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466 senior python developer jobs at 163 companies in Reading, PA

PromotedHiringCafe
Founding Backend / Infra Engineer
Cupertino, CA, US
$160k-$300k/yr On-SiteFull Time
HiringCafe
HiringCafe: Building a 100× better job search engine to take on Indeed and LinkedIn.
Own the crawlers, pipelines, and infrastructure powering a real-time job search engine. Strong Node.js and Python fundamentals; bonus points for security and reverse-engineering chops.
Node.js, Python, Elasticsearch, Redis
Help us #BeatIndeed & #BeatLinkedIn
PromotedHiringCafe
Founding Full-stack / Product Engineer
Cupertino, CA, US
$130k-$300k/yr On-SiteFull Time
HiringCafe
HiringCafe: Building a 100× better job search engine to take on Indeed and LinkedIn.
Help us build a 100× better job search engine. We need a full-stack engineer with great taste, sharp fundamentals, and a track record of shipping polished product on React/Next.js plus a real backend (Firebase, Elasticsearch, Redis, Stripe).
React, Next.js, TypeScript, Firebase, Elasticsearch, Redis, Stripe
Help us #BeatIndeed & #BeatLinkedIn
3d
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Python API Developer
Malvern, Pennsylvania, United States
$110k-$120k/yr OnsiteFull Time
Tata Consultancy Services
Tata Consultancy ServicesNational Stock Exchange of India: TCS: Global provider of IT services, consulting, and business solutions.
10+ YOEDesign and maintain REST APIs with Python and AWS Lambda; integrate with Amazon Aurora and DynamoDB; manage DB migrations with Liquibase; 10+ years experience and Bachelors in Computer Science required.
Python, Lambda, Aurora, DynamoDB, Liquidbase, CI/CD
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1mo
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Senior Python Development Lead
Philadelphia, Pennsylvania, United States
OnsiteFull Time
Brown Brothers Harriman
Brown Brothers Harriman: Providing global investment management, custody, and private banking services.
15+ YOE5+ Mgmt15+ years in data engineering/software development; Python/Django; ETL pipelines; data visualization; Agile; Linux; security; leads 5-6 juniors
Python, Django, SQL, Bash, JavaScript, Plotly Dash, D3.js, AG Grid, Apache Airflow, FastAPI, Linux, Git, CI/CD
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2mo
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Senior Software Engineer - Python - 1099
Conshohocken, Pennsylvania, United States
RemoteTemporary
Syzygy Integration
Syzygy Integration: Develops situational awareness and tactical communication technology for defense.
10+ YOE10+ years full stack experience; Python; remote US-based role; must pass background check; U.S. citizen.
Python
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1mo
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GenAI Python Systems Engineer –Senior Manager
Chicago or Raleigh or Charlotte or Cincinnati or Cleveland or Columbia or Columbus or Dallas or Baltimore or Richmond or Rosemont or Sacramento or Boston or St. Louis or Salt Lake City or San Antonio or San Diego or San Francisco or Silicon Valley or Seattle or Spartanburg or Albany or Stamford or Tampa or Atlanta or Toledo or Austin or Tulsa or Washington or Denver or Des Moines or Detroit or Buffalo or Florham Park or Kansas City or Las Vegas or Little Rock or Los Angeles or Louisville or Birmingham or Fayetteville or Miami or Milwaukee or Minneapolis or Nashville or New Orleans or New York or Oklahoma City or Philadelphia or Phoenix or Pittsburgh or Portland
$124k-$280k/yr HybridFull Time
PwC
PwC: Providing audit, tax, and management consulting services to businesses.
8+ YOESenior Manager level with 8+ years of experience; proficient in Python, SQL, FastAPI; cloud certifications a plus; willing to travel up to 80%; Bachelor's degree required.
Python, SQL, FastAPI, Cloud Platforms, LLM techniques, Data Warehousing, Data Lakes, IAM
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2w
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Python Developer- Quant Core Data | Experienced Hire
Bala Cynwyd, Pennsylvania, United States
OnsiteFull Time
Susquehanna International Group
Susquehanna International Group: Global quantitative trading firm specializing in proprietary financial markets.
PhD or postdoc in a quantitative field, strong high-performance Python (Cython/pybind11/numba) and large-data analysis (polars/pandas) skills, ability to translate research into production-quality code.
