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302 senior python developer jobs at 92 companies in Lancaster, PA

PromotedHiringCafe
Founding Backend / Infra Engineer
Cupertino, CA, US
$160k-$300k/yr On-SiteFull Time
HiringCafe
HiringCafe: Building a 100× better job search engine to take on Indeed and LinkedIn.
Own the crawlers, pipelines, and infrastructure powering a real-time job search engine. Strong Node.js and Python fundamentals; bonus points for security and reverse-engineering chops.
Node.js, Python, Elasticsearch, Redis
Help us #BeatIndeed & #BeatLinkedIn
PromotedHiringCafe
Founding Full-stack / Product Engineer
Cupertino, CA, US
$130k-$300k/yr On-SiteFull Time
HiringCafe
HiringCafe: Building a 100× better job search engine to take on Indeed and LinkedIn.
Help us build a 100× better job search engine. We need a full-stack engineer with great taste, sharp fundamentals, and a track record of shipping polished product on React/Next.js plus a real backend (Firebase, Elasticsearch, Redis, Stripe).
React, Next.js, TypeScript, Firebase, Elasticsearch, Redis, Stripe
Help us #BeatIndeed & #BeatLinkedIn
3d
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Python API Developer
Malvern, Pennsylvania, United States
$110k-$120k/yr OnsiteFull Time
Tata Consultancy Services
Tata Consultancy ServicesNational Stock Exchange of India: TCS: Global provider of IT services, consulting, and business solutions.
10+ YOEDesign and maintain REST APIs with Python and AWS Lambda; integrate with Amazon Aurora and DynamoDB; manage DB migrations with Liquibase; 10+ years experience and Bachelors in Computer Science required.
Python, Lambda, Aurora, DynamoDB, Liquidbase, CI/CD
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3mo
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Senior Software Developer
Aberdeen, Maryland, United States
$104k-$181k/yr OnsiteFull Time
Parsons
ParsonsNYSE: PSN: Provides engineering and technology services for infrastructure and defense.
5+ YOEDesign, develop, and implement software across multiple languages; lead components; troubleshoot; mentor and guide developers; ensure secure, maintainable results. Must be a US citizen with SECRET clearance.
Python, C++, Java, C#, Go, Docker, Kubernetes, CI/CD
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2mo
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AI Platform Engineer, Python - Principal Software Engineer
Wilmington or Jersey City
$204k-$285k/yr OnsiteFull Time
JPMorgan Chase
JPMorgan ChaseNYSE: JPM: Global financial services firm providing banking and investment solutions.
7+ YOE7+ years software engineering, cloud DevOps, Python expertise, secure production code delivery.
Python, Terraform
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2w
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Senior AI Engineer
United States or Wilmington
$126k-$197k/yr RemoteFull Time
Chemours
ChemoursNYSE: CC: Manufactures specialty chemicals, refrigerants, and high-performance industrial fluoropolymers.
8+ YOEDegree in Computer Science/Engineering, 8+ years backend development with Python and JavaScript, 2+ years production GenAI systems experience, React/TypeScript UI skills, Pydantic proficiency, strong stakeholder communication.
Python, JavaScript, React.js, TypeScript, HTML, Pydantic, PyTorch, Azure, Azure Kubernetes, Office 365, GitHub
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3w
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SENIOR SOFTWARE DEVELOPER/ENGINEER (CLOUD/CYBER)
Huntsville or Aberdeen or Colorado Springs or Crestview or Tupelo
OnsiteFull Time
Sentry Construction
Sentry Construction: Provides general contracting and comprehensive property maintenance services.
7+ YOEBS in CS/Software Eng or equivalent, 7+ years software development experience, DoD Top Secret/SCI eligibility, experience with Python, containers, AI/LLMs, databases, Linux, AWS, and Agile/Scrum.
LLMs, Ollama, LM Studio, Python, C#, Go Lang, React, JavaScript, HTML, CSS, Git, Docker, Bash, TensorFlow, PyTorch, SQL, MongoDB, PostgreSQL, Redis, Linux, AWS, RESTful API, Agile/Scrum
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2mo
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Lead Software Engineer II – Java & Python
Wilmington, Delaware, United States
$100k-$135k/yr RemoteMultiple Commitments Available
Best Egg
Best Egg: Provides personal loans and credit cards for prime borrowers.
