNIX, Procedures testing environments
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1mo
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Senior Mechanisms Engineer
Long Beach, California, United States
$132k-$182k/yr OnsiteFull Time
Relativity Space
Relativity Space: Designing and manufacturing 3D-printed rockets and launch vehicles.
5+ YOEBachelor's degree in engineering; 5+ years in full-cycle design engineering; CAD/analysis/build/test experience; knowledge of kinematic synthesis, actuation, mechatronics; strong structures and manufacturing understanding; hands-on hardware experience; good communication.
NX, TeamCenter, Ansys, Femap, Python, MATLAB
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2mo
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Senior Integration & Test Engineer
Los Angeles, California, United States
$140k-$175k/yr OnsiteFull Time
K2 Space
K2 Space: Develops high-power satellite platforms for heavy-lift launch vehicles.
5+ YOEBachelor’s in engineering; 5+ years integration/test/automation; 3+ years spacecraft testing; environmental testing experience; HITL/Flatsat experience; Python and/or Rust; Linux; contractual interfaces
Python, Rust, Linux, Electrical test equipment, HITL or Flatsat software verification testbeds
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Senior Simulation Engineer
Los Angeles, California, United States
$170k-$215k/yr OnsiteFull Time
Apex
Apex: Mass-manufactures standardized satellite buses for commercial and government use.
8+ YOE8+ years in closed-loop simulation tools (6DOF, SITL, HITL); BS in CS/CE/AE; MS a plus; proficient in C/C++, Rust, Python; Linux; Docker; CI/CD; experience with physics-based simulations.
C/C++, Rust, Python, Linux, Docker, CI/CD
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1mo
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Senior Software Engineer, Data Systems (Python)
Canada or United States or San Francisco or Los Angeles
$170k-$200k/yr RemoteFull Time
Northbeam
Northbeam: Marketing intelligence and attribution platform for eCommerce brands.
5+ YOE5+ years in data/software/integration engineering; strong Python, ETL, API/REST/GraphQL/Webhooks, auth flows; SQL and BigQuery; Airflow; Docker/Kubernetes; strong problem solving and observability skills.
Python, ETL, APIs, REST, GraphQL, Webhooks, OAuth 2.0, API keys, SQL, BigQuery, Airflow, Docker, Kubernetes
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3mo
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Senior Systems Engineer, Thermal & Fluid Dynamics
Hawthorne, California, United States
$140k-$200k/yr OnsiteFull Time
Critical Energy
Critical Energy: Builds modular power plants that convert heat into electricity.
5+ YOE5+ years in systems engineering with thermo-fluid modeling; CAD experience; Python; CFD; 1D thermo-fluid modeling; experience with heat exchangers, pumps, turbines preferred.
Siemens NX, Python, CAD, CFD, Aspen, Dymola, ANSYS, PFD, P&ID
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2mo
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Senior DevOps Engineer
Long Beach, California, United States
$159k-$268k/yr OnsiteFull Time
Vast
Vast: Develops and operates commercial artificial-gravity space stations.
3+ YOE3+ years in application development with Python/Go/JavaScript; large-scale data systems; Terraform; Docker/Kubernetes; networking; DevOps expertise.
Terraform, Docker, Kubernetes, Prometheus, Grafana, ELK, Kafka, SAST, SCA, CI/CD, Cloud, Linux Networking
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3mo
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Senior Avionics Engineer
Playa Vista, California, United States
$137k-$193k/yr OnsiteFull Time
Inversion Space
Inversion Space: Building autonomous re-entry vehicles for global space-to-Earth cargo delivery.
5+ YOE5+ years in design, build, and test of satellite/spacecraft flight hardware; PCB design; mixed-signal/digital design; RTL; C/C++, Python; Altium; fault-tolerant design; aerospace environment
Altium Designer, UART, I2C, SPI, RS422, RS485, CAN, PCIe, Ethernet, Oscilloscope, Multimeter, Power Supply, Spectrum Analyzer, Data Acquisition, PCB Design, Environmental Testing
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2mo
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Senior Data Engineer
Marina del Rey, California, United States
$160k-$180k/yr HybridFull Time
Zefr
Zefr: Provides AI-driven brand safety and suitability for social media.
8+ YOE8+ years in software/data engineering; dbt/SQL expert; strong Python; engineering degree; knowledge of systems engineering; strong communication.
dbt, SQL, Python, Snowflake, Airflow
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2mo
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Senior RF Test Engineer
Redondo Beach, California, United States
$135k-$180k/yr OnsiteFull Time
Impulse Space
Impulse Space: Developing in-space transportation services and orbital transfer vehicles.
5+ YOEBachelor's in EE/CE/Physics; 5+ years Python for RF test; hands-on RF lab experience; RF measurements; test procedures; lab troubleshooting and lab integration.
spectrum analyzer, network analyzer, signal generator, oscilloscope, GNSS simulator, Software-defined radio, GNU Radio, embedded Linux, Python
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3mo
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Senior Data Engineer
Chicago or Los Angeles or New York or Seattle
$160k-$220k/yr OnsiteFull Time
Metropolis
Metropolis: Computer vision technology for checkout-free parking and retail payments.
5+ YOE5+ years in data engineering, Python, SQL, Snowflake/dbt; cloud experience; Bachelor's in CS/Engineering; Masters preferred; on-site four days a week.
Python, SQL, Snowflake, dbt, Airflow, AWS, Glue, MWAA, DMS, EKS, SNS, Spark, PySpark
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