Python, Cython, pybind11, numba, polars, pandas
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2w
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Python Developer- Quant Core Data | Experienced Hire
Bala Cynwyd, Pennsylvania, United States
OnsiteFull Time
Susquehanna International Group
Susquehanna International Group: Global quantitative trading and market making firm.
PhD or postdoc in a quantitative field, strong high-performance Python skills (Cython/pybind11/numba), experience with large-data analysis (polars/pandas), and ability to translate research into robust engineering solutions.
Python, Cython, pybind11, Numba, polars, pandas
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2w
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Python Developer- Quant Core Data | Experienced Hire
Bala Cynwyd, Pennsylvania, United States
OnsiteFull Time
Susquehanna International Group
Susquehanna International Group: Global quantitative trading firm providing proprietary financial market liquidity.
PhD (by Summer 2026) or postdoc in a quantitative field; experience writing high-performance Python (Cython, pybind11, numba) and data analysis with polars/pandas for large datasets; ability to translate research into robust engineering solutions.
Python, Cython, pybind11, numba, polars, pandas
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2mo
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AI Platform Engineer, Python - Principal Software Engineer
Wilmington or Jersey City
$204k-$285k/yr OnsiteFull Time
JPMorgan Chase
JPMorgan ChaseNYSE: JPM: Global financial services firm providing banking and investment solutions.
7+ YOE7+ years software engineering, cloud DevOps, Python expertise, secure production code delivery.
Python, Terraform
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2mo
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Senior Software Engineer, Backend
Philadelphia, Pennsylvania, United States
$160k-$210k/yr OnsiteFull Time
Perpay
Perpay: Financial platform offering interest-free shopping and credit building via payroll.
5+ YOE5+ years web apps; 2+ years leading teams; PostgreSQL; AWS; Docker/Kubernetes; Python/Django or Rails; strong communication.
JavaScript, Python, Django, Flask, React, React Native, Redux, Kubernetes, AWS, Docker, Celery, Redis, Datadog, CloudWatch
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3mo
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Senior Software Developer
Conshohocken or Portland or Bucharest or Ia\u00021si or Barcelona or Tokyo or United States
OnsiteFull Time
Suvoda
Suvoda: Software for clinical trial randomization and patient data collection.
6+ YOE6+ years software development experience, deep Python, relational databases and AWS experience, EMR not stated, Django and Angular preferred, bachelor's or equivalent experience, production-support mindset.
Python, Django, Angular, AWS, Claude Code
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2w
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Senior AI Engineer
United States or Wilmington
$126k-$197k/yr RemoteFull Time
Chemours
ChemoursNYSE: CC: Manufactures specialty chemicals, refrigerants, and high-performance industrial fluoropolymers.
8+ YOEDegree in Computer Science/Engineering, 8+ years backend development with Python and JavaScript, 2+ years production GenAI systems experience, React/TypeScript UI skills, Pydantic proficiency, strong stakeholder communication.
Python, JavaScript, React.js, TypeScript, HTML, Pydantic, PyTorch, Azure, Azure Kubernetes, Office 365, GitHub
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2w
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Senior ServiceNow Engineer
Reston or Philadelphia
OnsiteFull Time
Comcast
ComcastNASDAQ: CMCSA: Provides global telecommunications, media content, and entertainment services.
7+ YOE7+ years delivering enterprise IT/software solutions with 3+ years hands-on ServiceNow development; experience with ITSM, CMDB, TSOM, telecom integrations, Python/scripting, CI/CD, and platform modernization. Bachelor's preferred; ServiceNow certifications preferred.
Python, Scripting, ServiceNow IT Service Management (ITSM), ServiceNow Platform, ServiceNow Platform Architecture, TSOM, TNI, NOW Assist, CMDB, Service Portal, GitHub, DevSecOps, CI/CD, Spec Driven Development
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2mo
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Lead Software Engineer II – Java & Python
Wilmington, Delaware, United States
$100k-$135k/yr RemoteMultiple Commitments Available
Best Egg
Best Egg: Provides personal loans and credit cards for prime borrowers.
4+ YOE4-6 years professional software engineering; strong backend Java and Python; SQL/data modeling; AWS; DynamoDB, RDS, PostgreSQL; CI/CD; Docker; ECS/EKS; CloudWatch/Datadog; excellent communication and collaboration.
AWS, Docker, Kubernetes, ECS, EKS, CloudWatch, Datadog, DynamoDB, RDS, PostgreSQL, DocumentDB, CI/CD
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2mo
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Senior Data Engineer
Philadelphia or Aurora or King of Prussia
$82k-$172k/yr OnsiteFull Time
CACI
CACINYSE: CACI: Provides information technology and professional services to government clients.