4+ YOE4-6 years professional software engineering; strong backend Java and Python; SQL/data modeling; AWS; DynamoDB, RDS, PostgreSQL; CI/CD; Docker; ECS/EKS; CloudWatch/Datadog; excellent communication and collaboration.
AWS, Docker, Kubernetes, ECS, EKS, CloudWatch, Datadog, DynamoDB, RDS, PostgreSQL, DocumentDB, CI/CD
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2mo
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Senior Data Engineer
Philadelphia or Aurora or King of Prussia
$82k-$172k/yr OnsiteFull Time
CACI
CACINYSE: CACI: Provides information technology and professional services to government clients.
5+ YOE5+ years in data engineering/science with TS/SCI clearance; BS in data science/CS; experience building data pipelines and using Python data libraries; experience with git.
Python, NumPy, Pandas, Polars, Git, Docker, Docker Compose, AWS, Spark, PySpark, Linux, CUDA
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1mo
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Senior Systems Engineer
Wilmington, Delaware, United States
RemoteFull Time
CSC
CSC: Provides global business administration and compliance solutions.
10+ YOE10+ years as a Network Engineer; expertise with Cisco, F5, Palo Alto, Infoblox, Zscaler ZPA, Azure Cloud, ISE, SD-WAN; CCNP/CCIE desirable; scripting in Ansible and Python.
Cisco routing and switching, Nexus, ACI, AWAF, Infoblox, Zscaler ZPA, Azure Cloud, ISE, SDWAN, Ansible, Python, F5, Palo Alto, VPN, TCP/IP, BGP, OSPF, EIGRP, MPLS
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2mo
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Senior Cybersecurity Engineer
Towson, Maryland, United States
$106k-$175k/yr OnsiteFull Time
Sheppard Pratt
Sheppard Pratt: Provides comprehensive mental health and addiction treatment services.
7+ YOEBachelor’s in cybersecurity/IT or related; 7+ years cybersecurity engineering; strong Microsoft security platform experience; hybrid AD/Azure; scripting with PowerShell, Python, or KQL; knowledge of NIST/CIS/ISO 27001.
Microsoft Defender, Sentinel, Purview, PowerShell, Python, KQL
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2mo
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Senior Cybersecurity Engineer
Towson, Maryland, United States
$51-$84/hr OnsiteFull Time
Sheppard Pratt
Sheppard Pratt: Provides comprehensive mental health, education, and social services.
7+ YOEBachelor's in cybersecurity/IT or related field, 7+ years cybersecurity engineering, strong Microsoft security platform experience, hybrid AD/Azure, scripting (PowerShell, Python, KQL), knowledge of NIST/CIS/ISO 27001.
Microsoft Defender, Microsoft Sentinel, Microsoft Purview, PowerShell, Python, KQL
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2d
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Senior DevSecOps Engineer
King of Prussia, Pennsylvania, United States
$97k-$171k/yr OnsiteFull Time
Lockheed Martin
Lockheed MartinNYSE: LMT: Designs and manufactures global security and aerospace systems.
US citizen with ability to obtain Secret clearance; experience with microservices, containerization, Linux/Windows administration, CI/CD DevSecOps, scripting (Bash/Python/Ansible/PowerShell), git/GitLab, and classified infrastructure support.
Kubernetes, VMWare, Linux, RHEL, RockyOS, Microsoft Windows, Git, GitLab, Bash, Python, Ansible, YAML, PowerShell, Vault
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2mo
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Senior Mechanical Engineer 1 - Nuclear
Wilmington, Delaware, United States
$85k-$129k/yr OnsiteFull Time
Sargent & Lundy
Sargent & Lundy: Engineering and consulting services for the power industry.
5+ YOESenior mechanical engineer with 5+ years in power industry; ABET-accredited BS or MS in Mechanical or Chemical Engineering; knowledge of nuclear plant codes and design; capable of leading automation and AI-enabled workflows.
Python, MATLAB, Excel
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1mo
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Sr. Software Engineer
Wayne or Naperville
$120k-$135k/yr HybridFull Time
Frontline Education
Frontline EducationNYSE: ROP: Provides administrative and management software for K-12 school districts.