5+ YOE5+ years in data engineering/science with TS/SCI clearance; BS in data science/CS; experience building data pipelines and using Python data libraries; experience with git.
Python, NumPy, Pandas, Polars, Git, Docker, Docker Compose, AWS, Spark, PySpark, Linux, CUDA
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1mo
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Senior Systems Engineer
Wilmington, Delaware, United States
RemoteFull Time
CSC
CSC: Provides global business administration and compliance solutions.
10+ YOE10+ years as a Network Engineer; expertise with Cisco, F5, Palo Alto, Infoblox, Zscaler ZPA, Azure Cloud, ISE, SD-WAN; CCNP/CCIE desirable; scripting in Ansible and Python.
Cisco routing and switching, Nexus, ACI, AWAF, Infoblox, Zscaler ZPA, Azure Cloud, ISE, SDWAN, Ansible, Python, F5, Palo Alto, VPN, TCP/IP, BGP, OSPF, EIGRP, MPLS
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1mo
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Senior Cloud Engineer
Barcelona or Batumi or Tbilisi or Philadelphia
HybridFull Time
MIGx
MIGx: Provides specialized IT consulting and digital transformation for life sciences.
6+ YOE6+ years cloud infrastructure deployment; 5+ years Linux engineering; AWS/Azure/Google Cloud; AWS Solutions Architect Professional; Bash/Shell scripting; Ansible, Chef, Terraform; Slurm/DRM; Python/R; Git/BitBucket.
AWS, Azure, Google Cloud, Ansible, Chef, Terraform, CFN, Slurm, Python, R, Shell scripting, Git, Bitbucket
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2mo
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Senior Database Engineer - Platform Engineering
Philadelphia, Pennsylvania, United States
RemoteFull Time
IntegriChain
IntegriChain: Provides data and applications for pharmaceutical therapy commercialization.
7+ YOE7+ years in database/platform engineering; multi-engine experience; cloud data platforms; IaC and CI/CD emphasis.
AWS, RDS, Aurora, DynamoDB, Redshift, Snowflake, Azure SQL, PostgreSQL, Kinesis, MSK, Glue, Lake Formation, dbt, Airflow, Terraform, AWS CDK, GitHub Actions, CodePipeline, Python, SQL, boto3, OpenSearch, DocumentDB, ElastiCache, SageMaker, Bedrock, pgvector, LLM
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Senior DevSecOps Engineer
King of Prussia, Pennsylvania, United States
$97k-$171k/yr OnsiteFull Time
Lockheed Martin
Lockheed MartinNYSE: LMT: Designs and manufactures global security and aerospace systems.
US citizen with ability to obtain Secret clearance; experience with microservices, containerization, Linux/Windows administration, CI/CD DevSecOps, scripting (Bash/Python/Ansible/PowerShell), git/GitLab, and classified infrastructure support.
Kubernetes, VMWare, Linux, RHEL, RockyOS, Microsoft Windows, Git, GitLab, Bash, Python, Ansible, YAML, PowerShell, Vault
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2w
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Senior AI Engineer
Philadelphia or Pennsylvania or New Jersey or Delaware or Maryland or Texas or Georgia or Iowa or Illinois or Indiana or Kansas or North Carolina or South Carolina or Tennessee or Vermont or West Virginia
$146k-$182k/yr HybridFull Time
NBME
NBME: Develops and manages medical licensing and healthcare professional assessments.
5+ YOEBachelor's or Master's in CS/Engineering/Data Science, 5+ years AI/ML engineering experience, proficiency with Python, PyTorch, TensorFlow, Hugging Face Transformers, cloud (AWS/GCP/Azure), Docker, Kubernetes, and familiarity with vector DBs and embeddings.
Python, PyTorch, TensorFlow, Hugging Face Transformers, AWS, GCP, Azure, Docker, Kubernetes
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2mo
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Senior Mechanical Engineer 1 - Nuclear
Wilmington, Delaware, United States
$85k-$129k/yr OnsiteFull Time
Sargent & Lundy
Sargent & Lundy: Engineering and consulting services for the power industry.
5+ YOESenior mechanical engineer with 5+ years in power industry; ABET-accredited BS or MS in Mechanical or Chemical Engineering; knowledge of nuclear plant codes and design; capable of leading automation and AI-enabled workflows.
Python, MATLAB, Excel
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