5+ YOE5–7 years backend engineering or intelligent systems with production impact; strong Python, CI/CD, and system design; experience with ML model APIs and cloud inference; familiarity with vector databases and retrieval systems.
Python, CI/CD, AWS Bedrock, Azure OpenAI, Google Vertex AI, PyTorch, Hugging Face Transformers, vLLM, FAISS, Pinecone, OpenSearch/KNN, LangChain, LlamaIndex, MLflow, Weights & Biases, Prometheus
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18h
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Senior Applied AI Engineer
Malvern, Pennsylvania, United States
HybridFull Time
Akuvo
Akuvo: Provides AI-powered collections and credit risk software for financial institutions.
6+ YOE6+ years software engineering experience, strong Python, 2+ years shipping LLM/generative-AI/agent capabilities, experience with evaluation/observability, cloud AI platforms, and translating workflows into scalable designs.
AKUVO IQ, Python, Microsoft Foundry, Azure OpenAI, Microsoft Agent Framework, LangGraph, Semantic Kernel
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4d
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Senior Software Engineer Applied AI
Harrisburg or United States
RemoteFull Time
AMC Health
AMC Health: Provides remote patient monitoring and virtual care technology.
7+ YOE7+ years building and operating production backend systems, strong Python skills, distributed systems/cloud experience, hands-on LLM/generative AI and traditional ML lifecycle experience, disciplined data handling in regulated environments.
Python, AWS, LLM
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1mo
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Software Developer
Belcamp, Maryland, United States
$83k-$140k/yr OnsiteFull Time
ManTech
ManTech: Provides technology solutions for defense and intelligence agencies.
10+ YOEBSc and 10+ years software development experience, U.S. citizenship with active Secret clearance, proficiency with Java/Python/C#/JavaScript, Linux/Windows experience, testing and documentation skills, DoD experience preferred.
Java, Python, C#, JavaScript, Linux, Windows
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1mo
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Senior Lead Data Engineer (Bank Tech)
Wilmington or McLean
$209k-$239k/yr OnsiteFull Time
Capital One
Capital OneNYSE: COF: Financial services offering credit cards, banking, and loans.
6+ YOEBachelor’s degree; 6+ years in application development; 2+ years in big data; 1+ year in cloud computing (AWS/Azure/GCP).
Python, Java, SQL, NoSQL, Redshift, Snowflake, AWS, Azure, GCP, Hadoop, Kafka, Spark
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3mo
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1650 - Software Developer
Belcamp, Maryland, United States
$83k-$140k/yr OnsiteFull Time
Sigma Defense: Develops tactical communications and intelligence systems for defense.
10+ YOE10+ years in software development; 5+ years DoD software support; strong requirements analysis, architecture, and coding skills; Java, Python, C#, and JavaScript; ability to document software; U.S. citizen; Secret security clearance or higher; Bachelor's Science degree.
Java, Python, C#, JavaScript
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1w
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DevSecOps Engineer
Sparks, Maryland, United States
$96k-$153k/yr OnsiteFull Time
BD
BDNYSE: BDX: Manufactures medical devices, surgical instruments, and pharmacy automation systems.
5+ YOEBachelor's in CS or STEM,5+ years software development,DevOps and CI/CD experience,experience with Terraform/IaC,cloud platforms (AWS/Azure/GCP),containerization,security tooling,proficiency in C# and Python.
Terraform, OpenTofu, Arm, Bicep, Ansible, Pulumi, Jenkins, GitLab CI, CircleCI, AWS, Azure, Google Cloud, Docker, Kubernetes, SonarCloud, OWASP ZAP, C#, Python, SQL, PowerShell
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2mo
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Full Stack Developer & AI/ML Engineer - Vision AI
Royersford, Pennsylvania, United States
OnsiteFull Time
Proconex
Proconex: Provider of industrial automation and process control solutions.
10+ YOE10+ years software development experience, strong computer vision and ML expertise, edge deployment experience, proficiency in Python and TypeScript, familiarity with modern ML frameworks and GPU acceleration, supervisory experience preferred.
Python, TypeScript, PyTorch, TensorFlow, Keras, Mask R-CNN, ResNet, U-Net, OpenCV, ONNX, CUDA, cuDNN
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